European Vaccine Research and Development Infrastructure

Livrables

Optimisation of array and RNASeq analysis for BAL samples
Appointment of all SEAC members
Establishment of Board of Stakeholders
Programme for customised training courses
Standardised assays for the characterisation of HCPs by 1D/2D-PAGE followed by MS or MS/MS analysis
Metabolomic profiles of host responses to vaccination
Extension and refinement of dcRT-MLPA platform for extended gene expression profiling
Reduction and optimisation of small sample quantities for use in platforms
Standardised assays for the characterisation of candidate vaccine structure and integrity
Standardised human whole-blood Luminex assay for the characterisation of cytokine and chemokine responses induced by whole vaccines or vaccine antigens

Standardised human wholeblood Luminex assay for the characterisation of cytokine and chemokine responses induced by whole vaccines or vaccine antigens

Standardised assays for the characterisation of immune sera by calibration-free concentration analysis
Contact with five external projects and initiatives
Two rounds of customised training courses completed
Regulatory database for market access
Further development and optimisation of CyTOF technology platforms
Mathematical dynamic models that identify factors determining the magnitude and efficiency of the immune response upon vaccination
Development of SB platforms and analysis tools for immune cell differentiation, migration, cytokine profile and T-cell phenotype using SB analysis

Development of SB platforms and analysis tools for immune cell differentiation migration cytokine profile and Tcell phenotype using SB analysis

Neural network models for pattern recognition/classification of data in biobanks
Optimisation of RNASeq platforms
Novel dcRT-MLPA assay for gene expression profiling in NHP models

Novel dcRTMLPA assay for gene expression profiling in NHP models

In vivo imaging for host pathogens interactions international workshop
Standardised assays for the functional characterisation of vaccine candidates using monoclonal antibodies and/or ligand interactions
Regulatory database for therapeutic or prophylactic vaccine clinical trials
Optimisation of cytokine/chemokine multiplex platform analysis as innovative assays to evaluate innate immune responses in vitro directly using blood samples

Reports on the presentation of results at events relevant to the scientific community and industry
Identification of regulatory bottlenecks affecting multinational cooperation in vaccine development
Report on COVID-19 services provided to TNA users.

Report on all services that will have been provided to TNA users for COVID19 projects

Communication policy and communication plan
Report on the future perspective of innovative telemetry and imaging methods
Impact reports
Workshop on mucosal vaccines and aerosol use in vaccine development

Workshop on aerosols in the development of mucosal vaccines and animal models

Provide and report on provision of access for structural analysis
Report on the activities of the consultancy group and the feasibility of a self-sustaining Regulatory Advisory Expert Group

Report on the activities of the consultancy group and the feasibility of a selfsustaining Regulatory Advisory Expert Group

Detailed report on the technical, economical and regulatory aspects of an existing bench-scale process
Protocol for the systematic organisation of a biobank and a corresponding database
Workshop on species-dependent aspects in animal models for vaccine evaluation

Workshop on speciesdependent aspects in animal models for vaccine evaluation

Business plan for a sustainable European vaccine R&D infrastructure
Report on all measures used to promote the uptake of TRANSVAC2 services by industry
Detailed description of the infrastructure for the TRANSVAC2 web site
Terms of reference for, and composition of the consultancy expert panel
Workshop on harmonization of animal studies across different species

Reports on the publication of results in specialised scientific-technical journals

Reports on the publication of results in specialised scientifictechnical journals

Promotional activities at six meetings/symposia per year

Promotional activities at six meetingssymposia per year

Networking with other SB initiatives
Implementation of an outreach campaign
Launch of TRANSVAC2 web site

Publications

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models

Auteurs: Jinpeng Su, Livia Brunner, Edanur Ates Oz, Julia Sacherl, Geraldine Frank, Helene Anne Kerth, Frank Thiele, Marian Wiegand, Carolin Mogler, Julio Cesar Aguilar, Percy A Knolle, Nicolas Collin, Anna D Kosinska, Ulrike Protzer
Publié dans: Journal of Hepatology, 2023, ISSN 1600-0641
Éditeur: Elsevier B.V.
DOI: 10.1016/j.jhep.2022.12.013

Immune Responses to Pandemic H1N1 Influenza Virus Infection in Pigs Vaccinated with a Conserved Hemagglutinin HA1 Peptide Adjuvanted with CAF ® 01 or CDA/αGalCerMPEG

