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European Vaccine Research and Development Infrastructure

Deliverables

Optimisation of array and RNASeq analysis for BAL samples

Optimisation of array and RNASeq analysis for BAL samples

Appointment of all SEAC members

Appointment of all SEAC members

Establishment of Board of Stakeholders

Establishment of Board of Stakeholders

Programme for customised training courses

Programme for customised training courses

Standardised assays for the characterisation of HCPs by 1D/2D-PAGE followed by MS or MS/MS analysis

Standardised assays for the characterisation of HCPs by 1D/2D-PAGE followed by MS or MS/MS analysis

Extension and refinement of dcRT-MLPA platform for extended gene expression profiling

Extension and refinement of dcRT-MLPA platform for extended gene expression profiling

Reduction and optimisation of small sample quantities for use in platforms

Reduction and optimisation of small sample quantities for use in platforms

Standardised assays for the characterisation of candidate vaccine structure and integrity

Standardised assays for the characterisation of candidate vaccine structure and integrity

Standardised assays for the characterisation of immune sera by calibration-free concentration analysis

Standardised assays for the characterisation of immune sera by calibration-free concentration analysis

Contact with five external projects and initiatives

Contact with five external projects and initiatives

Regulatory database for market access

Regulatory database for market access

Further development and optimisation of CyTOF technology platforms

Further development and optimisation of CyTOF technology platforms

Mathematical dynamic models that identify factors determining the magnitude and efficiency of the immune response upon vaccination

Mathematical dynamic models that identify factors determining the magnitude and efficiency of the immune response upon vaccination

Optimisation of RNASeq platforms

Optimisation of RNASeq platforms

In vivo imaging for host pathogens interactions international workshop

In vivo imaging for host pathogens interactions international workshop

Standardised assays for the functional characterisation of vaccine candidates using monoclonal antibodies and/or ligand interactions

Standardised assays for the functional characterisation of vaccine candidates using monoclonal antibodies and/or ligand interactions

Regulatory database for therapeutic or prophylactic vaccine clinical trials

Regulatory database for therapeutic or prophylactic vaccine clinical trials

Optimisation of cytokine/chemokine multiplex platform analysis as innovative assays to evaluate innate immune responses in vitro directly using blood samples

Optimisation of cytokine/chemokine multiplex platform analysis as innovative assays to evaluate innate immune responses in vitro directly using blood samples

Identification of regulatory bottlenecks affecting multinational cooperation in vaccine development

Identification of regulatory bottlenecks affecting multinational cooperation in vaccine development

Communication policy and communication plan

Communication policy and communication plan

Detailed report on the technical, economical and regulatory aspects of an existing bench-scale process

Detailed report on the technical, economical and regulatory aspects of an existing bench-scale process

Protocol for the systematic organisation of a biobank and a corresponding database

Protocol for the systematic organisation of a biobank and a corresponding database

Business plan for a sustainable European vaccine R&D infrastructure

Business plan for a sustainable European vaccine R&D infrastructure

Detailed description of the infrastructure for the TRANSVAC2 web site

Detailed description of the infrastructure for the TRANSVAC2 web site

Terms of reference for, and composition of the consultancy expert panel

Terms of reference for, and composition of the consultancy expert panel

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Publications

Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Author(s): Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz
Published in: Molecular Systems Biology, Issue 15/11, 2019, ISSN 1744-4292
DOI: 10.15252/msb.20198947

From Bivariate to Multivariate Analysis of Cytometric Data: Overview of Computational Methods and Their Application in Vaccination Studies

Author(s): Simone Lucchesi, Simone Furini, Donata Medaglini, Annalisa Ciabattini
Published in: Vaccines, Issue 8/1, 2020, Page(s) 138, ISSN 2076-393X
DOI: 10.3390/vaccines8010138

Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies

Author(s): Simone Lucchesi, Emanuele Nolfi, Elena Pettini, Gabiria Pastore, Fabio Fiorino, Gianni Pozzi, Donata Medaglini, Annalisa Ciabattini
Published in: Cytometry Part A, Issue 97/3, 2020, Page(s) 259-267, ISSN 1552-4922
DOI: 10.1002/cyto.a.23922

Optimized Protocol for the Detection of Multifunctional Epitope-Specific CD4+ T Cells Combining MHC-II Tetramer and Intracellular Cytokine Staining Technologies

Author(s): Gabiria Pastore, Monica Carraro, Elena Pettini, Emanuele Nolfi, Donata Medaglini, Annalisa Ciabattini
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02304

Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge

Author(s): Marta Sisteré-Oró, Júlia Vergara-Alert, Thomas Stratmann, Sergi López-Serrano, Sonia Pina-Pedrero, Lorena Córdoba, Mónica Pérez-Maillo, Patrícia Pleguezuelos, Enric Vidal, Veljko Veljkovic, Joaquim Segalés, Jens Nielsen, Anders Fomsgaard, Ayub Darji
Published in: PLOS ONE, Issue 14/3, 2019, Page(s) e0212431, ISSN 1932-6203
DOI: 10.1371/journal.pone.0212431