What Holds Cancer Cells Back?

Publicaciones

Comparative analysis of molecular signatures reveals a hybrid approach in breast cancer: Combining the Nottingham Prognostic Index with gene expressions into a hybrid signature

Autores: Dimitrij Tschodu, Bernhard Ulm, Klaus Bendrat, Jürgen Lippoldt, Pablo Gottheil, Josef A. Käs, Axel Niendorf
Publicado en: PLOS ONE, Edición 17/2, 2022, Página(s) e0261035, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0261035

Detecting heterogeneity in and between breast cancer cell lines

Autores: Yang Shen, B. U. Sebastian Schmidt, Hans Kubitschke, Erik W. Morawetz, Benjamin Wolf, Josef A. Käs, Wolfgang Losert
Publicado en: Cancer Convergence, Edición 4/1, 2020, ISSN 2366-6196
Editor: BioMed Central
DOI: 10.1186/s41236-020-0010-1

Jamming in Embryogenesis and Cancer Progression

Autores: Eliane Blauth, Hans Kubitschke, Pablo Gottheil, Steffen Grosser, Josef A. Käs
Publicado en: Frontiers in Physics, Edición 9, 2021, Página(s) 666709, ISSN 1022-1352
Editor: John Wiley & Sons Ltd.
DOI: 10.3389/fphy.2021.666709

Intermediate filaments ensure resiliency of single carcinoma cells, while active contractility of the actin cortex determines their invasive potential

Autores: Carlotta Ficorella, Hannah Marie Eichholz, Federico Sala, Rebeca Martinez Vazquez, Roberto Osellame, Josef A. Käs
Publicado en: New Journal of Physics, Edición 23, 2021, Página(s) 083028, ISSN 1367-2630
Editor: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac1899

Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures

Autores: Jörg Schnauß, Tom Kunschmann, Steffen Grosser, Paul Mollenkopf, Tobias Zech, Jessica S. Freitag, Dusan Prascevic, Roland Stange, Luisa S. Röttger, Susanne Rönicke, David M. Smith, Thomas M. Bayerl, Josef A. Käs
Publicado en: Advanced Materials, 2021, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202101840

Measuring structural parameters of crosslinked and entangled semiflexible polymer networks with single-filament tracing

Autores: Tina Händler, Cary Tutmarc, Martin Glaser, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Publicado en: Physical Review E, 2021, ISSN 1539-3755
Editor: American Physical Society
DOI: 10.1103/physreve.103.062501

Keratins determine network stress responsiveness in reconstituted actin–keratin filament systems

Autores: Iman Elbalasy, Paul Mollenkopf, Cary Tutmarc, Harald Herrmann, Jörg Schnauß
Publicado en: Soft Matter, Edición 17/14, 2021, Página(s) 3954-3962, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sm02261f

The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle.

Autores: Claudia Tanja Mierke; Frank Sauer; Steffen Grosser; Stefanie Puder; Tony Fischer; Josef A. Käs
Publicado en: NMR in Biomedicine, Edición 1, 2018, ISSN 0952-3480
Editor: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3831

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Autores: Olga Ilina, Pavlo G. Gritsenko, Simon Syga, Jürgen Lippoldt, Caterina A. M. La Porta, Oleksandr Chepizhko, Steffen Grosser, Manon Vullings, Gert-Jan Bakker, Jörn Starruß, Peter Bult, Stefano Zapperi, Josef A. Käs, Andreas Deutsch, Peter Friedl
Publicado en: Nature Cell Biology, Edición 22/9, 2020, Página(s) 1103-1115, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-020-0552-6

Large and stable: actin aster networks formed via entropic forces

Autores: Friedrich Fabian Spukti, Jörg Schnauß
Publicado en: Frontiers in Chemistry, Edición 22962646, 2022, ISSN 2296-2646
Editor: Frontiers Media S.A.
DOI: 10.3389/fchem.2022.899478

The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients

Autores: Bianca Mages, Thomas Fuhs, Susanne Aleithe, Alexandra Blietz, Constance Hobusch, Wolfgang Härtig, Stefan Schob, Martin Krueger, Dominik Michalski
Publicado en: Molecular Neurobiology, 2021, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-021-02372-3

Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells

Autores: Enrico Warmt, Steffen Grosser, Eliane Blauth, Xiaofan Xie, Hans Kubitschke, Roland Stange, Frank Sauer, Jörg Schnauß, Janina M. Tomm, Martin von Bergen
Publicado en: New Journal of Physics, Edición 23, 2021, Página(s) 133020, ISSN 1367-2630
Editor: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac254e

The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients

Autores: Ivonne Nel, Erik W. Morawetz, Dimitrij Tschodu, Josef A. Käs, Bahriye Aktas
Publicado en: Cancers, Edición 13/5, 2021, Página(s) 1119, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13051119

Anomalous cell sorting behavior in mixed monolayers discloses hidden system complexities

Autores: Paul Heine, Jürgen Lippoldt, Gudur Ashrith Reddy, Parag Katira, Josef A. Käs
Publicado en: New Journal of Physics, Edición 23, 2021, Página(s) 043034, ISSN 1367-2630
Editor: Institute of Physics Publishing
DOI: 10.1088/1367-2630/abf273

State of Cell Unjamming Correlates with Distant Metastasis in Cancer Patients

Autores: Pablo Gottheil, Jürgen Lippoldt, Steffen Grosser, Frederic Renner, Mohamad Saibah, Dimitrij Tschodu, Anne-Kathrin Poßögel, Anne-Sophie Wegscheider, Bernhard Ulm, Kay Friedrichs, Christoph Lindner, Christoph Engel, Markus Löffler, Benjamin Wolf, Michael Höckel, Bahriye Aktas, Hans Kubitschke, Axel Niendorf, Josef A. Kaes
Publicado en: Physical Review X, Edición 13, 2023, ISSN 2160-3308
Editor: American Physical Society
DOI: 10.1103/physrevx.13.031003

Constraint Release for Reptating Filaments in Semiflexible Networks Depends on Background Fluctuations

Autores: Tina Händler, Cary Tutmarc, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Publicado en: Polymers, 2022, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym14040707

Jamming transitions in cancer

Autores: Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Publicado en: Journal of Physics D: Applied Physics, Edición 50/48, 2017, Página(s) 483001, ISSN 0022-3727
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6463/aa8e83

Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials

Autores: Jessica S. Lorenz, Jörg Schnauß, Martin Glaser, Martin Sajfutdinow, Carsten Schuldt, Josef A. Käs, David M. Smith
Publicado en: Advanced Materials, Edición 30/13, 2018, Página(s) 1706092, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201706092

Glassy dynamics in composite biopolymer networks

Autores: Tom Golde, Constantin Huster, Martin Glaser, Tina Händler, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Publicado en: Soft Matter, Edición 14/39, 2018, Página(s) 7970-7978, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/c8sm01061g

Changing cell mechanics—a precondition for malignant transformation of oral squamous carcinoma cells

Autores: Felix Meinhövel, Roland Stange, Jörg Schnauß, Michael Sauer, Josef A Käs, Torsten W Remmerbach
Publicado en: Convergent Science Physical Oncology, Edición 4/3, 2018, Página(s) 034001, ISSN 2057-1739
Editor: IOP Publishing
DOI: 10.1088/2057-1739/aac72d

Single Actin Bundle Rheology

Autores: Dan Strehle, Paul Mollenkopf, Martin Glaser, Tom Golde, Carsten Schuldt, Josef A. Käs, Jörg Schnauß
Publicado en: Molecules, Edición 22/10, 2017, Página(s) 1804, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101804

Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

Autores: Frank Sauer, Linda Oswald, Angela Ariza de Schellenberger, Heiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack, Josef Alfons Käs
Publicado en: Soft Matter, Edición 15/14, 2019, Página(s) 3055-3064, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/c8sm02264j

The role of stickiness in the rheology of semiflexible polymers

Autores: Tom Golde, Martin Glaser, Cary Tutmarc, Iman Elbalasy, Constantin Huster, Gaizka Busteros, David M. Smith, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Publicado en: Soft Matter, Edición 15/24, 2019, Página(s) 4865-4872, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/C9SM00433E

Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement

Autores: Carlotta Ficorella, Rebeca Martínez Vázquez, Paul Heine, Eugenia Lepera, Jing Cao, Enrico Warmt, Roberto Osellame, Josef A Käs
Publicado en: New Journal of Physics, Edición 21/8, 2019, Página(s) 083016, ISSN 1367-2630
Editor: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3572

Roadmap to Local Tumour Growth: Insights from Cervical Cancer

Autores: Hans Kubitschke, Benjamin Wolf, Erik Morawetz, Lars-Christian Horn, Bahriye Aktas, Ulrich Behn, Michael Höckel, Josef Käs
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-49182-1

How tissue fluidity influences brain tumor progression

Autores: Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, Ingolf Sack
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/1, 2020, Página(s) 128-134, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1913511116

Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions

Autores: Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke, Ingolf Sack
Publicado en: Cancer Research, Edición 79/22, 2019, Página(s) 5704-5710, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2150

A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues

Autores: Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzàlez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo
Publicado en: Biomechanics and Modeling in Mechanobiology, Edición 19/1, 2020, Página(s) 189-220, ISSN 1617-7959
Editor: Springer Verlag
DOI: 10.1007/s10237-019-01204-7

Influence of hyaluronic acid binding on the actin cortex measured by optical forces

Autores: Jörg Schnauß, B.U. Sebastian Schmidt, Christina B. Brazel, Senol Dogan, Wolfgang Losert, Ulf Anderegg, Josef A. Käs
Publicado en: Journal of Biophotonics, 2020, Página(s) e201960215, ISSN 1864-063X
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960215

Whole tissue and single cell mechanics are correlated in human brain tumors

Autores: Frank Sauer, Anatol Fritsch, Steffen Grosser, Steve Pawlizak, Tobias Kießling, Martin Reiss-Zimmermann, Mehrgan Shahryari, Wolf C. Müller, Karl-Titus Hoffmann, Josef A. Käs, Ingolf Sack
Publicado en: Soft Matter, Edición 17, 2021, Página(s) 10744 - 10752, ISSN 1744-683X
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sm01291f

Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma

Autores: Steffen Grosser, Jürgen Lippoldt, Linda Oswald, Matthias Merkel, Daniel M. Sussman, Frédéric Renner, Pablo Gottheil, Erik W. Morawetz, Thomas Fuhs, Xiaofan Xie, Steve Pawlizak, Anatol W. Fritsch, Benjamin Wolf, Lars-Christian Horn, Susanne Briest, Bahriye Aktas, M. Lisa Manning, Josef A. Käs
Publicado en: Physical Review X, Edición 11/1, 2021, ISSN 2160-3308
Editor: American Physical Society
DOI: 10.1103/physrevx.11.011033

Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking

Autores: Martin Glaser, Paul Mollenkopf, Dusan Prascevic, Catarina Feraz, Josef A. Käs, Jörg Schnauß, David M. Smith
Publicado en: Nanoscale, 2023, ISSN 2040-3372
Editor: Royal Society of Chemistry
DOI: 10.1039/d2nr05615a

From Strain Stiffening to Softening—Rheological Characterization of Keratins 8 and 18 Networks Crosslinked via Electron Irradiation

Autores: Iman Elbalasy, Nils Wilharm, Erik Herchenhahn, Robert Konieczny, Stefan G. Mayr, Jörg Schnauß
Publicado en: Polymers, Edición 14/3, 2022, Página(s) 614, ISSN 2073-4360
Editor: Molecular Diversity Preservation International (MDPI)
DOI: 10.3390/polym14030614

Rigid tumours contain soft cancer cells

Autores: Thomas Fuhs, Franziska Wetzel, Anatol W. Fritsch, Xinzhi Li, Roland Stange, Steve Pawlizak, Tobias R. Kießling, Erik Morawetz, Steffen Grosser, Frank Sauer, Jürgen Lippoldt, Frederic Renner, Sabrina Friebe, Mareike Zink, Klaus Bendrat, Jürgen Braun, Maja H. Oktay, John Condeelis, Susanne Briest, Benjamin Wolf, Lars-Christian Horn, Michael Höckel, Bahriye Aktas, M. Cristina Marchetti, M. Lisa M
Publicado en: Nature Physics, Edición 17452473, 2022, ISSN 1745-2473
Editor: Nature Publishing Group
DOI: 10.1038/s41567-022-01755-0

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