Integrative development of smart drug-vector nanostructures for adaptive delivery to target cells

Informazioni relative al progetto

VAHVISTUS

ID dell’accordo di sovvenzione: 734759

DOI

10.3030/734759

Progetto chiuso

Data della firma CE 14 Dicembre 2016

Data di avvio 1 Marzo 2017

Data di completamento 28 Febbraio 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 1 012 500,00

Contributo UE

€ 990 000,00

Coordinato da

HELSINGIN YLIOPISTO
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (14)

A set of pH- and redox-sensitive nanoparticles based on self-assembling copolymers developed and validated in lab

Report on preparation and validation in lab of pH- and redox-sensitive nanoparticles based on self-assembling copolymers

Synthetic platform for obtaining of INMs developed and validated in lab

Report on validation of a synthetic platform for obtaining of INMs at the laboratory scale

Water soluble zerumbone and ellipticine derivatives provided

Report on synthesis of water soluble zerumbone and ellipticine derivatives

Theoretical study of INMs and their interaction with PhACs published

Open Access publication on theoretical studies of INMs and their interaction with PhACs

Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures provided

Report on docking and DFT modelling of protein-ligand interactions and selection of the most promising structures

The best PhACs to target the secretory pathway selected and transferred to WP3 and WP4 for DVN optimisation

Report on selection of the best PhACs to target the secretory pathways

Inorganic and inorgano-organic DVN preparation technology optimised and validated in the relevant environment

Report on validation of inorganic and inorganoorganic DVN preparation technology in the relevant environment

Samples of synthetic ellipticine provided for quality control and subsequent use as PhAC

Quality control report on samples of synthetic ellipticine provided for use as PhAC

Progress report, 1st year

Progress report for the first project year submitted to the EU

Progress report, 3rd year

Progress report for the third project year submitted to the EU

Data Management Plan elaborated and approved
Technology of pH- and redox-sensitive nanoparticles manufacturing validated in the relevant environment

Report on validation in the relevant environment of pH and redoxsensitive nanoparticle manufacturing technology

Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concluded

Report on stimuli-responsive drug release from polymer nanoparticles, their biocompatibility and cellular uptake

The best DVN-PhAC formulations determined in vitro and proposed for in vivo studies

Report on selection of the best DVN-PhAC formulations determined in vitro, which will be proposed for in vivo studies

Websites, patent fillings, videos etc. (1)

Public and non-public web-site of the Consortium created

Creation of public and non-public web-site of the Consortium

Other (3)

Summer school organised and held

Summer school will be organised and held during month 14 - 17. (exact date will be established by consensus of the Partners)

Organisation of the Project Workshops

Organisation of the Project Workshops on months 2, 15, 26, 36, 45

Mid-term meeting

Mid-term project review meeting between the Consortium and REA

Pubblicazioni

Peer reviewed articles (19)

Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions

Autori: F.E.Z.Amrati, M.Bourhia, H.Saghrouchni, M.Slighoua, A.Grafov, R.Ullah, E.Ezzeldin, G.A.Mostafa, A.Bari, S.Ibenmoussa, D.Bousta.
Pubblicato in: Molecules, 2021, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26030636

New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

Autori: Amal Amaghnouje; Serhii Bohza; Nathalie Bohdan; Imane Es-Safi; Andrii Kyrylchuk; Sanae Achour; Hinde El Fatemi; Dalila Bousta; Andriy Grafov
Pubblicato in: Pharmaceuticals, 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14080814

Ethnobotanical survey about the management of diabetes with medicinal plants used by diabetic patients in Region of Fez-Meknes, Morocco

Autori: Hamza Mechchate, Imane Es-safi, Fatima Zahra Jawhari, Amina Bari, Andriy Grafov, Dalila Bousta
Pubblicato in: Ethnobotany Research and Applications, Numero 19, 2020, ISSN 1547-3465
Editore: University of Hawaii Press
DOI: 10.32859/era.19.12.1-28

Stable Carbenes as Structural Components of Partially Saturated Sulfur-Containing Heterocycles

