Project description DEENESFRITPL Lab-on-chip platform for micromanipulation of cancer stem cells Cancer stem cells (CSCs) exist as a subpopulation of cells among the many different types of cells within a tumour. CSCs are capable of multiplying indefinitely and are more resistant to chemotherapy, leading to relapses after treatment. The goal of the EU-funded SUMCASTEC project is to develop an alternative treatment by selectively targeting quiescent CSCs and subsequently inducing differentiation to sensitise them to treatments. The project’s approach to isolating CSCs in real-time is based on an innovative micro-optofluidic lab-on-chip (LOC) platform developed through multidisciplinary effort. A single LOC will be able to compare cell spectral signatures and image subcellular features to modulate CSCs microenvironment conditions with ultra-high space and time resolution. Show the project objective Hide the project objective Objective SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue. This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy.By investing in efforts such as SUMCASTEC’s, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact.All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 €. Fields of science medical and health sciencesclinical medicinesurgeryengineering and technologyother engineering and technologiesmicrotechnologylab on a chipnatural sciencesphysical sciencesopticsmicroscopyelectron microscopymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncology Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Call for proposal H2020-FETOPEN-2016-2017 See other projects for this call Sub call H2020-FETOPEN-1-2016-2017 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITE DE LIMOGES Net EU contribution € 884 376,54 Address François Mitterrand 33 87032 Limoges France See on map Region Nouvelle-Aquitaine Limousin Haute-Vienne Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 994 946,25 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 110 569,71 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 569,71 BANGOR UNIVERSITY United Kingdom Net EU contribution € 705 050,00 Address COLLEGE ROAD LL57 2DG Bangor See on map Region Wales West Wales and The Valleys Gwynedd Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 705 050,00 IHP GMBH - INNOVATIONS FOR HIGH PERFORMANCE MICROELECTRONICS Germany Net EU contribution € 610 250,00 Address IM TECHNOLOGIEPARK 25 15236 Frankfurt Oder See on map Region Brandenburg Brandenburg Oder-Spree Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 610 250,00 AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE Italy Net EU contribution € 690 647,50 Address LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76 00196 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 690 647,50 UNIVERSITA DEGLI STUDI DI PADOVA Italy Net EU contribution € 446 717,50 Address VIA 8 FEBBRAIO 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 446 717,50 CREO MEDICAL LIMITED United Kingdom Net EU contribution € 530 906,25 Address RIVERSIDE COURT BEAUFORT PARK WAY NP16 5UH CHEPSTOW GWENT See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Wales East Wales Monmouthshire and Newport Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 530 906,25