Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-06-16

Versatile and environmentally friendly new reaction methodology for synthetic organic chemistry with application to medicinal chemistry

Obiettivo

Enantioselective catalysis is the most important frontier of synthetic organic chemistry and is essential to biomedical research and drug discovery. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that complex struc tures are essential to attain high enantioselectivity. However, it has now been illustrated that small molecule organic catalysts can approach the enantioselectivity and reactivity characteristics of enzymes, omitting the need for toxic organometallic cata lysts or ¿strong¿ Lewis acids. To date, surprisingly few asymmetric organocatalytic transformations have been developed, despite the availability of enantiopure organic chemicals and the accordant academic, industrial, environmental and economic benefits o ver existing methods.The proposed outgoing phase project would further the development of new enantioselective organocatalysis methods, within the pioneering research group of Prof. David MacMillan at Caltech. This research group recently designed a range of highly efficient new organocatalysts and pioneered a variety of catalytic asymmetric transformations of immense practicality and synthetic utility.The return phase would permit the development of a drug discovery project within the laboratories of Astr aZeneca. This work would complement the researcher¿s training and enable integration of the organocatalysis technologies within European industry.The mobility, importance of the research topic and high profile academia-industry collaboration would encourag e co-operation between research disciplines and provide opportunity to widely advertise participation in Marie Curie actions. Overall, the two phases would benefit a motivated European scientist to develop many new skills. Important networks of internation al communication would be established, providing a platform to assist research innovation and economic strengthening within Europe.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP6-2002-MOBILITY-6
Vedi altri progetti per questo bando

Meccanismo di finanziamento

OIF - Marie Curie actions-Outgoing International Fellowships

Coordinatore

ASTRAZENECA UK LIMITED
Contributo UE
Nessun dato
Costo totale
Nessun dato

Partecipanti (1)