Auteurs: Sergi López-Serrano, Lorena Cordoba, Mónica Pérez-Maillo, Patricia Pleguezuelos, Edmond J Remarque, Thomas Ebensen, Carlos A Guzmán, Dennis Christensen, Joaquim Segalés, Ayub Darji
Publié dans: Vaccines, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9070751

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

Auteurs: Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavi
Publié dans: Nature, 2020, ISSN 1476-4687
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-020-2558-4

Safety and immunogenicity of ChAd63-KH vaccine in post-kala-azar dermal leishmaniasis patients in Sudan

Auteurs: Brima M. Younis,1 Mohamed Osman,2 Eltahir A.G. Khalil,1 Francesco Santoro,3 Simone Furini,3 Rebecca Wiggins,2 Ada Keding,4 Monica Carraro,3 Anas E.A. Musa,1 Mujahid A.A. Abdarahaman,1 Laura Mandefield,4 Martin Bland,4 Toni Aebischer,5 Rhian Gabe,6 Alison M. Layton,2 Charles J.N. Lacey,2,7 Paul M. Kaye,2,7,∗ and Ahmed M. Musa1,7,∗∗
Publié dans: Molecular Therapy, 2019, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.03.020

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response

Auteurs: Pierre Rosenbaum, Nicolas Tchitchek, Candie Joly, André Rodriguez Pozo, Lev Stimmer, Sébastien Langlois, Hakim Hocini, Leslie Gosse, David Pejoski, Antonio Cosma, Anne-Sophie Beignon, Nathalie Dereuddre-Bosquet, Yves Levy, Roger Le Grand, Frédéric Martinon
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.645210

Scalable process for high-yield production of PfCyRPA using insect cells for inclusion in a malaria virosome-based vaccine candidate

Auteurs: Bárbara Fernandes, Marcos Sousa, Rute Castro, Anja Schäfer, Julia Hauser, Kai Schulze, Mario Amacker, Marco Tamborrini, Gerd Pluschke, Paula M Alves, Sylvain Fleury, António Roldão
Publié dans: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.879078

Lactoferrin retargets human adenoviruses to TLR4 to induce an abortive NLPR3-associated pyroptotic response in human phagocytes

Auteurs: Coraline Chéneau, Karsten Eichholz, Tuan Hiep Tran, Thi Thu Phuong Tran, Océane Paris, Corinne Henriquet, Jeffrey J Bajramovic, Martine Pugniere, Eric J Kremer
Publié dans: Frontiers Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.685218

Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?

Auteurs: Elena Pettini, Gabiria Pastore, Fabio Fiorino, Donata Medaglini, Annalisa Ciabattini
Publié dans: Vaccines, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030289

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

Auteurs: Jean-Louis Palgen, Nicolas Tchitchek, André Rodriguez-Pozo, Quentin Jouhault, Hadjer Abdelhouahab, Nathalie Dereuddre-Bosquet, Vanessa Contreras, Frédéric Martinon, Antonio Cosma, Yves Lévy, Roger Le Grand, and Anne-Sophie Beignon
Publié dans: NPJ Vaccines, 2020, ISSN 2059-0105
Éditeur: Springer Nature
DOI: 10.1038/s41541-020-0175-8

Prophylactic Multi-Subunit Vaccine against Chlamydia trachomatis: In Vivo Evaluation in Mice

Auteurs: Christian Lanfermann, Sebastian Wintgens, Thomas Ebensen, Martin Kohn, Robert Laudeley, Kai Schulze, Claudia Rheinheimer, Johannes H Hegemann, Carlos Alberto Guzmán, Andreas Klos
Publié dans: Vaccines, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060609

Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate

Auteurs: Marta Sisteré-Oró, Gabriel K. Pedersen, Lorena Córdoba, Sergi López-Serrano, Dennis Christensen & Ayub Darji
Publié dans: Veterinary Research, 2020, ISSN 1297-9716
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13567-020-00770-4

DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs.

