Objective
Body movement requires efficient transfer of force from contracting muscles to bone. Damage to the tendinous insertions is the 8th leading cause of disease burden and is the largest single cause of work loss in Europe. Historically, approaches for improving healing in these attachment units have focused on modifying repair techniques and rehabilitation protocols. These methods are proven to be very ineffective, since failure rates of as high as 94% are often reported.
We have discovered that two distinct pools of progenitor cells form the tendon-to-bone attachment unit, known as “enthesis”. Moreover, we showed that these two pools are regulated separately via certain signalling pathways. These recent, yet exciting, findings gave rise to the novel idea that we can use these progenitors to regenerate the unique attachment unit, with the help also of the identified signalling pathways.
The overall goal of our ERC PoC project is to take the first steps towards the development and pre-commercialisation of novel regenerative strategies for enhanced tendon-to-bone healing in the adult setting. Specifically, (1) the first target is to establish the technical feasibility of our idea by performing a series of in-vitro and in-vivo-experiments, the latter utilising a novel state-of-the-art rotator cuff enthesis injury model that we developed. If the results of our preclinical studies are successful, they will have a direct impact on future regenerative strategies for tendon-to-bone repair. (2) The second target of the kiNESIS project is to establish the commercialisation potential of our idea. The commercialisation can result in a truly revolutionising, simple and non-invasive needle-based therapy for tendon injuries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7610001 Rehovot
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.