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Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells

Deliverables

Minutes of the Steering Committee meeting at M36

Minutes of the 6th Steering Committee meeting

Minutes of the Steering Committee meeting at M30

Minutes of the 5th Steering Committee meeting

Scientific action check meeting M24

Scientific action check meeting related to reporting period 1

Minutes of the Steering Committee meetings at M12

Minutes of the 2nd Steering Committee meeting

List of ICT system specifications

Based on all partners’ available technologies as on its own insight on future biomedical devices, this deliverable will define the specification of the Lab on Chip’s key parameters including size, form factor, throughput, maximum sensitivity, available power, frequency range, waveform modulation, ambient sensitivity

Minutes of the Steering Committee meeting at M18

Minutes of the 3rd Steering Committee meeting

Biological protocols

This deliverable will define the protocols to be used for biological analysis, including: - cell culture protocol (UNILIM, ENEA and UNIPD) - protocols to isolate MB and GM CSC (ENEA, UNIPD and UNILIM) - in vitro ionizing radiations protocol (UNILIM and ENEA) - in vivo ionizing radiations protocol (ENEA) - tumour graft protocols for MB and GBM (UNIPD and ENEA).

Minutes of the Final Steering Committee meeting at M48

Minutes of the 7th and last Steering Committee meeting

Minutes of the Steering Committee meetings at M6

Minutes of the 1st Steering Committee meeting

In vitro CSCs isolation and characterization in human GBM and MB models

"This deliverable will present the results and the validation of the ""out of lab on chip"" CSCs isolation and biological characterization in GBM and MB cell lines according to the protocols defined in Task 1.1."

Minutes of the Steering Committee meeting at M24

Minutes of the 4th Steering Committee meeting

Scientific action check meeting M12

Scientific action check meeting related to project end of first year.

Synergic effects of EM field/radiation dose to sensitize CSC in vivo

This deliverable will presents results of in vivo tests combining non-ioninzing and ionizing radiation exposure of tumorand the evaluation of a possible reduction of standard treatment dose if combined with EM pretreatment of CSCs with equivalent efficiency.

Scientific action check meeting M42

Scientific action check meeting related to reporting period 1

Data Management Plan

A data Management Plan will be set to define data generated by the project to be kept confidential

Stakeholders management workshop

To prepare the next step of the technology development, we beleve that it is necessary to convince and mobilize both the medical and industrial worlds. To enhance the project visibility and stakeholder awareness, a “Stakeholders management” workshop will be organized in order to disseminate largely the project outcome and prepare for future R&D project or investments.

Project identity set (logo, brochure…)

This deliverable will deal with SUMACTEC visual identidy for efficient communication: logo, brochure, flyer...

Public Website

To promote the project and facilitate the communication and dissemination a public Website will be created and dedicatedfor SUMCASTEC. This website will display information about the project and will also be used as a resource for internal and external information dissemination. This website will also include a secure section for intraconsortium document share and exchange.

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Publications

Microsecond Pulsed Electric Fields: An Effective Way to Selectively Target and Radiosensitize Medulloblastoma Cancer Stem Cells

Author(s): Mirella Tanori, Arianna Casciati, Alessandro Zambotti, Rosanna Pinto, Isabella Gianlorenzi, Alessandro Pannicelli, Paola Giardullo, Barbara Benassi, Carmela Marino, Mariateresa Mancuso, Caterina Merla
Published in: International Journal of Radiation Oncology*Biology*Physics, 109/5, 2021, Page(s) 1495-1507, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.047

Microdosimetry Using Rhodamine B Within Macro- and Microsystems for Radiofrequency Signals Exposures of Biological Samples

Author(s): Amani Nefzi, Lynn Carr, Claire Dalmay, Arnaud Pothier, Philippe Leveque, Delia Arnaud-Cormos
Published in: IEEE Transactions on Microwave Theory and Techniques, 68/3, 2020, Page(s) 1142-1150, ISSN 0018-9480
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmtt.2019.2950191

High-voltage 10 ns delayed paired or bipolar pulses for in vitro bioelectric experiments

Author(s): Rosa Orlacchio, Lynn Carr, Cristiano Palego, Delia Arnaud-Cormos, Philippe Leveque
Published in: Bioelectrochemistry, 137, 2021, Page(s) 107648, ISSN 1567-5394
Publisher: Elsevier BV
DOI: 10.1016/j.bioelechem.2020.107648

