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Microelements in Life Expectancy and Aging

Objective

Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are:
1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu.
2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters.
3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.

Field of science

  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /social sciences/social and economic geography/transport
  • /natural sciences/chemical sciences/inorganic chemistry/metals
  • /medical and health sciences/health sciences/nutrition

Call for proposal

H2020-MSCA-RISE-2016
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITE DE PICARDIE JULES VERNE
Address
Chemin Du Thil
80025 Amiens
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 247 500

Participants (3)

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 292 500
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
LIMITED LIABILITY COMPANY RESEARCH AND PRODUCTION ENTERPRISE I.F. LAB
Ukraine
EU contribution
€ 211 500
Address
9 Druzhby Narodiv Blvd.
01042 Kyiv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 112 500
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations

Partners (3)

UNIVERSIDAD DE CHILE
Chile
Address
Av. Libertador Bernardo O'higgins 1058
10 Santiago
Activity type
Higher or Secondary Education Establishments
Instituto Nacional de Higiene, Epidemiología y Microbiología

Participation ended

Cuba
Address
Infanta No. 1158
10 300 Havana
Activity type
Other
THE UNIVERSITY OF THE WEST INDIES U WI*
Jamaica
Address
Mona
7 Kingston
Activity type
Higher or Secondary Education Establishments