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3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration

Deliverables

Data management Plan

A DMP will be realized and might change during the project. It will be made in accordance to the Consortium Agreement. It will describe how data and documents will be manage, explain choices, methods to use them and the means to protect them. This plan will outline how the research data collected and generated will be handled during a research project, and after it is completed, describing what data will be collected/generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved. It will be updated on Month 18.

Listing RNA and protein extracts from AD

From blood cells (MCM) isolated from AD, MCI, pre-MCI patients, and from control PiB-PET[-] subjects, and cells populations separated on the bases of the different AD-HS(+) and AD-HS(-) phenotypes. The first report will be on Month 24 end the second on month 36.

Dissemination and exploitation plan

"Guidelines regarding the PI management and dissemination actions will be defined in order to set several confidentiality issues allowing to promote the project without compromising forthcoming results exploitation. Two specific aspects for results diffusion will also be considered: - patent deposition with further publications, - publication of the mechanistic observations. Both aspects will respect the terms define in the Consortium Agreement, signed by the partners before project starts. An evolutive plan will be made to ensure effectiveness of disseminations actions : - Events like congress and symposiums will be identify and targeted as ""place to be"" - News on the website will be posted - A wild communication will be made toward the main centrers taking care of sick patients and associations/foundations dedicated to AD. "

Cohorts description

Cohorts (patients anonymat will be respected and kept confidential) are already identified and description will be reported at M1.

Website and Communication tools

A public website will be set-up: - One section will be for open access by the general public and contain information like : aims, objectives, technological implications, partners, etc. of the project. - Use of social media (blogs, Twitter) will be driven by the communication manager. A project identity set will be created both for internal and external use: - logo, - slide template, - brochure with challenges/context, objectives, - results/applications

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Publications

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

Author(s): Joanna Wojsiat, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Published in: Oxidative Medicine and Cellular Longevity, Issue 2018, 2018, Page(s) 1-16, ISSN 1942-0900
DOI: 10.1155/2018/6435861

[Heparan sulphates, amyloidosis and neurodegeneration]

Author(s): C. Vera, J.A. Álvarez-Orozco, A. Maïza, S. Chantepie, R.N. Chehín, M.O. Ouidja, D. Papy-Garcia
Published in: Revista de neurologia, Issue 65, 2017, Page(s) 457-468, ISSN 0210-0010

Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions

Author(s): Toin H. van Kuppevelt, Arie Oosterhof, Elly M. M. Versteeg, Emina Podhumljak, Els M. A. van de Westerlo, Willeke F. Daamen
Published in: Scientific Reports, Issue 7/1, 2017, Page(s) 14785, ISSN 2045-2322
DOI: 10.1038/s41598-017-15009-0

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Author(s): Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Published in: Biochemical Journal, Issue 475/15, 2018, Page(s) 2435-2455, ISSN 0264-6021
DOI: 10.1042/bcj20180266

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Author(s): Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Published in: Biochemical Journal, Issue 475/15, 2018, Page(s) 2417-2433, ISSN 0264-6021
DOI: 10.1042/BCJ20180265

Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging

Author(s): Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
Published in: The Journals of Gerontology: Series A, Issue 73/9, 2018, Page(s) 1147-1157, ISSN 1079-5006
DOI: 10.1093/gerona/gly031

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Author(s): Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Published in: Ageing Research Reviews, Issue 49, 2019, Page(s) 125-143, ISSN 1568-1637
DOI: 10.1016/j.arr.2018.10.008

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

Author(s): Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garcia
Published in: PLOS ONE, Issue 14/1, 2019, Page(s) e0209573, ISSN 1932-6203
DOI: 10.1371/journal.pone.0209573

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

Author(s): Auriane Maïza, Sandrine Chantepie, Cecilia Vera, Alexandre Fifre, Minh Bao Huynh, Olivier Stettler, Mohand Ouidir Ouidja, Dulce Papy‐Garcia
Published in: FEBS Letters, Issue 592/23, 2018, Page(s) 3806-3818, ISSN 0014-5793
DOI: 10.1002/1873-3468.13082

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

Author(s): Neil M. Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Berry, David G. Fernig, Patrick A. Eyers, Richard Cosstick
Published in: RSC Advances, Issue 9/55, 2019, Page(s) 32165-32173, ISSN 2046-2069
DOI: 10.1039/c9ra07567d

APID database: redefining protein–protein interaction experimental evidences and binary interactomes

Author(s): Diego Alonso-López, Francisco J Campos-Laborie, Miguel A Gutiérrez, Luke Lambourne, Michael A Calderwood, Marc Vidal, Javier De Las Rivas
Published in: Database, Issue 2019, 2019, ISSN 1758-0463
DOI: 10.1093/database/baz005

DECO: decompose heterogeneous population cohorts for patient stratification and discovery of sample biomarkers using omic data profiling

Author(s): F J Campos-Laborie, A Risueño, M Ortiz-Estévez, B Rosón-Burgo, C Droste, C Fontanillo, R Loos, J M Sánchez-Santos, M W Trotter, J De Las Rivas
Published in: Bioinformatics, Issue 35/19, 2019, Page(s) 3651-3662, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btz148

Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain

Author(s): Oscar González-Velasco, Dulce Papy-García, Gael Le Douaron, José M. Sánchez-Santos, Javier De Las Rivas
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020, Page(s) 194491, ISSN 1874-9399
DOI: 10.1016/j.bbagrm.2020.194491

Selective labelling of arginine residues engaged in binding sulfated glycosaminoglycans

Author(s): Bui TP, Li Y, Ngamlert P, Nunes QM, Wilkinson MC and Fernig DG
Published in: bioRxiv, 2019
DOI: 10.1101/574947