Push–pull configuration of high-power MOSFETs for generation of nanosecond pulses for electropermeabilization of cells

Author(s): Ilan Wyn Davies; Caterina Merla; Arianna Casciati; Mirella Tanori; Alessandro Zambotti; Mariateresa Mancuso; John Bishop; Malcom White; Cristiano Palego; Christopher Hancock
Published in: International Journal of Microwave and Wireless Technologies, 2019, Page(s) 1–13., ISSN 1759-0795
Publisher: Cambridge University Press
DOI: 10.1017/s1759078719000576

Experimental observation of a photonic hook

Author(s): I. V. Minin, O. V. Minin, G. M. Katyba, N. V. Chernomyrdin, V. N. Kurlov, K. I. Zaytsev, L. Yue, Z. Wang, D. N. Christodoulides
Published in: Applied Physics Letters, 114/3, 2019, Page(s) 031105, ISSN 0003-6951
Publisher: American Institute of Physics
DOI: 10.1063/1.5065899

UHF-Dielectrophoresis Crossover Frequency as a New Marker for Discrimination of Glioblastoma Undifferentiated Cells

Author(s): Remi Manczak, Sofiane Saada, Thomas Provent, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie-Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Fabrice Lalloue, Arnaud Pothier
Published in: IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, 2019, Page(s) 1-1, ISSN 2469-7249
Publisher: IEEE
DOI: 10.1109/jerm.2019.2895539

Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype

Author(s): Arianna Casciati, Mirella Tanori, Rémi Manczak, Sofiane Saada, Barbara Tanno, Paola Giardullo, Elena Porcù, Elena Rampazzo, Luca Persano, Giampietro Viola, Claire Dalmay, Fabrice Lalloué, Arnaud Pothier, Caterina Merla, Mariateresa Mancuso
Published in: Cancers, 12/1, 2020, Page(s) 226, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12010226

A New Label-Free Approach to Glioblastoma Cancer Stem Cell Sorting and Detection

Author(s): Aurélie Lacroix, Elise Deluche, Ling Yan Zhang, Claire Dalmay, Carole Mélin, Jonathan Leroy, Meissa Babay, Christophe Morand Du Puch, Stéphanie Giraud, Barbara Bessette, Gaëlle Bégaud, Sofiane Saada, Christophe Lautrette, Arnaud Pothier, Serge Battu, Fabrice Lalloué
Published in: Analytical Chemistry, 91/14, 2019, Page(s) 8948-8957, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b00913

A Novel Ultrashort Electric Field Pulse Generator using Avalanche Breakdown Transistors and the Open Circuit Transmission Line Technique for Nanosecond Electroporation

Author(s): I. W. Davies and C. P. Hancock
Published in: 2019 3rd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.4701937

ltrashort electric pulses: an effective way to target cancer stem cells

Author(s): M. Tanori ENEA, Rome ; A. Casciati; P. Giardullo; B. Tanno; A. Zambotti; B. Benassi; R. Pinto; I. Davis; C. Palego; C. Hancock; C. Marino; M. Mancuso; C. Merla
Published in: 2019 3rd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food & Environmental Technologies, 2019
Publisher: zenodo
DOI: 10.5281/zenodo.3612388

Investigating the role of pulsed electric fields as radiosensitizers of medulloblastoma cancer stem cells

Author(s): Mirella Tanori , Arianna Casciati, Paola Giardullo, Alessandro Zambotti, Rosanna Pinto, Carmela Marino, Caterina Merla and Mariateresa Mancuso
Published in: 2019 65th Annual Meeting of the Radiation Research Society, 2019
Publisher: Zenodo

The effect of nsPEF on glioblastoma cancer-like stem cell transcription and protein expression

Author(s): Lynn Carr; Cristiano Palego; Sofiane Saada; Barbara Bessette; Arnaud Pothier; Delia Arnaud-Cormos; Philippe Leveque; Fabrice Lalloué
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4700367

Dielectric parameters extraction and modeling of brain cancer stem-like cells

Author(s): C. Merla, C. Palego, S. Ghamal, N. Karim, R. Pinto, M. Tanori, A. Casciati, A. Zambotti, M. Mancuso
Published in: 2020 IEEE IMBIOC conference Workshop, 2020
Publisher: Zenodo

