Improving therapy of NPM1-mutated AML

Información del proyecto

TREAT-NPM1-AML

Identificador del acuerdo de subvención: 740230

DOI

10.3030/740230

Proyecto cerrado

Fecha de la firma de la CE 2 Octubre 2017

Fecha de inicio 1 Noviembre 2017

Fecha de finalización 31 Octubre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 895 836,00

Aportación de la UE

€ 2 895 836,00

Coordinado por

UNIVERSITA DEGLI STUDI DI PERUGIA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma

Autores: Venanzi, A; Marra, A; Schiavoni, G; Milner, SG; Limongello, R; Santi, A; Pettirossi, V; Ultimo, S; Tasselli, L; Pucciarini, A; Falini, L; Sciabolacci, S; Martelli, MP; Sportoletti, P; Ascani, S; Falini, B; Tiacci, E
Publicado en: Blood Cancer Discovery, 2021, ISSN 2643-3230
Editor: AMER ASSOC CANCER RESEARCH

Overlapping features of therapy-related and de novoNPM1-mutated AML.

Autores: Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard F Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda Frances Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo Maria Perriello, Vibeke Andresen, Bjorn T Gjertsen, Maria Paola Martelli, Christ
Publicado en: Blood, 2022, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2022018108

A Curious Novel Combination of Nucleophosmin ( NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Autores: Alessandra Venanzi; Roberta Rossi; Giovanni Martino; Giovanni Martino; Ombretta Annibali; Giuseppe Avvisati; Maria Grazia Mameli; Paolo Sportoletti; Enrico Tiacci; Brunangelo Falini; Maria Paola Martelli
Publicado en: Genes, Vol 12, Iss 1426, p 1426 (2021), Edición 2, 2021, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12091426

How I diagnose and treat NPM1-mutated AML

Autores: Falini, B; Brunetti, L; Martelli, MP
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology

NPM1-mutated acute myeloid leukemia: from bench to bedside

Autores: Falini, B; Brunetti, L; Sportoletti, P; Martelli, MP
Publicado en: Blood, 2020, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019004226

Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

Autores: Giulia Pianigiani, Andrea Gagliardi, Federica Mezzasoma, Francesca Rocchio, Valentina Tini, Barbara Bigerna, Paolo Sportoletti, Simona Caruso, Andrea Marra, Sara Peruzzi, Eleonora Petito, Giulio Spinozzi, Sharon Shacham, Yosef Landesman, Concetta Quintarelli, Paolo Gresele, Franco Locatelli, Maria Paola Martelli, Brunangelo Falini, Lorenzo Brunetti
Publicado en: Blood Advances, 2022, ISSN 2473-9529
Editor: Elsavier
DOI: 10.1182/bloodadvances.2022007563

A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas

Autores: Falini B, Martino G, Lazzi S
Publicado en: Leukemia, 2023, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-022-01764-1

Mutant NPM1: Nuclear export and the mechanism of leukemogenesis

Autores: Falini B, Martelli M.P, Brunetti L
Publicado en: American Journal of Hematology, 2023, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26862

Current status and future perspectives in targeted therapy of NPM1-mutated AML

Autores: Ranieri, R; Pianigiani, G; Sciabolacci, S; Perriello, VM; Marra, A; Cardinali, V; Pierangeli, S; Milano, F; Gionfriddo, I; Brunetti, L; Martelli, MP; Falini, B
Publicado en: Leukemia, 2022, ISSN 0887-6924
Editor: Nature Publishing Group

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Autores: Martelli, MP; Rossi, R; Venanzi, A; Meggendorfer, M; Perriello, VM; Martino, G; Spinelli, O; Ciurnelli, R; Varasano, E; Brunetti, L; Ascani, S; Quadalti, C; Cardinali, V; Mezzasoma, F; Gionfriddo, I; Milano, F; Pacini, R; Tabarrini, A; Bigerna, B; Albano, F; Specchia, G; Vetro, C; Di Raimondo, F; Annibali, O; Avvisati, G; Rambaldi, A; Falzetti, F; Tiacci, E; Sportoletti, P; Haferlach, T; Haferlach
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology

The NPM1 mutant defines AML irrespective of blast count

Autores: Brunangelo Falini, Maria Paola Martelli, Lorenzo Brunetti, Bjorn T. Gjertsen, Vibeke Andresen
Publicado en: American Journal of Hematology, 2023, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26946

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Autores: Wu, HC; Rerolle, D; Berthier, C; Hleihel, R; Sakamoto, T; Quentin, S; Benhenda, S; Morganti, C; Wu, CC; Conte, L; Rimsky, S; Sebert, M; Clappier, E; Souquere, S; Gachet, S; Soulier, J; Durand, S; Trowbridge, JJ; Benit, P; Rustin, P; El Hajj, H; Raffoux, E; Ades, L; Itzykson, R; Dombret, H; Fenaux, P; Espeli, O; Kroemer, G; Brunetti, L; Mak, TW; Lallemand-Breitenbach, V; Bazarbachi, A; Falini, B; I
Publicado en: Cancer Discovery, 2021, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein

Autores: Giulia Pianigiani, Francesca Rocchio, Sara Peruzzi, Vibeke Andresen, Barbara Bigerna, Daniele Sorcini, Michela Capurro, Bjørn Tore Gjertsen, Paolo Sportoletti, Mauro Di Ianni, Maria Paola Martelli, Lorenzo Brunetti, Brunangelo Falini
Publicado en: Nature-Leukemia, 2022, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-022-01593-2

Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma.