Auteurs: Marta Sisteré-Oró; Sergi López-Serrano; Veljko Veljkovic; Sonia Pina-Pedrero; Júlia Vergara-Alert; Lorena Córdoba; Mónica Pérez-Maillo; Patricia Pleguezuelos; Enric Vidal; Joaquim Segalés; Jens Nielsen; Anders Fomsgaard; Ayub Darji
Publié dans: instname:Universitat Autònoma de Barcelona, Numéro 21, 2019, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0222201

Recommendations for Standardizing Thorax PET-CT in Non-Human Primates by Recent Experience from Macaque Studies

Auteurs: Marieke A Stammes, Jaco Bakker, Richard A W Vervenne, Dian G M Zijlmans, Leo van Geest, Michel P M Vierboom, Jan A M Langermans, Frank A W Verreck
Publié dans: Animals, 2021, ISSN 2076-2615
Éditeur: MDPI
DOI: 10.3390/ani11010204

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques.

Auteurs: Romain Marlin; Véronique Godot; Sylvain Cardinaud; Mathilde Galhaut; Severin Coleon; Sandra Zurawski; Nathalie Dereuddre-Bosquet; Mariangela Cavarelli; Anne-Sophie Gallouet; Pauline Maisonnasse; Léa Dupaty; Craig Fenwick; Thibaut Naninck; Julien Lemaitre; Mario Gomez-Pacheco; Nidhal Kahlaoui; Vanessa Contreras; Francis Relouzat; Raphael Ho Tsong Fang; Zhiqing Wang; Jerome Ellis; Catherine Chapon
Publié dans: "Nature Communications, Nature Publishing Group, 2021, 12, pp.5215. ⟨10.1038/s41467-021-25382-0⟩", Numéro 38, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-25382-0

A call to action for translational sciences in COVID-19 and future pandemics

Auteurs: Kanny K Wan, Danielle Davis, Taylor N Lee, Stephanie L Ford-Scheimer, Antonio L Andreu, Florence Bietrix, Justin Bryans, Marco T Castro, Nobuyoshi Chiba, Jessica M Faupel-Badger, Brittany Haynes, Ryutaro Hirasawa, Carlos M Morel, Thiago Moreno L Souza, David Morrow, Trent Munro, Stuart Newman, Anton E Ussi, Poliana B Zorzal, Matthew D Hall, Donald C Lo, Christine M Cutillo
Publié dans: Nature Reviews Drug Discovery, 2022, ISSN 1474-1776
Éditeur: Nature Publishing Group
DOI: 10.1038/d41573-022-00020-6

COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Auteurs: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arri
Publié dans: Molecular Therapy, 2022, ISSN 1525-0024
Éditeur: Cell Press
DOI: 10.1016/j.ymthe.2021.09.011

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Auteurs: Philip J.M. Brouwer, Mitch Brinkkemper, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Marloes Grobben, Mathieu Claireaux, Marlon de Gast, Romain Marlin, Virginie Chesnais, Ségolène Diry, Joel D. Allen, Yasunori Watanabe, Julia M. Giezen, Gius Kerster, Hannah L. Turner, Karlijn van der Straten, Cynthia A. van der Linden, Yoann Aldon, Thibaut Naninck, Ilja Bontjer, Judith A. Burger, Meliawati P
Publié dans: Cell, 2021, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2021.01.035

Cyclic Di-Adenosine Monophosphate: A Promising Adjuvant Candidate for the Development of Neonatal Vaccines

Auteurs: Lirussi, Darío, Sebastian F. Weissmann, Thomas Ebensen, Ursula Nitsche-Gloy, Heiko B.G. Franz, and Carlos A. Guzmán
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020188

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

Auteurs: Pauline Maisonnasse, Yoann Aldon, Aurélien Marc, Romain Marlin, Nathalie Dereuddre-Bosquet, Natalia A. Kuzmina, Alec W. Freyn, Jonne L. Snitselaar, Antonio Gonçalves, Tom G. Caniels, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Virginie Chesnais, Ségolène Diry, Anton Iershov, Adam J. Ronk, Sonia Jangra, Raveen Rathnasinghe, Philip J. M. Brouwer, Tom P. L. Bijl, Jelle van Schooten, Mitch
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26354-0

Functionalizing Ferritin Nanoparticles for Vaccine Development

Auteurs: Margarida Q Rodrigues, Paula M Alves, António Roldão
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101621

