Glaucoma – Advanced, LAbel-free High resolution Automated OCT Diagnostics

Project Information

GALAHAD

Grant agreement ID: 732613

DOI 10.3030/732613

Project closed

EC signature date 29 November 2016

Start date 1 December 2016

End date 30 November 2019

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Total cost € 3 996 783,75

EU contribution € 3 996 780,00

Coordinated by

GOOCH & HOUSEGO (TORQUAY) LIMITED
United Kingdom

Deliverables

Websites, patent fillings, videos etc. (17)

Project conclusions promotional leaflet

Output from WP9.1 Promotional leaflets to show the results of the project and highlight its achievements.

Project newsletter 5

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Project presentation

Output from WP9.1 A project presentation will be produced and approved for release by the consortium. It will be available from the website for public dissemination, and may be used by all members to promote the project at suitable events.

Project close press release

Output from WP9.1 Press releases at the end of the project to raise awareness in the industrial and public media of the project achievements.

Project newsletter 6

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Project newsletter 3

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Public website online

Output from WP9.1 A project website (e.g. www.GALAHAD-project.eu) will be established by VIVID during the first three months of the project. The website will include an RSS feed with regular updates on the project progress.

Project update video

Output from WP9.1 Update video (which may be viewed from the public website) describing the project results of the project to date.

Dissemination kit

Output from WP9.1 A dissemination kit will be produced which contains suitable material (e.g. text and pictures including copyright clearance), which the Commission may use for its own dissemination of project results. These materials will also be available on the project web site and will remain accessible there for a reasonable period i.e. >5 years minimum after the project completion.

Project fact sheet

Output from WP9.1 A project fact sheet (D9.4) will be produced and approved for release by the consortium near the start of the project. It will be available from the website for public dissemination, and may be used by all members to promote the project at suitable events.

Project newsletter 4

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Technology transfer workshop

Output from WP9.1 A technology transfer workshop will be hosted by WWU to raise the profile of project.

Project newsletter 2

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Project outline promotional leaflet

Output from WP9.1 A promotional leaflets to introduce GALAHAD both to the research community and general public, and outline its aims and objectives, which will be distributed widely by partners at conferences, symposia, etc., and to their normal business contacts.

Project intro video

Output from WP9.1 Video describing the project aims and objectives which may be viewed from the public website.

Project newsletter 1

Output from WP9.1 A progress newsletter to publicise the results of the project. As much technical detail as possible on the project progress will be put into the public domain, within the limits of confidentiality restrictions.

Project start press release

Output from WP9.1 Press releases to announce the start of the project and raise awareness in the industrial and public media.

Publications

Conference proceedings (10)

Developmental approach towards high resolution optical coherence tomography for glaucoma diagnostics

Author(s): Jürgen Schnekenburger, Steffi Ketelhut, Björn Kemper, Peter Heiduschka, Michael Larsen, Marie Elise Wistrup Torm
Published in: Ophthalmic Technologies XXVIII, 2018, Page(s) 90, ISBN 9781-510614345
Publisher: SPIE
DOI: 10.1117/12.2290984

Multi-spectral digital holographic microscopy for enhanced quantitative phase imaging of living cells

Author(s): Björn Kemper, Steffi Ketelhut, Lena Kastl, Jürgen Schnekenburger
Published in: Quantitative Phase Imaging IV, 2018, Page(s) 37, ISBN 9781-510614925
Publisher: SPIE
DOI: 10.1117/12.2291071

Ultra-low noise supercontinuum source for ultra-high resolution optical coherence tomography at 1300 nm

Author(s): Michael Maria, Rasmus Dybbro Engelsholm, Thomas Feuchter, Lasse Leick, Peter Morten Moselund, Adrian G. H. Podoleanu, Ole Bang, Ivan Bravo Gonzalo
Published in: Design and Quality for Biomedical Technologies XI, 2018, Page(s) 22, ISBN 9781-510614581
Publisher: SPIE
DOI: 10.1117/12.2282412

Enhanced Quantitative Imaging of Living Cells and Dissected Tissues UtilizingMulti-Spectral Digital Holographic Microscopy

Author(s): Björn Kemper, Álvaro Barroso, Lena Kastl, Jürgen Schnekenburger, Steffi Ketelhut
Published in: Imaging and Applied Optics 2018 (3D, AO, AIO, COSI, DH, IS, LACSEA, LS&C, MATH, pcAOP), 2018, Page(s) DW3F.3, ISBN 978-1-943580-44-6
Publisher: OSA
DOI: 10.1364/dh.2018.dw3f.3

Refractive index determination of buffer solutions from visible to near-infrared spectral range for multispectral quantitative phase imaging using a calibrated Abbe refractometer

