Deliverables
Report on preparation and validation in lab of pH- and redox-sensitive nanoparticles based on self-assembling copolymers
Synthetic platform for obtaining of INMs developed and validated in labReport on validation of a synthetic platform for obtaining of INMs at the laboratory scale
Water soluble zerumbone and ellipticine derivatives providedReport on synthesis of water soluble zerumbone and ellipticine derivatives
Theoretical study of INMs and their interaction with PhACs publishedOpen Access publication on theoretical studies of INMs and their interaction with PhACs
Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures providedReport on docking and DFT modelling of protein-ligand interactions and selection of the most promising structures
The best PhACs to target the secretory pathway selected and transferred to WP3 and WP4 for DVN optimisationReport on selection of the best PhACs to target the secretory pathways
Inorganic and inorgano-organic DVN preparation technology optimised and validated in the relevant environmentReport on validation of inorganic and inorganoorganic DVN preparation technology in the relevant environment
Samples of synthetic ellipticine provided for quality control and subsequent use as PhACQuality control report on samples of synthetic ellipticine provided for use as PhAC
Progress report, 1st yearProgress report for the first project year submitted to the EU
Progress report, 3rd yearProgress report for the third project year submitted to the EU
Data Management Plan elaborated and approvedTechnology of pH- and redox-sensitive nanoparticles manufacturing validated in the relevant environment
Report on validation in the relevant environment of pH and redoxsensitive nanoparticle manufacturing technology
Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concludedReport on stimuli-responsive drug release from polymer nanoparticles, their biocompatibility and cellular uptake
The best DVN-PhAC formulations determined in vitro and proposed for in vivo studiesReport on selection of the best DVN-PhAC formulations determined in vitro, which will be proposed for in vivo studies
Creation of public and non-public web-site of the Consortium
Summer school will be organised and held during month 14 - 17. (exact date will be established by consensus of the Partners)
Organisation of the Project WorkshopsOrganisation of the Project Workshops on months 2, 15, 26, 36, 45
Mid-term meetingMid-term project review meeting between the Consortium and REA
Publications
Author(s):
F.E.Z.Amrati, M.Bourhia, H.Saghrouchni, M.Slighoua, A.Grafov, R.Ullah, E.Ezzeldin, G.A.Mostafa, A.Bari, S.Ibenmoussa, D.Bousta.
Published in:
Molecules, 2021, ISSN 1420-3049
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules26030636
Author(s):
Amal Amaghnouje; Serhii Bohza; Nathalie Bohdan; Imane Es-Safi; Andrii Kyrylchuk; Sanae Achour; Hinde El Fatemi; Dalila Bousta; Andriy Grafov
Published in:
Pharmaceuticals, 2021, ISSN 1424-8247
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14080814
Author(s):
Hamza Mechchate, Imane Es-safi, Fatima Zahra Jawhari, Amina Bari, Andriy Grafov, Dalila Bousta
Published in:
Ethnobotany Research and Applications, Issue 19, 2020, ISSN 1547-3465
Publisher:
University of Hawaii Press
DOI:
10.32859/era.19.12.1-28
Author(s):
Rozhenko AB, Horbenko YS, Kyrylchuk AA, Zarudnitskii EV, Mykhaylychenko SS, Shermolovich YG, Grafov AV
Published in:
Molecules, 2022, ISSN 1420-3049
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules27051458
Author(s):
Fatima ez-zahra Amrati, Mohammed Bourhia, Meryem Slighoua, Samir Ibnemoussa, Ahmed Bari, Riaz Ullah, Amal Amaghnouje, Francesca Di Cristo, Mohammed El Mzibri, Anna Calarco, Laila Benbacer, Dalila Bousta
Published in:
Evidence-Based Complementary and Alternative Medicine, Issue 2020, 2020, Page(s) 1-9, ISSN 1741-427X
Publisher:
Oxford University Press
DOI:
10.1155/2020/8409718
Author(s):
F.Zuppardi, M.Malinconico, F.D’Agosto, G.G.D’Ayala, P.Cerruti
Published in:
Nanomaterials, 2020, ISSN 2079-4991
Publisher:
MPDI
DOI:
10.3390/nano10091779
Author(s):
R.S.Mesquita, A.Kyrylchuk, A.Cherednichenko, I.S.C.Sá, LM. Bastos, FM.A.Silva, R.C.S. Nunomura, A.Grafov