Immature cancer cell discrimination using combined high frequency Electromagnetic Fields and dielectrophoresis forces

Author(s): C. Dalmay, R. Manczak, S. Saada, T. Provent, B. Bessette, A. Casciati, M. Tanori, E Porcù, E Rampazzo, L Persano, C. Baristiran Kaynak, M. Kaynak, C. Palego, G. Viola, C. Merla, M. Mancuso, F. Lalloue, A. Pothier
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4700388

Discrimination Cellulaire par Dielectrophorèse Ultra Haute Fréquence : Etude des Fréquences de Transition de Cellules de Glioblastomes

Author(s): R. Manczak, S. Saada, T. Provent, C. Dalmay, B. Bessette, G. Begaud, S. Battu, P. Blondy, M.O. Jauberteau, C. Baristiran Kaynak, M. Kaynak, C. Palego, F. Lalloue, A. Pothier
Published in: 2019 JNM conference, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.2652355

Continuous Cell Sorting by High Frequencies Dielectrophoresis

Author(s): T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Published in: 2019 Plumee conference, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.2652342

Radio Frequency sensors & lab-on-chip technologies: news opportunities for biomedical diagnosis

Author(s): A. Pothier , M. Babay, C. Dalmay , D. Cordeau, R. Manczak, S. Saada, B. Bessette, F. Lalloue, C. Merla , M. Mancuso, M. Tanori3, A. Casciati,E. Porcù, E. Rampazzo ,L. Persano, G.Viola, C. Palego, E.C Durmaz, C.B Kayank and M. Kaynak
Published in: 2021 EUMW Conference Workshop, 2021
Publisher: IEEE

Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces

Author(s): Thomas Provent, Remi Manczak, Sofiane Saada, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie Odile Jauberteau, Fabrice Lalloue, Arnaud Pothier
Published in: 2019 IEEE MTT-S International Microwave Symposium (IMS), 2019, Page(s) 224-227, ISBN 978-1-7281-1309-8
Publisher: IEEE
DOI: 10.1109/mwsym.2019.8701063

Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype

Author(s): A. Casciati; M. Tanori; B. Tanno; P. Giardullo; E. Porcù; E. Rampazzo; L. Persano; G. Viola; R. Manczak; S. Saada; C. Dalmay; F. Lalloué; A. Pothier; C. Merla; M. Mancuso;
Published in: 2019 3rd SUNRISE Meeting on New Advances in Cancer Stem Cells, 2019
Publisher: zenodo
DOI: 10.5281/zenodo.3603294

Des ondes électromagnétiques peuvent-elles être utilisées pour identifier et neutraliser des cellules souches cancéreuses?

Author(s): A. Pothier, R. Manczak, S. Saada, T. Provent, M. Tanori , A. Casciati , E. Porcù , E. Rampazzo , C. Dalmay, B. Bessette, G. Begaud, S. Battu, C, Merla , B. Tanno , L. Persano ,P. Blondy, M.O. Jauberteau, C. Baristiran Kaynak, M. Kaynak, C. Palego, G.Viola, M. Mancuso , F. Lalloue
Published in: 2019 JNM conference, 2019
Publisher: Zenodo

Lab-On-Chip platform for neutralization of cancer stem cells

Author(s): Cristiano Palego, Nissar Karim, Amira Eltokhy, Lynn Carr, Emre Can, Canan Baristiran, Mehmet Kaynak, Arnaud Pothier, Delia Arnaud-Cormos & Philippe Leveque
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4707171

Microsystem and Lab-On-Chip technologies might promote future generation of new tools for biological analysis

Author(s): T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Published in: 2019 SUMCASTEC Biomedical Applications of Electromagnetic Energy Workshop, 2019
Publisher: SUMCASTEC
DOI: 10.5281/zenodo.3408571

Microfluidic device for high-frequency dielectrophoresis characterization and single-cell discrimination

Author(s): Elisa Lambert, Elodie Barthout, Thomas Provent, Rémi Manczak , Sofiane Saada, Claire Dalmay, Barbara Bessette, Fabrice Lalloué , Arnaud Pothier ​
Published in: 2021 TECH DAY: Single Cell Analysis Conference, 2021
Publisher: Zenodo

