Risultati finali
Report on preparation and validation in lab of pH- and redox-sensitive nanoparticles based on self-assembling copolymers
Synthetic platform for obtaining of INMs developed and validated in labReport on validation of a synthetic platform for obtaining of INMs at the laboratory scale
Water soluble zerumbone and ellipticine derivatives providedReport on synthesis of water soluble zerumbone and ellipticine derivatives
Theoretical study of INMs and their interaction with PhACs publishedOpen Access publication on theoretical studies of INMs and their interaction with PhACs
Docking and DFT modelling of protein-ligand interactions concluded and list of the most promising structures providedReport on docking and DFT modelling of protein-ligand interactions and selection of the most promising structures
The best PhACs to target the secretory pathway selected and transferred to WP3 and WP4 for DVN optimisationReport on selection of the best PhACs to target the secretory pathways
Inorganic and inorgano-organic DVN preparation technology optimised and validated in the relevant environmentReport on validation of inorganic and inorganoorganic DVN preparation technology in the relevant environment
Samples of synthetic ellipticine provided for quality control and subsequent use as PhACQuality control report on samples of synthetic ellipticine provided for use as PhAC
Progress report, 1st yearProgress report for the first project year submitted to the EU
Progress report, 3rd yearProgress report for the third project year submitted to the EU
Data Management Plan elaborated and approvedTechnology of pH- and redox-sensitive nanoparticles manufacturing validated in the relevant environment
Report on validation in the relevant environment of pH and redoxsensitive nanoparticle manufacturing technology
Study on stimuli-responsive drug release, biocompatibility, and cellular uptake of polymer nanoparticles concludedReport on stimuli-responsive drug release from polymer nanoparticles, their biocompatibility and cellular uptake
The best DVN-PhAC formulations determined in vitro and proposed for in vivo studiesReport on selection of the best DVN-PhAC formulations determined in vitro, which will be proposed for in vivo studies
Creation of public and non-public web-site of the Consortium
Summer school will be organised and held during month 14 - 17. (exact date will be established by consensus of the Partners)
Organisation of the Project WorkshopsOrganisation of the Project Workshops on months 2, 15, 26, 36, 45
Mid-term meetingMid-term project review meeting between the Consortium and REA
Pubblicazioni
Autori:
F.E.Z.Amrati, M.Bourhia, H.Saghrouchni, M.Slighoua, A.Grafov, R.Ullah, E.Ezzeldin, G.A.Mostafa, A.Bari, S.Ibenmoussa, D.Bousta.
Pubblicato in:
Molecules, 2021, ISSN 1420-3049
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules26030636
Autori:
Amal Amaghnouje; Serhii Bohza; Nathalie Bohdan; Imane Es-Safi; Andrii Kyrylchuk; Sanae Achour; Hinde El Fatemi; Dalila Bousta; Andriy Grafov
Pubblicato in:
Pharmaceuticals, 2021, ISSN 1424-8247
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14080814
Autori:
Hamza Mechchate, Imane Es-safi, Fatima Zahra Jawhari, Amina Bari, Andriy Grafov, Dalila Bousta
Pubblicato in:
Ethnobotany Research and Applications, Numero 19, 2020, ISSN 1547-3465
Editore:
University of Hawaii Press
DOI:
10.32859/era.19.12.1-28
Autori:
Rozhenko AB, Horbenko YS, Kyrylchuk AA, Zarudnitskii EV, Mykhaylychenko SS, Shermolovich YG, Grafov AV
Pubblicato in:
Molecules, 2022, ISSN 1420-3049
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules27051458
Autori:
Fatima ez-zahra Amrati, Mohammed Bourhia, Meryem Slighoua, Samir Ibnemoussa, Ahmed Bari, Riaz Ullah, Amal Amaghnouje, Francesca Di Cristo, Mohammed El Mzibri, Anna Calarco, Laila Benbacer, Dalila Bousta
Pubblicato in:
Evidence-Based Complementary and Alternative Medicine, Numero 2020, 2020, Pagina/e 1-9, ISSN 1741-427X
Editore:
Oxford University Press
DOI:
10.1155/2020/8409718
Autori:
F.Zuppardi, M.Malinconico, F.D’Agosto, G.G.D’Ayala, P.Cerruti
Pubblicato in:
Nanomaterials, 2020, ISSN 2079-4991
Editore:
MPDI
DOI:
10.3390/nano10091779
Autori:
R.S.Mesquita, A.Kyrylchuk, A.Cherednichenko, I.S.C.Sá, LM. Bastos, FM.A.Silva, R.C.S. Nunomura, A.Grafov
Pubblicato in:
Molecules, 2022, ISSN 1420-3049