Author(s): Álvaro Barroso Peña, Rohan Radhakrishnan, Steffi Ketelhut, Jürgen Schnekenburger, Björn Kemper
Published in: Quantitative Phase Imaging V, 2019, Page(s) 80, ISBN 9781-510624177
Publisher: SPIE
DOI: 10.1117/12.2509221

Refractive index properties of the retina accessed by multi-wavelength digital holographic microscopy

Author(s): Jürgen Schnekenburger, Björn Kemper, Geburg Nettels-Hackert, Álvaro Barroso Peña, Steffi Ketelhut, Peter Heiduschka
Published in: Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI, 2019, Page(s) 30, ISBN 9781-510624092
Publisher: SPIE
DOI: 10.1117/12.2508976

Ultra-low Noise Supercontinuum Generation with Flat-near Zero All Normal Dispersion Pure Silica Fiber at GHz Reptition Rate

Author(s): D. S. Shreesha Rao, Rasmus D. Engelsholm, Ivan B. Gonzalo, Binbin Zhou, Patrick Bowen, Peter M. Moselund, Morten Bache, Ole Bang
Published in: Advanced Photonics 2018 (BGPP, IPR, NP, NOMA, Sensors, Networks, SPPCom, SOF), 2018, Page(s) NpTh2I.7, ISBN 978-1-943580-43-9
Publisher: OSA
DOI: 10.1364/np.2018.npth2i.7

Hyperspectral digital holographic microscopy approach for reduction of coherence induced disturbances in quantitative phase imaging of biological specimens

Author(s): Björn Kemper, Alvaro Barroso, Steffi Ketelhut, Lena Kastl, Jürgen Schnekenburger, Peter Heiduschka
Published in: Speckle 2018: VII International Conference on Speckle Metrology, 2018, Page(s) 49, ISBN 9781-510622982
Publisher: SPIE
DOI: 10.1117/12.2319179

All-Fiber-Based All-Normal Dispersion Supercontinuum Source Using a Femtosecond Fiber Laser with Hollow-Core Fiber Pulse Compression

Author(s): I. B. Gonzalo, T. Vestergaard, O. Bang
Published in: Advanced Photonics 2018 (BGPP, IPR, NP, NOMA, Sensors, Networks, SPPCom, SOF), 2018, Page(s) NpTh2I.3, ISBN 978-1-943580-43-9
Publisher: OSA
DOI: 10.1364/np.2018.npth2i.3

The Role of the Raman Gain in the Noise Dynamics of All-Normal Dispersion Silica Fiber Supercontinuum Generation

Author(s): I. B. Gonzalo, O. Bang
Published in: Advanced Photonics 2018 (BGPP, IPR, NP, NOMA, Sensors, Networks, SPPCom, SOF), 2018, Page(s) NpTh1H.3, ISBN 978-1-943580-43-9
Publisher: OSA
DOI: 10.1364/np.2018.npth1h.3

Other (1)

In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography (Conference Presentation)

Author(s): Mikkel Jensen, Ole Bang, Niels M. Israelsen, Adrian Podoleanu, Mette Mogensen, Merete Haedersdal, Sophie Bojesen, Michael Maria
Published in: Photonics in Dermatology and Plastic Surgery 2018, Issue Presentation only-no paper published, 2018, Page(s) 4, ISBN 9781-510614208
Publisher: SPIE
DOI: 10.1117/12.2289880

Peer reviewed articles (12)

Polarization noise places severe constraints on coherence of all-normal dispersion femtosecond supercontinuum generation

Author(s): Iván Bravo Gonzalo, Rasmus Dybbro Engelsholm, Mads Peter Sørensen, Ole Bang
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24691-7

The value of ultrahigh resolution OCT in dermatology - delineating the dermo-epidermal junction, capillaries in the dermal papillae and vellus hairs

Author(s): Niels Møller Israelsen, Michael Maria, Mette Mogensen, Sophie Bojesen, Mikkel Jensen, Merete Haedersdal, Adrian Podoleanu, Ole Bang
Published in: Biomedical Optics Express, Issue 9/5, 2018, Page(s) 2240, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.9.002240

Q-switch-pumped supercontinuum for ultra-high resolution optical coherence tomography

Author(s): Michael Maria, Ivan Bravo Gonzalo, Thomas Feuchter, Mark Denninger, Peter M. Moselund, Lasse Leick, Ole Bang, Adrian Podoleanu
Published in: Optics Letters, Issue 42/22, 2017, Page(s) 4744, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/OL.42.004744

Role of the Raman gain in the noise dynamics of all-normal dispersion silica fiber supercontinuum generation

Author(s): Iván Bravo Gonzalo, Ole Bang
Published in: Journal of the Optical Society of America B, Issue 35/9, 2018, Page(s) 2102, ISSN 0740-3224
Publisher: Optical Society of America
DOI: 10.1364/josab.35.002102

