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High-density cortical implants for cognitive neuroscience and rehabilitation of speech using brain-computer interfaces.


Initial evaluation of the newly developed technology

Functionality of the implants and ASIC as well as biocompatibility will be tested in freely moving animals.

Multiplexed surface conformal µECoG

Prototype and report of prototype assessment. The prototype will integrate the developed capabilities of multiplexing technology and the novel µECoG designs. The report will assess the device performance in terms of number of active sites, site dimension, electronic noise, and maximum sampling frequency.

Report on novel cortical µECoG and intracortical technologies

Report on the performance of non-multiplexed µECoG surface probes and intracortical devices based on graphene field-effect transistors and PEDOT:PSS organic-electrochemical transistors and electrodes. Benchmarking with competing technologies (metal electrode arrays).

System integration of first multiplexed neural interfaces with digital output

Discrete electronics, ASIC, data management and packaging developments to integrate the developed small area neural interfaces with frequency-domain multiple access (FDMA) multiplexing technique of up to 8x8 recording sites into electrophysiological recording systems. This first ASIC also includes the A/D conversion of all the multiplexed channels but not any digital post-processing oriented to data compression. This deliverable improves the initial description of D2.1 by introducing a novel continuous-time multiplexing capability, whose number of channels can be up-scaled in the subsequent deliverables.

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When Bio Meets Technology: Biohybrid Neural Interfaces

Author(s): Amy E. Rochford, Alejandro Carnicer‐Lombarte, Vincenzo F. Curto, George G. Malliaras, Damiano G. Barone
Published in: Advanced Materials, Issue 32/15, 2020, Page(s) 1903182, ISSN 0935-9648
DOI: 10.1002/adma.201903182

Is the European Data Protection Regulation sufficient to deal with emerging data concerns relating to neurotechnology?

Author(s): Stephen Rainey, Kevin McGillivray, Simi Akintoye, Tyr Fothergill, Christoph Bublitz, Bernd Stahl
Published in: Journal of Law and the Biosciences, Issue Journal of law and the Biosciences, 2020, Page(s) 1-19, ISSN 2053-9711
DOI: 10.1093/jlb/lsaa051

When Thinking is Doing: Responsibility for BCI-Mediated Action

Author(s): Stephen Rainey, Hannah Maslen, Julian Savulescu
Published in: AJOB Neuroscience, Issue 11/1, 2020, Page(s) 46-58, ISSN 2150-7740
DOI: 10.1080/21507740.2019.1704918

Multiplexed neural sensor array of graphene solution-gated field-effect transistors

Author(s): Javier Martínez-Aguilar; Javier Martínez-Aguilar; Sara Santiago; Anton Sirota; Ramon Garcia-Cortadella; Ramon Garcia-Cortadella; Clement Hébert; Rosa Villa; Rosa Villa; Anton Guimerà-Brunet; Anton Guimerà-Brunet; Gonzalo Guirado; Jose A. Garrido; Xavi Illa; Xavi Illa; Ana Moya Lara; Ana Moya Lara; Gerrit Schwesig; Nathan Schaefer; Nathan Schaefer
Published in: 2D Materials, Issue Vol 7, Issue 2, 2020, ISSN 2053-1583
DOI: 10.1088/2053-1583/ab7976

Switchless Multiplexing of Graphene Active Sensor Arrays for Brain Mapping

Author(s): Ramon Garcia-Cortadella, Nathan Schäfer, Jose Cisneros-Fernandez, Lucia Ré, Xavi Illa, Gerrit Schwesig, Ana Moya, Sara Santiago, Gonzalo Guirado, Rosa Villa, Anton Sirota, Francesc Serra-Graells, Jose A. Garrido, Anton Guimerà-Brunet
Published in: Nano Letters, Issue 20/5, 2020, Page(s) 3528-3537, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.0c00467

Data as a Cross-Cutting Dimension of Ethical Importance in Direct-to-Consumer Neurotechnologies

Author(s): Stephen Rainey, Jan Christoph Bublitz, Hannah Maslen, Hannah Thornton
Published in: AJOB Neuroscience, Issue 10/4, 2019, Page(s) 180-182, ISSN 2150-7740
DOI: 10.1080/21507740.2019.1665134

Neuroprosthetic Speech: The Ethical Significance of Accuracy, Control and Pragmatics

Published in: Cambridge Quarterly of Healthcare Ethics, Issue 28/04, 2019, Page(s) 657-670, ISSN 0963-1801
DOI: 10.1017/s0963180119000604

Brain Recording, Mind-Reading, and Neurotechnology: Ethical Issues from Consumer Devices to Brain-Based Speech Decoding.