Autori: Rozhenko AB, Horbenko YS, Kyrylchuk AA, Zarudnitskii EV, Mykhaylychenko SS, Shermolovich YG, Grafov AV
Pubblicato in: Molecules, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051458

Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes

Autori: Fatima ez-zahra Amrati, Mohammed Bourhia, Meryem Slighoua, Samir Ibnemoussa, Ahmed Bari, Riaz Ullah, Amal Amaghnouje, Francesca Di Cristo, Mohammed El Mzibri, Anna Calarco, Laila Benbacer, Dalila Bousta
Pubblicato in: Evidence-Based Complementary and Alternative Medicine, Numero 2020, 2020, Pagina/e 1-9, ISSN 1741-427X
Editore: Oxford University Press
DOI: 10.1155/2020/8409718

Well-Defined Thermo-Responsive Copolymers Based on Oligo(Ethylene Glycol) Methacrylate and Pentafluorostyrene for the Removal of Organic Dyes from Water

Autori: F.Zuppardi, M.Malinconico, F.D’Agosto, G.G.D’Ayala, P.Cerruti
Pubblicato in: Nanomaterials, 2020, ISSN 2079-4991
Editore: MPDI
DOI: 10.3390/nano10091779

In vitro and in silico evaluation of cholinesterase inhibition by alkaloids obtained from branches of Abuta panurensis Eichler

Autori: R.S.Mesquita, A.Kyrylchuk, A.Cherednichenko, I.S.C.Sá, LM. Bastos, FM.A.Silva, R.C.S. Nunomura, A.Grafov
Pubblicato in: Molecules, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27103138

Anticancer and Immunomodulatory Activities of a Novel Water-Soluble Derivative of Ellipticine

Autori: Regiane Costa de Oliveira, Gemilson Soares Pontes, Aleksandr Kostyuk, Gabriel B. Coutinho Camargo, Anamika Dhyani, Tetiana Shvydenko, Kostiantyn Shvydenko, Andriy Grafov
Pubblicato in: Molecules, Numero 25/9, 2020, Pagina/e 2130, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092130

Alkaloids of Abuta panurensis Eichler: In silico and in vitro study of acetylcholinesterase inhibition, cytotoxic and immunomodulatory activities

Autori: Rochelly da Silva Mesquita, Andrii Kyrylchuk, Regiane Costa de Oliveira, Ingrity Suelen Costa Sá, Gabriel Coutinho Borges Camargo, Gemilson Soares Pontes, Felipe Moura Araújo da Silva, Rita de Cássia Saraiva Nunomura, Andriy Grafov
Pubblicato in: PLOS ONE, Numero 15/9, 2020, Pagina/e e0239364, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0239364

In-Vivo Antidiabetic Activity and In-Silico Mode of Action of LC/MS-MS Identified Flavonoids in Oleaster Leaves

Autori: Hamza Mechchate, Imane Es-Safi, Mohammed Bourhia, Andrii Kyrylchuk, Abdelfattah El Moussaoui, Raffaele Conte, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Hicham Bekkari, Dalila Bousta
Pubblicato in: Molecules, Numero 25/21, 2020, Pagina/e 5073, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25215073

Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds

Autori: Hamza Mechchate; Regiane Costa de Oliveira; Imane Es-Safi; Emmily Myrella Vasconcelos Mourão; Mohamed Bouhrim; Andrii Kyrylchuk; Gemilson Soares Pontes; Gemilson Soares Pontes; Dalila Bousta; Andriy Grafov
Pubblicato in: Pharmaceuticals, 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14080770

Cationic Polymer Nanoparticles-Mediated Delivery of miR-124 Impairs Tumorigenicity of Prostate Cancer Cells

Autori: Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco
Pubblicato in: International Journal of Molecular Sciences, Numero 21/3, 2020, Pagina/e 869, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030869

Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Depression and Anxiety in Fez-Meknes Region

Autori: A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov
Pubblicato in: Phytothérapie, 2020, ISSN 1624-8597
Editore: Springer Verlag
DOI: 10.3166/phyto-2020-0225

