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Dynamics of avian influenza in a changing world

Objective

DELTA-FLU aims to determine the key viral, host-related, and environmental factors that determine the dynamics of avian influenza (AI) in poultry and other host species, with the goal of improving prevention and control strategies against this disease. As a result of rapidly changing dynamics, AI continues to cause unexpected and devastating outbreaks in poultry in the EU, as well as world-wide. Its potential to become pandemic is also of great concern to public health. The key viral, host-related, and environmental factors that drive AI dynamics are poorly understood, which currently impedes the development of effective control and prevention strategies. As the problems caused by AI require global solutions, DELTA-FLU is a consortium with top-level experts from Europe, North America, and Asia. Through interdisciplinary research focused on key questions of AI, DELTA-FLU will determine 1) potential for some highly pathogenic avian influenza viruses (HPAIV, e.g. H5N8 clade 2.3.4.4) to be maintained in wild bird populations and spread over long-distances, 2) key viral, host, and environmental factors for incursion of HPAIV from wild birds into poultry holdings, 3) roles of viral, host, and environmental factors in the transition of low pathogenic avian influenza virus to HPAIV in poultry, 4) effect of flock immunity against AI on early detection and viral genetic drift, and 5) viral genetic factors that allow reassortants of avian and mammalian influenza viruses to transmit efficiently among pigs. Primary sectors and end-users are involved through participation in the Multi-Actor Panel, which will also play an important role in the translation of the results into effective prevention and control strategies. As such, DELTA-FLU will make significant advances in knowledge of AIV dynamics and provide the evidence base for improved diagnosis, prevention, and control strategies for AI in poultry, as well as for reducing the possible risk of AI to become potentially pandemic.

Call for proposal

H2020-SFS-2016-2
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Coordinator

FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Address
Sudufer 10
17493 Greifswald-insel Riems
Germany
Activity type
Research Organisations
EU contribution
€ 1 425 000

Participants (8)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 1 187 500
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
EU contribution
€ 687 500
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE
Italy
EU contribution
€ 625 000
Address
Viale Dell Universita 10
35020 Legnaro
Activity type
Other
UNIVERSITEIT GENT
Belgium
EU contribution
€ 524 611,25
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 524 385
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
LINNEUNIVERSITETET
Sweden
EU contribution
€ 523 797,50
Address
Linnaeus University
35195 Vaxjo
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF HONG KONG
Hong Kong
EU contribution
€ 0
Address
Pokfulam Road
Pokfulam
Activity type
Higher or Secondary Education Establishments
UNITED STATES DEPARTMENT OF AGRICULTURE
United States
EU contribution
€ 0
Address
Independence Ave. S.w. 1400
DC 20250 Washington
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)