Deliverables Demonstrators, pilots, prototypes (2) Cell jet injection established and evaluated in vitro and in vivo Water jet cell injection technique to apply viable MPCs in vitro on surfaces as well as in predetermined areas of the urethral sphincter muscle explants. Definition of the best option for delivery of MPCs Conclusion if needle-less injection of MPCs is superior to needle-application and recommendation for further surgical regimen and cell application strategy. Documents, reports (1) CE Certification of Injection Device The injection of the final MPC product will be performed during Treatment Visit under general or spinal anesthesia. To allow standardized injections into the pelvic floor of female patients, the cells will be injected under real-time ultrasound guidance by the use of an Injection device (linker-device between ultrasound and syringe with needle) As required by Swissmedic (Swiss Regulatory Agency), the developed Injection Device will be CE certified before start of the clinical trial by the Swiss Center of Regeneration Medicine (SCRM) of UZH. Websites, patent fillings, videos etc. (2) Project webpage online The MUSIC website will combine functionalities to streamline communication and material exchange between partners, as well as to monitor progress and dissemination of project results to stakeholders. A password-protected internal part of the website will be accessible for all project Participants only, providing helpful information, documents and schedules. To raise the public interest, this website will disseminate any information which can be disclosed to the public and it will be updated regularly. Workshops to be held within the consortium and external candidates XPD and UZH will organize yearly workshops for translational stem cell research for the other consortium partners as well as for external candidates from universities hospitals and industry Publications Peer reviewed articles (18) Evaluation of Urinary Sphincter Function by Rapid Magnetic Resonance Diffusion Tensor Imaging Author(s): Florian A. Schmid, Ryszard S. Gomolka, Andreas M. Hötker, Andreas Boss, Thomas M. Kessler, Cristina Rossi, Daniel Eberli Published in: International Neurourology Journal, Issue 24/4, 2020, Page(s) 349-357, ISSN 2093-6931 Publisher: International Neurourology Journal DOI: 10.5213/inj.2040208.104 Moderne Inkontinenztherapie mittels Muskelstammzellen Author(s): Florian Schmid, Daniel Eberli Published in: Praxis, Issue 109/6, 2020, Page(s) 447-452, ISSN 1661-8157 Publisher: Verlag Hans Huber DOI: 10.1024/1661-8157/a003421 Feasibility, technique and accuracy of ultrasound-guided transurethral injections into the urinary sphincter of female cadavers: proof of concept Author(s): Florian A. Schmid, Dominic Gascho, Niklaus Zoelch, Jenny A. Prange, Giovanni Colacicco, Daniel Eberli Published in: BMC Urology, Issue 20/1, 2020, ISSN 1471-2490 Publisher: BioMed Central DOI: 10.1186/s12894-020-00719-x Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Author(s): André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk Published in: International Journal of Molecular Sciences, Issue 22/8, 2021, Page(s) 3890, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22083890 Allogenic Use of Human Placenta-Derived Stromal Cells as a Highly Active Subtype of Mesenchymal Stromal Cells for Cell-Based Therapies Author(s): Raphael Gorodetsky, Wilhelm K. Aicher Published in: International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5302, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22105302 Novel Techniques to Improve Precise Cell Injection Author(s): Walter Linzenbold, Andreas Fech, Manuela Hofmann, Wilhelm K. Aicher, Markus D. Enderle Published in: International Journal of Molecular Sciences, Issue 22/12, 2021, Page(s) 6367, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22126367 Acoustophoresis Enables the Label‐Free Separation of Functionally Different Subsets of Cultured Bone Marrow Stromal Cells Author(s): Franziska Olm, Hooi Ching Lim, Katharina Schallmoser, Dirk Strunk, Thomas Laurell, Stefan Scheding Published in: Cytometry Part A, Issue 99/5, 2021, Page(s) 476-487, ISSN 1552-4922 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cyto.a.24171 Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production Author(s): Michaela Oeller, Sandra Laner-Plamberger, Linda Krisch, Eva Rohde, Dirk Strunk, Katharina Schallmoser Published in: International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5178, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22105178 Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle‐free waterjet technology Author(s): Walter Linzenbold, Luise Jäger, Hartmut Stoll, Tanja Abruzzese, Niklas Harland, Nicolas Bézière, Andreas Fech, Markus Enderle, Bastian Amend, Arnulf Stenzl, Wilhelm K. Aicher Published in: BJU International, Issue 127/4, 2021, Page(s) 463-472, ISSN 1464-4096 Publisher: Blackwell Publishing Inc. DOI: 10.1111/bju.15249 Large Animal Models for Investigating Cell Therapies of Stress Urinary Incontinence Author(s): Bastian Amend, Niklas Harland, Jasmin Knoll, Arnulf Stenzl, Wilhelm K. Aicher Published in: International Journal of Molecular Sciences, Issue 22/11, 2021, Page(s) 6092, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22116092 Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells Author(s): Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk Published in: Theranostics, Issue 8/5, 2018, Page(s) 1421-1434, ISSN 1838-7640 Publisher: Ivyspring International Publisher DOI: 10.7150/thno.21906 Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice Author(s): Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti Published in: Nature Protocols, Issue 12/10, 2017, Page(s) 2169-2188, ISSN 1754-2189 Publisher: Nature Publishing Group DOI: 10.1038/nprot.2017.088 International Forum on GMP-grade human platelet lysate for cell propagation: summary Author(s): D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J Published in: Vox Sanguinis, Issue 113/1, 2018, Page(s) 80-87, ISSN 0042-9007 Publisher: Blackwell Publishing Inc. DOI: 10.1111/vox.12593 Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate Author(s): Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser Published in: Journal of Translational Medicine, Issue 17/1, 2019, ISSN 1479-5876 Publisher: BioMed Central DOI: 10.1186/s12967-019-02183-0 Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues Author(s): Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-019-43700-x A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex Author(s): Luise Jäger, Walter Linzenbold, Andreas Fech, Markus Enderle, Tanja Abruzzese, Arnulf Stenzl, Wilhelm K. Aicher Published in: Neurourology and Urodynamics, Issue 39/2, 2019, Page(s) 594-602, ISSN 0733-2467 Publisher: John Wiley & Sons Inc. DOI: 10.1002/nau.24261 Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis Author(s): Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster Published in: Journal of Molecular Medicine, Issue 98/2, 2020, Page(s) 193-207, ISSN 0946-2716 Publisher: Springer Verlag DOI: 10.1007/s00109-019-01866-x Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo Author(s): Athanasia Warnecke, Jennifer Harre, Hinrich Staecker, Nils Prenzler, Dirk Strunk, Sebastien Couillard‐Despres, Pasquale Romanelli, Julia Hollerweger, Teresa Lassacher, Daniela Auer, Karin Pachler, Georg Wietzorrek, Ulrike Köhl, Thomas Lenarz, Katharina Schallmoser, Sandra Laner‐Plamberger, Christine S. Falk, Eva Rohde, Mario Gimona Published in: Clinical and Translational Medicine, Issue 10/8, 2020, ISSN 2001-1326 Publisher: Springer Verlag DOI: 10.1002/ctm2.262 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
