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Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells

Objective

SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue.
This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy.
By investing in efforts such as SUMCASTEC’s, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact.
All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 €.

Call for proposal

H2020-FETOPEN-2016-2017

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Sub call

H2020-FETOPEN-1-2016-2017

Coordinator

UNIVERSITE DE LIMOGES
Net EU contribution
€ 884 376,54
Address
François Mitterrand 33
87032 Limoges
France

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Region
Nouvelle-Aquitaine Limousin Haute-Vienne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (6)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 110 569,71
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BANGOR UNIVERSITY
United Kingdom
Net EU contribution
€ 705 050,00
Address
College Road
LL57 2DG Bangor

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Region
Wales West Wales and The Valleys Gwynedd
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IHP GMBH - INNOVATIONS FOR HIGH PERFORMANCE MICROELECTRONICS/LEIBNIZ-INSTITUT FUER INNOVATIVE MIKROELEKTRONIK
Germany
Net EU contribution
€ 610 250,00
Address
Im Technologiepark 25
15236 Frankfurt Oder

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Region
Brandenburg Brandenburg Oder-Spree
Activity type
Other
Non-EU contribution
€ 0,00
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy
Net EU contribution
€ 690 647,50
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
00196 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Net EU contribution
€ 446 717,50
Address
Via 8 Febbraio 2
35122 Padova

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CREO MEDICAL LIMITED
United Kingdom
Net EU contribution
€ 530 906,25
Address
Riverside Court Beaufort Park Way
NP16 5UH Chepstow Gwent

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wales East Wales Monmouthshire and Newport
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00