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Early-life stressors and LifeCycle health

Deliverables

Report on associations of early-life stressors with DNA methylation at birth

We will use an EWAS approach to study the associations of the main indicators of early-life stressors and the integrated early-life exposome, before and during pregnancy on DNA methylation at birth measured in cord blood. We will also explore the associations of the overall early-life exposome, developed in WP3, during pregnancy, on cord blood methylation at birth.

External project website launched

Project website accessible for general public and specific public. The website will be multi-layered. The homepage will be accessible to everyone; it will be based mainly on visual communication (videoclips, data visualisations, etc.); and it will link to specific pages for various stakeholder or target groups, including researchers, health care providers, patient organizations, patients and policymakers.

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Publications

Availability, use of, and satisfaction with green space, and children's mental wellbeing at age 4 years in a multicultural, deprived, urban area: results from the Born in Bradford cohort study

Author(s): Rosemary R C McEachan, Tiffany C Yang, Hannah Roberts, Kate E Pickett, Diana Arseneau-Powell, Christopher J Gidlow, John Wright, Mark Nieuwenhuijsen
Published in: The Lancet Planetary Health, Issue 2/6, 2018, Page(s) e244-e254, ISSN 2542-5196
DOI: 10.1016/S2542-5196(18)30119-0

Increased correlation between methylation sites in epigenome-wide replication studies: impact on analysis and results

Author(s): Maja Popovic, Francesca Fasanelli, Valentina Fiano, Annibale Biggeri, Lorenzo Richiardi
Published in: Epigenomics, Issue 9/12, 2017, Page(s) 1489-1502, ISSN 1750-1911
DOI: 10.2217/epi-2017-0073

Effects decomposition in mediation analysis: a numerical example


Published in: ISSN 1120-9763
DOI: 10.19191/EP18.2.P127.041

Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Author(s): Vehmeijer, F. O. L., Guxens, M., Duijts, L., El Marroun, H.
Published in: Journal of Developmental Origins of Health and Disease, 2018, ISSN 2040-1744
DOI: 10.1017/S2040174418000557

Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author(s): Zuelma A Contreras, Zhanghua Chen, Theano Roumeliotaki, Isabella Annesi-Maesano, Nour Baïz, Andrea von Berg, Anna Bergström, Sarah Crozier, Liesbeth Duijts, Sandra Ekström, Esben Eller, Maria P Fantini, Henrik Fomsgaard Kjaer, Francesco Forastiere, Beatrix Gerhard, Davide Gori, Margreet W Harskamp-van Ginkel, Joachim Heinrich, Carmen Iñiguez, Hazel Inskip, Thomas Keil, Manolis Kogevinas, Susan
Published in: European Respiratory Journal, 2018, ISSN 0903-1936

Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

Author(s): Emilie M. Herzog, Alex J. Eggink, Sten P. Willemsen, Roderick C. Slieker, Kim P.J. Wijnands, Janine F. Felix, Jun Chen, Andrew Stubbs, Peter J. van der Spek, Joyce B. van Meurs, Régine P.M. Steegers-Theunissen
Published in: Placenta, Issue 58, 2017, Page(s) 122-132, ISSN 0143-4004
DOI: 10.1016/j.placenta.2017.08.070

Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework

Author(s): J. F. Felix, C. A. M. Cecil
Published in: Journal of Developmental Origins of Health and Disease, 2018, Page(s) 1-8, ISSN 2040-1744
DOI: 10.1017/S2040174418000442

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

Author(s): Maribel Casas, Herman T den Dekker, Claudia J Kruithof, Irwin K Reiss, Martine Vrijheid, Jordi Sunyer, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
Published in: Thorax, 2018, Page(s) thoraxjnl-2017-211216, ISSN 0040-6376
DOI: 10.1136/thoraxjnl-2017-211216

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author(s): Janine F Felix, Bonnie R Joubert, Andrea A Baccarelli, Gemma C Sharp, Catarina Almqvist, Isabella Annesi-Maesano, Hasan Arshad, Nour Baïz, Marian J Bakermans-Kranenburg, Kelly M Bakulski, Elisabeth B Binder, Luigi Bouchard, Carrie V Breton, Bert Brunekreef, Kelly J Brunst, Esteban G Burchard, Mariona Bustamante, Leda Chatzi, Monica Cheng Munthe-Kaas, Eva Corpeleijn, Darina Czamara, Dana Dabelea,
Published in: International Journal of Epidemiology, Issue 47/1, 2017, Page(s) 22-23u, ISSN 0300-5771
DOI: 10.1093/ije/dyx190

Premature birth and circadian preference in young adulthood: evidence from two birth cohorts

