Deliverables Websites, patent fillings, videos etc. (2) Programme Website Social media accounts Other (3) Inform the Project Officer on publication of call Inform for each call the Project Officer by sending the link to the Euraxess website where the Call has been published Programme posters and flyers Media coverages Media coverages, also done later in the Project when applicable Publications Peer reviewed articles (28) FTLD Patient–Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Author(s): Stina Leskelä; Dorit Hoffmann; Hannah Rostalski; Nadine Huber; Rebekka Wittrahm; Päivi Hartikainen; Ville E. Korhonen; Ville Leinonen; Mikko Hiltunen; Eino Solje; Anne M. Remes; Anne M. Remes; Annakaisa Haapasalo Published in: Molecular Neurobiology, Issue 58, 2021, Page(s) 5438-5458, ISSN 0893-7648 Publisher: Humana Press, Inc. DOI: 10.1007/s12035-021-02475-x The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions Author(s): Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, and Christian Haass Published in: Molecular Neurodegeneration, Issue 15, 2020, Page(s) 52, ISSN 1750-1326 Publisher: BioMed Central DOI: 10.1186/s13024-020-00402-7 GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance Author(s): Katisko K, Cajanus A, Huber N, Jääskeläinen O, Kokkola T, Kärkkäinen V, Rostalski H, Hartikainen P, Koivisto AM, Hannonen S, Lehtola JM, Korhonen VE, Helisalmi S, Koivumaa-Honkanen H, Herukka SK, Remes AM, Solje E, Haapasalo A Published in: Journal of Neurology, Neurosurgery and Psychiatry, Issue vol. 92, no. 12, 2021, Page(s) 1-8, ISSN 0022-3050 Publisher: BMJ Publishing Group DOI: 10.1136/jnnp-2021-326487 C9orf72 proteins regulate autophagy and undergo autophagosomal or proteasomal degradation in a cell type-dependent manner Author(s): Leskelä; Huber; Rostalski; Natunen; Remes; Takalo; Hiltunen; Haapasalo Published in: Cells, Issue 84, 2019, Page(s) E1233, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells8101233 PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer Author(s): Sarang S. Talwelkar, Mikko I. Mäyränpää, Julia Schüler, Nora Linnavirta, Annabrita Hemmes, Simone Adinolfi, Matti Kankainen, Wolfgang Sommergruber, Anna-Liisa Levonen, Jari Räsänen, Aija Knuuttila, Emmy W. Verschuren, Krister Wennerberg Published in: Molecular Oncology, 2022, ISSN 1574-7891 Publisher: Elsevier BV DOI: 10.1002/1878-0261.13342 Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease Author(s): Sehgal, R., de Mello, V. D., Männistö, V., Lindström, J., Tuomilehto, J., Pihlajamäki, J., Uusitupa, M Published in: Nutrients, Issue 14(21), 2022, Page(s) 1-18, ISSN 2072-6643 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/nu14214695 A consensus protocol for functional connectivity analysis in the rat brain Author(s): Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Célestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Published in: Nature Neuroscience, 2023, ISSN 1097-6256 Publisher: Nature Publishing Group DOI: 10.1038/s41593-023-01286-8 Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury Author(s): "De Feo, Riccardo; Hä mä lä inen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Grö hn, Olli; Pitkä nen, Asla; Tohka, Jussi" Published in: Frontiers in Neurology, Issue 13, 2022, Page(s) 820267, ISSN 1664-2295 Publisher: Frontiers Research Foundation DOI: 10.3389/fneur.2022.820267 Region-wise loss for biomedical image segmentation Author(s): J.M. Valverde, J. Tohka Published in: Pattern Recognition, Issue 136, 2023, Page(s) 109208, ISSN 0031-3203 Publisher: Pergamon Press DOI: 10.1016/j.patcog.2022.109208 Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis Author(s): Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam Published in: Nucleic Acids Research, Issue vol. 49, no. 14, 2021, Page(s) 8078-8096, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkab633 Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids Author(s): de Mello VD, Sehgal