3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration

Informazioni relative al progetto

ArrestAD

ID dell’accordo di sovvenzione: 737390

DOI 10.3030/737390

Progetto chiuso

Data della firma CE 13 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Maggio 2022

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 3 991 096,25

Contributo UE € 3 991 096,25

Coordinato da

UNIVERSITE PARIS XII VAL DE MARNE
France

Risultati finali

Open Research Data Pilot (1)

Data management Plan

A DMP will be realized and might change during the project. It will be made in accordance to the Consortium Agreement. It will describe how data and documents will be manage, explain choices, methods to use them and the means to protect them. This plan will outline how the research data collected and generated will be handled during a research project, and after it is completed, describing what data will be collected/generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved. It will be updated on Month 18.

Documents, reports (3)

Listing RNA and protein extracts from AD

From blood cells (MCM) isolated from AD, MCI, pre-MCI patients, and from control PiB-PET[-] subjects, and cells populations separated on the bases of the different AD-HS(+) and AD-HS(-) phenotypes. The first report will be on Month 24 end the second on month 36.

Dissemination and exploitation plan

"Guidelines regarding the PI management and dissemination actions will be defined in order to set several confidentiality issues allowing to promote the project without compromising forthcoming results exploitation. Two specific aspects for results diffusion will also be considered: - patent deposition with further publications, - publication of the mechanistic observations. Both aspects will respect the terms define in the Consortium Agreement, signed by the partners before project starts. An evolutive plan will be made to ensure effectiveness of disseminations actions : - Events like congress and symposiums will be identify and targeted as ""place to be"" - News on the website will be posted - A wild communication will be made toward the main centrers taking care of sick patients and associations/foundations dedicated to AD. "

Cohorts description

Cohorts patients anonymat will be respected and kept confidential are already identified and description will be reported at M1

Websites, patent fillings, videos etc. (1)

Website and Communication tools

A public website will be setup One section will be for open access by the general public and contain information like aims objectives technological implications partners etc of the project Use of social media blogs Twitter will be driven by the communication managerA project identity set will be created both for internal and external use logo slide template brochure with challengescontext objectives resultsapplications

Pubblicazioni

Peer reviewed articles (32)

Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity

Autori: Simon Wheeler; Colum Breen; Yong Li; Sarah H. Hewitt; Erin Robertson; Edwin A. Yates; Igor L. Barsukov; David G. Fernig; Stephen J. Butler
Pubblicato in: Org. Biomol. Chem., Numero 2, 2022, ISSN 1477-0539
Editore: The royal society of chemistry
DOI: 10.1039/d1ob02071d

3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro.

Autori: Walid Redouane; Patrick P. Michel; Auriane Maïza; Carine Dalle; T.H. van Kuppevelt; Sandrine Chantepie; Nazha Sidahmed-Adrar; Magda Hamza; Olivier Stettler; Gilles Carpentier; Dulce Papy-Garcia; Damien Habert; Mohand Ouidir Ouidja; José Courty
Pubblicato in: EISSN: 2045-2322, Numero 4, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-76030-4

Phosphorylation and sulfation sharea common biosynthetic pathway, butextend biochemical and evolutionarydiversity of biological macromoleculesin distinct ways

Autori: M. A. Lima, T. R. Rudd, D. G. Fernig and E. A. Yates
Pubblicato in: interface, 2022, ISSN 1742-5689
Editore: The Royal Society
DOI: 10.1098/rsif.2022.0391

Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments

Autori: Muntsant A, Giménez-Llort L
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9070715

Analysis of protein-heparin interactions using a portable SPR instrument.

Autori: Su D, Li Y, Yates EA, Skidmore MA, Lima MA, Fernig DG
Pubblicato in: PeerJ Analytical Chemistry, 2022, ISSN 2691-6630
Editore: PeerJ
DOI: 10.7717/peerj-achem.15

Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging

Autori: Muntsant A, Jiménez-Altayó F, Puertas-Umbert L, Jiménez-Xarrie E, Vila E, Giménez-Llort L
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9020111

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born.

