Objective
MAGNAMED designs, fabricates, and assesses novel magnetic nanostructures (MNS) with unique spin configurations for innovative diagnostics and therapy techniques. An early stage detection and an effective treatment are keystones to reduce cancer mortality. Current clinical procedures fail to detect small concentration of tumoral biomarkers. Magnetic nanoparticles (MNP), like beads, have attracted much attention for their capability to improve cancer detection limits and treatment technologies. However, there are several limitations to the use of MNP. As an emerging alternative, MNS are being explored. Unlike MNP, MNS (e.g. nanodisks) present a planar shape with novel properties for diagnosis: high magnetic moment and large size, which can significantly improve the sensor sensitivity, and for therapy: due to their planar shape, alternate magnetic fields provoke a magneto-mechanical action on the cell membrane that triggers cell death. The efficiency of MNS in these two medical applications has not been investigated yet for MNS at the nanometer scale. The challenge of this project is to produce MNS with nanometer dimensions suitable for medical applications. Several lithography techniques will be used to fabricate MNS in vortex and antiferromagnetic spin configurations covering a broad size range (40 to 4000 nm). After functionalization, MNS will be exploited in: (i) Diagnostics, using giant magnetoresistance (GMR) sensors for the detection of tumoral biomarkers (dermcidin and carcinoembryonic antigen), and (ii) Therapy, effectiveness of tumoral cell annihilation by the magneto-mechanical action of MNS will be evaluated in vitro assays of melanoma and colorectal cancer cells. MAGNAMED is a cross-sectoral and interdisciplinary project involving Physics, Chemistry and Medicine. Findings will have a medium-term impact on the European strategy for early stage detection of cancer and a long-term impact on the development of novel and groundbreaking therapeutics techniques.
Fields of science
- social sciencessociologydemographymortality
- medical and health sciencesclinical medicineoncologyskin cancermelanoma
- medical and health sciencesclinical medicineoncologycolorectal cancer
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- engineering and technologynanotechnologynano-materials
Programme(s)
Coordinator
48940 Leioa
Spain
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Participants (8)
48160 Derio
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
33428 Llanera
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
28040 Madrid
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1000 029 Lisboa
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4099-002 Porto
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Participation ended
1030 Wien
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
4051 401 Porto
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28006 Madrid
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Partners (9)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
9170022 Santiago
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1429 Buenos Aires
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
22290 901 Rio De Janeiro
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
94607 Oakland Ca
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
78701 2982 Austin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
. Valparaiso
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
13083 875 Campinas Sp
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3465548 Talca
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Bogota Dc
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