Multisystem Cell Therapy for Improvement of Urinary Continence

Risultati finali

Cell jet injection established and evaluated in vitro and in vivo

Water jet cell injection technique to apply viable MPCs in vitro on surfaces as well as in predetermined areas of the urethral sphincter muscle explants.

Definition of the best option for delivery of MPCs

Conclusion if needle-less injection of MPCs is superior to needle-application and recommendation for further surgical regimen and cell application strategy.

CE Certification of Injection Device

The injection of the final MPC product will be performed during Treatment Visit under general or spinal anesthesia. To allow standardized injections into the pelvic floor of female patients, the cells will be injected under real-time ultrasound guidance by the use of an Injection device (linker-device between ultrasound and syringe with needle) As required by Swissmedic (Swiss Regulatory Agency), the developed Injection Device will be CE certified before start of the clinical trial by the Swiss Center of Regeneration Medicine (SCRM) of UZH.

Project webpage online

The MUSIC website will combine functionalities to streamline communication and material exchange between partners, as well as to monitor progress and dissemination of project results to stakeholders. A password-protected internal part of the website will be accessible for all project Participants only, providing helpful information, documents and schedules. To raise the public interest, this website will disseminate any information which can be disclosed to the public and it will be updated regularly.

Workshops to be held within the consortium and external candidates

XPD and UZH will organize yearly workshops for translational stem cell research for the other consortium partners as well as for external candidates from universities hospitals and industry

Pubblicazioni

Evaluation of Urinary Sphincter Function by Rapid Magnetic Resonance Diffusion Tensor Imaging

Autori: Florian A. Schmid, Ryszard S. Gomolka, Andreas M. Hötker, Andreas Boss, Thomas M. Kessler, Cristina Rossi, Daniel Eberli
Pubblicato in: International Neurourology Journal, Numero 24/4, 2020, Pagina/e 349-357, ISSN 2093-6931
Editore: International Neurourology Journal
DOI: 10.5213/inj.2040208.104

Moderne Inkontinenztherapie mittels Muskelstammzellen

Autori: Florian Schmid, Daniel Eberli
Pubblicato in: Praxis, Numero 109/6, 2020, Pagina/e 447-452, ISSN 1661-8157
Editore: Verlag Hans Huber
DOI: 10.1024/1661-8157/a003421

Feasibility, technique and accuracy of ultrasound-guided transurethral injections into the urinary sphincter of female cadavers: proof of concept

Autori: Florian A. Schmid, Dominic Gascho, Niklaus Zoelch, Jenny A. Prange, Giovanni Colacicco, Daniel Eberli
Pubblicato in: BMC Urology, Numero 20/1, 2020, ISSN 1471-2490
Editore: BioMed Central
DOI: 10.1186/s12894-020-00719-x

Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles

Autori: André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk
Pubblicato in: International Journal of Molecular Sciences, Numero 22/8, 2021, Pagina/e 3890, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22083890

Novel Techniques to Improve Precise Cell Injection

Autori: Walter Linzenbold, Andreas Fech, Manuela Hofmann, Wilhelm K. Aicher, Markus D. Enderle
Pubblicato in: International Journal of Molecular Sciences, Numero 22/12, 2021, Pagina/e 6367, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126367

Acoustophoresis Enables the Label‐Free Separation of Functionally Different Subsets of Cultured Bone Marrow Stromal Cells

Autori: Franziska Olm, Hooi Ching Lim, Katharina Schallmoser, Dirk Strunk, Thomas Laurell, Stefan Scheding
Pubblicato in: Cytometry Part A, Numero 99/5, 2021, Pagina/e 476-487, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24171

Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production

Autori: Michaela Oeller, Sandra Laner-Plamberger, Linda Krisch, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Pubblicato in: International Journal of Molecular Sciences, Numero 22/10, 2021, Pagina/e 5178, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105178

Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle‐free waterjet technology

Autori: Walter Linzenbold, Luise Jäger, Hartmut Stoll, Tanja Abruzzese, Niklas Harland, Nicolas Bézière, Andreas Fech, Markus Enderle, Bastian Amend, Arnulf Stenzl, Wilhelm K. Aicher
Pubblicato in: BJU International, Numero 127/4, 2021, Pagina/e 463-472, ISSN 1464-4096
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bju.15249

Large Animal Models for Investigating Cell Therapies of Stress Urinary Incontinence

Autori: Bastian Amend, Niklas Harland, Jasmin Knoll, Arnulf Stenzl, Wilhelm K. Aicher
Pubblicato in: International Journal of Molecular Sciences, Numero 22/11, 2021, Pagina/e 6092, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22116092

Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells

Autori: Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk
Pubblicato in: Theranostics, Numero 8/5, 2018, Pagina/e 1421-1434, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.21906

Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice

Autori: Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti
Pubblicato in: Nature Protocols, Numero 12/10, 2017, Pagina/e 2169-2188, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/nprot.2017.088

International Forum on GMP-grade human platelet lysate for cell propagation: summary

Autori: D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J
Pubblicato in: Vox Sanguinis, Numero 113/1, 2018, Pagina/e 80-87, ISSN 0042-9007
Editore: Blackwell Publishing Inc.
DOI: 10.1111/vox.12593

Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate

Autori: Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Pubblicato in: Journal of Translational Medicine, Numero 17/1, 2019, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/s12967-019-02183-0

Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues

Autori: Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-43700-x

A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex

Autori: Luise Jäger, Walter Linzenbold, Andreas Fech, Markus Enderle, Tanja Abruzzese, Arnulf Stenzl, Wilhelm K. Aicher
Pubblicato in: Neurourology and Urodynamics, Numero 39/2, 2019, Pagina/e 594-602, ISSN 0733-2467
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nau.24261

Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis

Autori: Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster
Pubblicato in: Journal of Molecular Medicine, Numero 98/2, 2020, Pagina/e 193-207, ISSN 0946-2716
Editore: Springer Verlag
DOI: 10.1007/s00109-019-01866-x

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo

Autori: Athanasia Warnecke, Jennifer Harre, Hinrich Staecker, Nils Prenzler, Dirk Strunk, Sebastien Couillard‐Despres, Pasquale Romanelli, Julia Hollerweger, Teresa Lassacher, Daniela Auer, Karin Pachler, Georg Wietzorrek, Ulrike Köhl, Thomas Lenarz, Katharina Schallmoser, Sandra Laner‐Plamberger, Christine S. Falk, Eva Rohde, Mario Gimona
Pubblicato in: Clinical and Translational Medicine, Numero 10/8, 2020, ISSN 2001-1326
Editore: Springer Verlag
DOI: 10.1002/ctm2.262

Risultati finali

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