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Integrative development of smart drug-vector nanostructures for adaptive delivery to target cells

Deliverables

A set of pH- and redox-sensitive nanoparticles based on self-assembling copolymers developed and validated in lab

Report on preparation and validation in lab of pH- and redox-sensitive nanoparticles based on self-assembling copolymers

Synthetic platform for obtaining of INMs developed and validated in lab

Report on validation of a synthetic platform for obtaining of INMs at the laboratory scale

Water soluble zerumbone and ellipticine derivatives provided

Report on synthesis of water soluble zerumbone and ellipticine derivatives

Theoretical study of INMs and their interaction with PhACs published

Open Access publication on theoretical studies of INMs and their interaction with PhACs

Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures provided

Report on docking and DFT modelling of protein-ligand interactions and selection of the most promising structures

Inorganic and inorgano-organic DVN preparation technology optimised and validated in the relevant environment

Report on validation of inorganic and inorganoorganic DVN preparation technology in the relevant environment

Samples of synthetic ellipticine provided for quality control and subsequent use as PhAC

Quality control report on samples of synthetic ellipticine provided for use as PhAC

Progress report, 1st year

Progress report for the first project year submitted to the EU

Progress report, 3rd year

Progress report for the third project year submitted to the EU

Data Management Plan elaborated and approved

Data Management Plan elaborated and approved

Technology of pH- and redox-sensitive nanoparticles manufacturing validated in the relevant environment

Report on validation in the relevant environment of pH and redoxsensitive nanoparticle manufacturing technology

Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concluded

Report on stimuli-responsive drug release from polymer nanoparticles, their biocompatibility and cellular uptake

The best DVN-PhAC formulations determined in vitro and proposed for in vivo studies

Report on selection of the best DVN-PhAC formulations determined in vitro, which will be proposed for in vivo studies

Summer school organised and held

Summer school will be organised and held during month 14 - 17. (exact date will be established by consensus of the Partners)

Organisation of the Project Workshops

Organisation of the Project Workshops on months 2, 15, 26, 36, 45

Mid-term meeting

Mid-term project review meeting between the Consortium and REA

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Publications

Ethnobotanical survey about the management of diabetes with medicinal plants used by diabetic patients in Region of Fez-Meknes, Morocco

Author(s): Hamza Mechchate, Imane Es-safi, Fatima Zahra Jawhari, Amina Bari, Andriy Grafov, Dalila Bousta
Published in: Ethnobotany Research and Applications, 19, 2020, ISSN 1547-3465
Publisher: University of Hawaii Press
DOI: 10.32859/era.19.12.1-28

Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes

Author(s): Fatima ez-zahra Amrati, Mohammed Bourhia, Meryem Slighoua, Samir Ibnemoussa, Ahmed Bari, Riaz Ullah, Amal Amaghnouje, Francesca Di Cristo, Mohammed El Mzibri, Anna Calarco, Laila Benbacer, Dalila Bousta
Published in: Evidence-Based Complementary and Alternative Medicine, 2020, 2020, Page(s) 1-9, ISSN 1741-427X
Publisher: Oxford University Press
DOI: 10.1155/2020/8409718

Anticancer and Immunomodulatory Activities of a Novel Water-Soluble Derivative of Ellipticine

Author(s): Regiane Costa de Oliveira, Gemilson Soares Pontes, Aleksandr Kostyuk, Gabriel B. Coutinho Camargo, Anamika Dhyani, Tetiana Shvydenko, Kostiantyn Shvydenko, Andriy Grafov
Published in: Molecules, 25/9, 2020, Page(s) 2130, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092130

Alkaloids of Abuta panurensis Eichler: In silico and in vitro study of acetylcholinesterase inhibition, cytotoxic and immunomodulatory activities

Author(s): Rochelly da Silva Mesquita, Andrii Kyrylchuk, Regiane Costa de Oliveira, Ingrity Suelen Costa Sá, Gabriel Coutinho Borges Camargo, Gemilson Soares Pontes, Felipe Moura Araújo da Silva, Rita de Cássia Saraiva Nunomura, Andriy Grafov
Published in: PLOS ONE, 15/9, 2020, Page(s) e0239364, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239364

In-Vivo Antidiabetic Activity and In-Silico Mode of Action of LC/MS-MS Identified Flavonoids in Oleaster Leaves

Author(s): Hamza Mechchate, Imane Es-Safi, Mohammed Bourhia, Andrii Kyrylchuk, Abdelfattah El Moussaoui, Raffaele Conte, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Hicham Bekkari, Dalila Bousta
Published in: Molecules, 25/21, 2020, Page(s) 5073, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25215073

Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells

Author(s): Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco
Published in: International Journal of Molecular Sciences, 21/3, 2020, Page(s) 869, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030869

Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Depression and Anxiety in Fez-Meknes Region

Author(s): A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov
Published in: Phytothérapie, 2020, ISSN 1624-8597
Publisher: Springer Verlag
DOI: 10.3166/phyto-2020-0225

Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae

Author(s): Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov
Published in: PLOS ONE, 15/2, 2020, Page(s) e0227811, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0227811

Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications

Author(s): M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Published in: ACS Applied Nano Materials, 3/1, 2019, Page(s) 428-439, ISSN 2574-0970
Publisher: American Chemical Society
DOI: 10.1021/acsanm.9b02035

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Author(s): Irene Bonadies, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Calarco, Anna Di Salle
Published in: Nanomaterials, 10/6, 2020, Page(s) 1175, ISSN 2079-4991
Publisher: MPDI
DOI: 10.3390/nano10061175

Study of electronic structure of antimony (V) oxide clusters

Author(s): M.El Abbasy, A.Grafov, D.Sundholm, H.Rabaa
Published in: Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017,, 2017, Page(s) 128
Publisher: UIT, Kenitra (MA)

On structure and stability of complexes of aroyl-anions with lewis acids

Author(s): A.B.Rozhenko, O.I.Guzyr, S.V.Zasukha, Yu.G.Shermolovich
Published in: Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017, 2017, Page(s) 25
Publisher: UIT, Kenitra (MA)

Quantum Chemical Investigations of N-heterocyclic carbenes and their homologues

Author(s): A.A.Kyrylchuk, A.B.Rozhenko
Published in: Abstr. Int.Conf.Teor.Chem.Model. ICTCM’2017, 2017, Page(s) 28
Publisher: UIT, Kenitra (MA)

Synthesis and biological activity of ellipticine derivatives

Author(s): Shvydenko T.I., Shvydenko K.V., Grafova I.A., Kostyuk O.M., Rudyuk V.V., Grafov A.V.
Published in: VIII International Conference “Chemistry of Nitrogen Containing Heterocycles”, (CNCH-2018) in memoriam of Prof. Valeriy Orlov, 2018
Publisher: Kharkiv University

Synthesis and characterization of metal complexes with mefenamic and bile acids

Author(s): Vernydub M.P., Vernydub O.V., Bovsunovska Y.V., Rudiuk V.V., Nahorichna I.V., Grafov A.V.
Published in: "17th Scientific Conference ""Lviv Chemical Readings-2019“", 2020, Page(s) O32
Publisher: Lviv University

Stable carbenes as structural components of sulfur containing heterocycles: X-ray and quantum chemical studies

Author(s): A.B.Rozhenko, Yu. Gorbenko, Yu.Shermolovich
Published in: 10th ICTK, International Chemistry Conference Toulouse-Kiev, 2019, Page(s) P64
Publisher: Université Toulouse III