Author(s): Johan Björkqvist, Anu-Katriina Pesonen, Liisa Kuula, Hanna-Maria Matinolli, Aulikki Lano, Marika Sipola-Leppänen, Marjaana Tikanmäki, Dieter Wolke, Marjo-Riitta Järvelin, Johan G Eriksson, Sture Andersson, Marja Vääräsmäki, Kati Heinonen, Katri Räikkönen, Petteri Hovi, Eero Kajantie
Published in: Chronobiology International, Issue 35/4, 2018, Page(s) 555-564, ISSN 0742-0528
DOI: 10.1080/07420528.2017.1420078

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

Author(s): Rebecca C. Richmond, Nicholas J. Timpson, Janine F. Felix, Tom Palmer, Romy Gaillard, George McMahon, George Davey Smith, Vincent W. Jaddoe, Debbie A. Lawlor
Published in: PLOS Medicine, Issue 14/1, 2017, Page(s) e1002221, ISSN 1549-1277
DOI: 10.1371/journal.pmed.1002221

Sources of confounding in life course epidemiology

Author(s): S. Santos, D. Zugna, C. Pizzi, L. Richiardi
Published in: Journal of Developmental Origins of Health and Disease, 2018, Page(s) 1-7, ISSN 2040-1744
DOI: 10.1017/S2040174418000582

Exposure to elemental composition of outdoor PM 2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts

Author(s): Małgorzata J. Lubczyńska, Jordi Sunyer, Henning Tiemeier, Daniela Porta, Monika Kasper-Sonnenberg, Vincent W.V. Jaddoe, Xavier Basagaña, Albert Dalmau-Bueno, Francesco Forastiere, Jürgen Wittsiepe, Barbara Hoffmann, Mark Nieuwenhuijsen, Gerard Hoek, Kees de Hoogh, Bert Brunekreef, Mònica Guxens
Published in: Environment International, Issue 109, 2017, Page(s) 170-180, ISSN 0160-4120
DOI: 10.1016/j.envint.2017.09.015

Fetal and Infant Growth Patterns and Risk of Lower Lung Function and Asthma. The Generation R Study

Author(s): Herman T. den Dekker, Vincent W. V. Jaddoe, Irwin K. Reiss, Johan C. de Jongste, Liesbeth Duijts
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 197/2, 2018, Page(s) 183-192, ISSN 1073-449X
DOI: 10.1164/rccm.201703-0631oc

Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study

Author(s): Maria C Magnus, Kozeta Miliku, Anna Bauer, Stephanie M Engel, Janine F Felix, Vincent W V Jaddoe, Debbie A Lawlor, Stephanie J London, Per Magnus, Ralph McGinnis, Wenche Nystad, Christian M Page, Fernando Rivadeneira, Lars C Stene, German Tapia, Nicholas Williams, Carolina Bonilla, Abigail Fraser
Published in: BMJ, 2018, Page(s) k2167, ISSN 0959-8138
DOI: 10.1136/bmj.k2167

Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts

Author(s): Gemma C Sharp, Ryan Arathimos, Sarah E Reese, Christian M Page, Janine Felix, Leanne K Küpers, Sheryl L Rifas-Shiman, Chunyu Liu, Kimberley Burrows, Shanshan Zhao, Maria C Magnus, Liesbeth Duijts, Eva Corpeleijn, Dawn L DeMeo, Augusto Litonjua, Andrea Baccarelli, Marie-France Hivert, Emily Oken, Harold Snieder, Vincent Jaddoe, Wenche Nystad, Stephanie J London, Caroline L Relton, Luisa Zuccolo
Published in: Epigenomics, Issue 10/1, 2018, Page(s) 27-42, ISSN 1750-1911
DOI: 10.2217/epi-2017-0095

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Author(s): Robin N Beaumont, Nicole M Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C Richmond, Lavinia Paternoster, Jonathan P Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L Lunetta, Jodie N Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J Barton, Ana Espinosa, Julie A Marsh, Catherine Potter, Ge Zhang
Published in: Human Molecular Genetics, Issue 27/4, 2018, Page(s) 742-756, ISSN 0964-6906
DOI: 10.1093/hmg/ddx429

A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma

Author(s): Evelien R van Meel, Herman T den Dekker, Niels J Elbert, Pauline W Jansen, Henriëtte A Moll, Irwin K Reiss, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
Published in: Thorax, Issue 73/2, 2018, Page(s) 167-173, ISSN 0040-6376
DOI: 10.1136/thoraxjnl-2017-210149

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Author(s): Johannes Waage, Marie Standl, John A. Curtin, Leon E. Jessen, Jonathan Thorsen, Chao Tian, Nathan Schoettler, Carlos Flores, Abdel Abdellaoui, Tarunveer S. Ahluwalia, Alexessander C. Alves, Andre F. S. Amaral, Josep M. Antó, Andreas Arnold, Amalia Barreto-Luis, Hansjörg Baurecht, Catharina E. M. van Beijsterveldt, Eugene R. Bleecker, Sílvia Bonàs-Guarch, Dorret I. Boomsma, Susanne Brix, Supind
Published in: Nature Genetics, Issue 50/8, 2018, Page(s) 1072-1080, ISSN 1061-4036
DOI: 10.1038/s41588-018-0157-1

Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children

Author(s): Mònica Guxens, Małgorzata J. Lubczyńska, Ryan L. Muetzel, Albert Dalmau-Bueno, Vincent W.V. Jaddoe, Gerard Hoek, Aad van der Lugt, Frank C. Verhulst, Tonya White, Bert Brunekreef, Henning Tiemeier, Hanan El Marroun
Published in: Biological Psychiatry, Issue 84/4, 2018, Page(s) 295-303, ISSN 0006-3223
DOI: 10.1016/j.biopsych.2018.01.016

Maternal and fetal genetic contribution to gestational weight gain

Author(s): N M Warrington, R Richmond, B Fenstra, R Myhre, R Gaillard, L Paternoster, C A Wang, R N Beaumont, S Das, M Murcia, S J Barton, A Espinosa, E Thiering, M Atalay, N Pitkänen, I Ntalla, A E Jonsson, R Freathy, V Karhunen, C M T Tiesler, C Allard, A Crawford, S M Ring, M Melbye, P Magnus, F Rivadeneira, L Skotte, T Hansen, J Marsh, M Guxens, J W Holloway, H Grallert, V W V Jaddoe, W L Lowe Jr, T Rou
Published in: International Journal of Obesity, Issue 42/4, 2017, Page(s) 775-784, ISSN 0307-0565
DOI: 10.1038/ijo.2017.248

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author(s): Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C. Barnes, William O. C. Cookson, Janine Altmüller, Wei Ang, R. Graham Barr, Terri H. Beaty, Allan B. Becker, John Beilby, Hans Bisgaard, Unnur Steina Bjornsdottir, Eugene Bleecker, Klaus Bønnelykke, Dorret I. Boomsma, Emmanuelle Bouzigon, Christopher E. Brightling, Myriam Brossard, Guy G. Brusselle, Esteban Burchard, Kristin M. Burkart, A
Published in: Nature Genetics, Issue 50/1, 2018, Page(s) 42-53, ISSN 1061-4036
DOI: 10.1038/s41588-017-0014-7

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Author(s): Gemma C Sharp, Lucas A Salas, Claire Monnereau, Catherine Allard, Paul Yousefi, Todd M Everson, Jon Bohlin, Zongli Xu, Rae-Chi Huang, Sarah E Reese, Cheng-Jian Xu, Nour Baïz, Cathrine Hoyo, Golareh Agha, Ritu Roy, John W Holloway, Akram Ghantous, Simon K Merid, Kelly M Bakulski, Leanne K Küpers, Hongmei Zhang, Rebecca C Richmond, Christian M Page, Liesbeth Duijts, Rolv T Lie, Phillip E Melton, J
Published in: Human Molecular Genetics, Issue 26/20, 2017, Page(s) 4067-4085, ISSN 0964-6906
DOI: 10.1093/hmg/ddx290

Baseline selection on a collider: a ubiquitous mechanism occurring in both representative and selected cohort studies

Author(s): Lorenzo Richiardi, Neil Pearce, Eva Pagano, Daniela Di Cuonzo, Daniela Zugna, Costanza Pizzi
Published in: Journal of Epidemiology and Community Health, Issue 73/5, 2019, Page(s) 475-480, ISSN 0143-005X
DOI: 10.1136/jech-2018-211829

Narrative review of reviews of preconception interventions to prevent an increased risk of obesity and non‐communicable diseases in children

Author(s): Chandni Maria Jacob, Marie‐Louise Newell, Mark Hanson
Published in: Obesity Reviews, Issue 20/S1, 2019, Page(s) 5-17, ISSN 1467-7881
DOI: 10.1111/obr.12769

Research question and study validity

Author(s): Richiardi L
Published in: Epidemiologia e prevenzione, Issue 43/4, 2019, Page(s) 217-219, ISSN 1120-9763
DOI: 10.19191/ep19.4.p217.073

Differentially methylated DNA regions in early childhood wheezing: An epigenome‐wide study using saliva

Author(s): Maja Popovic, Valentina Fiano, Francesca Fasanelli, Morena Trevisan, Chiara Grasso, Manuela Bianca Assumma, Anna Gillio‐Tos, Silvia Polidoro, Laura De Marco, Franca Rusconi, Franco Merletti, Daniela Zugna, Lorenzo Richiardi
Published in: Pediatric Allergy and Immunology, Issue 30/3, 2019, Page(s) 305-314, ISSN 0905-6157
DOI: 10.1111/pai.13023

