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Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Objectif

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

Appel à propositions

FETPROACT-2016
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Régime de financement

RIA - Research and Innovation action

Coordinateur

UNIVERSITY OF BATH
Adresse
Claverton Down
BA2 7AY Bath
United Kingdom
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 1 548 936,25

Participants (7)

UNIVERSITY OF BRISTOL

Participation terminée

United Kingdom
Contribution de l’UE
€ 431 668,75
Adresse
Beacon House Queens Road
BS8 1QU Bristol
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Suisse
Contribution de l’UE
€ 833 367,50
Adresse
Ramistrasse 71
8006 Zurich
Type d’activité
Higher or Secondary Education Establishments
MICROCHIP TECHNOLOGY CALDICOT LIMITED
United Kingdom
Contribution de l’UE
€ 403 125
Adresse
Phase 2 Castlegate Business Park
NP26 5YW Gwent
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Pays-Bas
Contribution de l’UE
€ 550 000
Adresse
Endepolsdomein 5
6229GW Maastricht
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE UNIVERSITAET WIEN
Autriche
Contribution de l’UE
€ 584 375
Adresse
Spitalgasse 23
1090 Wien
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Pays-Bas
Contribution de l’UE
€ 490 625
Adresse
Heidelberglaan 100
3584 CX Utrecht
Type d’activité
Higher or Secondary Education Establishments
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Tchéquie
Contribution de l’UE
€ 102 250
Adresse
Pekarska 53
656 91 Brno
Type d’activité
Higher or Secondary Education Establishments