R, Männistö V, Klåvus A, Nilsson E, Perfilyev A, Kaminska D, Miao Z, Pajukanta P, Ling C, Hanhineva K, Pihlajamäki J. Published in: Liver International, Issue 41, 2021, Page(s) 754-763, ISSN 1478-3231 Publisher: John Wiley & Sons Ltd DOI: 10.1111/liv.14743 Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches Author(s): Nadine Huber, Sonja Korhonen, Dorit Hoffmann, Stina Leskelä, Hannah Rostalski, Anne M. Remes, Paavo Honkakoski, Eino Solje, Annakaisa Haapasalo Published in: Molecular Psychiatry, Issue 27, 2022, Page(s) 1300-1309, ISSN 1359-4184 Publisher: Nature Publishing Group DOI: 10.1038/s41380-021-01384-8 Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases Author(s): Riccardo De Feo, Artem Shatillo, Alejandra Sierra, Juan Miguel Valverde, Olli Gröhn, Federico Giove, Jussi Tohka Published in: NeuroImage, Issue 229, 2021, Page(s) 117734, ISSN 1053-8119 Publisher: Academic Press DOI: 10.1016/j.neuroimage.2021.117734 MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation. Author(s): Rebekka Wittrahm; Mari Takalo; Mikael Marttinen; Teemu Kuulasmaa; Petra Mäkinen; Susanna Kemppainen; Henna Martiskainen; Tuomas Rauramaa; Ian Pike; Ville Leinonen; Teemu Natunen; Annakaisa Haapasalo; Mikko Hiltunen Published in: Cells, Issue 10, 2021, Page(s) 860, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells10040860 Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells Author(s): Liu, O. H. F., Kiema, M., Beter, M., Ylä-Herttuala, S., Laakkonen, J. P., & Kaikkonen, M. U. Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 40, 2020, Page(s) 2665-2667, ISSN 1079-5642 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/atvbaha.120.315214 Transfer Learning in Magnetic Resonance Brain Imaging: A Systematic Review. Author(s): Juan Miguel Valverde; Vandad Imani; Ali Abdollahzadeh; Riccardo De Feo; Mithilesh Prakash; Robert Ciszek; Jussi Tohka Published in: Journal of Imaging, Issue 7, 2021, Page(s) 66, ISSN 2313-433X Publisher: MDPI DOI: 10.3390/jimaging7040066 Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis Author(s): Sehgal, Ratika, Mariana Ilha, Maija Vaittinen, Dorota Kaminska, Ville Männistö, Vesa Kärjä, Marjo Tuomainen, Kati Hanhineva, Stefano Romeo, Päivi Pajukanta, Jussi Pihlajamäki, and Vanessa D. de Mello Published in: Nutrients, Issue 13, 2021, Page(s) 3509, ISSN 2072-6643 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/nu13103509 Light sedation with short habituation time for large-scale functional magnetic resonance imaging studies in rats Author(s): Lenka Dvořáková, Petteri Stenroos, Ekaterina Paasonen, Raimo A. Salo, Jaakko Paasonen, Olli Gröhn Published in: NMR in Biomedicine, Issue vol. 35, no. 6, 2021, Page(s) 1-13, ISSN 0952-3480 Publisher: John Wiley & Sons Inc. DOI: 10.1002/nbm.4679 Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Author(s): Hannah Rostalski, Stina Leskelä, Nadine Huber, Kasper Katisko, Antti Cajanus, Eino Solje, Mikael Marttinen, Teemu Natunen, Anne M. Remes, Mikko Hiltunen, Annakaisa Haapasalo Published in: Frontiers in Neuroscience, Issue 13, 2019, ISSN 1662-453X Publisher: Frontiers Media SA DOI: 10.3389/fnins.2019.00486 RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation Author(s): "Juan Miguel Valverde,; Artem, Shatillo; De Feo, Riccardo; Olli, Grö hn; Alejandra, Sierra; Jussi, Tohka" Published in: Frontiers in Neuroscience, Issue 14, 2020, Page(s) 610239, ISSN 1662-453X Publisher: Frontiers Media S.A. DOI: 10.3389/fnins.2020.610239 C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction Author(s): Huber N, Hoffmann D, Giniatullina R, Rostalski H, Leskelä S, Takalo M, Natunen T, Solje E, Remes AM, Giniatullin R, Hiltunen M, Haapasalo A Published in: Neurobiology of Disease, Issue 162, 2022, Page(s) 105584, ISSN 0969-9961 Publisher: Academic Press DOI: 10.1016/j.nbd.2021.105584 Liver saturated fat content associates with hepatic DNA methylation in obese individuals