What Holds Cancer Cells Back?

Project Information

HoldCancerBack

Grant agreement ID: 741350

DOI 10.3030/741350

Project closed

EC signature date 27 June 2017

Start date 1 August 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 379 250,00

EU contribution € 2 379 250,00

Coordinated by

UNIVERSITAET LEIPZIG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (34)

Comparative analysis of molecular signatures reveals a hybrid approach in breast cancer: Combining the Nottingham Prognostic Index with gene expressions into a hybrid signature

Author(s): Dimitrij Tschodu, Bernhard Ulm, Klaus Bendrat, Jürgen Lippoldt, Pablo Gottheil, Josef A. Käs, Axel Niendorf
Published in: PLOS ONE, Issue 17/2, 2022, Page(s) e0261035, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0261035

Detecting heterogeneity in and between breast cancer cell lines

Author(s): Yang Shen, B. U. Sebastian Schmidt, Hans Kubitschke, Erik W. Morawetz, Benjamin Wolf, Josef A. Käs, Wolfgang Losert
Published in: Cancer Convergence, Issue 4/1, 2020, ISSN 2366-6196
Publisher: BioMed Central
DOI: 10.1186/s41236-020-0010-1

Jamming in Embryogenesis and Cancer Progression

Author(s): Eliane Blauth, Hans Kubitschke, Pablo Gottheil, Steffen Grosser, Josef A. Käs
Published in: Frontiers in Physics, Issue 9, 2021, Page(s) 666709, ISSN 1022-1352
Publisher: John Wiley & Sons Ltd.
DOI: 10.3389/fphy.2021.666709

Intermediate filaments ensure resiliency of single carcinoma cells, while active contractility of the actin cortex determines their invasive potential

Author(s): Carlotta Ficorella, Hannah Marie Eichholz, Federico Sala, Rebeca Martinez Vazquez, Roberto Osellame, Josef A. Käs
Published in: New Journal of Physics, Issue 23, 2021, Page(s) 083028, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac1899

Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures

Author(s): Jörg Schnauß, Tom Kunschmann, Steffen Grosser, Paul Mollenkopf, Tobias Zech, Jessica S. Freitag, Dusan Prascevic, Roland Stange, Luisa S. Röttger, Susanne Rönicke, David M. Smith, Thomas M. Bayerl, Josef A. Käs
Published in: Advanced Materials, 2021, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202101840

Measuring structural parameters of crosslinked and entangled semiflexible polymer networks with single-filament tracing

Author(s): Tina Händler, Cary Tutmarc, Martin Glaser, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Published in: Physical Review E, 2021, ISSN 1539-3755
Publisher: American Physical Society
DOI: 10.1103/physreve.103.062501

Keratins determine network stress responsiveness in reconstituted actin–keratin filament systems

Author(s): Iman Elbalasy, Paul Mollenkopf, Cary Tutmarc, Harald Herrmann, Jörg Schnauß
Published in: Soft Matter, Issue 17/14, 2021, Page(s) 3954-3962, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm02261f

The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle.

Author(s): Claudia Tanja Mierke; Frank Sauer; Steffen Grosser; Stefanie Puder; Tony Fischer; Josef A. Käs
Published in: NMR in Biomedicine, Issue 1, 2018, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3831

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Author(s): Olga Ilina, Pavlo G. Gritsenko, Simon Syga, Jürgen Lippoldt, Caterina A. M. La Porta, Oleksandr Chepizhko, Steffen Grosser, Manon Vullings, Gert-Jan Bakker, Jörn Starruß, Peter Bult, Stefano Zapperi, Josef A. Käs, Andreas Deutsch, Peter Friedl
Published in: Nature Cell Biology, Issue 22/9, 2020, Page(s) 1103-1115, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0552-6

Large and stable: actin aster networks formed via entropic forces

Author(s): Friedrich Fabian Spukti, Jörg Schnauß
Published in: Frontiers in Chemistry, Issue 22962646, 2022, ISSN 2296-2646
Publisher: Frontiers Media S.A.
DOI: 10.3389/fchem.2022.899478