Infant breastfeeding and childhood general, visceral, liver, and pericardial fat measures assessed by magnetic resonance imaging

Author(s): Suzanne Vogelezang, Susana Santos, Eline M van der Beek, Marieke Abrahamse-Berkeveld, Liesbeth Duijts, Aad van der Lugt, Janine F Felix, Vincent W V Jaddoe
Published in: The American Journal of Clinical Nutrition, Issue 108/4, 2018, Page(s) 722-729, ISSN 0002-9165
DOI: 10.1093/ajcn/nqy137

Exposure to Maternal Depressive Symptoms in Fetal Life or Childhood and Offspring Brain Development: A Population-Based Imaging Study

Author(s): Runyu Zou, Henning Tiemeier, Jan van der Ende, Frank C. Verhulst, Ryan L. Muetzel, Tonya White, Manon Hillegers, Hanan El Marroun
Published in: American Journal of Psychiatry, Issue 176/9, 2019, Page(s) 702-710, ISSN 0002-953X
DOI: 10.1176/appi.ajp.2019.18080970

Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort

Author(s): Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling, Debbie A. Lawlor
Published in: BMC Medicine, Issue 16/1, 2018, ISSN 1741-7015
DOI: 10.1186/s12916-018-1191-7

The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial

Author(s): Harriet L. Mills, Nashita Patel, Sara L. White, Dharmintra Pasupathy, Annette L. Briley, Diana L. Santos Ferreira, Paul T. Seed, Scott M. Nelson, Naveed Sattar, Kate Tilling, Lucilla Poston, Deborah A. Lawlor
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
DOI: 10.1186/s12916-018-1248-7

Epigenome-wide association study of seizures in childhood and adolescence

Author(s): Doretta Caramaschi, Charlie Hatcher, Rosa H. Mulder, Janine F. Felix, Charlotte A. M. Cecil, Caroline L. Relton, Esther Walton
Published in: Clinical Epigenetics, Issue 12/1, 2020, ISSN 1868-7075
DOI: 10.1186/s13148-019-0793-z

Income inequality and social gradients in children’s height: a comparison of cohort studies from five high-income countries

Author(s): Philippa K Bird, Kate E Pickett, Hilary Graham, Tomas Faresjö, Vincent W V Jaddoe, Johnny Ludvigsson, Hein Raat, Louise Seguin, Anne I Wijtzes, Jennifer J McGrath
Published in: BMJ Paediatrics Open, Issue 3/1, 2019, Page(s) e000568, ISSN 2399-9772
DOI: 10.1136/bmjpo-2019-000568

Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author(s): Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Luigi Gagliardi, Vagelis Georgiu, Keith M. Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barb
Published in: BMC Medicine, Issue 16/1, 2018, ISSN 1741-7015
DOI: 10.1186/s12916-018-1189-1

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Author(s): Andres Cardenas, Sabrina Faleschini, Andrea Cortes Hidalgo, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Dawn L. DeMeo, Augusto A. Litonjua, Alexander Neumann, Janine F. Felix, Vincent W. V. Jaddoe, Hanan El Marroun, Henning Tiemeier, Emily Oken, Marie-France Hivert, Heather H. Burris
Published in: Clinical Epigenetics, Issue 11/1, 2019, ISSN 1868-7075
DOI: 10.1186/s13148-019-0653-x

Observed infant-parent attachment and brain morphology in middle childhood– A population-based study

Author(s): Andrea P. Cortes Hidalgo, Ryan Muetzel, Maartje P.C.M. Luijk, Marian J. Bakermans-Kranenburg, Hanan El Marroun, Meike W. Vernooij, Marinus H. van IJzendoorn, Tonya White, Henning Tiemeier
Published in: Developmental Cognitive Neuroscience, Issue 40, 2019, Page(s) 100724, ISSN 1878-9293
DOI: 10.1016/j.dcn.2019.100724

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Author(s): Petri Wiklund, Ville Karhunen, Rebecca C. Richmond, Priyanka Parmar, Alina Rodriguez, Maneka De Silva, Matthias Wielscher, Faisal I. Rezwan, Tom G. Richardson, Juha Veijola, Karl-Heinz Herzig, John W. Holloway, Caroline L. Relton, Sylvain Sebert, Marjo-Riitta Järvelin
Published in: Clinical Epigenetics, Issue 11/1, 2019, ISSN 1868-7075
DOI: 10.1186/s13148-019-0683-4

Newborn and childhood differential DNA methylation and liver fat in school-age children

Author(s): Madelon L. Geurtsen, Vincent W. V. Jaddoe, Lucas A. Salas, Susana Santos, Janine F. Felix
Published in: Clinical Epigenetics, Issue 12/1, 2020, ISSN 1868-7075
DOI: 10.1186/s13148-019-0799-6

