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Multisystem Cell Therapy for Improvement of Urinary Continence

Deliverables

Cell jet injection established and evaluated in vitro and in vivo

Water jet cell injection technique to apply viable MPCs in vitro on surfaces as well as in predetermined areas of the urethral sphincter muscle explants.

Definition of the best option for delivery of MPCs

Conclusion if needle-less injection of MPCs is superior to needle-application and recommendation for further surgical regimen and cell application strategy.

CE Certification of Injection Device

The injection of the final MPC product will be performed during Treatment Visit under general or spinal anesthesia. To allow standardized injections into the pelvic floor of female patients, the cells will be injected under real-time ultrasound guidance by the use of an Injection device (linker-device between ultrasound and syringe with needle) As required by Swissmedic (Swiss Regulatory Agency), the developed Injection Device will be CE certified before start of the clinical trial by the Swiss Center of Regeneration Medicine (SCRM) of UZH.

Project webpage online

The MUSIC website will combine functionalities to streamline communication and material exchange between partners, as well as to monitor progress and dissemination of project results to stakeholders. A password-protected internal part of the website will be accessible for all project Participants only, providing helpful information, documents and schedules. To raise the public interest, this website will disseminate any information which can be disclosed to the public and it will be updated regularly.

Publications

Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells

Author(s): Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk
Published in: Theranostics, Issue 8/5, 2018, Page(s) 1421-1434, ISSN 1838-7640
DOI: 10.7150/thno.21906

Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice

Author(s): Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti
Published in: Nature Protocols, Issue 12/10, 2017, Page(s) 2169-2188, ISSN 1754-2189
DOI: 10.1038/nprot.2017.088

International Forum on GMP-grade human platelet lysate for cell propagation: summary

Author(s): D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J
Published in: Vox Sanguinis, Issue 113/1, 2018, Page(s) 80-87, ISSN 0042-9007
DOI: 10.1111/vox.12593

Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate

Author(s): Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Published in: Journal of Translational Medicine, Issue 17/1, 2019, ISSN 1479-5876
DOI: 10.1186/s12967-019-02183-0

Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues

Author(s): Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-43700-x

Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis

Author(s): Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster
Published in: Journal of Molecular Medicine, Issue 98/2, 2020, Page(s) 193-207, ISSN 0946-2716
DOI: 10.1007/s00109-019-01866-x