A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge

Auteurs: Gerrit Koopman, Mario Amacker, Toon Stegmann, Ernst J. Verschoor, Babs E. Verstrepen, Farien Bhoelan, Denzel Bemelman, Kinga P. Böszörményi, Zahra Fagrouch, Gwendoline Kiemenyi-Kayere, Daniella Mortier, Dagmar E. Verel, Henk Niphuis, Roja Fidel Acar, Ivanela Kondova, Yolanda S. Kap, Willy M. J. M. Bogers, Petra Mooij & Sylvain Fleury
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-31818-y

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Auteurs: Michel P M Vierboom, Karin Dijkman, Claudia C Sombroek, Sam O Hofman, Charelle Boot, Richard A W Vervenne, Krista G Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J C F M Moorlag, Clemens H M Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H A Martens, Reinout van Crevel, Mihai G Netea, Nacho Aguilo, Carlos Martin, Frank A W Verreck
Publié dans: Cell Rep Med., 2021, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2020.100185

Applying Microfluidics for the Production of the Cationic Liposome-Based Vaccine Adjuvant CAF09b

Auteurs: Signe Tandrup Schmidt, Dennis Christensen, Yvonne Perrie
Publié dans: Pharmaceutics, 2020, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121237

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

Auteurs: Guidenn Sulbaran; Pauline Maisonnasse; Axelle Amen; Delphine Guilligay; Nathalie Dereuddre-Bosquet; Judith A. Burger; Meliawati Poniman; M. Buisson; Sebastian Dergan Dylon; Thibaut Naninck; Julien Lemaitre; Wesley Gros; Anne-Sophie Gallouet; Romain Marlin; Camille Bouillier; Vanessa Contreras; Francis Relouzat; Daphna Fenel; Michel Thépaut; Isabelle Bally; Nicole M. Thielens; Franck Fieschi; Guy
Publié dans: Cell Reports Medicine, 3(2):100528. Cell Press, Numéro 35, 2022, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1101/2021.07.26.453755

Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate

Auteurs: Bárbara Fernandes , Rute Castro , Farien Bhoelan , Denzel Bemelman , Ricardo A Gomes , Júlia Costa , Patrícia Gomes-Alves , Toon Stegmann , Mario Amacker 5, Paula M Alves , Sylvain Fleury , António Roldão
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040854

An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

Auteurs: Nerea Zabaleta,1,2,3,4 Wenlong Dai,1,2,3,4 Urja Bhatt,1,2,3,4 Cécile Hérate,5 Pauline Maisonnasse,5 Jessica A. Chichester,6 Julio Sanmiguel,1,2,3,4 Reynette Estelien,1,2,3,4 Kristofer T. Michalson,6 Cheikh Diop,1,2,3,4 Dawid Maciorowski,1,2,3,4 Nathalie Dereuddre-Bosquet,5 Mariangela Cavarelli,5 Anne-Sophie Gallouët,5 Thibaut Naninck,5 Nidhal Kahlaoui,5 Julien Lemaitre,5 Wenbin Qi,7 Elissa Huds
Publié dans: Cell Host & Microbe, 2021, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2021.08.002

Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection

Auteurs: Karin Dijkman Nacho Aguilo Charelle Boot Sam O. Hofman Claudia C. Sombroek Richard A.W. Vervenne Clemens H.M. Kocken Dessislava Marinova Jelle Thole Esteban Rodríguez Michel P.M. Vierboom Krista G. Haanstra Eugenia Puentes Carlos Martin Frank A.W. Verreck
Publié dans: Cell Rep Med., 2021, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2020.100187

Dissecting insect cell heterogeneity during influenza VLP production using single-cell transcriptomics

Auteurs: Marco Silvano, Nikolaus Virgolini, Ricardo Correia, Colin Clarke, Inês A Isidro, Paula M Alves, António Roldão
Publié dans: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1143255

Immune responses following neonatal vaccination with conserved antigen F4 of virulent Glaesserella parasuis adjuvanted with CAF®01 or CDA

Auteurs: S. Lopez-Serrano, Y.S. Mahmmod, D. Christensen, T. Ebensen, C.A. Guzman, F. Rodríguez, J. Segalés, V. Aragón
Publié dans: Vaccine X, 2023, ISSN 2590-1362
Éditeur: Elsevier Ltd.
DOI: 10.1016/j.jvacx.2023.100330

DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model

Auteurs: Mirco Compagnone, Eleonora Pinto, Erika Salvatori, Lucia Lione, Antonella Conforti, Silvia Marchese, Micol Ravà, Kathryn Ryan, Yper Hall, Emma Rayner, Francisco J Salguero, Jemma Paterson, Matteo Iannacone, Raffaele De Francesco, Luigi Aurisicchio, Fabio Palombo
Publié dans: Vaccines, 2022, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10081178

Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Auteurs: Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz
Publié dans: Molecular Systems Biology, Numéro 15/11, 2019, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.20198947

From Bivariate to Multivariate Analysis of Cytometric Data: Overview of Computational Methods and Their Application in Vaccination Studies

Auteurs: Simone Lucchesi, Simone Furini, Donata Medaglini, Annalisa Ciabattini
Publié dans: Vaccines, Numéro 8/1, 2020, Page(s) 138, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010138

Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies

Auteurs: Simone Lucchesi, Emanuele Nolfi, Elena Pettini, Gabiria Pastore, Fabio Fiorino, Gianni Pozzi, Donata Medaglini, Annalisa Ciabattini
Publié dans: Cytometry Part A, Numéro 97/3, 2020, Page(s) 259-267, ISSN 1552-4922
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23922

Optimized Protocol for the Detection of Multifunctional Epitope-Specific CD4+ T Cells Combining MHC-II Tetramer and Intracellular Cytokine Staining Technologies

Auteurs: Gabiria Pastore, Monica Carraro, Elena Pettini, Emanuele Nolfi, Donata Medaglini, Annalisa Ciabattini
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2019.02304

Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge

Auteurs: Marta Sisteré-Oró, Júlia Vergara-Alert, Thomas Stratmann, Sergi López-Serrano, Sonia Pina-Pedrero, Lorena Córdoba, Mónica Pérez-Maillo, Patrícia Pleguezuelos, Enric Vidal, Veljko Veljkovic, Joaquim Segalés, Jens Nielsen, Anders Fomsgaard, Ayub Darji
Publié dans: PLOS ONE, Numéro 14/3, 2019, Page(s) e0212431, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0212431

Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates

Auteurs: Romain Marlin; Delphine Desjardins; Vanessa Contreras; Guillaume Lingas; Caroline Solas; Pierre Roques; Thibaut Naninck; Quentin Pascal; Sylvie Behillil; Pauline Maisonnasse; Julien Lemaitre; Nidhal Kahlaoui; Benoit Delache; Andrés Pizzorno; Antoine Nougairede; Camille Ludot; Olivier Terrier; Nathalie Dereuddre-Bosquet; Francis Relouzat; Catherine Chapon; Raphael Ho Tsong Fang; Sylvie van der Wer
Publié dans: "Nature Communications, 2022, 13 (1), pp.5108. ⟨10.1038/s41467-022-32565-w⟩", Numéro 34, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32565-w

Efficacy and immunogenicity of different BCG doses in BALB/c and CB6F1 mice when challenged with H37Rv or Beijing HN878

Auteurs: Khatri B, Keeble J, Dagg B, Kaveh DA, Hogarth PJ, Ho MM
Publié dans: Scientific Reports, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-02442-5

Non-human primate models of human respiratory infections

Auteurs: Julien Lemaitre, Thibaut Naninck, Benoît Delache, Justina Creppy, Philippe Huber, Marion Holzapfel, Camille Bouillier, Vanessa Contreras, Frédéric Martinon, Nidhal Kahlaoui, Quentin Pascal, Sabine Tricot, Frédéric Ducancel, Laurent Vecellio, Roger Le Grand, Pauline Maisonnasse
Publié dans: Molecular Immunology, 2021, ISSN 0161-5890
Éditeur: Pergamon Press
DOI: 10.1016/j.molimm.2021.04.010

Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts.