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Author(s): Priyanka Parmar, Estelle Lowry, Giovanni Cugliari, Matthew Suderman, Rory Wilson, Ville Karhunen, Toby Andrew, Petri Wiklund, Matthias Wielscher, Simonetta Guarrera, Alexander Teumer, Benjamin Lehne, Lili Milani, Niek de Klein, Pashupati P. Mishra, Phillip E. Melton, Pooja R. Mandaviya, Silva Kasela, Jana Nano, Weihua Zhang, Yan Zhang, Andre G. Uitterlinden, Annette Peters, Ben Schöttker, Christi
Published in: EBioMedicine, Issue 38, 2018, Page(s) 206-216, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2018.10.066

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Author(s): Olena Gruzieva, Cheng-Jian Xu, Paul Yousefi, Caroline Relton, Simon Kebede Merid, Carrie V. Breton, Lu Gao, Heather E. Volk, Jason I. Feinberg, Christine Ladd-Acosta, Kelly Bakulski, Charles Auffray, Nathanaël Lemonnier, Michelle Plusquin, Akram Ghantous, Zdenko Herceg, Tim S. Nawrot, Costanza Pizzi, Lorenzo Richiardi, Franca Rusconi, Paolo Vineis, Manolis Kogevinas, Janine F. Felix, Liesbeth Dui
Published in: Environmental Health Perspectives, Issue 127/5, 2019, Page(s) 057012, ISSN 0091-6765
DOI: 10.1289/ehp4522

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Author(s): Sinjini Sikdar, Roby Joehanes, Bonnie R Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I Rezwan, Janine F Felix, James M Ward, Weihua Guan, Rebecca C Richmond, Jennifer A Brody, Leanne K Küpers, Nour Baïz, Siri E Håberg, Jennifer A Smith, Sarah E Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A Markunas, Tao Xu, Lindsay M Reynolds, Allan C Just, Pooja R Mandaviya, Akram
Published in: Epigenomics, Issue 11/13, 2019, Page(s) 1487-1500, ISSN 1750-1911
DOI: 10.2217/epi-2019-0066

Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents

Author(s): Małgorzata J. Lubczyńska, Ryan L. Muetzel, Hanan El Marroun, Xavier Basagaña, Maciej Strak, William Denault, Vincent W.V. Jaddoe, Manon Hillegers, Meike W. Vernooij, Gerard Hoek, Tonya White, Bert Brunekreef, Henning Tiemeier, Mònica Guxens
Published in: Environmental Health Perspectives, Issue 128/2, 2020, Page(s) 027005, ISSN 0091-6765
DOI: 10.1289/ehp4709

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Author(s): Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Published in: Epigenetics, 2020, Page(s) 1-15, ISSN 1559-2294
DOI: 10.1080/15592294.2020.1719303

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA)

Author(s): Cheng Peng, Martijn den Dekker, Andres Cardenas, Sheryl L. Rifas-Shiman, Heike Gibson, Golareh Agha, Maria H. Harris, Brent A. Coull, Joel Schwartz, Augusto A. Litonjua, Dawn L. DeMeo, Marie-France Hivert, Matthew W. Gilman, Sharon K. Sagiv, Yvonne de Kluizenaar, Janine F. Felix, Vincent W. Jaddoe, Emily Oken, Liesbeth Duijts, Diane R. Gold, Andrea A. Baccarelli
Published in: Environmental Health Perspectives, Issue 126/9, 2018, Page(s) 097006, ISSN 0091-6765
DOI: 10.1289/ehp2034

Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course

Author(s): Herman T. den Dekker, Kimberley Burrows, Janine F. Felix, Lucas A. Salas, Ivana Nedeljkovic, Jin Yao, Sheryl L. Rifas-Shiman, Carlos Ruiz-Arenas, N. Amin, Mariona Bustamante, Dawn L. DeMeo, A. John Henderson, Caitlin G. Howe, Marie-France Hivert, M. Arfan Ikram, Johan C. de Jongste, Lies Lahousse, Pooja R. Mandaviya, Joyce B. van Meurs, Mariona Pinart, Gemma C. Sharp, Lisette Stolk, André G. U
Published in: European Respiratory Journal, Issue 53/4, 2019, Page(s) 1801795, ISSN 0903-1936
DOI: 10.1183/13993003.01795-2018

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Author(s): Jonathan P Bradfield, Suzanne Vogelezang, Janine F Felix, Alessandra Chesi, Øyvind Helgeland, Momoko Horikoshi, Ville Karhunen, Estelle Lowry, Diana L Cousminer, Tarunveer S Ahluwalia, Elisabeth Thiering, Eileen Tai-Hui Boh, Mohammad H Zafarmand, Natalia Vilor-Tejedor, Carol A Wang, Raimo Joro, Zhanghua Chen, William J Gauderman, Niina Pitkänen, Esteban J Parra, Lindsay Fernandez-Rhodes, Akram A
Published in: Human Molecular Genetics, Issue 28/19, 2019, Page(s) 3327-3338, ISSN 0964-6906
DOI: 10.1093/hmg/ddz161

