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Glaucoma – Advanced, LAbel-free High resolution Automated OCT Diagnostics

Objective

The project GALAHAD targets the critical need for better glaucoma diagnostic systems. Glaucoma is an age-related major cause of blindness. The eye disease is characterized by an irreversible damage to the optic nerve head caused by increased intra-ocular pressure. The current screening and basic diagnostics for the disease involve intra-ocular pressure measurement, visual field tests and detection of structural damage to the optic nerve head and retinal nerve fibre layer. The present methods have high rates of false positive or false negative results since the in depth analysis of optical nerve head damage is not possible due to the poor resolution of available optical technologies. A leading candidate is optical coherence tomography (OCT), but the required axial resolution is ~1 μm, well beyond the 3-5 μm resolution of commercial systems. GALAHAD aims to develop a label free, compact and easy to operate high resolution diagnostic OCT system. The multiband and multimodal system will use submicron ultra-high resolution polarisation sensitive OCT (UHR PS OCT). The key breakthrough elements are: (i) A revolutionary low cost multiband supercontinuum light source. (ii.) Ground-breaking ultra-broadband photonic components required to exploit such a source. (iii.) Automated glaucoma screening algorithms: using end user evaluation of cell and animal models and tissue samples, automated algorithms will be developed, trained and tested so that non-expert operators will be able to perform glaucoma screening. The GALAHAD in depth glaucoma diagnostics after a positive screening with conventional methods will dramatically reduce false positive and false negative screening results and decrease the number of patients suffering from glaucoma-related disability. The project is driven by world leading companies and manufacturers of OCT systems and guided by requirement specifications and validated by high ranking clinical and experimental ophthalmologists in their clinical settings.

Field of science

  • /medical and health sciences/clinical medicine/ophthalmology/glaucoma

Call for proposal

H2020-ICT-2016-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

Gooch & Housego (Torquay) Limited
Address
Broomhill Way Unit A
TQ2 7QL Torquay Devon
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 779 156

Participants (9)

OPTOS PUBLIC LIMITED COMPANY
United Kingdom
EU contribution
€ 490 227
Address
Queensferry House Carnegie Campus
KY11 8GR Dunfermline Fife
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NKT PHOTONICS A/S
Denmark
EU contribution
€ 543 793
Address
Blokken 84
3460 Birkerod
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IBSEN PHOTONICS AS
Denmark
EU contribution
€ 480 240
Address
Ryttermarken 15-21
3520 Farum
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VIVID COMPONENTS LTD
United Kingdom
EU contribution
€ 214 487
Address
Sigma House Oak View Close
TQ27FF Torquay
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 317 002
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
EU contribution
€ 329 390
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 129 580
Address
Trust Headquarters Alexandra House Cheltenham General Hospital Sandford Road
GL53 7AN Cheltenham
Activity type
Research Organisations
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 473 246
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 239 659
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)