Author(s): Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Vanessa D. de Mello, Jussi Pihlajamäki Published in: Clinical Epigenetics, Issue 15, 2023, Page(s) 21, ISSN 1868-7083 Publisher: BioMed Central Ltd DOI: 10.1186/s13148-023-01431-x BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Author(s): Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen and Annakaisa Haapasalo Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 1-21, ISSN 1664-2295 Publisher: Frontiers Research Foundation DOI: 10.3389/fneur.2020.550140 BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelialcell response to VEGF Author(s): Pulkkinen, H. H., Kiema, M., Lappalainen, J. P., Toropainen, A., Beter, M., Tirronen, A., ... & Laakkonen, J. P Published in: Angiogenesis, Issue 24, 2021, Page(s) 139-144, ISSN 0969-6970 Publisher: Kluwer Academic Publishers DOI: 10.1007/s10456-020-09748-4 A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population Author(s): Rostalski H, Korhonen V, Kuulasmaa T, Solje E, Krüger J, Gen F, Kaivola K, Eide PK, Lambert JC, Julkunen V, Tienari PJ, Remes AM, Leinonen V, Hiltunen M, Haapasalo A Published in: Journal of Alzheimer's Disease, Issue vol. 83, no. 3, 2021, Page(s) 1325-1332, ISSN 1387-2877 Publisher: IOS Press DOI: 10.3233/jad-210599 Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Author(s): Leskelä S, Huber N, Hoffmann D, Rostalski H, Remes AM, Takalo M, Hiltunen M, Haapasalo A Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue vol. 1868, no. 7, 2021, Page(s) 119021, ISSN 0167-4889 Publisher: Elsevier BV DOI: 10.1016/j.bbamcr.2021.119021 Automatic Cerebral Hemisphere Segmentation in Rat MRI with Ischemic Lesions via Attention-based Convolutional Neural Networks Author(s): Juan Miguel Valverde, Artem Shatillo, Riccardo De Feo, and Jussi Tohka Published in: Neuroinformatics, 2022, ISSN 1539-2791 Publisher: Humana Press, Inc. DOI: 10.1007/s12021-022-09607-1 Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study Author(s): Ravi R, Fernandes Silva L, Vangipurapu J, Maria M, Raivo J, Helisalmi S, Laakso M Published in: Metabolites, Issue 12(5), 2022, Page(s) 437, ISSN 2218-1989 Publisher: MDPI DOI: 10.3390/metabo12050437 Thesis and dissertations (4) C9orf72 hexanucleotide repeat expansion in frontotemporal dementia special focus on genetics and microglia Author(s): Rostalski, Hannah Published in: Dissertations in Health Sciences, Issue 688, 2022, ISBN 978-952-61-4570-9 Publisher: PunaMusta Oy Metabolomics and genomics approach in cardiovascular diseases Author(s): Rowmika Ravi Published in: Dissertations in Health Sciences, Issue 742, 2023, ISBN 978-952-61-4821-2 Publisher: PunaMusta Oy MRI Segmentation With Deep Learning: Application in Rodent Brain Images with Lesions Author(s): Valverde, Juan Miguel Published in: Dissertations in Health Sciences, Issue 700, 2022, ISBN 978-952-61-4623-2 Publisher: PunaMusta Oy Nutrient-related metabolites in non-alcoholic fatty liver disease: Association with molecular & clinical characteristics Author(s): Sehgal, Ratika Published in: Dissertations in Health Sciences, Issue 703, 2022, ISBN 978-952-61-4639-3 Publisher: PunaMusta Oy Book chapters (1) Predicting intelligence based on cortical WM/GM contrast, cortical thickness and volumetry Author(s): Valverde, Juan Miguel; Imani, Vandad; Lewis, John D.; Tohka, Jussi Published in: Lecture Notes in Computer Science, Issue 11791, 2019, Page(s) 57-65, ISBN 978-3-030-31901-4 Publisher: Springer, Cham DOI: 10.1007/978-3-030-31901-4_7 Conference proceedings (1) Automatic Rodent Brain MRI Lesion Segmentation with Fully Convolutional Networks Author(s): Valverde, Juan Miguel; Shatillo, Artem; de Feo, Riccardo; Gröhn, Olli; Sierra, Alejandra; Tohka, Jussi Published in: Lecture Notes in Computer Science, Issue 11861, 2019, Page(s) 195-202, ISBN 978-3-030-32692-0 Publisher: Springer, Cham DOI: 10.48550/arxiv.1908.08746 Searching for OpenAIRE data... 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