Project description
Sustainable mouse model resources for biomedical research
Mouse models play a crucial role in biomedical research, serving as valuable tools to study human diseases, investigate genetic functions, and test potential therapeutic interventions. Their short reproductive cycles and ability to be genetically manipulated make them a powerful model organism. The EU-funded INFRAFRONTIER2020 project aims to ensure access to mouse models by expanding the INFRAFRONTIER network of research infrastructure, facilitating engagement with industry and global consortia for collaborative efforts. The project will develop business models, a legal framework, customised services, and raise awareness to ensure long-term sustainability of the network.
Objective
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society.
The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is strategically responding to the INFRADEV3 call with aligned objectives to advance the long-term sustainability which are 1) development of business models and a stable legal framework; 2) raise awareness of the INFRAFRONTIER RI; 3) provide bespoke services aligned with user demands; 4) promote best practices in mouse phenogenomics; 5) enhance robustness of the INFRAFRONTIER IT infrastructure and use of the EMMA strain resource; and 6) improve business processes. Towards achieving these objectives key INFRAFRONTIER2020 project deliverables are:
• INFRAFRONTIER Business Plan2.0 and business models for all services
• Stable legal framework built on the INFRAFRONTIER legal entity
• INFRAFRONTIER annual stakeholder conferences
• Customised mouse model and secondary phenotyping pilot services
• INFRAFRONTIER advanced training schools in mouse phenogenomics
• Reengineered EMMA Database2.0 system
• Annotated mouse models of human diseases
• Quality management system for the legal entity
INFRAFRONTIER2020 will 1) enhance the sustainable operation of the INFRAFRONTIER RI; 2) continue to structure the ERA, 3) foster innovation, and 4) address major societal challenges in human health by customised service pilots supporting research into common and rare diseases. A sustainable INFRAFRONTIER RI will ensure the quality of deposited mice and support the reproducibility of biological results. Outreach efforts will raise awareness of resources and services and facilitate sustainable engagement with industry and global consortia such as the International Mouse Phenotyping Consortium
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CSA - Coordination and support actionCoordinator
85764 Neuherberg
Germany
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Participants (28)
85764 Neuherberg
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142 20 Praha 4
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90014 Oulu
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67404 Illkirch Graffenstaden
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16672 Vari-Athens
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1210 Wien
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M5T 3H7 Toronto
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69117 Heidelberg
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38124 Braunschweig
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30625 Hannover
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12489 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
50829 Cologne
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1165 Kobenhavn
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28006 Madrid
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08193 Cerdanyola Del Valles
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75654 Paris
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75794 Paris
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75724 Paris
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16672 Vari
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
69978 Tel Aviv
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00185 Roma
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1066 CX Amsterdam
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9713 GZ Groningen
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1067-001 LISBOA
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17177 Stockholm
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SN2 1FL Swindon
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CB10 1SA SAFFRON WALDEN
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S10 2TN Sheffield
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