Published in:
Molecules, 2022, ISSN 1420-3049
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules27103138
Author(s):
Regiane Costa de Oliveira, Gemilson Soares Pontes, Aleksandr Kostyuk, Gabriel B. Coutinho Camargo, Anamika Dhyani, Tetiana Shvydenko, Kostiantyn Shvydenko, Andriy Grafov
Published in:
Molecules, Issue 25/9, 2020, Page(s) 2130, ISSN 1420-3049
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules25092130
Author(s):
Rochelly da Silva Mesquita, Andrii Kyrylchuk, Regiane Costa de Oliveira, Ingrity Suelen Costa Sá, Gabriel Coutinho Borges Camargo, Gemilson Soares Pontes, Felipe Moura Araújo da Silva, Rita de Cássia Saraiva Nunomura, Andriy Grafov
Published in:
PLOS ONE, Issue 15/9, 2020, Page(s) e0239364, ISSN 1932-6203
Publisher:
Public Library of Science
DOI:
10.1371/journal.pone.0239364
Author(s):
Hamza Mechchate, Imane Es-Safi, Mohammed Bourhia, Andrii Kyrylchuk, Abdelfattah El Moussaoui, Raffaele Conte, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Hicham Bekkari, Dalila Bousta
Published in:
Molecules, Issue 25/21, 2020, Page(s) 5073, ISSN 1420-3049
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules25215073
Author(s):
Hamza Mechchate; Regiane Costa de Oliveira; Imane Es-Safi; Emmily Myrella Vasconcelos Mourão; Mohamed Bouhrim; Andrii Kyrylchuk; Gemilson Soares Pontes; Gemilson Soares Pontes; Dalila Bousta; Andriy Grafov
Published in:
Pharmaceuticals, 2021, ISSN 1424-8247
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14080770
Author(s):
Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco
Published in:
International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 869, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21030869
Author(s):
A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov
Published in:
Phytothérapie, 2020, ISSN 1624-8597
Publisher:
Springer Verlag
DOI:
10.3166/phyto-2020-0225
Author(s):
Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov
Published in:
PLOS ONE, Issue 15/2, 2020, Page(s) e0227811, ISSN 1932-6203
Publisher:
Public Library of Science
DOI:
10.1371/journal.pone.0227811
Author(s):
M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Published in:
ACS Applied Nano Materials, Issue 3/1, 2019, Page(s) 428-439, ISSN 2574-0970
Publisher:
American Chemical Society
DOI:
10.1021/acsanm.9b02035
Author(s):
Irene Bonadies, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Calarco, Anna Di Salle
Published in:
Nanomaterials, Issue 10/6, 2020, Page(s) 1175, ISSN 2079-4991
Publisher:
MPDI
DOI:
10.3390/nano10061175
Author(s):
Mechchate, H.; Es-safi, I.; Conte, R.; Hano, C.; Amaghnouje, A.; Jawhari, F.Z.; Radouane, N.; Bencheikh, N.; Grafov, A.; Bousta, D.
Published in:
Nutrients, 2021, ISSN 2072-6643
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13082759
Author(s):
Ouedrhiri W, Mechchate H, Moja S, Baudino S, Saleh A, Al Kamaly OM, Grafov A, Greche H.
Published in:
Foods, 2022, ISSN 2304-8158
Publisher:
MPDI
DOI:
10.3390/foods11010132
Author(s):
E.Craig, A.Calarco, R.Conte, V.Ambrogi, G.G.d'Ayala, P.Alabi, J.K.Sello, P.Cerruti, P.E.Kima.
Published in:
Frontiers in Cellular and Infection Microbiology, 2021, ISSN 2235-2988
Publisher:
Frontiers Media S. A.
DOI:
10.3389/fcimb.2021.702676
Intellectual Property Rights
Application/Publication number:
UA
116830
Date:
2018-05-10
Applicant(s):
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Application/Publication number:
UA
116492
Date:
2018-03-26
Application/Publication number:
UA
116830
Date:
2018-05-10
Applicant(s):
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Application/Publication number:
UA
116492
Date:
2018-03-26
Applicant(s):
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Application/Publication number:
BR
10 2019 005007 1
Date:
2019-03-14
Application/Publication number:
BR
10 2019 005007 1
Date:
2018-03-28
Application/Publication number:
UA
116492
Date:
2018-03-26
Applicant(s):
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Application/Publication number:
UA
116492
Date:
2018-03-26
Application/Publication number:
UA
116830
Date:
2018-05-10
Application/Publication number:
UA
116830
Date:
2018-05-10
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