The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients

Author(s): Bianca Mages, Thomas Fuhs, Susanne Aleithe, Alexandra Blietz, Constance Hobusch, Wolfgang Härtig, Stefan Schob, Martin Krueger, Dominik Michalski
Published in: Molecular Neurobiology, 2021, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-021-02372-3

Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells

Author(s): Enrico Warmt, Steffen Grosser, Eliane Blauth, Xiaofan Xie, Hans Kubitschke, Roland Stange, Frank Sauer, Jörg Schnauß, Janina M. Tomm, Martin von Bergen
Published in: New Journal of Physics, Issue 23, 2021, Page(s) 133020, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac254e

The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients

Author(s): Ivonne Nel, Erik W. Morawetz, Dimitrij Tschodu, Josef A. Käs, Bahriye Aktas
Published in: Cancers, Issue 13/5, 2021, Page(s) 1119, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13051119

Anomalous cell sorting behavior in mixed monolayers discloses hidden system complexities

Author(s): Paul Heine, Jürgen Lippoldt, Gudur Ashrith Reddy, Parag Katira, Josef A. Käs
Published in: New Journal of Physics, Issue 23, 2021, Page(s) 043034, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/abf273

State of Cell Unjamming Correlates with Distant Metastasis in Cancer Patients

Author(s): Pablo Gottheil, Jürgen Lippoldt, Steffen Grosser, Frederic Renner, Mohamad Saibah, Dimitrij Tschodu, Anne-Kathrin Poßögel, Anne-Sophie Wegscheider, Bernhard Ulm, Kay Friedrichs, Christoph Lindner, Christoph Engel, Markus Löffler, Benjamin Wolf, Michael Höckel, Bahriye Aktas, Hans Kubitschke, Axel Niendorf, Josef A. Kaes
Published in: Physical Review X, Issue 13, 2023, ISSN 2160-3308
Publisher: American Physical Society
DOI: 10.1103/physrevx.13.031003

Constraint Release for Reptating Filaments in Semiflexible Networks Depends on Background Fluctuations

Author(s): Tina Händler, Cary Tutmarc, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Published in: Polymers, 2022, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14040707

Jamming transitions in cancer

Author(s): Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Published in: Journal of Physics D: Applied Physics, Issue 50/48, 2017, Page(s) 483001, ISSN 0022-3727
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6463/aa8e83

Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials

Author(s): Jessica S. Lorenz, Jörg Schnauß, Martin Glaser, Martin Sajfutdinow, Carsten Schuldt, Josef A. Käs, David M. Smith
Published in: Advanced Materials, Issue 30/13, 2018, Page(s) 1706092, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201706092

Glassy dynamics in composite biopolymer networks

Author(s): Tom Golde, Constantin Huster, Martin Glaser, Tina Händler, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Published in: Soft Matter, Issue 14/39, 2018, Page(s) 7970-7978, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sm01061g

Changing cell mechanics—a precondition for malignant transformation of oral squamous carcinoma cells

Author(s): Felix Meinhövel, Roland Stange, Jörg Schnauß, Michael Sauer, Josef A Käs, Torsten W Remmerbach
Published in: Convergent Science Physical Oncology, Issue 4/3, 2018, Page(s) 034001, ISSN 2057-1739
Publisher: IOP Publishing
DOI: 10.1088/2057-1739/aac72d

Single Actin Bundle Rheology

Author(s): Dan Strehle, Paul Mollenkopf, Martin Glaser, Tom Golde, Carsten Schuldt, Josef A. Käs, Jörg Schnauß
Published in: Molecules, Issue 22/10, 2017, Page(s) 1804, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101804

Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

Author(s): Frank Sauer, Linda Oswald, Angela Ariza de Schellenberger, Heiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack, Josef Alfons Käs
Published in: Soft Matter, Issue 15/14, 2019, Page(s) 3055-3064, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sm02264j

The role of stickiness in the rheology of semiflexible polymers

Author(s): Tom Golde, Martin Glaser, Cary Tutmarc, Iman Elbalasy, Constantin Huster, Gaizka Busteros, David M. Smith, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Published in: Soft Matter, Issue 15/24, 2019, Page(s) 4865-4872, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/C9SM00433E

Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement

Author(s): Carlotta Ficorella, Rebeca Martínez Vázquez, Paul Heine, Eugenia Lepera, Jing Cao, Enrico Warmt, Roberto Osellame, Josef A Käs
Published in: New Journal of Physics, Issue 21/8, 2019, Page(s) 083016, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3572

Roadmap to Local Tumour Growth: Insights from Cervical Cancer

Author(s): Hans Kubitschke, Benjamin Wolf, Erik Morawetz, Lars-Christian Horn, Bahriye Aktas, Ulrich Behn, Michael Höckel, Josef Käs
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-49182-1

How tissue fluidity influences brain tumor progression

Author(s): Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, Ingolf Sack
Published in: Proceedings of the National Academy of Sciences, Issue 117/1, 2020, Page(s) 128-134, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913511116

Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions

Author(s): Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke, Ingolf Sack
Published in: Cancer Research, Issue 79/22, 2019, Page(s) 5704-5710, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2150

A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues

Author(s): Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzàlez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo
Published in: Biomechanics and Modeling in Mechanobiology, Issue 19/1, 2020, Page(s) 189-220, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-019-01204-7

Influence of hyaluronic acid binding on the actin cortex measured by optical forces

Author(s): Jörg Schnauß, B.U. Sebastian Schmidt, Christina B. Brazel, Senol Dogan, Wolfgang Losert, Ulf Anderegg, Josef A. Käs
Published in: Journal of Biophotonics, 2020, Page(s) e201960215, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960215

Whole tissue and single cell mechanics are correlated in human brain tumors

Author(s): Frank Sauer, Anatol Fritsch, Steffen Grosser, Steve Pawlizak, Tobias Kießling, Martin Reiss-Zimmermann, Mehrgan Shahryari, Wolf C. Müller, Karl-Titus Hoffmann, Josef A. Käs, Ingolf Sack
Published in: Soft Matter, Issue 17, 2021, Page(s) 10744 - 10752, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sm01291f

Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma

Author(s): Steffen Grosser, Jürgen Lippoldt, Linda Oswald, Matthias Merkel, Daniel M. Sussman, Frédéric Renner, Pablo Gottheil, Erik W. Morawetz, Thomas Fuhs, Xiaofan Xie, Steve Pawlizak, Anatol W. Fritsch, Benjamin Wolf, Lars-Christian Horn, Susanne Briest, Bahriye Aktas, M. Lisa Manning, Josef A. Käs
Published in: Physical Review X, Issue 11/1, 2021, ISSN 2160-3308
Publisher: American Physical Society
DOI: 10.1103/physrevx.11.011033

Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking

Author(s): Martin Glaser, Paul Mollenkopf, Dusan Prascevic, Catarina Feraz, Josef A. Käs, Jörg Schnauß, David M. Smith
Published in: Nanoscale, 2023, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr05615a

From Strain Stiffening to Softening—Rheological Characterization of Keratins 8 and 18 Networks Crosslinked via Electron Irradiation

Author(s): Iman Elbalasy, Nils Wilharm, Erik Herchenhahn, Robert Konieczny, Stefan G. Mayr, Jörg Schnauß
Published in: Polymers, Issue 14/3, 2022, Page(s) 614, ISSN 2073-4360
Publisher: Molecular Diversity Preservation International (MDPI)
DOI: 10.3390/polym14030614

Rigid tumours contain soft cancer cells

Author(s): Thomas Fuhs, Franziska Wetzel, Anatol W. Fritsch, Xinzhi Li, Roland Stange, Steve Pawlizak, Tobias R. Kießling, Erik Morawetz, Steffen Grosser, Frank Sauer, Jürgen Lippoldt, Frederic Renner, Sabrina Friebe, Mareike Zink, Klaus Bendrat, Jürgen Braun, Maja H. Oktay, John Condeelis, Susanne Briest, Benjamin Wolf, Lars-Christian Horn, Michael Höckel, Bahriye Aktas, M. Cristina Marchetti, M. Lisa M
Published in: Nature Physics, Issue 17452473, 2022, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-022-01755-0