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules27103138
Autori:
Regiane Costa de Oliveira, Gemilson Soares Pontes, Aleksandr Kostyuk, Gabriel B. Coutinho Camargo, Anamika Dhyani, Tetiana Shvydenko, Kostiantyn Shvydenko, Andriy Grafov
Pubblicato in:
Molecules, Numero 25/9, 2020, Pagina/e 2130, ISSN 1420-3049
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules25092130
Autori:
Rochelly da Silva Mesquita, Andrii Kyrylchuk, Regiane Costa de Oliveira, Ingrity Suelen Costa Sá, Gabriel Coutinho Borges Camargo, Gemilson Soares Pontes, Felipe Moura Araújo da Silva, Rita de Cássia Saraiva Nunomura, Andriy Grafov
Pubblicato in:
PLOS ONE, Numero 15/9, 2020, Pagina/e e0239364, ISSN 1932-6203
Editore:
Public Library of Science
DOI:
10.1371/journal.pone.0239364
Autori:
Hamza Mechchate, Imane Es-Safi, Mohammed Bourhia, Andrii Kyrylchuk, Abdelfattah El Moussaoui, Raffaele Conte, Riaz Ullah, Essam Ezzeldin, Gamal A. Mostafa, Andriy Grafov, Hicham Bekkari, Dalila Bousta
Pubblicato in:
Molecules, Numero 25/21, 2020, Pagina/e 5073, ISSN 1420-3049
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules25215073
Autori:
Hamza Mechchate; Regiane Costa de Oliveira; Imane Es-Safi; Emmily Myrella Vasconcelos Mourão; Mohamed Bouhrim; Andrii Kyrylchuk; Gemilson Soares Pontes; Gemilson Soares Pontes; Dalila Bousta; Andriy Grafov
Pubblicato in:
Pharmaceuticals, 2021, ISSN 1424-8247
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ph14080770
Autori:
Raffaele Conte, Anna Valentino, Francesca Di Cristo, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Di Salle, Anna Calarco
Pubblicato in:
International Journal of Molecular Sciences, Numero 21/3, 2020, Pagina/e 869, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21030869
Autori:
A. Amaghnouje, M. Slighoua, I. Es-safi, R. El Jaoudi, A. Elyoubi, D. Bousta, A. Grafov
Pubblicato in:
Phytothérapie, 2020, ISSN 1624-8597
Editore:
Springer Verlag
DOI:
10.3166/phyto-2020-0225
Autori:
Rochelly da Silva Mesquita, Andrii Kyrylchuk, Iryna Grafova, Denys Kliukovskyi, Andriy Bezdudnyy, Alexander Rozhenko, Wanderli Pedro Tadei, Markku Leskelä, Andriy Grafov
Pubblicato in:
PLOS ONE, Numero 15/2, 2020, Pagina/e e0227811, ISSN 1932-6203
Editore:
Public Library of Science
DOI:
10.1371/journal.pone.0227811
Autori:
M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Pubblicato in:
ACS Applied Nano Materials, Numero 3/1, 2019, Pagina/e 428-439, ISSN 2574-0970
Editore:
American Chemical Society
DOI:
10.1021/acsanm.9b02035
Autori:
Irene Bonadies, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Calarco, Anna Di Salle
Pubblicato in:
Nanomaterials, Numero 10/6, 2020, Pagina/e 1175, ISSN 2079-4991
Editore:
MPDI
DOI:
10.3390/nano10061175
Autori:
Mechchate, H.; Es-safi, I.; Conte, R.; Hano, C.; Amaghnouje, A.; Jawhari, F.Z.; Radouane, N.; Bencheikh, N.; Grafov, A.; Bousta, D.
Pubblicato in:
Nutrients, 2021, ISSN 2072-6643
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13082759
Autori:
Ouedrhiri W, Mechchate H, Moja S, Baudino S, Saleh A, Al Kamaly OM, Grafov A, Greche H.
Pubblicato in:
Foods, 2022, ISSN 2304-8158
Editore:
MPDI
DOI:
10.3390/foods11010132
Autori:
E.Craig, A.Calarco, R.Conte, V.Ambrogi, G.G.d'Ayala, P.Alabi, J.K.Sello, P.Cerruti, P.E.Kima.
Pubblicato in:
Frontiers in Cellular and Infection Microbiology, 2021, ISSN 2235-2988
Editore:
Frontiers Media S. A.
DOI:
10.3389/fcimb.2021.702676
Diritti di proprietà intellettuale
Numero candidatura/pubblicazione:
UA
116830
Data:
2018-05-10
Candidato/i:
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Numero candidatura/pubblicazione:
UA
116492
Data:
2018-03-26
Numero candidatura/pubblicazione:
UA
116830
Data:
2018-05-10
Candidato/i:
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Numero candidatura/pubblicazione:
UA
116492
Data:
2018-03-26
Candidato/i:
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Numero candidatura/pubblicazione:
BR
10 2019 005007 1
Data:
2019-03-14
Numero candidatura/pubblicazione:
BR
10 2019 005007 1
Data:
2018-03-28
Numero candidatura/pubblicazione:
UA
116492
Data:
2018-03-26
Candidato/i:
INSTITUTE OF ORGANIC CHEMISTRY OF NATIONAL ACADEMY SCIENCES OF UKRAINE
Numero candidatura/pubblicazione:
UA
116492
Data:
2018-03-26
Numero candidatura/pubblicazione:
UA
116830
Data:
2018-05-10
Numero candidatura/pubblicazione:
UA
116830
Data:
2018-05-10
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