Proof of principle for a first in class neuroprotective therapy in stroke and other acute neurodegenerative conditions

Project Information

SAVEBRAIN

Grant agreement ID: 737586

DOI

10.3030/737586

Project closed

EC signature date 11 December 2017

Start date 1 April 2018

End date 30 September 2019

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 149 993,71

EU contribution

€ 149 993,71

Coordinated by

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

Author(s): Ana I. Casas, Eva Geuss, Pamela W. M. Kleikers, Stine Mencl, Alexander M. Herrmann, Izaskun Buendia, Javier Egea, Sven G. Meuth, Manuela G. Lopez, Christoph Kleinschnitz, Harald H. H. W. Schmidt
Published in: Proceedings of the National Academy of Sciences, Issue 114/46, 2017, Page(s) 12315-12320, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1705034114

From single drug targets to synergistic network pharmacology in ischemic stroke

Author(s): Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. López, Jan Baumbach, Harald H. H. W. Schmidt
Published in: Proceedings of the National Academy of Sciences, Issue 116/14, 2019, Page(s) 7129-7136, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1820799116

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Author(s): Ana I. Casas, Pamela W.M. Kleikers, Eva Geuss, Friederike Langhauser, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Martin Hrabê de Angelis, Javier Egea, Manuela G. Lopez, Christoph Kleinschnitz, Harald H.H.W. Schmidt
Published in: Journal of Clinical Investigation, Issue 129/4, 2019, Page(s) 1772-1778, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci124283