Autores: Alessandra Venanzi; Andrea Marra; Gianluca Schiavoni; Sara Giulia Milner; Roberto Limongello; Alessia Santi; Valentina Pettirossi; Simona Ultimo; Luisa Tasselli; Alessandra Pucciarini; Lorenza Falini; Sofia Sciabolacci; Maria Paola Martelli; Paolo Sportoletti; Stefano Ascani; Brunangelo Falini; Enrico Tiacci
Publicado en: BLOOD CANCER DISCOV, Edición 1, 2021, ISSN 2643-3230
Editor: AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2643-3230.bcd-20-0203

Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Autores: Gionfriddo, I; Brunetti, L; Mezzasoma, F; Milano, F; Cardinali, V; Ranieri, R; Venanzi, A; Pierangeli, S; Vetro, C; Spinozzi, G; Dorillo, E; Wu, HC; Berthier, C; Ciurnelli, R; Griffin, MJ; Jennings, CE; Tiacci, E; Sportoletti, P; Falzetti, F; de The, H; Veal, GJ; Martelli, MP; Falini, B
Publicado en: Leukemia, 2021, ISSN 0887-6924
Editor: Nature Publishing Group

Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field

Autores: Falini, B; Sciabolacci, S; Falini, L; Brunetti, L; Martelli, MP
Publicado en: Leukemia, 2021, ISSN 0887-6924
Editor: Nature Publishing Group

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions

Autores: Brunangelo Falini
Publicado en: American Journal of Hematology, 2023, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26989

Other (1)

NPM1-mutated AML with starry sky pattern

Autores: Brunangelo Falini, Valeria Cardinali, Lorenzo Brunetti, Maria Paola Martelli
Publicado en: 2023
Editor: John Wiley and Sons
DOI: 10.1111/bjh.18808

Non-peer reviewed articles (6)

IDH1-R132 changes vary according to NPM1 and other mutations status in AML

Autores: Brunangelo Falini, Orietta Spinelli, Manja Meggendorfer, Maria Paola Martelli, Barbara Bigerna, Stefano Ascani, Harald Stein, Alessandro Rambaldi, Torsten Haferlach
Publicado en: Leukemia, Edición 33/4, 2019, Página(s) 1043-1047, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-018-0299-2

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

Autores: Paolo Sportoletti, Letizia Celani, Emanuela Varasano, Roberta Rossi, Daniele Sorcini, Chiara Rompietti, Francesca Strozzini, Beatrice Del Papa, Valerio Guarente, Giulio Spinozzi, Debora Cecchini, Oxana Bereshchenko, Torsten Haferlach, Maria Paola Martelli, Franca Falzetti, Brunangelo Falini
Publicado en: Leukemia, 2019, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-019-0399-7

Mutant NPM1 Maintains the Leukemic State through HOX Expression

Autores: Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, Anna G. Guzman, Yung-Hsin Huang, Raghav Ramabadran, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Behnam Nabet, Dennis L. Buckley, Steven M. Kornblau, Charles Y. Lin, Paolo Sportoletti, Maria Paola Martelli, Brunangelo Falini, Margaret A. Goodell
Publicado en: Cancer Cell, Edición 34/3, 2018, Página(s) 499-512.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2018.08.005

High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1 -Mutated AML

Autores: Enrico Tiacci, Alessandra Venanzi, Stefano Ascani, Andrea Marra, Valeria Cardinali, Giovanni Martino, Veronica Codoni, Gianluca Schiavoni, Maria Paola Martelli, Brunangelo Falini
Publicado en: New England Journal of Medicine, Edición 379/10, 2018, Página(s) 981-984, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmc1806413

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

Autores: Xiaorong Gu, Quteba Ebrahem, Reda Z. Mahfouz, Metis Hasipek, Francis Enane, Tomas Radivoyevitch, Nicolas Rapin, Bartlomiej Przychodzen, Zhenbo Hu, Ramesh Balusu, Claudiu V. Cotta, David Wald, Christian Argueta, Yosef Landesman, Maria Paola Martelli, Brunangelo Falini, Hetty Carraway, Bo T. Porse, Jaroslaw Maciejewski, Babal K. Jha, Yogen Saunthararajah
Publicado en: Journal of Clinical Investigation, Edición 128/10, 2018, Página(s) 4260-4279, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci97117

Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

Autores: Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D. Lee, Emanuele Monteleone, Ke Cheng, Yang Zhang, Assaf C. Bester, Alison Guzzetti, Caitlin A. Mitchell, Lourdes M. Mendez, Olga Pozdnyakova, Paolo Sportoletti, Maria-Paola Martelli, Tom J. Vulliamy, Modi Safra, Schraga Schwartz, Lucio Luzzatto, Olivier Bluteau, Jean Soulier, Robert B. Darnell, Brunangelo Fali
Publicado en: Nature Genetics, Edición 51/10, 2019, Página(s) 1518-1529, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-019-0502-z