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Novel magnetic nanostructures for medical applications

Objective

MAGNAMED designs, fabricates, and assesses novel magnetic nanostructures (MNS) with unique spin configurations for innovative diagnostics and therapy techniques. An early stage detection and an effective treatment are keystones to reduce cancer mortality. Current clinical procedures fail to detect small concentration of tumoral biomarkers. Magnetic nanoparticles (MNP), like beads, have attracted much attention for their capability to improve cancer detection limits and treatment technologies. However, there are several limitations to the use of MNP. As an emerging alternative, MNS are being explored. Unlike MNP, MNS (e.g. nanodisks) present a planar shape with novel properties for diagnosis: high magnetic moment and large size, which can significantly improve the sensor sensitivity, and for therapy: due to their planar shape, alternate magnetic fields provoke a magneto-mechanical action on the cell membrane that triggers cell death. The efficiency of MNS in these two medical applications has not been investigated yet for MNS at the nanometer scale. The challenge of this project is to produce MNS with nanometer dimensions suitable for medical applications. Several lithography techniques will be used to fabricate MNS in vortex and antiferromagnetic spin configurations covering a broad size range (40 to 4000 nm). After functionalization, MNS will be exploited in: (i) Diagnostics, using giant magnetoresistance (GMR) sensors for the detection of tumoral biomarkers (dermcidin and carcinoembryonic antigen), and (ii) Therapy, effectiveness of tumoral cell annihilation by the magneto-mechanical action of MNS will be evaluated in vitro assays of melanoma and colorectal cancer cells. MAGNAMED is a cross-sectoral and interdisciplinary project involving Physics, Chemistry and Medicine. Findings will have a medium-term impact on the European strategy for early stage detection of cancer and a long-term impact on the development of novel and groundbreaking therapeutics techniques.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

H2020-MSCA-RISE-2016
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Address
Barrio Sarriena S N
48940 Leioa
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 310 500

Participants (7)

IMG PHARMA BIOTECH SOCIEDAD LIMITADA
Spain
EU contribution
€ 54 000
Address
Parque Tecnologico De Zamudio, Astrondo Bidea, Ed. Bicbizkaia 612, Mod.5
48160 Derio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NANOVEX BIOTECHNOLOGIES SL
Spain
EU contribution
€ 22 500
Address
Parque Tecnologico De Asturias
33428 Llanera
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 27 000
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
INESC MICROSISTEMAS E NANOTECNOLOGIAS - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS
Portugal
EU contribution
€ 99 000
Address
Rua Alves Redol 9
1000 029 Lisboa
Activity type
Research Organisations
UNIVERSIDADE DO PORTO
Portugal
EU contribution
€ 148 500
Address
Praca Gomes Teixeira
4099 002 Porto
Activity type
Higher or Secondary Education Establishments
VIENNA BIOCENTER CORE FACILITES GMBH
Austria
EU contribution
€ 117 000
Address
Dr Bohr Gasse 3
1030 Wien
Activity type
Other
ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO
Portugal
EU contribution
€ 67 500
Address
Rua D Manuel Ii Apartado 55142
4051 401 Porto
Activity type
Research Organisations

Partners (7)

UNIVERSIDAD DE SANTIAGO DE CHILE
Chile
Address
Avenida Libertador Bernardo O'higgins 3363
9170022 Santiago
Activity type
Higher or Secondary Education Establishments
COMISION NACIONAL DE ENERGIA ATOMICA
Argentina
Address
Avda. Del Libertador 8250
1429 Buenos Aires
Activity type
Research Organisations
COMISSAO NACIONAL DE ENERGIA NUCLEAR- CENTRO DE DESENVOLVIMENTO DA TECNOLOGIA NUCLEAR
Brazil
Address
Rua General Severiano 90
22290 901 Rio De Janeiro
Activity type
Research Organisations
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF TEXAS SYSTEM
United States
Address
Colorado Street 601
78701 2982 Austin
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD TECNICA FEDERICO SANTA MARIA
Chile
Address
Avenida Espana 1680
239-0123 Valparaiso
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE ESTADUAL DE CAMPINAS
Brazil
Address
Cidade Universitaria Zeferino Sn
13083 875 Campinas Sp
Activity type
Higher or Secondary Education Establishments