Design and Implementation of Injection Locked Oscillator Biosensors

Author(s): M. Babay, C. Dalmay, B. Barelaud, E.C. Durmaz, C. Baristiran Kaynak, M. Kaynak, D. Cordeau, A. Pothier
Published in: 2019 49th European Microwave Conference (EuMC), 2019, Page(s) 168-171, ISBN 978-2-87487-055-2
Publisher: IEEE
DOI: 10.23919/eumc.2019.8910746

BiCMOS integrated microfluidic cell sorting platform for CSC cell study

Author(s): Arnaud Pothier
Published in: 2018 Sumcastec workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Zenodo

Progress in dielectric spectroscopy for biological cell characterization and cell sorting at MHz frequencies

Author(s): A. Pothier; R. Manczak; S. Saada; M. Tanori; A. Casciati; E. Porcù; E. Rampazzo; C. Dalmay; B. Bessette; G. Begaud; S. Battu; C. Merla; B. Tanno; L. Persano; P. Blondy; M.O. Jauberteau; C. Baristiran Kaynak; M. Kaynak; C. Palego; G. Viola; M. Mancuso; F. Lalloue
Published in: 2019 Européan Microwave Conference Week conference Workshop, 2019
Publisher: Zenodo

High frequency Electromagnetic Fields sensing based on lab-on-chip technology for Cancer Stem Cells Isolation and Analysis

Author(s): Claire Dalmay, Barbara Bessette, Fabrice Lalloué, Arnaud Pothier
Published in: 2020 IEEE IMBIOC conference Workshop, 2020
Publisher: Zenodo

HF-Dielectrophoresis crossover frequency measurements do allow discriminating cancerous stem cells from differentiated cells

Author(s): A. Pothier, R. Manczak, S. Saada, T. Provent, M. Tanori , A. Casciati , E. Porcù , E. Rampazzo , C. Dalmay, B. Bessette, G. Begaud, S. Battu, C, Merla , B. Tanno , L. Persano ,P. Blondy, M.O. Jauberteau, C. Baristiran Kaynak, M. Kaynak, C. Palego, G.Viola, M. Mancuso , F. Lalloue
Published in: 2019 SUMCASTEC Biomedical Applications of Electromagnetic Energy Workshop, 2019
Publisher: Zenodo

A Novel Ultrashort Electric Field Pulse Generator using Avalanche Breakdown Transistors and the Open Circuit Transmission Line Technique for Nanosecond Electroporation

Author(s): Ilan Wyn Davies; Christopher Paul Hancock
Published in: 2019 IEEE Asia-Pacific Microwave Conference, 2019
Publisher: IEEE
DOI: 10.1109/apmc46564.2019.9038660

Push-Pull Configuration of High Power MOSFETs for Generation of Nanosecond Pulses for Electropermeabilization of Medulobastoma Cells

Author(s): I. W. Davies
Published in: 2019 Bangor University College of Environmental Sciences and Engineering (CoESE) PhD conference, 2019
Publisher: zenodo

Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada, R. Manczak, B. Bessette, L Persano, E Percu, G. Begaud, C. Dalmay, S Battu, P. Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C. Palego, G Viola, M.O. Jauberteau, A. Pothier, F. Lalloué
Published in: 2018 11th International Conference on Cancer Stem Cells and Oncology Research, 2018
Publisher: Zenodo
DOI: 10.5281/zenodo.4699734

Rhodamine B Temperature Dosimetry of Biological Samples Interacting with Electromagnetic Fields in Macrosystems

Author(s): Amani Nefzi, Lynn Carr, Claire Dalmay, Arnaud Pothier, Philippe Leveque, Delia Arnaud-Cormos
Published in: 2019 IEEE MTT-S International Microwave Symposium (IMS), 2019, Page(s) 1454-1457, ISBN 978-1-7281-1309-8
Publisher: IEEE
DOI: 10.1109/mwsym.2019.8700784

Bipolar nanosecond pulse electric field generator using open circuit transmission line technique andavalanche transistors for nanosecond electroporation

Author(s): Ilan Davies1 & Christopher Hancock
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4707197

Lab-On-A-Chip For Cellular Analysis By Dielectric Spectroscopy Based On Injection Locked Oscillators

Author(s): M. Babay, C. Dalmay, B. Barelaud, M. Kaynak, E. Can Durmaz, C. Baristiran Kaynak D.Cordeau, A. Pothier
Published in: 2019 Plumee conference, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.2652075

