Water jet cell injection technique to apply viable MPCs in vitro on surfaces as well as in predetermined areas of the urethral sphincter muscle explants.
Conclusion if needle-less injection of MPCs is superior to needle-application and recommendation for further surgical regimen and cell application strategy.
The injection of the final MPC product will be performed during Treatment Visit under general or spinal anesthesia. To allow standardized injections into the pelvic floor of female patients, the cells will be injected under real-time ultrasound guidance by the use of an Injection device (linker-device between ultrasound and syringe with needle) As required by Swissmedic (Swiss Regulatory Agency), the developed Injection Device will be CE certified before start of the clinical trial by the Swiss Center of Regeneration Medicine (SCRM) of UZH.
The MUSIC website will combine functionalities to streamline communication and material exchange between partners, as well as to monitor progress and dissemination of project results to stakeholders. A password-protected internal part of the website will be accessible for all project Participants only, providing helpful information, documents and schedules. To raise the public interest, this website will disseminate any information which can be disclosed to the public and it will be updated regularly.
Author(s): Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk
Published in: Theranostics, Issue 8/5, 2018, Page(s) 1421-1434, ISSN 1838-7640
Author(s): Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti
Published in: Nature Protocols, Issue 12/10, 2017, Page(s) 2169-2188, ISSN 1754-2189
Author(s): D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J
Published in: Vox Sanguinis, Issue 113/1, 2018, Page(s) 80-87, ISSN 0042-9007
Author(s): Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Published in: Journal of Translational Medicine, Issue 17/1, 2019, ISSN 1479-5876
Author(s): Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Published in: ISSN 0733-2467
Author(s): Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster
Published in: Journal of Molecular Medicine, Issue 98/2, 2020, Page(s) 193-207, ISSN 0946-2716