Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer

Informazioni relative al progetto

IMMUNOSABR

ID dell’accordo di sovvenzione: 733008

DOI

10.3030/733008

Progetto chiuso

Data della firma CE 12 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 994 176,25

Contributo UE

€ 5 994 176,25

Coordinato da

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Online version of public web site

Documents, reports (1)

Informed Consent Form

Pubblicazioni

Non-peer reviewed articles (1)

Improving Patient Engagement in Phase 2 Clinical Trials with a Trial-specific Patient Decision Aid (tPDA): A Development and Usability Study

Autori: Iva Halilaj, Relinde I.Y. Lieverse, Cary J.G. Oberije, Lizza E.L. Hendriks, Charlotte Billiet, Ines Joye, Brice van Eeckhout, Anke Wind, Anshu Ankolekar, Philippe Lambin
Pubblicato in: MedRxiv, 2025, ISSN 2331-8422
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.02.25.25322591

Peer reviewed articles (13)

Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study

Autori: Evert Jan Van Limbergen, Ann Hoeben, Relinde I.Y. Lieverse, Ruud Houben, Chantal Overhof, Alida Postma, Jaap Zindler, Frans Verhelst, Ludwig J. Dubois, Dirk De Ruysscher, Esther G.C. Troost, Philippe Lambin
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 109/5, 2021, Pagina/e 1421-1430, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.053

Harmonizing CT scanner acquisition variability in an anthropomorphic phantom: A comparative study of image-level and feature-level harmonization using GAN, ComBat, and their combination

Autori: Shruti Atul Mali, Nastaran Mohammadian Rad, Henry C. Woodruff, Adrien Depeursinge, Vincent Andrearczyk, Philippe Lambin
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0322365, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0322365

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

Autori: Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 9/3, 2021, Pagina/e e001764, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2020-001764

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 ^th immunorad conference

Autori: Pierre-Antoine Laurent, Fabrice André, Alexandre Bobard, Desiree Deandreis, Sandra Demaria, Stephane Depil, Stefan B. Eichmüller, Cristian Fernandez-Palomo, Floris Foijer, Lorenzo Galluzzi, Jérôme Galon, Matthias Guckenberger, Kevin J. Harrington, Fernanda G. Herrera, Peter E. Huber, Antoine Italiano, Sana D. Karam, Guido Kroemer, Philippe Lambin, Carola Leuschner, Alberto Mantovani, Etienne M
Pubblicato in: OncoImmunology, Numero 14, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2024.2432726

A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy

Autori: Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S. Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
Pubblicato in: Acta Oncologica, Numero 57/2, 2017, Pagina/e 226-230, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1385842

18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC) – A prospective externally validated study

Autori: Sara Carvalho, Ralph T. H. Leijenaar, Esther G. C. Troost, Janna E. van Timmeren, Cary Oberije, Wouter van Elmpt, Lioe-Fee de Geus-Oei, Johan Bussink, Philippe Lambin
Pubblicato in: PLOS ONE, Numero 13/3, 2018, Pagina/e e0192859, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0192859

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

Autori: Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. Wiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Pubblicato in: Molecular Oncology, 2020, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.12705

Will immunotherapy really change radiotherapy?

Autori: Lambin, P., Lieverse, R., Baumann, M., Ebert, N.
Pubblicato in: The Lancet Oncology, Numero 20/12, 2019, Pagina/e 1642-1644, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30682-5

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Autori: Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina,
Pubblicato in: BMC Cancer, Numero 20/1, 2020, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-020-07055-1

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Autori: Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Pubblicato in: Seminars in Radiation Oncology, Numero 30/2, 2020, Pagina/e 187-193, ISSN 1053-4296
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2019.12.003

Structural and functional radiomics for lung cancer

Autori: G.Y. Wu, A. Jochems, T. Refaee, A. Ibrahim, C.G. Yan, S. Sanduleanu, H.C. Woodruff, P. Lambin
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, 2021, Pagina/e 3961-3974, ISSN 1619-7089
Editore: Springer Link
DOI: 10.1007/s00259-021-05242-1

Non-invasive imaging prediction of tumor hypoxia: A novel developed and externally validated CT and FDG-PET-based radiomic signatures

Autori: Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Mathieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven, Rathan M. Subramiam, Shao Hui Huang, Brian O'Sullivan, Scott V. Bratman, Ludwig J. Dubois, Razvan L. Miclea, Dario Di Perri, Xavier Geets, Mireia Crispin-Ortuzar, Adi
Pubblicato in: Radiotherapy and Oncology, Numero 153, 2020, Pagina/e 97-105, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2020.10.016

Automated detection and segmentation of non-small cell lung cancer computed tomography images

Autori: S.P. Primakov, A. Ibrahim, J.E. van Timmeren, G.Y. Wu, S.A. Keek, M. Beuque, R.W.Y. Granzier, E. Lavrova, M. Scrivener, S. Sanduleanu, E. Kayan, I. Halilaj, Anouk Lenaers, J.L. Wu, R. Monshouwer, X. Geets, H.A. Gietema, L.E.L. Hendriks, O. Morin, A. Jochems, H.C. Woodruff, P. Lambin
Pubblicato in: Nature Communications, Numero 3423, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30841-3