Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer

Información del proyecto

IMMUNOSABR

Identificador del acuerdo de subvención: 733008

DOI

10.3030/733008

Proyecto cerrado

Fecha de la firma de la CE 12 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 994 176,25

Aportación de la UE

€ 5 994 176,25

Coordinado por

UNIVERSITEIT MAASTRICHT
Netherlands

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Resultado final

Websites, patent fillings, videos etc. (1)

Online version of public web site

Documents, reports (1)

Informed Consent Form

Publicaciones

Non-peer reviewed articles (1)

Improving Patient Engagement in Phase 2 Clinical Trials with a Trial-specific Patient Decision Aid (tPDA): A Development and Usability Study

Autores: Iva Halilaj, Relinde I.Y. Lieverse, Cary J.G. Oberije, Lizza E.L. Hendriks, Charlotte Billiet, Ines Joye, Brice van Eeckhout, Anke Wind, Anshu Ankolekar, Philippe Lambin
Publicado en: MedRxiv, 2025, ISSN 2331-8422
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.25.25322591

Peer reviewed articles (13)

Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study

Autores: Evert Jan Van Limbergen, Ann Hoeben, Relinde I.Y. Lieverse, Ruud Houben, Chantal Overhof, Alida Postma, Jaap Zindler, Frans Verhelst, Ludwig J. Dubois, Dirk De Ruysscher, Esther G.C. Troost, Philippe Lambin
Publicado en: International Journal of Radiation Oncology*Biology*Physics, Edición 109/5, 2021, Página(s) 1421-1430, ISSN 0360-3016
Editor: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.053

Harmonizing CT scanner acquisition variability in an anthropomorphic phantom: A comparative study of image-level and feature-level harmonization using GAN, ComBat, and their combination

Autores: Shruti Atul Mali, Nastaran Mohammadian Rad, Henry C. Woodruff, Adrien Depeursinge, Vincent Andrearczyk, Philippe Lambin
Publicado en: PLOS One, Edición 20, 2025, Página(s) e0322365, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0322365

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

Autores: Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 9/3, 2021, Página(s) e001764, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2020-001764

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 ^th immunorad conference

Autores: Pierre-Antoine Laurent, Fabrice André, Alexandre Bobard, Desiree Deandreis, Sandra Demaria, Stephane Depil, Stefan B. Eichmüller, Cristian Fernandez-Palomo, Floris Foijer, Lorenzo Galluzzi, Jérôme Galon, Matthias Guckenberger, Kevin J. Harrington, Fernanda G. Herrera, Peter E. Huber, Antoine Italiano, Sana D. Karam, Guido Kroemer, Philippe Lambin, Carola Leuschner, Alberto Mantovani, Etienne M
Publicado en: OncoImmunology, Edición 14, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2432726

A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy

Autores: Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S. Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
Publicado en: Acta Oncologica, Edición 57/2, 2017, Página(s) 226-230, ISSN 0284-186X
Editor: Taylor & Francis
DOI: 10.1080/0284186X.2017.1385842

18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) – A prospective externally validated study

Autores: Sara Carvalho, Ralph T. H. Leijenaar, Esther G. C. Troost, Janna E. van Timmeren, Cary Oberije, Wouter van Elmpt, Lioe-Fee de Geus-Oei, Johan Bussink, Philippe Lambin
Publicado en: PLOS ONE, Edición 13/3, 2018, Página(s) e0192859, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0192859

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

Autores: Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. Wiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Publicado en: Molecular Oncology, 2020, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.12705

Will immunotherapy really change radiotherapy?

Autores: Lambin, P., Lieverse, R., Baumann, M., Ebert, N.
Publicado en: The Lancet Oncology, Edición 20/12, 2019, Página(s) 1642-1644, ISSN 1470-2045
Editor: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30682-5

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Autores: Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina,
Publicado en: BMC Cancer, Edición 20/1, 2020, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-020-07055-1

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Autores: Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Publicado en: Seminars in Radiation Oncology, Edición 30/2, 2020, Página(s) 187-193, ISSN 1053-4296
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2019.12.003

Structural and functional radiomics for lung cancer

Autores: G.Y. Wu, A. Jochems, T. Refaee, A. Ibrahim, C.G. Yan, S. Sanduleanu, H.C. Woodruff, P. Lambin
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, 2021, Página(s) 3961-3974, ISSN 1619-7089
Editor: Springer Link
DOI: 10.1007/s00259-021-05242-1

Non-invasive imaging prediction of tumor hypoxia: A novel developed and externally validated CT and FDG-PET-based radiomic signatures

Autores: Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Mathieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven, Rathan M. Subramiam, Shao Hui Huang, Brian O'Sullivan, Scott V. Bratman, Ludwig J. Dubois, Razvan L. Miclea, Dario Di Perri, Xavier Geets, Mireia Crispin-Ortuzar, Adi
Publicado en: Radiotherapy and Oncology, Edición 153, 2020, Página(s) 97-105, ISSN 0167-8140
Editor: Elsevier BV
DOI: 10.1016/j.radonc.2020.10.016

Automated detection and segmentation of non-small cell lung cancer computed tomography images

Autores: S.P. Primakov, A. Ibrahim, J.E. van Timmeren, G.Y. Wu, S.A. Keek, M. Beuque, R.W.Y. Granzier, E. Lavrova, M. Scrivener, S. Sanduleanu, E. Kayan, I. Halilaj, Anouk Lenaers, J.L. Wu, R. Monshouwer, X. Geets, H.A. Gietema, L.E.L. Hendriks, O. Morin, A. Jochems, H.C. Woodruff, P. Lambin
Publicado en: Nature Communications, Edición 3423, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30841-3