Skip to main content
Go to the home page of the European Commission (opens in new window)
English en
CORDIS - EU research results
CORDIS
Content archived on 2024-06-16

Versatile and environmentally friendly new reaction methodology for synthetic organic chemistry with application to medicinal chemistry

Objective

Enantioselective catalysis is the most important frontier of synthetic organic chemistry and is essential to biomedical research and drug discovery. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that complex struc tures are essential to attain high enantioselectivity. However, it has now been illustrated that small molecule organic catalysts can approach the enantioselectivity and reactivity characteristics of enzymes, omitting the need for toxic organometallic cata lysts or ¿strong¿ Lewis acids. To date, surprisingly few asymmetric organocatalytic transformations have been developed, despite the availability of enantiopure organic chemicals and the accordant academic, industrial, environmental and economic benefits o ver existing methods.The proposed outgoing phase project would further the development of new enantioselective organocatalysis methods, within the pioneering research group of Prof. David MacMillan at Caltech. This research group recently designed a range of highly efficient new organocatalysts and pioneered a variety of catalytic asymmetric transformations of immense practicality and synthetic utility.The return phase would permit the development of a drug discovery project within the laboratories of Astr aZeneca. This work would complement the researcher¿s training and enable integration of the organocatalysis technologies within European industry.The mobility, importance of the research topic and high profile academia-industry collaboration would encourag e co-operation between research disciplines and provide opportunity to widely advertise participation in Marie Curie actions. Overall, the two phases would benefit a motivated European scientist to develop many new skills. Important networks of internation al communication would be established, providing a platform to assist research innovation and economic strengthening within Europe.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

You need to log in or register to use this function

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2002-MOBILITY-6
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinator

ASTRAZENECA UK LIMITED
EU contribution
No data
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (1)