Synthesis, molecular docking studies, and larvicidal activity evaluation of new fluorinated neonicotinoids against Anopheles darlingi larvae

Autori: Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov
Pubblicato in: PLOS ONE, Numero 15/2, 2020, Pagina/e e0227811, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0227811

Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications

Autori: M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Pubblicato in: ACS Applied Nano Materials, Numero 3/1, 2019, Pagina/e 428-439, ISSN 2574-0970
Editore: American Chemical Society
DOI: 10.1021/acsanm.9b02035

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

Autori: Irene Bonadies, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Calarco, Anna Di Salle
Pubblicato in: Nanomaterials, Numero 10/6, 2020, Pagina/e 1175, ISSN 2079-4991
Editore: MPDI
DOI: 10.3390/nano10061175

In Vivo and In Vitro Antidiabetic and Anti-Inflammatory Properties of Flax (Linum usitatissimum L.) Seed Polyphenols

Autori: Mechchate, H.; Es-safi, I.; Conte, R.; Hano, C.; Amaghnouje, A.; Jawhari, F.Z.; Radouane, N.; Bencheikh, N.; Grafov, A.; Bousta, D.
Pubblicato in: Nutrients, 2021, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13082759

Optimized Antibacterial Effects in a Designed Mixture of Essential Oils of Myrtus communis, Artemisia herba-alba and Thymus serpyllum for Wide Range of Applications

Autori: Ouedrhiri W, Mechchate H, Moja S, Baudino S, Saleh A, Al Kamaly OM, Grafov A, Greche H.
Pubblicato in: Foods, 2022, ISSN 2304-8158
Editore: MPDI
DOI: 10.3390/foods11010132

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

Autori: E.Craig, A.Calarco, R.Conte, V.Ambrogi, G.G.d'Ayala, P.Alabi, J.K.Sello, P.Cerruti, P.E.Kima.
Pubblicato in: Frontiers in Cellular and Infection Microbiology, 2021, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.702676

Diritti di proprietà intellettuale

Patent (10)

1,5-Bis-(4-aminodiphenoxy)-2,2,3,3,4,4-hexafluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116830
Data: 2018-05-10
Candidato/i: INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE

1,5-Bis-(4-aminodiphenoxy)-3,3-difluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116492
Data: 2018-03-26
Candidato/i: HELSINGIN YLIOPISTO

Bioactive Inorganic Nanomatrices Based on Hydrated Polyvalent Transition Metal Oxides : Preparation Process and Applications

Numero candidatura/pubblicazione: BR 10 2019 005007 1
Data: 2019-03-14
Candidato/i: HELSINGIN YLIOPISTO

Bioactive Inorganic Nanomatrices Based on Hydrated Polyvalent Transition Metal Oxides : Preparation Process and Applications

Numero candidatura/pubblicazione: BR 10 2019 005007 1
Data: 2018-03-28
Candidato/i: HELSINGIN YLIOPISTO

1,5-Bis-(4-aminodiphenoxy)-3,3-difluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116492
Data: 2018-03-26
Candidato/i: INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE

1,5-Bis-(4-aminodiphenoxy)-3,3-difluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116492
Data: 2018-03-26
Candidato/i: INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE

1,5-Bis-(4-aminodiphenoxy)-2,2,3,3,4,4-hexafluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116830
Data: 2018-05-10
Candidato/i: HELSINGIN YLIOPISTO

1,5-Bis-(4-aminodiphenoxy)-2,2,3,3,4,4-hexafluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116830
Data: 2018-05-10
Candidato/i: INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE

1,5-Bis-(4-aminodiphenoxy)-2,2,3,3,4,4-hexafluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116830
Data: 2018-05-10
Candidato/i: HELSINGIN YLIOPISTO

1,5-Bis-(4-aminodiphenoxy)-3,3-difluoropentane dihydrochloride

Numero candidatura/pubblicazione: UA 116492
Data: 2018-03-26
Candidato/i: HELSINGIN YLIOPISTO