Stem Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada, R. Manczak, B. Bessette, L Persano, E Percu, G. Begaud, C. Dalmay, S Battu, P. Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C. Palego, G Viola, M.O. Jauberteau, A. Pothier, F. Lalloué
Published in: 2019 Brain Tumor Meeting, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.3408553

Electromanipulate biological cells with high frequency signals: a new way to characterize cell aggressiveness in the frame of cancer treatment

Author(s): R. Manczak; S. Saada; T. Provent; C. Dalmay; B. Bessette; C.Merla; B. Tanno; M. Mancuso; C. Baristiran Kaynak; M. Kaynak; C. Palego; F. Lalloue; A. Pothier
Published in: 2019 IEEE IMS conference Workhop, 2019
Publisher: IEEE

Dielectric Spectroscopy and RF and Microwave Passive Microsystems for Biological Applications and Discrimination of Cells

Author(s): A. Pothier, C.Dalmay, F. Hjeij P. Blondy, F.Lalloué, B.Bessette, M.Kaynak, C. Palego
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), 2017
Publisher: IEEE

Biological cell discrimination based on their high frequency dielectropheretic signatures at UHF frequencies

Author(s): F. Hjeij, C. Dalmay, B. Bessette, G. Begaud, A. Bessaudou, Pierre Blondy, M. O. Jauberteau, F. Lalloue, C. Baristiran Kaynak, Mehmet Kaynak, W. Gamal, C. Palego, Arnaud Pothier
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), 2017, Page(s) 533-536, ISBN 978-1-5090-6360-4
Publisher: IEEE
DOI: 10.1109/MWSYM.2017.8058618

Oxide surface roughness optimization of BiCMOS beol wafers for 200 mm wafer level microfluidic packaging based on fusion bonding

Author(s): M. Inac, M. Wietstruck, A. Goritz, B. Cetindogan, C. Baristiran-Kaynak, M. Lisker, A. Kruger, A. Trusch, U. Saarow, P. Heinrich, T. Voss, M. Kaynak
Published in: 2017 IEEE 19th Electronics Packaging Technology Conference (EPTC), 2017, Page(s) 1-4, ISBN 978-1-5386-3042-6
Publisher: IEEE
DOI: 10.1109/eptc.2017.8277523

BiCMOS Integrated Microfluidic Packaging by Wafer Bonding for Lab-on-Chip Applications

Author(s): Mesut Inac, Matthias Wietstruck, Alexander Goritz, Barbaros Cetindogan, Canan Baristiran-Kaynak, Steffen Marschmeyer, Mirko Fraschke, Thomas Voss, Andreas Mai, Cristiano Palego, Arnaud Pothier, Mehmet Kaynak
Published in: 2017 IEEE 67th Electronic Components and Technology Conference (ECTC), 2017, Page(s) 786-791, ISBN 978-1-5090-6315-4
Publisher: IEEE
DOI: 10.1109/ECTC.2017.153

BiCMOS Embedded Microfluidic Technology Based on Wafer Bonding Techniques for Biosensor Applications

Author(s): M. Inac, M. Wietstruck, A. Göritz, B. Cetindogan, C. Baristiran Kaynak, S. Marschmeyer, M. Fraschke, T. Voss, A. Mai, C. Palego, A. Pothier, M. Kaynak
Published in: 2017 MikroSystemTechnik Kongress (MST 2017), 2017, Page(s) 273-276, ISBN 978-3-8007-4491-6
Publisher: VDE Verband der Elektrotechnik Elektronik Informationstechnik

BiCMOS/microfluidics lab-on-chip

Author(s): C. Palego, C. Hancock, A. Porch, M. Kaynak
Published in: 2017 Engineering Wales Conference, 2017
Publisher: National Research Network in Advanced Engineering and Materials

BiCMOS Microfluidic Microwave Platform for Biological Cell Sensing and Manipulation

Author(s): B. Cetindogan, ,M. Inac, A. Goritz, M. Wietstruck, C. Baristiran-Kaynak, C. Palego, A. Pothier, ,M. Kaynak
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS), Workshop on Thermal vs non-thermal effects of electromagnetic waves for biomedical application, 2017
Publisher: IEEE

Advanced RF, Microwave and Millimeter Wave Energy Based Systemsto Address A Range of Unmet and Growing Clinical Needs

Author(s): C. Hancock
Published in: 2017 IEEE MTT-S International Microwave Symposium (IMS) Workshop, Workshop on Thermal vs non-thermal effects of electromagnetic waves for biomedical application, 2017
Publisher: IEEE

