3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration

Resultado final

A DMP will be realized and might change during the project. It will be made in accordance to the Consortium Agreement. It will describe how data and documents will be manage, explain choices, methods to use them and the means to protect them. This plan will outline how the research data collected and generated will be handled during a research project, and after it is completed, describing what data will be collected/generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved. It will be updated on Month 18.

Listing RNA and protein extracts from AD

From blood cells (MCM) isolated from AD, MCI, pre-MCI patients, and from control PiB-PET[-] subjects, and cells populations separated on the bases of the different AD-HS(+) and AD-HS(-) phenotypes. The first report will be on Month 24 end the second on month 36.

Dissemination and exploitation plan

"Guidelines regarding the PI management and dissemination actions will be defined in order to set several confidentiality issues allowing to promote the project without compromising forthcoming results exploitation. Two specific aspects for results diffusion will also be considered: - patent deposition with further publications, - publication of the mechanistic observations. Both aspects will respect the terms define in the Consortium Agreement, signed by the partners before project starts. An evolutive plan will be made to ensure effectiveness of disseminations actions : - Events like congress and symposiums will be identify and targeted as ""place to be"" - News on the website will be posted - A wild communication will be made toward the main centrers taking care of sick patients and associations/foundations dedicated to AD. "

Cohorts description

Cohorts patients anonymat will be respected and kept confidential are already identified and description will be reported at M1

Website and Communication tools

A public website will be setup One section will be for open access by the general public and contain information like aims objectives technological implications partners etc of the project Use of social media blogs Twitter will be driven by the communication managerA project identity set will be created both for internal and external use logo slide template brochure with challengescontext objectives resultsapplications

Publicaciones

Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity

Autores: Simon Wheeler; Colum Breen; Yong Li; Sarah H. Hewitt; Erin Robertson; Edwin A. Yates; Igor L. Barsukov; David G. Fernig; Stephen J. Butler
Publicado en: Org. Biomol. Chem., Edición 2, 2022, ISSN 1477-0539
Editor: The royal society of chemistry
DOI: 10.1039/d1ob02071d

3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro.

Autores: Walid Redouane; Patrick P. Michel; Auriane Maïza; Carine Dalle; T.H. van Kuppevelt; Sandrine Chantepie; Nazha Sidahmed-Adrar; Magda Hamza; Olivier Stettler; Gilles Carpentier; Dulce Papy-Garcia; Damien Habert; Mohand Ouidir Ouidja; José Courty
Publicado en: EISSN: 2045-2322, Edición 4, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-76030-4

Phosphorylation and sulfation sharea common biosynthetic pathway, butextend biochemical and evolutionarydiversity of biological macromoleculesin distinct ways

Autores: M. A. Lima, T. R. Rudd, D. G. Fernig and E. A. Yates
Publicado en: interface, 2022, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2022.0391

Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments

Autores: Muntsant A, Giménez-Llort L
Publicado en: Biomedicines, 2021, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9070715

Analysis of protein-heparin interactions using a portable SPR instrument.

Autores: Su D, Li Y, Yates EA, Skidmore MA, Lima MA, Fernig DG
Publicado en: PeerJ Analytical Chemistry, 2022, ISSN 2691-6630
Editor: PeerJ
DOI: 10.7717/peerj-achem.15

Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging

Autores: Muntsant A, Jiménez-Altayó F, Puertas-Umbert L, Jiménez-Xarrie E, Vila E, Giménez-Llort L
Publicado en: Biomedicines, 2021, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9020111

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born.

Autores: Gimenez-Llort L., Alveal-Mellado D.
Publicado en: Frontiers in behavioral Neuroscience, 2020, ISSN 1662-5153
Editor: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2020.611384

Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations

Autores: Monica M. Arroyo, Alberto Berral-González, Santiago Bueno-Fortes, Diego Alonso-López, Javier De Las Rivas
Publicado en: Biomolecules, Edición 10/5, 2020, Página(s) 667, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom10050667

Construction and evaluation of an antibody phage display library targeting heparan sulfate.