Author(s): Stephen Rainey; Pierre Mégevand; Eric Fourneret; Andy Christen; Stephanie Martin
Published in: Science and Engineering Ethics, Issue 26, 2020, Page(s) 2295–2311, ISSN 1353-3452
DOI: 10.1007/s11948-020-00218-0

Velocity Saturation effect on Low Frequency Noise in short channel Single Layer Graphene FETs

Author(s): Ramon Garcia Cortadella; Nikolaos Mavredakis; Jose A. Garrido; Andrea Bonaccini Calia; Henri Happy; D. Vignaud; David Jiménez; Emiliano Pallecchi; W. Wei
Published in: Applied Electronic Materials, Issue Vol 1, Issue 12, 2019, Page(s) 2626-2636, ISSN 2637-6113
DOI: 10.1021/acsaelm.9b00604

Impact of contact overlap on transconductance and noise in organic electrochemical transistors

Author(s): Nathan Schaefer; Anton Guimerà-Brunet; Andrea Bonaccini Calia; George G. Malliaras; Jose A. Garrido; Anastasios G. Polyravas; Vincenzo F. Curto
Published in: Flexible and Printed Electronics, Issue 4, 2019, Page(s) 044003, ISSN 2058-8585
DOI: 10.17863/cam.44933

Key considerations in designing a speech brain-computer interface

Author(s): Florent Bocquelet, Thomas Hueber, Laurent Girin, Stéphan Chabardès, Blaise Yvert
Published in: Journal of Physiology-Paris, Issue 110/4, 2016, Page(s) 392-401, ISSN 0928-4257
DOI: 10.1016/j.jphysparis.2017.07.002

High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors

Author(s): Masvidal Codina, Eduard; Illa Vila, Xavier; Dasilva, Miguel; Bonaccini Calia, Andrea; Dragojević, Tanja; Vidal Rosas, Ernesto E.; Prats Alfonso, Elisabet; Martínez Aguilar, Javier; De la Cruz Sánchez, José M.; Garcia Cortadella, Ramon; Godignon, Philippe; Rius Suñé, Gemma; Camassa, Alessandra; Del Corro Garcia, Elena; Bousquet, Jessica; Hébert, Clement; Durduran, Turgut; Villa, Rosa; Sánch
Published in: Nature Materials, Issue 18, 2019, Page(s) 280–288, ISSN 1476-1122
DOI: 10.1038/s41563-018-0249-4

Organic electrochemical transistors

Author(s): Jonathan Rivnay, Sahika Inal, Alberto Salleo, Róisín M. Owens, Magnus Berggren, George G. Malliaras
Published in: Nature Reviews Materials, Issue 3/2, 2018, Page(s) 17086, ISSN 2058-8437
DOI: 10.1038/natrevmats.2017.86

A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes

Author(s): Jolien Pas, Alexandra L Rutz, Pascale P Quilichini, Andrea Slézia, Antoine Ghestem, Attila Kaszas, Mary J Donahue, Vincenzo F Curto, Rodney P O’Connor, Christophe Bernard, Adam Williamson, George G Malliaras
Published in: Journal of Neural Engineering, Issue 15/6, 2018, Page(s) 065001, ISSN 1741-2560
DOI: 10.1088/1741-2552/aadc1d

" ""A Steadying Hand"": Ascribing Speech Acts to Users of Predictive Speech Assistive Technologies. "

Author(s): Stephen Rainey
Published in: Journal of law and medicine, Issue 26, 2018, Page(s) 44-53, ISSN 1320-159X
DOI: 10.5281/zenodo.2535459

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation

Author(s): Bijan Pesaran, Martin Vinck, Gaute T. Einevoll, Anton Sirota, Pascal Fries, Markus Siegel, Wilson Truccolo, Charles E. Schroeder, Ramesh Srinivasan
Published in: Nature Neuroscience, Issue 21/7, 2018, Page(s) 903-919, ISSN 1097-6256
DOI: 10.1038/s41593-018-0171-8

An Attention-Based Spiking Neural Network for Unsupervised Spike-Sorting

Author(s): Marie Bernert, Blaise Yvert
Published in: International Journal of Neural Systems, Issue 29, 2019, Page(s) 1850059, ISSN 0129-0657
DOI: 10.1142/s0129065718500594

Improved metal-graphene contacts for low-noise, high-density microtransistor arrays for neural sensing