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author(s): Sarah E. Reese, Cheng-Jian Xu, Herman T. den Dekker, Mi Kyeong Lee, Sinjini Sikdar, Carlos Ruiz-Arenas, Simon K. Merid, Faisal I. Rezwan, Christian M. Page, Vilhelmina Ullemar, Phillip E. Melton, Sam S. Oh, Ivana V. Yang, Kimberley Burrows, Cilla Söderhäll, Dereje D. Jima, Lu Gao, Ryan Arathimos, Leanne K. Küpers, Matthias Wielscher, Peter Rzehak, Jari Lahti, Catherine Laprise, Anne-Marie Mador
Published in: Journal of Allergy and Clinical Immunology, Issue 143/6, 2019, Page(s) 2062-2074, ISSN 0091-6749
DOI: 10.1016/j.jaci.2018.11.043

Maternal body mass index, gestational weight gain, and childhood abdominal, pericardial, and liver fat assessed by magnetic resonance imaging

Author(s): Susana Santos, Claire Monnereau, Janine F. Felix, Liesbeth Duijts, Romy Gaillard, Vincent W. V. Jaddoe
Published in: International Journal of Obesity, Issue 43/3, 2019, Page(s) 581-593, ISSN 0307-0565
DOI: 10.1038/s41366-018-0186-y

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

Author(s): Liang-Dar Hwang, Deborah A Lawlor, Rachel M Freathy, David M Evans, Nicole M Warrington
Published in: International Journal of Epidemiology, Issue 48/5, 2019, Page(s) 1457-1467, ISSN 0300-5771
DOI: 10.1093/ije/dyz160

Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts

Author(s): Juan Verdejo-Román, Lassi Björnholm, Ryan L. Muetzel, Francisco José Torres-Espínola, Johannes Lieslehto, Vincent Jaddoe, Daniel Campos, Juha Veijola, Tonya White, Andrés Catena, Juha Nikkinen, Vesa Kiviniemi, Marjo-Riitta Järvelin, Henning Tiemeier, Cristina Campoy, Sylvain Sebert, Hanan El Marroun
Published in: International Journal of Obesity, Issue 43/10, 2019, Page(s) 1995-2006, ISSN 0307-0565
DOI: 10.1038/s41366-018-0268-x

Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts

Author(s): Tom A Bond, Ville Karhunen, Matthias Wielscher, Juha Auvinen, Minna Männikkö, Sirkka Keinänen-Kiukaanniemi, Marc J Gunter, Janine F Felix, Inga Prokopenko, Jian Yang, Peter M Visscher, David M Evans, Sylvain Sebert, Alex Lewin, Paul F O’Reilly, Debbie A Lawlor, Marjo-Riitta Jarvelin
Published in: International Journal of Epidemiology, 2019, ISSN 0300-5771
DOI: 10.1093/ije/dyz095

A Cross‐Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children

Author(s): Markus Juonala, Susan Ellul, Debbie A. Lawlor, Diana L. Santos Ferreira, John B. Carlin, Michael Cheung, Terence Dwyer, Melissa Wake, Richard Saffery, David P. Burgner
Published in: Journal of the American Heart Association, Issue 8/14, 2019, ISSN 2047-9980
DOI: 10.1161/jaha.118.011852

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author(s): Leanne K. Küpers, Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, Sarah E. Reese, Allen J. Wilcox, Darina Czamara, Anne P. Starling, Alexei Novoloaca, Samantha Lent, Ritu Roy, Cathrine Hoyo, Carrie V. Breton, Catherine Allard, Allan C. Just, Kelly M. Bakulski, John W. Holloway, Todd M. Everson, Cheng-Jian Xu, Rae-Chi Huang, Diana A. van der Plaat
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09671-3

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

Author(s): Ellis Voerman, Susana Santos, Hazel Inskip, Pilar Amiano, Henrique Barros, Marie-Aline Charles, Leda Chatzi, George P. Chrousos, Eva Corpeleijn, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Davide Gori, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Carmen Iñiguez, Anne M. Karvone
Published in: JAMA, Issue 321/17, 2019, Page(s) 1702, ISSN 0098-7484
DOI: 10.1001/jama.2019.3820

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Author(s): Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P. Prins, Janine F. Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L. Min, Lærke Sass, Paul R. H. J. Timmers, George Davey Smith, Simon E.
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-018-07863-x