The Effect of Surface Optimization on Post-grinding Yield of 200 mm Wafer Level Packaging Applications

Author(s): Mesut Inac, Matthias Wietstruck, Alexander Goritz, Barbaros Cetindogan, Canan Baristiran-Kaynak, Marco Lisker, Andreas Kruger, Ulrike Saarow, Patric Heinrich, Thomas Voss, Kasim Altin, Mehmet Kaynak
Published in: 2018 7th Electronic System-Integration Technology Conference (ESTC), 2018, Page(s) 1-4, ISBN 978-1-5386-6814-6
Publisher: IEEE
DOI: 10.1109/ESTC.2018.8546457

Push-Pull Configuration of High Power MOSFETs for Generation of Nanosecond Pulses for Electropermeabilization of Isolated Cancer Stem Cells

Author(s): I.W. Davies, C. Merla, M. Tanori, A. Zambotti, J. Bishop, C. Palego, C. P. Hancock
Published in: 2018 48th European Microwave Conference (EuMC), 2018, Page(s) 866-869, ISBN 978-2-87487-051-4
Publisher: IEEE
DOI: 10.23919/EuMC.2018.8541734

Electropermeabilization of Isolated Cancer Stem Cells with a Novel and Versatile Nanosecond Pulse Generator

Author(s): I. W. Davies, C. Merla, A. Casciati, A. Zambotti, J. Bishop, G. Hodgkins, C. Palego, C. P. Hancock
Published in: 2018 IEEE International Microwave Biomedical Conference (IMBioC), 2018, Page(s) 106-108, ISBN 978-1-5386-5918-2
Publisher: IEEE
DOI: 10.1109/IMBIOC.2018.8428941

Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells

Author(s): Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina
Published in: 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), 2018
Publisher: EMF-Med
DOI: 10.5281/zenodo.1443523

High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells

Author(s): Remi Manczak, Sofiane Saada, Mirella Tanori, Arianna Casciati, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Caterina Merla, Barbara Tanno, Mariateresa Mancuso, Fabrice Lalloue, Arnaud Pothier
Published in: 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), 2018, Page(s) 1-2, ISBN 978-9-5329-0079-8
Publisher: IEEE
DOI: 10.23919/EMF-MED.2018.8526006

Tracking Cancer Cells with Microfluidic High Frequency DEP Cytometer Implemented on BiCMOS Lab-on-Chip Platform

Author(s): R. Manczak, F. Hjeij, T. Provent, S. Saada, C. Dalmay, B. Bessette, G. Begaud, S. Battu, P. Blondy, M.O. Jauberteau, F. Lalloue, M. Inac, C. Baristiran Kaynak, M. Kaynak, C. Palego, A. Pothier
Published in: 2018 IEEE/MTT-S International Microwave Symposium - IMS, 2018, Page(s) 104-107, ISBN 978-1-5386-5067-7
Publisher: IEEE
DOI: 10.1109/MWSYM.2018.8439466

New therapeutic strategy for medulloblastoma: µs pulse electric fields exposure targeting cancer stem cells to promote radiosensitization

Author(s): Mirella Tanori, Arianna Casciati, Barbara Tanno, Paola Giardullo, Alessandro Zambotti, Carmela Marino, Caterina Merla, Mariateresa Mancuso
Published in: 2019 International Conference on Radiation in Various Fields of Research (RAD 2019), 2019
Publisher: RAD 2019

Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces,

Author(s): T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Published in: 2019 IEEE MTT-S International Microwave Symposium (IMS), 2019
Publisher: IEEE

On-chip Flow Cell Sorting System Based on High frequency Dielectrophoresis implemented on CMOS technology

Author(s): R Manzac, A Pothier. C. Dalamy, P. Blondy, S. Saada, F. Lalloue
Published in: 2018 Workshop of GDR Micronanofluidics, 2018
Publisher: Gdr Micronanofluidics

Ultra-short pulsed electric fields: a first study on cancer stem cells

Author(s): C. Merla
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Bangor University

BiCMOS integrated microfluidic cell sorting platform for CSC cell study

Author(s): A Pothier
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Bangor University

Isolation and characterization of the Cancer Stem cells (CSCs): one question, many answers

Author(s): S Saada
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Bangor University

