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Novel magnetic nanostructures for medical applications

Objective

MAGNAMED designs, fabricates, and assesses novel magnetic nanostructures (MNS) with unique spin configurations for innovative diagnostics and therapy techniques. An early stage detection and an effective treatment are keystones to reduce cancer mortality. Current clinical procedures fail to detect small concentration of tumoral biomarkers. Magnetic nanoparticles (MNP), like beads, have attracted much attention for their capability to improve cancer detection limits and treatment technologies. However, there are several limitations to the use of MNP. As an emerging alternative, MNS are being explored. Unlike MNP, MNS (e.g. nanodisks) present a planar shape with novel properties for diagnosis: high magnetic moment and large size, which can significantly improve the sensor sensitivity, and for therapy: due to their planar shape, alternate magnetic fields provoke a magneto-mechanical action on the cell membrane that triggers cell death. The efficiency of MNS in these two medical applications has not been investigated yet for MNS at the nanometer scale. The challenge of this project is to produce MNS with nanometer dimensions suitable for medical applications. Several lithography techniques will be used to fabricate MNS in vortex and antiferromagnetic spin configurations covering a broad size range (40 to 4000 nm). After functionalization, MNS will be exploited in: (i) Diagnostics, using giant magnetoresistance (GMR) sensors for the detection of tumoral biomarkers (dermcidin and carcinoembryonic antigen), and (ii) Therapy, effectiveness of tumoral cell annihilation by the magneto-mechanical action of MNS will be evaluated in vitro assays of melanoma and colorectal cancer cells. MAGNAMED is a cross-sectoral and interdisciplinary project involving Physics, Chemistry and Medicine. Findings will have a medium-term impact on the European strategy for early stage detection of cancer and a long-term impact on the development of novel and groundbreaking therapeutics techniques.

Coordinator

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Net EU contribution
€ 328 500,00
Address
Barrio Sarriena S N
48940 Leioa
Spain

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Region
Noreste País Vasco Bizkaia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (8)

IMG PHARMA BIOTECH SOCIEDAD LIMITADA
Spain
Net EU contribution
€ 85 500,00
Address
Parque Tecnologico De Zamudio, Astrondo Bidea, Ed. Bicbizkaia 612, Mod.5
48160 Derio

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Bizkaia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NANOVEX BIOTECHNOLOGIES SL

Participation ended

Spain
Net EU contribution
€ 9 000,00
Address
Parque Tecnologico De Asturias
33428 Llanera

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Principado de Asturias Asturias
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 45 000,00
Address
Avenida De Seneca 2
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INESC MICROSISTEMAS E NANOTECNOLOGIAS - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS
Portugal
Net EU contribution
€ 99 000,00
Address
Rua Alves Redol 9
1000 029 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDADE DO PORTO
Portugal
Net EU contribution
€ 166 500,00
Address
Praca Gomes Teixeira
4099-002 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VIENNA BIOCENTER CORE FACILITES GMBH

Participation ended

Austria
Net EU contribution
€ 27 000,00
Address
Dr Bohr Gasse 3
1030 Wien

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wien Wien
Activity type
Other
Non-EU contribution
€ 0,00
ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO
Portugal
Net EU contribution
€ 27 000,00
Address
Rua D Manuel Ii Apartado 55142
4051 401 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 58 500,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (9)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD DE SANTIAGO DE CHILE
Chile
Net EU contribution
€ 0,00
Address
Avenida Libertador Bernardo O'higgins 3363
9170022 Santiago

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 49 500,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

COMISION NACIONAL DE ENERGIA ATOMICA
Argentina
Net EU contribution
€ 0,00
Non-EU contribution
€ 54 000,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

COMISSAO NACIONAL DE ENERGIA NUCLEAR- CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR
Brazil
Net EU contribution
€ 0,00
Address
Rua General Severiano 90
22290 901 Rio De Janeiro

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Activity type
Research Organisations
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
€ 0,00
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE UNIVERSITY OF TEXAS SYSTEM
United States
Net EU contribution
€ 0,00
Address
Colorado Street 601
78701 2982 Austin

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA
Chile
Net EU contribution
€ 0,00
Address
Avenida Espana 1680
. Valparaiso

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 139 500,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDADE ESTADUAL DE CAMPINAS
Brazil
Net EU contribution
€ 0,00
Address
Cidade Universitaria Zeferino Sn
13083 875 Campinas Sp

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD DE TALCA
Chile
Net EU contribution
€ 0,00
Address
2 Norte 685, Casilla 721
3465548 Talca

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 18 000,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSIDAD DE LOS ANDES FUNDACION
Colombia
Net EU contribution
€ 0,00
Address
Carrera 1 18a-10
- Bogota Dc

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 36 000,00