Author(s): Jose Manuel de la Cruz; Jessica Bousquet; Clement Hébert; Ramon Garcia-Cortadella; Ramon Garcia-Cortadella; Anton Guimerà-Brunet; Anton Guimerà-Brunet; Nikolaos Mavredakis; Rosa Villa; Rosa Villa; Andrea Bonaccini Calia; Andrea Bonaccini Calia; David Jiménez; Laura Rodríguez; Jose A. Garrido; Javier Martínez-Aguilar; Javier Martínez-Aguilar; Xavi Illa; Xavi Illa; Nathan Schaefer; Nathan Sch
Published in: Carbon, Issue Vol 161, 2020, Page(s) 647-655, ISSN 0008-6223
DOI: 10.1016/j.carbon.2020.01.066

Distortion‐Free Sensing of Neural Activity Using Graphene Transistors

Author(s): Maria V. Sanchez-Vives; Christoph Jeschke; Anton Guimerà; Anton Guimerà; Javier Martínez-Aguilar; Javier Martínez-Aguilar; Nathan Schäfer; Anton Sirota; Jose Manuel de la Cruz; Xavi Illa; Xavi Illa; Rosa Villa; Rosa Villa; Ramon Garcia-Cortadella; Jose A. Garrido; Eduard Masvidal-Codina; Gerrit Schwesig
Published in: Small, Issue 8, 2020, ISSN 1613-6829
DOI: 10.1002/smll.201906640

Observation and assessment of acoustic contamination of electrophysiological brain signals during speech production and sound perception

Author(s): Philémon Roussel, Gaël Le Godais, Florent Bocquelet, Marie Palma, Jiang Hongjie, Shaomin Zhang, Anne-Lise Giraud, Pierre Mégevand, Kai Miller, Johannes Gehrig, Christian Kell, Philippe Kahane, Stéphan Chabardés, Blaise Yvert
Published in: Journal of Neural Engineering, Issue 17/5, 2020, Page(s) 056028, ISSN 1741-2552
DOI: 10.1088/1741-2552/abb25e

Effect of channel thickness on noise in organic electrochemical transistors

Author(s): Anastasios G. Polyravas, Nathan Schaefer, Vincenzo F. Curto, Andrea Bonaccini Calia, Anton Guimera-Brunet, Jose A. Garrido, George G. Malliaras
Published in: Applied Physics Letters, Issue 117/7, 2020, Page(s) 073302, ISSN 0003-6951
DOI: 10.1063/5.0019693

Recent advances in neural interfaces—Materials chemistry to clinical translation

Author(s): Christopher J. Bettinger, Melanie Ecker, Takashi Daniel Yoshida Kozai, George G. Malliaras, Ellis Meng, Walter Voit
Published in: MRS Bulletin, Issue 45/8, 2020, Page(s) 655-668, ISSN 0883-7694
DOI: 10.1557/mrs.2020.195

A 1024-Channel GFET 10-bit 5-kHz 36-μW Read-Out Integrated Circuit for Brain JLECoG

Author(s): Jose Cisneros-Fernandez, Anton Guimera-Brunet, Ramon Garcia-Cortadella, Nathan Schafer, Jose A. Garrido, Lluis Teres, Francisco Serra-Graells
Published in: 2020 27th IEEE International Conference on Electronics, Circuits and Systems (ICECS), Issue Proceedings of the IEEE ICECS 2020, 2020, Page(s) 1-4
DOI: 10.1109/icecs49266.2020.9294890

Switch-Less Frequency-Domain Multiplexing of GFET Sensors and Low-Power CMOS Frontend for 1024-Channel μECoG

Author(s): Jose Cisneros-Fernandez, Michele Dei, Lluis Teres, Francisco Serra-Graells
Published in: 2019 IEEE International Symposium on Circuits and Systems (ISCAS), 2019, Page(s) 1-5
DOI: 10.1109/iscas.2019.8702544

Coherence-based spectro-spatial filters for stimulus features prediction from electrocorticographic recordings

Author(s): Delgado J, Christen A, Martin S, Pasley B, Knight R, Giraud A
Published in: BioRxiv, 2018
DOI: 10.1101/481572

Fully unsupervised online spike sorting based on an artificial spiking neural network

Author(s): Marie Bernert, Blaise Yvert
Published in: BioRxiv, 2017
DOI: 10.1101/236224

Breathing coordinates limbic network dynamics underlying memory consolidation

Author(s): Nikolaos Karalis, Anton Sirota
Published in: bioRxiv, 2018
DOI: 10.1101/392530