Dielectric characterization of brain cancer cell lines

Author(s): W Gamal
Published in: 2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Bangor University

Strategy for brain stem cell sorting with SDFF

Author(s): G. Begaud; B. Bessette; S. Saad; R. Manczak; M. Mancuso; F. Lalloue; C. Dalmay; A Pothier; P.J.P. Cardot; S. Battu
Published in: 2018 International Symposium on Field and Flow Based Separations, 2018
Publisher: ISFFS

Novel and versatile instrumentation for electro-manipulation of cancer stem cells

Author(s): I. Davies; C. Merla; A. Zambotti; A. Casciati; M. Tanori; J. Bishop; C. Palego; M. Mancuso; C. Hancock
Published in: 2018 BioEM 2018 The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association, 2018
Publisher: BioEM
DOI: 10.5281/zenodo.2529512

Detection and Neutralization of Cancerous Stem Cells with lab on chip

Author(s): A. Pothier
Published in: 2018 Workshop of GDR Happybio 06-08 November 201, 2018
Publisher: GDR Happybio

Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Published in: 2018 Workshop of French Canceropole GSO, 2018
Publisher: Canceropole GSO

Tiny chips: from bee wearable electronics to cancer stem cells seek and destroy

Author(s): C. Palego
Published in: 2018 Center for High Frequency Electronics Seminar, 2018
Publisher: Cardiff University

Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Published in: 2018 International Conference on Cancer Stem Cells and Oncology Research, 2018
Publisher: ICCS

Electro-permeabilization of isolated cancer stem cells with a push-pull configuration of high power MOSFETs

Author(s): I. Davies
Published in: 2018 Sumcastec workshop on EM field interaction with biological tissues for cancer and regenerative medicine, 2018
Publisher: Bangor University

Highly Sensitive Capacitive Sensor Based on Injection Locked Oscillators with ppm Sensing Resolution

Author(s): Meissa Babay, Clement Hallepee, Claire Dalmay, Bruno Barelaud, Emre Can Durmaz, Canan Baristiran Kaynak, Mehmet Kaynak, David Cordeau, Arnaud Pothier
Published in: 2020 IEEE/MTT-S International Microwave Symposium (IMS), 2020, Page(s) 456-459, ISBN 978-1-7281-6815-9
Publisher: IEEE
DOI: 10.1109/ims30576.2020.9223884

Ultrashort electric pulses: a way to sensitize cancer stem cells

Author(s): M. Tanori, C. Casciati, P. Giardullo, B. Benassi, B. Tanno, A. Zambotti, R. Pinto, I. Davis, C. Palego, C. Hancook, C. Marino, M. Mancuso, C. Merla
Published in: 2019 SUMCASTEC Biomedical Applications of Electromagnetic Energy Workshop, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.4707045

Ultrashort electric pulses: an effective way to target cancer stem cells

Author(s): M. Tanori, C. Casciati, P. Giardullo, B. Tanno, A. Zambotti, B. Benassi, R. Pinto, I. W. Davis, C. Palego, C. Hancok, C. Marino, M. Mancuso and C. Merla
Published in: 2021 URSI GASS, 2021
Publisher: URSI
DOI: 10.5281/zenodo.4707081

New Generation of Microwave Lab-on-Chip for Cancer Stem Cells Neutralization using Electromagnetic Waves Stimulation

Author(s): Saada S., Bessette B, Manczak R, Begaud G, Dalmay C, Battu S, Blondy P, Inac M, Baristiran Kaynak C, Kaynak M, Palego C, Jauberteau MO, Pothier A and Lalloué F
Published in: 2017 RoadShow Cancer, 2017
Publisher: zenodo

Ultrashort pulsed electric fields as specific radiosensitizer of medulloblastoma cancer stem cells

Author(s): M. Tanori, C. Casciati, P. Giardullo, B. Benassi, B. Tanno, A. Zambotti, R. Pinto, C. Marino, M. Mancuso, C. Merla
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4707461

SUMCASTEC: Track, target and neutralize cancer stem cells in solid tumors using micro and nano technologies and electromagnetic waves

Author(s): Arnaud Pothier
Published in: 2017 Roawshow cancer, 2017
Publisher: zenodo

Generating Bipolar nsPulsed Electric Field using Transmission Line & Avalanche Transistors

