Towards enduring mouse resources and services advancing research into human health and disease

Project Information

INFRAFRONTIER2020

Grant agreement ID: 730879

DOI

10.3030/730879

Project closed

EC signature date 14 December 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - Research Infrastructures

Total cost

€ 4 968 252,16

EU contribution

€ 4 955 877,16

Coordinated by

INFRAFRONTIER GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data management plan

Documents, reports (5)

INFRAFRONTIER annual conferences
Funder conference
Midterm review meeting
INFRAFRONTIER Advanced Training Schools
Publication outlining a common INFRAFRONTIER quality management framework

A Position Paper outlining a common INFRAFRONTIER quality management framework and highlighting common quality principles in mouse phenotyping and EMMA archiving

Other (7)

Production of 22 genome-edited mouse models

Production of 22 genomeedited mouse models

INFRAFRONTIER Business Plan 2.0

INFRAFRONTIER Business Plan 20

Derivation of 10 germ-free mouse lines

Derivation of 10 germfree mouse lines

Characterisation of 5 anti-viral therapeutics in preclinical COVID-19 mouse models

Characterisation of 5 antiviral therapeutics in preclinical COVID19 mouse models

Secondary phenotyping analysis of 15 mouse models
Production of 6 genome-edited rat models

Production of 6 genomeedited rat models

Systemic late onset phenotyping analysis of 4 mutant mouse lines

Systemic late onset phenotyping analysis of 5 mutant mouse lines

Websites, patent fillings, videos etc. (2)

Bibliography of publications using INFRAFRONTIER resources
List of validated mouse models of human diseases

Publications

Peer reviewed articles (5)

INFRAFRONTIER quality principles in systemic phenotyping.

Author(s): Hilke Ehlich; Heather L. Cater; Ann M. Flenniken; Isabelle Goncalves Da Cruz; Anne-Marie Mura; Vasileios Ntafis; Michael Raess; Mohammed Selloum; Claudia Stoeger; Sarka Suchanova; Reetta Vuolteenaho; Steve D. M. Brown; Yann Hérault; Reetta Hinttala; Martin Hrabě de Angelis; George Kollias; Dimitris L. Kontoyiannis; Bernard Malissen; Colin McKerlie; Radislav Sedláček; Sara E. Wells; Ana Zarubic
Published in: Mammalian Genome, Issue 1, 2021, ISSN 0938-8990
Publisher: Springer Verlag
DOI: 10.1007/s00335-021-09892-2

Modelling physical resilience in ageing mice

Author(s): Schosserer, Markus; Banks, Gareth; Dogan, Soner; Dungel, Peter; Fernandes, Adelaide; Marolt Presen, Darja; Matheu, Ander; Osuchowski, Marcin; Potter, Paul; Sanfeliu, Coral; Tuna, Bilge Guvenc; Varela-Nieto, Isabel; Bellantuono, Ilaria
Published in: Mechanisms of Ageing and Development, Issue 4, 2019, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2018.10.001

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

Author(s): Lee Mulderrig, Juan I. Garaycoechea, Zewen K. Tuong, Christopher L. Millington, Felix A. Dingler, John R. Ferdinand, Liam Gaul, John A. Tadross, Mark J. Arends, Stephen O’Rahilly, Gerry P. Crossan, Menna R. Clatworthy & Ketan J. Patel
Published in: Nature, 2021, ISSN 1476-4687
Publisher: Springer Nature Limited
DOI: 10.1038/s41586-021-04133-7

A toolbox for the longitudinal assessment of healthspan in aging mice

Author(s): I. Bellantuono, R. de Cabo, D. Ehninger, C. Di Germanio, A. Lawrie, J. Miller, S. J. Mitchell, I. Navas-Enamorado, P. K. Potter, T. Tchkonia, J. L. Trejo & D. W. Lamming
Published in: Nature Protocols, 2020, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0256-1

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

Author(s): Henning Jacobsen, Kerstin Walendy-Gnirß, Nilgün Tekin-Bubenheim, Nancy Mounogou Kouassi, Isabel Ben-Batalla, Nikolaus Berenbrok, Martin Wolff, Vinicius Pinho dos Reis, Martin Zickler, Lucas Scholl, Annette Gries, Hanna Jania, Andreas Kloetgen, Arne Düsedau, Gundula Pilnitz-Stolze, Aicha Jeridi, Ali Önder Yildirim, Helmut Fuchs, Valerie Gailus-Durner, Claudia Stoeger, Martin Hrabe de Angelis, T
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25220-3