Auteurs: Gebremedhin Gebremicael; Desta Kassa; Yodit Alemayehu; Atsbeha Gebreegziaxier; Yonas Kassahun; Debbie van Baarle; Tom H. M. Ottenhoff; Jacqueline M. Cliff; Mariëlle C. Haks
Publié dans: PLoS ONE, Numéro 35, 2019, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0226137

Computed tomography and [18F]-FDG PET imaging provide additional readouts for COVID-19 pathogenesis and therapies evaluation in non-human primates

Auteurs: Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Pauline Maisonnasse, Antoine De Mori, Quentin Pascal, Vanessa Contreras, Romain Marlin, Francis Relouzat, Benoît Delache, Cécile Hérate, Yoann Aldon, Marit van Gils, Nerea Zabaleta, Raphaël Ho Tsong Fang, Nathalie Bosquet, Rogier W. Sanders, Luk H. Vandenberghe, Catherine Chapon, and Roger Le Grand
Publié dans: iScience, 2022, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2022.104101

Likelihood-free nested sampling for parameter inference of biochemical reaction networks

Auteurs: Mikelson, Jan; Khammash, Mustafa Hani; id_orcid0000-0002-4855-9220
Publié dans: PLoS Computational Biology, 16 (10), Numéro 8, 2020, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1008264

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques

Auteurs: Matthieu Van Tilbeurgh , Pauline Maisonnasse , Jean-Louis Palgen , Monica Tolazzi, Yoann Aldon, Nathalie Dereuddre-Bosquet , Mariangela Cavarelli , Anne-Sophie Beignon , Ernesto Marcos-Lopez , Anne-Sophie Gallouet , Emmanuel Gilson, Gabriel Ozorowski, Andrew B Ward, Ilja Bontjer, Paul F McKay, Robin J Shattock, Gabriella Scarlatti, Rogier W Sanders, Roger Le Grand
Publié dans: Cell Reports Medicine, 2022, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2022.100751

The Route of Vaccine Administration Determines Whether Blood Neutrophils Undergo Long-Term Phenotypic Modifications

Auteurs: Yanis Feraoun , Jean-Louis Palgen , Candie Joly , Nicolas Tchitchek , Ernesto Marcos-Lopez , Nathalie Dereuddre-Bosquet , Anne-Sophie Gallouet , Vanessa Contreras , Yves Lévy, Frédéric Martinon , Roger Le Grand , Anne-Sophie Beignon
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.784813

Heterologous Systemic Prime-Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters

Auteurs: Paidamoyo M Katsande, Leira Fernández-Bastit, William T Ferreira, Júlia Vergara-Alert, Mateusz Hess, Katie Lloyd-Jones, Huynh A Hong, Joaquim Segales, Simon M Cutting
Publié dans: Vaccines, 2022, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111900

Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Auteurs: Coralie Dessauges; Jan Mikelson; Maciej Dobrzyński; Marc‐Antoine Jacques; Agne Frismantiene; Paolo Armando Gagliardi; Mustafa Khammash; Olivier Pertz
Publié dans: Molecular Systems Biology, 18 (6), Numéro 33, 2022, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.3929/ethz-b-000553522

Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement

Auteurs: Karsten Eichholz, Tuan Hiep Tran, Coraline Chéneau, Thi Thu Phuong Tran, Océane Paris, Martine Pugniere, Eric J Kremer
Publié dans: Journal of Virology, 2022, ISSN 1098-5514
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01850-21

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients.

Auteurs: Simon G. P. Funnell; W. E. Dowling; César Muñoz-Fontela; Pierre Stéphane Gsell; Donald E. Ingber; G. A. Hamilton; Leen Delang; Joana Rocha-Pereira; Suzanne J.F. Kaptein; Kai Dallmeier; Johan Neyts; Kyle Rosenke; E. de Wit; H. Feldmann; Pauline Maisonnasse; R. Le Grand; Matthew B. Frieman; C. M. Coleman
Publié dans: "Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.4253. ⟨10.1038/s41467-020-17907-w⟩", Numéro 40, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17907-w

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

Auteurs: Annalisa Ciabattini, Paolo Garagnani, Francesco Santoro, Rino Rappuoli, Claudio Franceschi, and Donata Medaglini
Publié dans: Seminars in Immunopathology, 2020, ISSN 1863-2297
Éditeur: Springer Verlag
DOI: 10.1007/s00281-020-00821-0

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

Auteurs: Brendan Farrell, Nawsad Alam, Melissa N. Hart, Abhishek Jamwal, Robert J. Ragotte, Hannah Walters-Morgan, Simon J. Draper, Ellen Knuepfer, Matthew K. Higgins
Publié dans: bioRxiv, 2023, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.30.526221

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