Author(s): Ilan W. Davies, Chris P. Hancock
Published in: 2020 50th European Microwave Conference (EuMC), 2021, Page(s) 1003-1006, ISBN 978-2-87487-059-0
Publisher: IEEE
DOI: 10.23919/eumc48046.2021.9338198

Targeting in vitro 3D models of glioblastoma with sinusoidal EM fields

Author(s): Elena Rampazzo, Luca Persano, Caterina Merla, Arianna Casciati, Mirella Tanori, Mariateresa Mancuso, Christopher Hancock, George Hodgkins, Ilan W. Davis, Cristiano Palego, Nissar Karim, Alice Cani, Silvia Bresolin & Giampietro Viola
Published in: 2020 BIOEM Conference, 2020
Publisher: Bioelectromagnetics Society
DOI: 10.5281/zenodo.4707146

Potentialités d’architectures de biocapteurs basées sur des oscillateurs hyperfréquences verrouillés par injection

Author(s): M. Babay, C. Dalmay, B. Barelaud, M. Kaynak, E. Can Durmaz, C. Baristiran Kaynak D.Cordeau, A. Pothier
Published in: 2019 JNM conference, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.2652695

New Method for Detection and Neutralization of Cancer Stem Cells (CSCs) in Brain Tumors Using Electromagnetic Signatures

Author(s): Saada S., Bessette B, Manczak R, Begaud G, Dalmay C, Battu S, Blondy P, Inac M, Baristiran Kaynak C, Kaynak M, Palego C, Jauberteau MO, Pothier A and Lalloué F
Published in: 2019 Assemblée Générale Ligue contre le cancer Régional, 2019
Publisher: zenodo

Cytomètre électromagnétique pour tri continu de cellules biologiques basé sur l’effet de forces diélectrophoretiques hautes fréquences

Author(s): T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Published in: 2019 JNM conference, 2019
Publisher: Zenodo
DOI: 10.5281/zenodo.2652699

Strategy for Brain Cancer Stem Cell sorting with SdFFF. Routine BTSC subpopulations preparation for biosensor calibration

Author(s): Bégaud, G., Bessette, B., Saada, S., Manczak, R.,Mancuso, M., Lalloué, F., Dalmay, C., Pothier, A., Cardot, P.J.P., Battu, S., S. Saada, R. Manczak, B. Bessette, L Persano, E Porcù, G. Begaud, C. Dalmay, S Battu, P. Blondy, C. Baristiran Kaynak, M. Kaynak, C. Palego, G Viola, M.O. Jauberteau, A. Pothier, F. Lalloué
Published in: 2018 19th International Symposium on Field- and Flow-Based Separation, 2018
Publisher: zenodo

Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency

Author(s): S. Saada, R. Manczak, B. Bessette , C. Dalmay, G. Begaud, S. Battu, P. Blondy, M.O. Jauberteau, M. Inac, C. Baristiran Kaynak, M. Kaynak, C. Palego, A. Pothier and F. Lalloue
Published in: 2018 11th International Conference on Cancer Stem Cells and Oncology Research, 2018
Publisher: zenodo

Micro-Pulse Electric Fields exposure targeting medulloblastoma cancer stem cells

Author(s): M. Tanori; A. Casciati; B. Tanno; P. Giardullo; A. Zambotti; C. Marino; C. Merla; M. Mancuso
Published in: 2019 3rd SUNRISE Meeting on New Advances in Cancer Stem Cells, 2019
Publisher: zenodo
DOI: 10.5281/zenodo.3602738

A High Frequency Dielectrophoresis Cytometer for Continuous Flow Biological Cells Refinement

Author(s): Thomas Provent, Audrey Mauvy, Remi Manczak, Sofiane Saada, Claire Dalmay, Barbara Bessette, Fabrice Lalloue, Arnaud Pothier
Published in: 2020 50th European Microwave Conference (EuMC), 2021, Page(s) 921-924, ISBN 978-2-87487-059-0
Publisher: IEEE
DOI: 10.23919/eumc48046.2021.9338228

Discrimination and Neutralization of Cancer Stem-like Cells (CSCs) (Glioblastoma)

Author(s): Saada S., Bessette B, Manczak R, Begaud G, Dalmay C, Battu S, Blondy P, Inac M, Baristiran Kaynak C, Kaynak M, Palego C, Jauberteau MO, Pothier A and Lalloué F
Published in: 2019 Annual day GEIST, 2019
Publisher: zenodo