CNNs for automatic glaucoma assessment using fundus images: an extensive validation

Author(s): Andres Diaz-Pinto, Sandra Morales, Valery Naranjo, Thomas Köhler, Jose M. Mossi, Amparo Navea
Published in: BioMedical Engineering OnLine, Issue 18/1, 2019, ISSN 1475-925X
Publisher: BioMed Central
DOI: 10.1186/s12938-019-0649-y

Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

Author(s): Mette Mogensen, Sophie Bojesen, Niels M. Israelsen, Michael Maria, Mikkel Jensen, Adrian Podoleanu, Ole Bang, Merete Haedersdal
Published in: Journal of Biophotonics, Issue 11/9, 2018, Page(s) e201700348, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201700348

Amplitude noise and coherence degradation of femtosecond supercontinuum generation in all-normal-dispersion fibers

Author(s): Etienne Genier, Patrick Bowen, Thibaut Sylvestre, John M. Dudley, Peter Moselund, Ole Bang
Published in: Journal of the Optical Society of America B, Issue 36/2, 2019, Page(s) A161, ISSN 0740-3224
Publisher: Optical Society of America
DOI: 10.1364/josab.36.00a161

Retinal Image Synthesis and Semi-supervised Learning for Glaucoma Assessment

Author(s): Andres Diaz-Pinto, Adrian Colomer, Valery Naranjo, Sandra Morales, Yanwu Xu, Alejandro F Frangi
Published in: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2903434

All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations

Author(s): Mikkel Jensen, Niels Møller Israelsen, Michael Maria, Thomas Feuchter, Adrian Podoleanu, Ole Bang
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-27388-z

Noise of supercontinuum sources in spectral domain optical coherence tomography

Author(s): Mikkel Jensen, Iván Bravo Gonzalo, Rasmus Dybbro Engelsholm, Michael Maria, Niels Møller Israelsen, Adrian Podoleanu, Ole Bang
Published in: Journal of the Optical Society of America B, Issue 36/2, 2019, Page(s) A154, ISSN 0740-3224
Publisher: Optical Society of America
DOI: 10.1364/josab.36.00a154

Supercontinuum noise reduction by fiber undertapering

Author(s): Rasmus Dybbro Engelsholm, Ole Bang
Published in: Optics Express, Issue 27/7, 2019, Page(s) 10320, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.27.010320

Computer-Aided Glaucoma Diagnosis Using Stochastic Watershed Transformation on Single Fundus Images

Author(s): Andres Diaz-Pinto, Sandra Morales, Valery Naranjo, Amparo Navea
Published in: Journal of Medical Imaging and Health Informatics, Issue 9/6, 2019, Page(s) 1057-1065, ISSN 2156-7018
Publisher: American Scientific Publishers
DOI: 10.1166/jmihi.2019.2721

Book chapters (4)

Comparison of Local Analysis Strategies for Exudate Detection in Fundus Images

Author(s): Joana Pereira, Adrián Colomer, Valery Naranjo
Published in: Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Madrid, Spain, November 21–23, 2018, Proceedings, Part I, Issue 11314, 2018, Page(s) 174-183, ISBN 978-3-030-03492-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-03493-1_19

Retinal Image Synthesis for Glaucoma Assessment Using DCGAN and VAE Models

Author(s): Andres Diaz-Pinto, Adrián Colomer, Valery Naranjo, Sandra Morales, Yanwu Xu, Alejandro F. Frangi
Published in: Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Madrid, Spain, November 21–23, 2018, Proceedings, Part I, Issue 11314, 2018, Page(s) 224-232, ISBN 978-3-030-03492-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-03493-1_24

Deep-Learning-Based Classification of Rat OCT Images After Intravitreal Injection of ET-1 for Glaucoma Understanding

Author(s): Félix Fuentes-Hurtado, Sandra Morales, Jose M. Mossi, Valery Naranjo, Vadim Fedulov, David Woldbye, Kristian Klemp, Marie Torm, Michael Larsen
Published in: Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Madrid, Spain, November 21–23, 2018, Proceedings, Part I, Issue 11314, 2018, Page(s) 27-34, ISBN 978-3-030-03492-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-03493-1_4

Deep Learning-Based Approach for the Semantic Segmentation of Bright Retinal Damage

Author(s): Cristiana Silva, Adrián Colomer, Valery Naranjo
Published in: Intelligent Data Engineering and Automated Learning – IDEAL 2018 - 19th International Conference, Madrid, Spain, November 21–23, 2018, Proceedings, Part I, Issue 11314, 2018, Page(s) 164-173, ISBN 978-3-030-03492-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-03493-1_18