Improving therapy of NPM1-mutated AML

Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma

Autori: Venanzi, A; Marra, A; Schiavoni, G; Milner, SG; Limongello, R; Santi, A; Pettirossi, V; Ultimo, S; Tasselli, L; Pucciarini, A; Falini, L; Sciabolacci, S; Martelli, MP; Sportoletti, P; Ascani, S; Falini, B; Tiacci, E
Pubblicato in: Blood Cancer Discovery, 2021, ISSN 2643-3230
Editore: AMER ASSOC CANCER RESEARCH

Overlapping features of therapy-related and de novoNPM1-mutated AML.

Autori: Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard F Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda Frances Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo Maria Perriello, Vibeke Andresen, Bjorn T Gjertsen, Maria Paola Martelli, Christ
Pubblicato in: Blood, 2022, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2022018108

A Curious Novel Combination of Nucleophosmin ( NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Autori: Alessandra Venanzi; Roberta Rossi; Giovanni Martino; Giovanni Martino; Ombretta Annibali; Giuseppe Avvisati; Maria Grazia Mameli; Paolo Sportoletti; Enrico Tiacci; Brunangelo Falini; Maria Paola Martelli
Pubblicato in: Genes, Vol 12, Iss 1426, p 1426 (2021), Numero 2, 2021, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12091426

How I diagnose and treat NPM1-mutated AML

Autori: Falini, B; Brunetti, L; Martelli, MP
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology

NPM1-mutated acute myeloid leukemia: from bench to bedside

Autori: Falini, B; Brunetti, L; Sportoletti, P; Martelli, MP
Pubblicato in: Blood, 2020, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019004226

Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

Autori: Giulia Pianigiani, Andrea Gagliardi, Federica Mezzasoma, Francesca Rocchio, Valentina Tini, Barbara Bigerna, Paolo Sportoletti, Simona Caruso, Andrea Marra, Sara Peruzzi, Eleonora Petito, Giulio Spinozzi, Sharon Shacham, Yosef Landesman, Concetta Quintarelli, Paolo Gresele, Franco Locatelli, Maria Paola Martelli, Brunangelo Falini, Lorenzo Brunetti
Pubblicato in: Blood Advances, 2022, ISSN 2473-9529
Editore: Elsavier
DOI: 10.1182/bloodadvances.2022007563

A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas

Autori: Falini B, Martino G, Lazzi S
Pubblicato in: Leukemia, 2023, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-022-01764-1

Mutant NPM1: Nuclear export and the mechanism of leukemogenesis

Autori: Falini B, Martelli M.P, Brunetti L
Pubblicato in: American Journal of Hematology, 2023, ISSN 0361-8609
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26862

Current status and future perspectives in targeted therapy of NPM1-mutated AML

Autori: Ranieri, R; Pianigiani, G; Sciabolacci, S; Perriello, VM; Marra, A; Cardinali, V; Pierangeli, S; Milano, F; Gionfriddo, I; Brunetti, L; Martelli, MP; Falini, B
Pubblicato in: Leukemia, 2022, ISSN 0887-6924
Editore: Nature Publishing Group

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Autori: Martelli, MP; Rossi, R; Venanzi, A; Meggendorfer, M; Perriello, VM; Martino, G; Spinelli, O; Ciurnelli, R; Varasano, E; Brunetti, L; Ascani, S; Quadalti, C; Cardinali, V; Mezzasoma, F; Gionfriddo, I; Milano, F; Pacini, R; Tabarrini, A; Bigerna, B; Albano, F; Specchia, G; Vetro, C; Di Raimondo, F; Annibali, O; Avvisati, G; Rambaldi, A; Falzetti, F; Tiacci, E; Sportoletti, P; Haferlach, T; Haferlach
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology

The NPM1 mutant defines AML irrespective of blast count

Autori: Brunangelo Falini, Maria Paola Martelli, Lorenzo Brunetti, Bjorn T. Gjertsen, Vibeke Andresen
Pubblicato in: American Journal of Hematology, 2023, ISSN 0361-8609
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26946

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Autori: Wu, HC; Rerolle, D; Berthier, C; Hleihel, R; Sakamoto, T; Quentin, S; Benhenda, S; Morganti, C; Wu, CC; Conte, L; Rimsky, S; Sebert, M; Clappier, E; Souquere, S; Gachet, S; Soulier, J; Durand, S; Trowbridge, JJ; Benit, P; Rustin, P; El Hajj, H; Raffoux, E; Ades, L; Itzykson, R; Dombret, H; Fenaux, P; Espeli, O; Kroemer, G; Brunetti, L; Mak, TW; Lallemand-Breitenbach, V; Bazarbachi, A; Falini, B; I
Pubblicato in: Cancer Discovery, 2021, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein

Autori: Giulia Pianigiani, Francesca Rocchio, Sara Peruzzi, Vibeke Andresen, Barbara Bigerna, Daniele Sorcini, Michela Capurro, Bjørn Tore Gjertsen, Paolo Sportoletti, Mauro Di Ianni, Maria Paola Martelli, Lorenzo Brunetti, Brunangelo Falini
Pubblicato in: Nature-Leukemia, 2022, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-022-01593-2

Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma.

