Towards enduring mouse resources and services advancing research into human health and disease

Informations projet

INFRAFRONTIER2020

N° de convention de subvention: 730879

DOI 10.3030/730879

Projet clôturé

Date de signature de la CE 14 Decembre 2016

Date de début 1 Janvier 2017

Date de fin 31 Decembre 2021

Financé au titre de

• EXCELLENT SCIENCE - Research Infrastructures

Coût total € 4 968 252,16

Contribution de l’UE € 4 955 877,16

Coordonné par

INFRAFRONTIER GMBH
Germany

Livrables

Open Research Data Pilot (1)

Data management plan

Documents, reports (5)

INFRAFRONTIER annual conferences
Funder conference
Midterm review meeting
INFRAFRONTIER Advanced Training Schools
Publication outlining a common INFRAFRONTIER quality management framework

A Position Paper outlining a common INFRAFRONTIER quality management framework and highlighting common quality principles in mouse phenotyping and EMMA archiving

Other (7)

Production of 22 genome-edited mouse models

Production of 22 genomeedited mouse models

INFRAFRONTIER Business Plan 2.0

INFRAFRONTIER Business Plan 20

Derivation of 10 germ-free mouse lines

Derivation of 10 germfree mouse lines

Characterisation of 5 anti-viral therapeutics in preclinical COVID-19 mouse models

Characterisation of 5 antiviral therapeutics in preclinical COVID19 mouse models

Secondary phenotyping analysis of 15 mouse models
Production of 6 genome-edited rat models

Production of 6 genomeedited rat models

Systemic late onset phenotyping analysis of 4 mutant mouse lines

Systemic late onset phenotyping analysis of 5 mutant mouse lines

Websites, patent fillings, videos etc. (2)

Bibliography of publications using INFRAFRONTIER resources
List of validated mouse models of human diseases

Publications

Peer reviewed articles (5)

INFRAFRONTIER quality principles in systemic phenotyping.

Auteurs: Hilke Ehlich; Heather L. Cater; Ann M. Flenniken; Isabelle Goncalves Da Cruz; Anne-Marie Mura; Vasileios Ntafis; Michael Raess; Mohammed Selloum; Claudia Stoeger; Sarka Suchanova; Reetta Vuolteenaho; Steve D. M. Brown; Yann Hérault; Reetta Hinttala; Martin Hrabě de Angelis; George Kollias; Dimitris L. Kontoyiannis; Bernard Malissen; Colin McKerlie; Radislav Sedláček; Sara E. Wells; Ana Zarubic
Publié dans: Mammalian Genome, Numéro 1, 2021, ISSN 0938-8990
Éditeur: Springer Verlag
DOI: 10.1007/s00335-021-09892-2

Modelling physical resilience in ageing mice

Auteurs: Schosserer, Markus; Banks, Gareth; Dogan, Soner; Dungel, Peter; Fernandes, Adelaide; Marolt Presen, Darja; Matheu, Ander; Osuchowski, Marcin; Potter, Paul; Sanfeliu, Coral; Tuna, Bilge Guvenc; Varela-Nieto, Isabel; Bellantuono, Ilaria
Publié dans: Mechanisms of Ageing and Development, Numéro 4, 2019, ISSN 0047-6374
Éditeur: Elsevier BV
DOI: 10.1016/j.mad.2018.10.001

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

Auteurs: Lee Mulderrig, Juan I. Garaycoechea, Zewen K. Tuong, Christopher L. Millington, Felix A. Dingler, John R. Ferdinand, Liam Gaul, John A. Tadross, Mark J. Arends, Stephen O’Rahilly, Gerry P. Crossan, Menna R. Clatworthy & Ketan J. Patel
Publié dans: Nature, 2021, ISSN 1476-4687
Éditeur: Springer Nature Limited
DOI: 10.1038/s41586-021-04133-7

A toolbox for the longitudinal assessment of healthspan in aging mice

Auteurs: I. Bellantuono, R. de Cabo, D. Ehninger, C. Di Germanio, A. Lawrie, J. Miller, S. J. Mitchell, I. Navas-Enamorado, P. K. Potter, T. Tchkonia, J. L. Trejo & D. W. Lamming
Publié dans: Nature Protocols, 2020, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/s41596-019-0256-1

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

Auteurs: Henning Jacobsen, Kerstin Walendy-Gnirß, Nilgün Tekin-Bubenheim, Nancy Mounogou Kouassi, Isabel Ben-Batalla, Nikolaus Berenbrok, Martin Wolff, Vinicius Pinho dos Reis, Martin Zickler, Lucas Scholl, Annette Gries, Hanna Jania, Andreas Kloetgen, Arne Düsedau, Gundula Pilnitz-Stolze, Aicha Jeridi, Ali Önder Yildirim, Helmut Fuchs, Valerie Gailus-Durner, Claudia Stoeger, Martin Hrabe de Angelis, T
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25220-3