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Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells

Deliverables

Data Management Plan

A data Management Plan will be set to define data generated by the project to be kept confidential

Scientific action check meeting M24

Scientific action check meeting related to reporting period 1

Minutes of the Steering Committee meetings at M12

Minutes of the 2nd Steering Committee meeting

List of ICT system specifications

Based on all partners’ available technologies as on its own insight on future biomedical devices, this deliverable will define the specification of the Lab on Chip’s key parameters including size, form factor, throughput, maximum sensitivity, available power, frequency range, waveform modulation, ambient sensitivity

Minutes of the Steering Committee meeting at M18

Minutes of the 3rd Steering Committee meeting

Biological protocols

This deliverable will define the protocols to be used for biological analysis, including: - cell culture protocol (UNILIM, ENEA and UNIPD) - protocols to isolate MB and GM CSC (ENEA, UNIPD and UNILIM) - in vitro ionizing radiations protocol (UNILIM and ENEA) - in vivo ionizing radiations protocol (ENEA) - tumour graft protocols for MB and GBM (UNIPD and ENEA).

Minutes of the Steering Committee meetings at M6

Minutes of the 1st Steering Committee meeting

In vitro CSCs isolation and characterization in human GBM and MB models

"This deliverable will present the results and the validation of the ""out of lab on chip"" CSCs isolation and biological characterization in GBM and MB cell lines according to the protocols defined in Task 1.1."

Minutes of the Steering Committee meeting at M24

Minutes of the 4th Steering Committee meeting

Scientific action check meeting M12

Scientific action check meeting related to project end of first year.

Stakeholders management workshop

To prepare the next step of the technology development, we beleve that it is necessary to convince and mobilize both the medical and industrial worlds. To enhance the project visibility and stakeholder awareness, a “Stakeholders management” workshop will be organized in order to disseminate largely the project outcome and prepare for future R&D project or investments.

Project identity set (logo, brochure…)

This deliverable will deal with SUMACTEC visual identidy for efficient communication: logo, brochure, flyer...

Public Website

To promote the project and facilitate the communication and dissemination a public Website will be created and dedicatedfor SUMCASTEC. This website will display information about the project and will also be used as a resource for internal and external information dissemination. This website will also include a secure section for intraconsortium document share and exchange.

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Publications

Dielectric Spectroscopy and RF and Microwave Passive Microsystems for Biological Applications and Discrimination of Cells

Author(s): A. Pothier, C.Dalmay, F. Hjeij P. Blondy, F.Lalloué, B.Bessette, M.Kaynak, C. Palego
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), 2017

Biological cell discrimination based on their high frequency dielectropheretic signatures at UHF frequencies

Author(s): F. Hjeij, C. Dalmay, B. Bessette, G. Begaud, A. Bessaudou, Pierre Blondy, M. O. Jauberteau, F. Lalloue, C. Baristiran Kaynak, Mehmet Kaynak, W. Gamal, C. Palego, Arnaud Pothier
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), 2017, Page(s) 533-536
DOI: 10.1109/MWSYM.2017.8058618

Oxide surface roughness optimization of BiCMOS beol wafers for 200 mm wafer level microfluidic packaging based on fusion bonding

Author(s): M. Inac, M. Wietstruck, A. Goritz, B. Cetindogan, C. Baristiran-Kaynak, M. Lisker, A. Kruger, A. Trusch, U. Saarow, P. Heinrich, T. Voss, M. Kaynak
Published in: 2017 IEEE 19th Electronics Packaging Technology Conference (EPTC), 2017, Page(s) 1-4
DOI: 10.1109/eptc.2017.8277523

BiCMOS Integrated Microfluidic Packaging by Wafer Bonding for Lab-on-Chip Applications

Author(s): Mesut Inac, Matthias Wietstruck, Alexander Goritz, Barbaros Cetindogan, Canan Baristiran-Kaynak, Steffen Marschmeyer, Mirko Fraschke, Thomas Voss, Andreas Mai, Cristiano Palego, Arnaud Pothier, Mehmet Kaynak
Published in: 2017 IEEE 67th Electronic Components and Technology Conference (ECTC), 2017, Page(s) 786-791
DOI: 10.1109/ECTC.2017.153

BiCMOS Embedded Microfluidic Technology Based on Wafer Bonding Techniques for Biosensor Applications

Author(s): M. Inac, M. Wietstruck, A. Göritz, B. Cetindogan, C. Baristiran Kaynak, S. Marschmeyer, M. Fraschke, T. Voss, A. Mai, C. Palego, A. Pothier, M. Kaynak
Published in: 2017 MikroSystemTechnik Kongress (MST 2017), 2017, Page(s) 273-276

BiCMOS/microfluidics lab-on-chip

Author(s): C. Palego, C. Hancock, A. Porch, M. Kaynak
Published in: 2017 Engineering Wales Conference, 2017

BiCMOS Microfluidic Microwave Platform for Biological Cell Sensing and Manipulation

Author(s): B. Cetindogan, ,M. Inac, A. Goritz, M. Wietstruck, C. Baristiran-Kaynak, C. Palego, A. Pothier, ,M. Kaynak
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), Issue Workshop on Thermal vs non-thermal effects of electromagnetic waves for biomedical application, 2017

Advanced RF, Microwave and Millimeter Wave Energy Based Systems to Address A Range of Unmet and Growing Clinical Needs

Author(s): C. Hancock
Published in: 2017 Workshop IEEE MTT-S International Microwave Symposium (IMS), Issue Workshop on Thermal vs non-thermal effects of electromagnetic waves for biomedical application, 2017

The Effect of Surface Optimization on Post-grinding Yield of 200 mm Wafer Level Packaging Applications