Autori: Gimenez-Llort L., Alveal-Mellado D.
Pubblicato in: Frontiers in behavioral Neuroscience, 2020, ISSN 1662-5153
Editore: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2020.611384

Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations

Autori: Monica M. Arroyo, Alberto Berral-González, Santiago Bueno-Fortes, Diego Alonso-López, Javier De Las Rivas
Pubblicato in: Biomolecules, Numero 10/5, 2020, Pagina/e 667, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom10050667

Construction and evaluation of an antibody phage display library targeting heparan sulfate.

Autori: Toin H. van Kuppevelt; Els M. A. van de Westerlo; Willeke F. Daamen; Elly M. M. Versteeg; Lars Damen; Thierry van Wessel
Pubblicato in: Glycoconjugate Journal, Numero 1, 2020, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-020-09925-z

Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm

Autori: Grabowska-Pyrzewicz W, Want A, Leszek J, Wojda U
Pubblicato in: EBioMedicine, 2021, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103691

Impact of Social Isolation on the Behavioral, Functional Profiles, and Hippocampal Atrophy Asymmetry in Dementia in Times of Coronavirus Pandemic (COVID-19): A Translational Neuroscience Approach

Autori: Aida Muntsant, Lydia Giménez-Llort
Pubblicato in: Frontiers in Psychiatry, Numero 11, 2020, ISSN 1664-0640
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.572583

Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering: Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging

Autori: Virginia Torres-Lista, Lydia Giménez-Llort
Pubblicato in: Journal of Alzheimer's Disease, Numero 69/4, 2019, Pagina/e 969-977, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-190253

Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation

Autori: Marín-Pardo D, Giménez-Llort L
Pubblicato in: Front Neurosci., 2021, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fnins.2021.733984

Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells.

Autori: Andrea Joaquín-García; Elena Sánchez-Luis; Javier De Las Rivas; Fermín Sánchez-Guijo; Francisco J Campos-Laborie; Francisco J Campos-Laborie
Pubblicato in: Biomolecules, Numero 2, 2020, ISSN 2218-273X
Editore: MDPI
DOI: 10.17863/cam.51211

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

Autori: Joanna Wojsiat, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Pubblicato in: Oxidative Medicine and Cellular Longevity, Numero 2018, 2018, Pagina/e 1-16, ISSN 1942-0900
Editore: Landes Bioscience
DOI: 10.1155/2018/6435861

[Heparan sulphates, amyloidosis and neurodegeneration]

Autori: C. Vera, J.A. Álvarez-Orozco, A. Maïza, S. Chantepie, R.N. Chehín, M.O. Ouidja, D. Papy-Garcia
Pubblicato in: Revista de neurologia, Numero 65, 2017, Pagina/e 457-468, ISSN 0210-0010
Editore: Viguera Editores

Sequencing of glycosaminoglycans with potential to interrogate sequence-specific interactions

Autori: Toin H. van Kuppevelt, Arie Oosterhof, Elly M. M. Versteeg, Emina Podhumljak, Els M. A. van de Westerlo, Willeke F. Daamen
Pubblicato in: Scientific Reports, Numero 7/1, 2017, Pagina/e 14785, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-15009-0

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Autori: Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Pubblicato in: Biochemical Journal, Numero 475/15, 2018, Pagina/e 2435-2455, ISSN 0264-6021
Editore: Portland Press, Ltd.
DOI: 10.1042/bcj20180266

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Autori: Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers
Pubblicato in: Biochemical Journal, Numero 475/15, 2018, Pagina/e 2417-2433, ISSN 0264-6021
Editore: Portland Press, Ltd.
DOI: 10.1042/BCJ20180265

Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging

Autori: Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
Pubblicato in: The Journals of Gerontology: Series A, Numero 73/9, 2018, Pagina/e 1147-1157, ISSN 1079-5006
Editore: Gerontological Society of America
DOI: 10.1093/gerona/gly031

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Autori: Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Pubblicato in: Ageing Research Reviews, Numero 49, 2019, Pagina/e 125-143, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2018.10.008

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

Autori: Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garcia
Pubblicato in: PLOS ONE, Numero 14/1, 2019, Pagina/e e0209573, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0209573

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

Autori: Auriane Maïza, Sandrine Chantepie, Cecilia Vera, Alexandre Fifre, Minh Bao Huynh, Olivier Stettler, Mohand Ouidir Ouidja, Dulce Papy‐Garcia
Pubblicato in: FEBS Letters, Numero 592/23, 2018, Pagina/e 3806-3818, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13082