Autori: Alessandra Venanzi; Andrea Marra; Gianluca Schiavoni; Sara Giulia Milner; Roberto Limongello; Alessia Santi; Valentina Pettirossi; Simona Ultimo; Luisa Tasselli; Alessandra Pucciarini; Lorenza Falini; Sofia Sciabolacci; Maria Paola Martelli; Paolo Sportoletti; Stefano Ascani; Brunangelo Falini; Enrico Tiacci
Pubblicato in: BLOOD CANCER DISCOV, Numero 1, 2021, ISSN 2643-3230
Editore: AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2643-3230.bcd-20-0203

Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Autori: Gionfriddo, I; Brunetti, L; Mezzasoma, F; Milano, F; Cardinali, V; Ranieri, R; Venanzi, A; Pierangeli, S; Vetro, C; Spinozzi, G; Dorillo, E; Wu, HC; Berthier, C; Ciurnelli, R; Griffin, MJ; Jennings, CE; Tiacci, E; Sportoletti, P; Falzetti, F; de The, H; Veal, GJ; Martelli, MP; Falini, B
Pubblicato in: Leukemia, 2021, ISSN 0887-6924
Editore: Nature Publishing Group

Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field

Autori: Falini, B; Sciabolacci, S; Falini, L; Brunetti, L; Martelli, MP
Pubblicato in: Leukemia, 2021, ISSN 0887-6924
Editore: Nature Publishing Group

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions

Autori: Brunangelo Falini
Pubblicato in: American Journal of Hematology, 2023, ISSN 0361-8609
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26989

NPM1-mutated AML with starry sky pattern

Autori: Brunangelo Falini, Valeria Cardinali, Lorenzo Brunetti, Maria Paola Martelli
Pubblicato in: 2023
Editore: John Wiley and Sons
DOI: 10.1111/bjh.18808

IDH1-R132 changes vary according to NPM1 and other mutations status in AML

Autori: Brunangelo Falini, Orietta Spinelli, Manja Meggendorfer, Maria Paola Martelli, Barbara Bigerna, Stefano Ascani, Harald Stein, Alessandro Rambaldi, Torsten Haferlach
Pubblicato in: Leukemia, Numero 33/4, 2019, Pagina/e 1043-1047, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-018-0299-2

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

Autori: Paolo Sportoletti, Letizia Celani, Emanuela Varasano, Roberta Rossi, Daniele Sorcini, Chiara Rompietti, Francesca Strozzini, Beatrice Del Papa, Valerio Guarente, Giulio Spinozzi, Debora Cecchini, Oxana Bereshchenko, Torsten Haferlach, Maria Paola Martelli, Franca Falzetti, Brunangelo Falini
Pubblicato in: Leukemia, 2019, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0399-7

Mutant NPM1 Maintains the Leukemic State through HOX Expression

Autori: Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, Anna G. Guzman, Yung-Hsin Huang, Raghav Ramabadran, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Behnam Nabet, Dennis L. Buckley, Steven M. Kornblau, Charles Y. Lin, Paolo Sportoletti, Maria Paola Martelli, Brunangelo Falini, Margaret A. Goodell
Pubblicato in: Cancer Cell, Numero 34/3, 2018, Pagina/e 499-512.e9, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2018.08.005

High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1 -Mutated AML

Autori: Enrico Tiacci, Alessandra Venanzi, Stefano Ascani, Andrea Marra, Valeria Cardinali, Giovanni Martino, Veronica Codoni, Gianluca Schiavoni, Maria Paola Martelli, Brunangelo Falini
Pubblicato in: New England Journal of Medicine, Numero 379/10, 2018, Pagina/e 981-984, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmc1806413

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

Autori: Xiaorong Gu, Quteba Ebrahem, Reda Z. Mahfouz, Metis Hasipek, Francis Enane, Tomas Radivoyevitch, Nicolas Rapin, Bartlomiej Przychodzen, Zhenbo Hu, Ramesh Balusu, Claudiu V. Cotta, David Wald, Christian Argueta, Yosef Landesman, Maria Paola Martelli, Brunangelo Falini, Hetty Carraway, Bo T. Porse, Jaroslaw Maciejewski, Babal K. Jha, Yogen Saunthararajah
Pubblicato in: Journal of Clinical Investigation, Numero 128/10, 2018, Pagina/e 4260-4279, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci97117

Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

Autori: Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D. Lee, Emanuele Monteleone, Ke Cheng, Yang Zhang, Assaf C. Bester, Alison Guzzetti, Caitlin A. Mitchell, Lourdes M. Mendez, Olga Pozdnyakova, Paolo Sportoletti, Maria-Paola Martelli, Tom J. Vulliamy, Modi Safra, Schraga Schwartz, Lucio Luzzatto, Olivier Bluteau, Jean Soulier, Robert B. Darnell, Brunangelo Fali
Pubblicato in: Nature Genetics, Numero 51/10, 2019, Pagina/e 1518-1529, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0502-z

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