Author(s): Mesut Inac, Matthias Wietstruck, Alexander Goritz, Barbaros Cetindogan, Canan Baristiran-Kaynak, Marco Lisker, Andreas Kruger, Ulrike Saarow, Patric Heinrich, Thomas Voss, Kasim Altin, Mehmet Kaynak
Published in: 2018 7th Electronic System-Integration Technology Conference (ESTC), 2018, Page(s) 1-4
DOI: 10.1109/ESTC.2018.8546457

Push-Pull Configuration of High Power MOSFETs for Generation of Nanosecond Pulses for Electropermeabilization of Isolated Cancer Stem Cells

Author(s): I.W. Davies, C. Merla, M. Tanori, A. Zambotti, J. Bishop, C. Palego, C. P. Hancock
Published in: 2018 48th European Microwave Conference (EuMC), 2018, Page(s) 866-869
DOI: 10.23919/EuMC.2018.8541734

Electropermeabilization of Isolated Cancer Stem Cells with a Novel and Versatile Nanosecond Pulse Generator

Author(s): I. W. Davies, C. Merla, A. Casciati, A. Zambotti, J. Bishop, G. Hodgkins, C. Palego, C. P. Hancock
Published in: 2018 IEEE International Microwave Biomedical Conference (IMBioC), 2018, Page(s) 106-108
DOI: 10.1109/IMBIOC.2018.8428941

Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells, 1st EMF-Med World Conference on Biomedical Applications

Author(s): Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina
Published in: 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), 2018
DOI: 10.5281/zenodo.1443523

High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells

Author(s): Remi Manczak, Sofiane Saada, Mirella Tanori, Arianna Casciati, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Caterina Merla, Barbara Tanno, Mariateresa Mancuso, Fabrice Lalloue, Arnaud Pothier
Published in: 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), 2018, Page(s) 1-2
DOI: 10.23919/EMF-MED.2018.8526006

Tracking Cancer Cells with Microfluidic High Frequency DEP Cytometer Implemented on BiCMOS Lab-on-Chip Platform

Author(s): R. Manczak, F. Hjeij, T. Provent, S. Saada, C. Dalmay, B. Bessette, G. Begaud, S. Battu, P. Blondy, M.O. Jauberteau, F. Lalloue, M. Inac, C. Baristiran Kaynak, M. Kaynak, C. Palego, A. Pothier
Published in: 2018 IEEE/MTT-S International Microwave Symposium - IMS, 2018, Page(s) 104-107
DOI: 10.1109/MWSYM.2018.8439466

New therapeutic strategy for medulloblastoma: µs pulse electric fields exposure targeting cancer stem cells to promote radiosensitization

Author(s): Mirella Tanori, Arianna Casciati, Barbara Tanno, Paola Giardullo, Alessandro Zambotti, Carmela Marino, Caterina Merla, Mariateresa Mancuso
Published in: 2019 International Conference on Radiation in Various Fields of Research (RAD 2019), 2019

Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces,

Author(s): T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Published in: 2019 IEEE MTT-S International Microwave Symposium (IMS), 2019

On-chip Flow Cell Sorting System Based on High frequency Dielectrophoresis implemented on CMOS technology

Author(s): R Manzac, A Pothier. C. Dalamy, P. Blondy, S. Saada, F. Lalloue
Published in: 2018 Workshop of GDR Micronanofluidics, 2018

Ultra-short pulsed electric fields: a first study on cancer stem cells

Author(s): C. Merla
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018

BiCMOS integrated microfluidic cell sorting platform for CSC cell study

Author(s): A Pothier
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018

Isolation and characterization of the Cancer Stem cells (CSCs): one question, many answers

Author(s): S Saada
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018

Dielectric characterization of brain cancer cell lines

Author(s): W Ramal
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018

Strategy for brain stem cell sorting with SDFF

Author(s): G. Begaud; B. Bessette; S. Saad; R. Manczak; M. Mancuso; F. Lalloue; C. Dalmay; A Pothier; P.J.P. Cardot; S. Battu
Published in: 2018 International Symposium on Field and Flow Based Separations, 2018

Novel and versatile instrumentation for electro-manipulation of cancer stem cells

Author(s): C. Merla
Published in: 2018 BioEM 2018 The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association, 2018

Detection and Neutralization of Cancerous Stem Cells with lab on chip

Author(s): A. Pothier
Published in: 2018 Workshop of GDR Happybio 06-08 November 201, 2018

Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Published in: 2018 Workshop of French Canceropole GSO, 2018

Tiny chips: from bee wearable electronics to cancer stem cells seek and destroy

Author(s): C. Palego
Published in: 2018 Center for High Frequency Electronics Seminar, 2018

Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Published in: 2018 International Conference on Cancer Stem Cells and Oncology Research, 2018

Electro-permeabilization of isolated cancer stem cells with a push-pull configuration of high power MOSFETs

Author(s): I. Davies
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018

Experimental observation of a photonic hook

Author(s): I. V. Minin, O. V. Minin, G. M. Katyba, N. V. Chernomyrdin, V. N. Kurlov, K. I. Zaytsev, L. Yue, Z. Wang, D. N. Christodoulides
Published in: Applied Physics Letters, Issue 114/3, 2019, Page(s) 031105, ISSN 0003-6951
DOI: 10.1063/1.5065899

UHF-Dielectrophoresis Crossover Frequency as a New Marker for Discrimination of Glioblastoma Undifferentiated Cells

Author(s): Remi Manczak, Sofiane Saada, Thomas Provent, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie-Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Fabrice Lalloue, Arnaud Pothier
Published in: IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, 2019, Page(s) 1-1, ISSN 2469-7249
DOI: 10.1109/jerm.2019.2895539