Autores: Toin H. van Kuppevelt; Els M. A. van de Westerlo; Willeke F. Daamen; Elly M. M. Versteeg; Lars Damen; Thierry van Wessel
Publicado en: Glycoconjugate Journal, Edición 1, 2020, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-020-09925-z

Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm

Autores: Grabowska-Pyrzewicz W, Want A, Leszek J, Wojda U
Publicado en: EBioMedicine, 2021, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103691

Impact of Social Isolation on the Behavioral, Functional Profiles, and Hippocampal Atrophy Asymmetry in Dementia in Times of Coronavirus Pandemic (COVID-19): A Translational Neuroscience Approach

Autores: Aida Muntsant, Lydia Giménez-Llort
Publicado en: Frontiers in Psychiatry, Edición 11, 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.572583

Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering: Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging

Autores: Virginia Torres-Lista, Lydia Giménez-Llort
Publicado en: Journal of Alzheimer's Disease, Edición 69/4, 2019, Página(s) 969-977, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-190253

Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation

Autores: Marín-Pardo D, Giménez-Llort L
Publicado en: Front Neurosci., 2021, ISSN 1662-4548
Editor: Frontiers Research Foundation
DOI: 10.3389/fnins.2021.733984

Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells.

Autores: Andrea Joaquín-García; Elena Sánchez-Luis; Javier De Las Rivas; Fermín Sánchez-Guijo; Francisco J Campos-Laborie; Francisco J Campos-Laborie
Publicado en: Biomolecules, Edición 2, 2020, ISSN 2218-273X
Editor: MDPI
DOI: 10.17863/cam.51211

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

Autores: Joanna Wojsiat, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Publicado en: Oxidative Medicine and Cellular Longevity, Edición 2018, 2018, Página(s) 1-16, ISSN 1942-0900
Editor: Landes Bioscience
DOI: 10.1155/2018/6435861

[Heparan sulphates, amyloidosis and neurodegeneration]

Autores: C. Vera, J.A. Álvarez-Orozco, A. Maïza, S. Chantepie, R.N. Chehín, M.O. Ouidja, D. Papy-Garcia
Publicado en: Revista de neurologia, Edición 65, 2017, Página(s) 457-468, ISSN 0210-0010
Editor: Viguera Editores

Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions

Autores: Toin H. van Kuppevelt, Arie Oosterhof, Elly M. M. Versteeg, Emina Podhumljak, Els M. A. van de Westerlo, Willeke F. Daamen
Publicado en: Scientific Reports, Edición 7/1, 2017, Página(s) 14785, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-15009-0

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Autores: Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Publicado en: Biochemical Journal, Edición 475/15, 2018, Página(s) 2435-2455, ISSN 0264-6021
Editor: Portland Press, Ltd.
DOI: 10.1042/bcj20180266

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Autores: Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Publicado en: Biochemical Journal, Edición 475/15, 2018, Página(s) 2417-2433, ISSN 0264-6021
Editor: Portland Press, Ltd.
DOI: 10.1042/BCJ20180265

Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging

Autores: Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
Publicado en: The Journals of Gerontology: Series A, Edición 73/9, 2018, Página(s) 1147-1157, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/gly031

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Autores: Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Publicado en: Ageing Research Reviews, Edición 49, 2019, Página(s) 125-143, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2018.10.008

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

Autores: Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garcia
Publicado en: PLOS ONE, Edición 14/1, 2019, Página(s) e0209573, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0209573

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

Autores: Auriane Maïza, Sandrine Chantepie, Cecilia Vera, Alexandre Fifre, Minh Bao Huynh, Olivier Stettler, Mohand Ouidir Ouidja, Dulce Papy‐Garcia
Publicado en: FEBS Letters, Edición 592/23, 2018, Página(s) 3806-3818, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.13082

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

Autores: Neil M. Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Berry, David G. Fernig, Patrick A. Eyers, Richard Cosstick
Publicado en: RSC Advances, Edición 9/55, 2019, Página(s) 32165-32173, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/c9ra07567d