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Author(s): Alexander Teumer, Yong Li, Sahar Ghasemi, Bram P. Prins, Matthias Wuttke, Tobias Hermle, Ayush Giri, Karsten B. Sieber, Chengxiang Qiu, Holger Kirsten, Adrienne Tin, Audrey Y. Chu, Nisha Bansal, Mary F. Feitosa, Lihua Wang, Jin-Fang Chai, Massimiliano Cocca, Christian Fuchsberger, Mathias Gorski, Anselm Hoppmann, Katrin Horn, Man Li, Jonathan Marten, Damia Noce, Teresa Nutile, Sanaz Sedaghat, Gard
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-11576-0

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Author(s): Jun Liu, Elena Carnero-Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. de Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christ
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-10487-4

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

Author(s): Ellis Voerman, Susana Santos, Bernadeta Patro Golab, Pilar Amiano, Ferran Ballester, Henrique Barros, Anna Bergström, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Graham Devereux, Merete Eggesbø, Sandra Ekström, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Keith M. Godfrey, Davide Gori, Veit Gro
Published in: PLOS Medicine, Issue 16/2, 2019, Page(s) e1002744, ISSN 1549-1676
DOI: 10.1371/journal.pmed.1002744

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Author(s): M. Wuttke; Y. Li; M. Li; K. B. Sieber; M. F. Feitosa; M. Gorski; A. Tin; L. Wang; A. Y. Chu; A. Hoppmann; H. Kirsten; A. Giri; J. F. Chai; G. Sveinbjornsson; B. O. Tayo; T. Nutile; C. Fuchsberger; J. Marten; M. Cocca; S. Ghasemi; Y. Xu; K. Horn; D. Noce; P. J. van der Most; S. Sedaghat; Z. Yu; M. Akiyama; S. Afaq; T. S. Ahluwalia; P. Almgren; N. Amin; J. Arnlov; S. J. L. Bakker; N. Bansal; D. Bapt
Published in: Nature Genetics, 2019, ISSN 1061-4036
DOI: 10.1038/s41588-019-0407-x

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Author(s): Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, N. William Rayner, Zhen Qiao, Gunn-Helen Moen, Marc Vaudel, Carmen J. Marsit, Jia Chen, Michael Nodzenski, Theresia M. Schnurr, Mohammad H. Zafarmand, Jonathan P. Bradfi
Published in: Nature Genetics, Issue 51/5, 2019, Page(s) 804-814, ISSN 1061-4036
DOI: 10.1038/s41588-019-0403-1

Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies

Author(s): Judith S. Brand, Romy Gaillard, Jane West, Rosemary R. C. McEachan, John Wright, Ellis Voerman, Janine F. Felix, Kate Tilling, Deborah A. Lawlor
Published in: PLOS Medicine, Issue 16/11, 2019, Page(s) e1002972, ISSN 1549-1676
DOI: 10.1371/journal.pmed.1002972

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Author(s): Alexessander Couto Alves, N. Maneka G. De Silva, Ville Karhunen, Ulla Sovio, Shikta Das, H. Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Diana L. Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Tom A. Bond, Estelle Lowry, Christopher D. Brown, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Doug Speed, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton,
Published in: Science Advances, Issue 5/9, 2019, Page(s) eaaw3095, ISSN 2375-2548
DOI: 10.1126/sciadv.aaw3095

Caesarean section, but not induction of labour, is associated with major changes in cord blood metabolome

Author(s): Linda Marchioro, Engy Shokry, Aisling A. Geraghty, Eileen C. O’Brien, Olaf Uhl, Berthold Koletzko, Fionnuala M. McAuliffe
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-53810-1

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns


Published in: ISSN 0194-911X
DOI: 10.1161/hypertensionaha.119.12634

Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial

Author(s): Franca Fabiana Kirchberg, Christian Hellmuth, Martina Totzauer, Olaf Uhl, Ricardo Closa-Monasterolo, Joaquin Escribano, Dariusz Gruszfeld, Kinga Gradowska, Elvira Verduci, Benedetta Mariani, Melissa Moretti, Déborah Rousseaux, Berthold Koletzko
Published in: International Journal of Obesity, Issue 44/1, 2020, Page(s) 69-81, ISSN 0307-0565
DOI: 10.1038/s41366-019-0398-9

Validated inference of smoking habits from blood with a finite DNA methylation marker set

Author(s): Silvana C. E. Maas, Athina Vidaki, Rory Wilson, Alexander Teumer, Fan Liu, Joyce B. J. van Meurs, André G. Uitterlinden, Dorret I. Boomsma, Eco J. C. de Geus, Gonneke Willemsen, Jenny van Dongen, Carla J. H. van der Kallen, P. Eline Slagboom, Marian Beekman, Diana van Heemst, Leonard H. van den Berg, Liesbeth Duijts, Vincent W. V. Jaddoe, Karl-Heinz Ladwig, Sonja Kunze, Annette Peters, M. Arfan I
Published in: European Journal of Epidemiology, Issue 34/11, 2019, Page(s) 1055-1074, ISSN 0393-2990
DOI: 10.1007/s10654-019-00555-w

Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age

Author(s): Ahmed Elhakeem, Monika Frysz, Kate Tilling, Jon H. Tobias, Deborah A. Lawlor
Published in: JAMA Network Open, Issue 2/8, 2019, Page(s) e198918, ISSN 2574-3805
DOI: 10.1001/jamanetworkopen.2019.8918

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits

Author(s): Tao Huang, Tiange Wang, Yan Zheng, Christina Ellervik, Xiang Li, Meng Gao, Zhe Fang, Jin-Fang Chai, Tarun veer S. Ahluwalia, Yujie Wang, Trudy Voortman, Raymond Noordam, Alexis Frazier-Wood, Markus Scholz, Emily Sonestedt, Masato Akiyama, Rajkumar Dorajoo, Ang Zhou, Tuomas O. Kilpeläinen, Marcus E. Kleber, Sarah R. Crozier, Keith M. Godfrey, Rozenn Lemaitre, Janine F. Felix, Yuan Shi, Preeti Gupt
Published in: JAMA Network Open, Issue 2/9, 2019, Page(s) e1910915, ISSN 2574-3805
DOI: 10.1001/jamanetworkopen.2019.10915

A prospective population-based study of gestational vitamin D status and brain morphology in preadolescents

Author(s): Runyu Zou, Hanan El Marroun, John J. McGrath, Ryan L. Muetzel, Manon Hillegers, Tonya White, Henning Tiemeier
Published in: NeuroImage, Issue 209, 2020, Page(s) 116514, ISSN 1053-8119
DOI: 10.1016/j.neuroimage.2020.116514

Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children

Author(s): A. C. Viuff, G. C. Sharp, D. Rai, T. B. Henriksen, L. H. Pedersen, K. J. Kyng, N. H. Staunstrup, A. Cortes, A. Neumann, J. F. Felix, H. Tiemeier, V. W. V. Jaddoe, C. L. Relton
Published in: Translational Psychiatry, Issue 8/1, 2018, ISSN 2158-3188
DOI: 10.1038/s41398-018-0286-4

Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium

Author(s): Adrien M. Aubert, Anne Forhan, Blandine de Lauzon-Guillain, Ling-Wei Chen, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Sara M. Mensink-Bout, Liesbeth Duijts, Matthew Suderman, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Fionnuala M. McAuliffe, Cecily C. Kelleher, Catherine M. Phillips, Barbara Heude, Jonathan Y. Bernard
Published in: Nutrients, Issue 11/11, 2019, Page(s) 2706, ISSN 2072-6643
DOI: 10.3390/nu11112706

Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations

Author(s): Berthold Koletzko, K.M. Godfrey, Lucilla Poston, Hania Szajewska, Johannes B. van Goudoever, Marita de Waard, Brigitte Brands, Rosalie M. Grivell, Andrea R. Deussen, Jodie M. Dodd, Bernadeta Patro-Golab, Bartlomiej M. Zalewski
Published in: Annals of Nutrition and Metabolism, Issue 74/2, 2019, Page(s) 93-106, ISSN 0250-6807
DOI: 10.1159/000496471

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

Author(s): Jacob P. Thyssen, Tarunveer S. Ahluwalia, Lavinia Paternoster, Natalia Ballardini, Anna Bergström, Erik Melén, Bo L. Chawes, Jakob Stokholm, Jonathan O'B Hourihane, Donnchadh M. O'Sullivan, Peter Bager, Mads Melbye, Mariona Bustamante, Maties Torrent, Ana Esplugues, Liesbeth Duijts, Chen Hu, Niels J. Elbert, Suzanne G. M. A. Pasmans, Tamar E. C. Nijsten, Andrea Berg, Marie Standl, Tamara Schikow
Published in: Allergy, 2020, ISSN 0105-4538
DOI: 10.1111/all.14162

Causal Inference in Environmental Epidemiology


Published in: ISSN 1044-3983
DOI: 10.1097/ede.0000000000000987

Commercial complementary food use amongst European infants and children: results from the EU Childhood Obesity Project

Author(s): Melissa A. Theurich, Marta Zaragoza-Jordana, Veronica Luque, Dariusz Gruszfeld, Kinga Gradowska, Annick Xhonneux, Enrica Riva, Elvira Verduci, Pascale Poncelet, Louiza Damianidi, Berthold Koletzko, Veit Grote
Published in: European Journal of Nutrition, 2019, ISSN 1436-6207
DOI: 10.1007/s00394-019-02023-3

What quantitative and qualitative methods have been developed to measure the implementation of a life-course approach in public health policies at the national level?

Author(s): Jacob CM, Cooper C, Baird J, Hanson M
Published in: WHO Health Evidence Network Synthesis Reports, 2019