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

Autori: Neil M. Kershaw, Dominic P. Byrne, Hollie Parsons, Neil G. Berry, David G. Fernig, Patrick A. Eyers, Richard Cosstick
Pubblicato in: RSC Advances, Numero 9/55, 2019, Pagina/e 32165-32173, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ra07567d

APID database: redefining protein–protein interaction experimental evidences and binary interactomes

Autori: Diego Alonso-López, Francisco J Campos-Laborie, Miguel A Gutiérrez, Luke Lambourne, Michael A Calderwood, Marc Vidal, Javier De Las Rivas
Pubblicato in: Database, Numero 2019, 2019, ISSN 1758-0463
Editore: Oxford University Press
DOI: 10.1093/database/baz005

DECO: decompose heterogeneous population cohorts for patient stratification and discovery of sample biomarkers using omic data profiling

Autori: F J Campos-Laborie, A Risueño, M Ortiz-Estévez, B Rosón-Burgo, C Droste, C Fontanillo, R Loos, J M Sánchez-Santos, M W Trotter, J De Las Rivas
Pubblicato in: Bioinformatics, Numero 35/19, 2019, Pagina/e 3651-3662, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btz148

Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain

Autori: Oscar González-Velasco, Dulce Papy-García, Gael Le Douaron, José M. Sánchez-Santos, Javier De Las Rivas
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020, Pagina/e 194491, ISSN 1874-9399
Editore: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194491

Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations

Autori: Carolina Cortes-Urrea, Fernando Bueno-Gutiérrez, Melissa Solarte, Miguel Guevara-Burbano, Fabian Tobar-Tosse, Patricia E. Vélez-Varela, Juan Carlos Bonilla, Guillermo Barreto, Jaime Velasco-Medina, Pedro A. Moreno, Javier De Las Rivas
Pubblicato in: Biomolecules, Numero 10/5, 2020, Pagina/e 698, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom10050698

Social Nesting, Animal Welfare and Disease Monitoring

Autori: Lydia Giménez-Llort; Virginia Torres-Lista
Pubblicato in: Animals (Basel), 2021, ISSN 2076-2615
Editore: MDPI
DOI: 10.3390/ani11041079

Sex-Dependent Signatures, Time Frames and Longitudinal Fine-Tuning of the Marble Burying Test in Normal and AD-Pathological Aging Mice.

Autori: Santana-Santana M, Bayascas JR, Giménez-Llort L
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9080994

Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer's Disease: Studies in the 3xTg-AD Mice.

Autori: Castillo-Mariqueo L, Pérez-García MJ, Giménez-Llort L
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9101365

Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression

Autori: Nagaraj S, Want A, Laskowska-Kaszub K, Fesiuk A, Vaz S, Logarinho E, Wojda U
Pubblicato in: Int J Mol Sci, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073653

Other (2)

Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfates diversity. A systematic review and analysis

Autori: Ouidja MO, Biard DSF, Chantepie S, Laffray X, Le Douaron G, Huynh MB, Rebergue N, Maïza A, Rubio K, Gonzalez-Velasco O, Barreto G, De Las Rivas J, Papy-Garcia D
Pubblicato in: MedRxiv preprint, 2022
Editore: MedRxiv
DOI: 10.1101/2022.04.18.22273971

Selective labelling of arginine residues engaged in binding sulfated glycosaminoglycans

Autori: Bui TP, Li Y, Ngamlert P, Nunes QM, Wilkinson MC and Fernig DG
Pubblicato in: bioRxiv, 2019
Editore: Cold spring harbor laboratory
DOI: 10.1101/574947

Conference proceedings (1)

Heparan sulfate: in vitro and in vivo proof of efficacy of this new therapeutic strategy for halting Alzheimer disease related tauopathies development. AAIC Abstract Published in Alzheimer and dementia

Autori: Maïza A, Le Douaron G, Muntsant Soria A, Li Y, Ramakrishnan K, Ouidja MO, Fifre A, Chantepie-Laborde S, Jospin E, Laffray X, Ramos I, Fernig D, Gimenez Llort L, Papy-Garcia D and ArrestAD consortium Team
Pubblicato in: AAIC Abstract Published in Alzheimer and dementia, 2021
Editore: Alzheimer association
DOI: 10.1002/alz.051607