NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
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Autori:
Ana I. Casas, Eva Geuss, Pamela W. M. Kleikers, Stine Mencl, Alexander M. Herrmann, Izaskun Buendia, Javier Egea, Sven G. Meuth, Manuela G. Lopez, Christoph Kleinschnitz, Harald H. H. W. Schmidt
Pubblicato in:
Proceedings of the National Academy of Sciences, Numero 114/46, 2017, Pagina/e 12315-12320, ISSN 0027-8424
Editore:
National Academy of Sciences
DOI:
10.1073/pnas.1705034114
From single drug targets to synergistic network pharmacology in ischemic stroke
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Autori:
Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. López, Jan Baumbach, Harald H. H. W. Schmidt
Pubblicato in:
Proceedings of the National Academy of Sciences, Numero 116/14, 2019, Pagina/e 7129-7136, ISSN 0027-8424
Editore:
National Academy of Sciences
DOI:
10.1073/pnas.1820799116
Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
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Autori:
Ana I. Casas, Pamela W.M. Kleikers, Eva Geuss, Friederike Langhauser, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Martin Hrabê de Angelis, Javier Egea, Manuela G. Lopez, Christoph Kleinschnitz, Harald H.H.W. Schmidt
Pubblicato in:
Journal of Clinical Investigation, Numero 129/4, 2019, Pagina/e 1772-1778, ISSN 0021-9738
Editore:
American Society for Clinical Investigation
DOI:
10.1172/jci124283