APID database: redefining protein–protein interaction experimental evidences and binary interactomes

Autores: Diego Alonso-López, Francisco J Campos-Laborie, Miguel A Gutiérrez, Luke Lambourne, Michael A Calderwood, Marc Vidal, Javier De Las Rivas
Publicado en: Database, Edición 2019, 2019, ISSN 1758-0463
Editor: Oxford University Press
DOI: 10.1093/database/baz005

DECO: decompose heterogeneous population cohorts for patient stratification and discovery of sample biomarkers using omic data profiling

Autores: F J Campos-Laborie, A Risueño, M Ortiz-Estévez, B Rosón-Burgo, C Droste, C Fontanillo, R Loos, J M Sánchez-Santos, M W Trotter, J De Las Rivas
Publicado en: Bioinformatics, Edición 35/19, 2019, Página(s) 3651-3662, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btz148

Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain

Autores: Oscar González-Velasco, Dulce Papy-García, Gael Le Douaron, José M. Sánchez-Santos, Javier De Las Rivas
Publicado en: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020, Página(s) 194491, ISSN 1874-9399
Editor: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194491

Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations

Autores: Carolina Cortes-Urrea, Fernando Bueno-Gutiérrez, Melissa Solarte, Miguel Guevara-Burbano, Fabian Tobar-Tosse, Patricia E. Vélez-Varela, Juan Carlos Bonilla, Guillermo Barreto, Jaime Velasco-Medina, Pedro A. Moreno, Javier De Las Rivas
Publicado en: Biomolecules, Edición 10/5, 2020, Página(s) 698, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom10050698

Social Nesting, Animal Welfare and Disease Monitoring

Autores: Lydia Giménez-Llort; Virginia Torres-Lista
Publicado en: Animals (Basel), 2021, ISSN 2076-2615
Editor: MDPI
DOI: 10.3390/ani11041079

Sex-Dependent Signatures, Time Frames and Longitudinal Fine-Tuning of the Marble Burying Test in Normal and AD-Pathological Aging Mice.

Autores: Santana-Santana M, Bayascas JR, Giménez-Llort L
Publicado en: Biomedicines, 2021, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9080994

Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer's Disease: Studies in the 3xTg-AD Mice.

Autores: Castillo-Mariqueo L, Pérez-García MJ, Giménez-Llort L
Publicado en: Biomedicines, 2021, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9101365

Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression

Autores: Nagaraj S, Want A, Laskowska-Kaszub K, Fesiuk A, Vaz S, Logarinho E, Wojda U
Publicado en: Int J Mol Sci, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073653

Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfates diversity. A systematic review and analysis

Autores: Ouidja MO, Biard DSF, Chantepie S, Laffray X, Le Douaron G, Huynh MB, Rebergue N, Maïza A, Rubio K, Gonzalez-Velasco O, Barreto G, De Las Rivas J, Papy-Garcia D
Publicado en: MedRxiv preprint, 2022
Editor: MedRxiv
DOI: 10.1101/2022.04.18.22273971

Selective labelling of arginine residues engaged in binding sulfated glycosaminoglycans

Autores: Bui TP, Li Y, Ngamlert P, Nunes QM, Wilkinson MC and Fernig DG
Publicado en: bioRxiv, 2019
Editor: Cold spring harbor laboratory
DOI: 10.1101/574947

Heparan sulfate: in vitro and in vivo proof of efficacy of this new therapeutic strategy for halting Alzheimer disease related tauopathies development. AAIC Abstract Published in Alzheimer and dementia

Autores: Maïza A, Le Douaron G, Muntsant Soria A, Li Y, Ramakrishnan K, Ouidja MO, Fifre A, Chantepie-Laborde S, Jospin E, Laffray X, Ramos I, Fernig D, Gimenez Llort L, Papy-Garcia D and ArrestAD consortium Team
Publicado en: AAIC Abstract Published in Alzheimer and dementia, 2021
Editor: Alzheimer association
DOI: 10.1002/alz.051607

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