What Holds Cancer Cells Back?

Informazioni relative al progetto

HoldCancerBack

ID dell’accordo di sovvenzione: 741350

DOI

10.3030/741350

Progetto chiuso

Data della firma CE 27 Giugno 2017

Data di avvio 1 Agosto 2017

Data di completamento 30 Aprile 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 379 250,00

Contributo UE

€ 2 379 250,00

Coordinato da

UNIVERSITAET LEIPZIG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (34)

Comparative analysis of molecular signatures reveals a hybrid approach in breast cancer: Combining the Nottingham Prognostic Index with gene expressions into a hybrid signature

Autori: Dimitrij Tschodu, Bernhard Ulm, Klaus Bendrat, Jürgen Lippoldt, Pablo Gottheil, Josef A. Käs, Axel Niendorf
Pubblicato in: PLOS ONE, Numero 17/2, 2022, Pagina/e e0261035, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0261035

Detecting heterogeneity in and between breast cancer cell lines

Autori: Yang Shen, B. U. Sebastian Schmidt, Hans Kubitschke, Erik W. Morawetz, Benjamin Wolf, Josef A. Käs, Wolfgang Losert
Pubblicato in: Cancer Convergence, Numero 4/1, 2020, ISSN 2366-6196
Editore: BioMed Central
DOI: 10.1186/s41236-020-0010-1

Jamming in Embryogenesis and Cancer Progression

Autori: Eliane Blauth, Hans Kubitschke, Pablo Gottheil, Steffen Grosser, Josef A. Käs
Pubblicato in: Frontiers in Physics, Numero 9, 2021, Pagina/e 666709, ISSN 1022-1352
Editore: John Wiley & Sons Ltd.
DOI: 10.3389/fphy.2021.666709

Intermediate filaments ensure resiliency of single carcinoma cells, while active contractility of the actin cortex determines their invasive potential

Autori: Carlotta Ficorella, Hannah Marie Eichholz, Federico Sala, Rebeca Martinez Vazquez, Roberto Osellame, Josef A. Käs
Pubblicato in: New Journal of Physics, Numero 23, 2021, Pagina/e 083028, ISSN 1367-2630
Editore: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac1899

Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures

Autori: Jörg Schnauß, Tom Kunschmann, Steffen Grosser, Paul Mollenkopf, Tobias Zech, Jessica S. Freitag, Dusan Prascevic, Roland Stange, Luisa S. Röttger, Susanne Rönicke, David M. Smith, Thomas M. Bayerl, Josef A. Käs
Pubblicato in: Advanced Materials, 2021, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202101840

Measuring structural parameters of crosslinked and entangled semiflexible polymer networks with single-filament tracing

Autori: Tina Händler, Cary Tutmarc, Martin Glaser, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Pubblicato in: Physical Review E, 2021, ISSN 1539-3755
Editore: American Physical Society
DOI: 10.1103/physreve.103.062501

Keratins determine network stress responsiveness in reconstituted actin–keratin filament systems

Autori: Iman Elbalasy, Paul Mollenkopf, Cary Tutmarc, Harald Herrmann, Jörg Schnauß
Pubblicato in: Soft Matter, Numero 17/14, 2021, Pagina/e 3954-3962, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sm02261f

The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle.

Autori: Claudia Tanja Mierke; Frank Sauer; Steffen Grosser; Stefanie Puder; Tony Fischer; Josef A. Käs
Pubblicato in: NMR in Biomedicine, Numero 1, 2018, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3831

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Autori: Olga Ilina, Pavlo G. Gritsenko, Simon Syga, Jürgen Lippoldt, Caterina A. M. La Porta, Oleksandr Chepizhko, Steffen Grosser, Manon Vullings, Gert-Jan Bakker, Jörn Starruß, Peter Bult, Stefano Zapperi, Josef A. Käs, Andreas Deutsch, Peter Friedl
Pubblicato in: Nature Cell Biology, Numero 22/9, 2020, Pagina/e 1103-1115, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-020-0552-6

Large and stable: actin aster networks formed via entropic forces

Autori: Friedrich Fabian Spukti, Jörg Schnauß
Pubblicato in: Frontiers in Chemistry, 2022, ISSN 2296-2646
Editore: Frontiers Media S.A.
DOI: 10.3389/fchem.2022.899478

The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients

Autori: Bianca Mages, Thomas Fuhs, Susanne Aleithe, Alexandra Blietz, Constance Hobusch, Wolfgang Härtig, Stefan Schob, Martin Krueger, Dominik Michalski
Pubblicato in: Molecular Neurobiology, 2021, ISSN 0893-7648
Editore: Humana Press, Inc.
DOI: 10.1007/s12035-021-02372-3

Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells

Autori: Enrico Warmt, Steffen Grosser, Eliane Blauth, Xiaofan Xie, Hans Kubitschke, Roland Stange, Frank Sauer, Jörg Schnauß, Janina M. Tomm, Martin von Bergen
Pubblicato in: New Journal of Physics, Numero 23, 2021, Pagina/e 133020, ISSN 1367-2630
Editore: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac254e

The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients

Autori: Ivonne Nel, Erik W. Morawetz, Dimitrij Tschodu, Josef A. Käs, Bahriye Aktas
Pubblicato in: Cancers, Numero 13/5, 2021, Pagina/e 1119, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13051119

Anomalous cell sorting behavior in mixed monolayers discloses hidden system complexities

Autori: Paul Heine, Jürgen Lippoldt, Gudur Ashrith Reddy, Parag Katira, Josef A. Käs
Pubblicato in: New Journal of Physics, Numero 23, 2021, Pagina/e 043034, ISSN 1367-2630
Editore: Institute of Physics Publishing
DOI: 10.1088/1367-2630/abf273

State of Cell Unjamming Correlates with Distant Metastasis in Cancer Patients

Autori: Pablo Gottheil, Jürgen Lippoldt, Steffen Grosser, Frederic Renner, Mohamad Saibah, Dimitrij Tschodu, Anne-Kathrin Poßögel, Anne-Sophie Wegscheider, Bernhard Ulm, Kay Friedrichs, Christoph Lindner, Christoph Engel, Markus Löffler, Benjamin Wolf, Michael Höckel, Bahriye Aktas, Hans Kubitschke, Axel Niendorf, Josef A. Kaes
Pubblicato in: Physical Review X, Numero 13, 2023, ISSN 2160-3308
Editore: American Physical Society
DOI: 10.1103/physrevx.13.031003

Constraint Release for Reptating Filaments in Semiflexible Networks Depends on Background Fluctuations

Autori: Tina Händler, Cary Tutmarc, Jessica S. Freitag, David M. Smith, Jörg Schnauß
Pubblicato in: Polymers, 2022, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym14040707

Jamming transitions in cancer

Autori: Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Pubblicato in: Journal of Physics D: Applied Physics, Numero 50/48, 2017, Pagina/e 483001, ISSN 0022-3727
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6463/aa8e83

Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials

Autori: Jessica S. Lorenz, Jörg Schnauß, Martin Glaser, Martin Sajfutdinow, Carsten Schuldt, Josef A. Käs, David M. Smith
Pubblicato in: Advanced Materials, Numero 30/13, 2018, Pagina/e 1706092, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201706092

Glassy dynamics in composite biopolymer networks

Autori: Tom Golde, Constantin Huster, Martin Glaser, Tina Händler, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Pubblicato in: Soft Matter, Numero 14/39, 2018, Pagina/e 7970-7978, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sm01061g

Changing cell mechanics—a precondition for malignant transformation of oral squamous carcinoma cells

Autori: Felix Meinhövel, Roland Stange, Jörg Schnauß, Michael Sauer, Josef A Käs, Torsten W Remmerbach
Pubblicato in: Convergent Science Physical Oncology, Numero 4/3, 2018, Pagina/e 034001, ISSN 2057-1739
Editore: IOP Publishing
DOI: 10.1088/2057-1739/aac72d

Single Actin Bundle Rheology

Autori: Dan Strehle, Paul Mollenkopf, Martin Glaser, Tom Golde, Carsten Schuldt, Josef A. Käs, Jörg Schnauß
Pubblicato in: Molecules, Numero 22/10, 2017, Pagina/e 1804, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101804

Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

Autori: Frank Sauer, Linda Oswald, Angela Ariza de Schellenberger, Heiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack, Josef Alfons Käs
Pubblicato in: Soft Matter, Numero 15/14, 2019, Pagina/e 3055-3064, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sm02264j

The role of stickiness in the rheology of semiflexible polymers

Autori: Tom Golde, Martin Glaser, Cary Tutmarc, Iman Elbalasy, Constantin Huster, Gaizka Busteros, David M. Smith, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Pubblicato in: Soft Matter, Numero 15/24, 2019, Pagina/e 4865-4872, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/C9SM00433E

Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement

Autori: Carlotta Ficorella, Rebeca Martínez Vázquez, Paul Heine, Eugenia Lepera, Jing Cao, Enrico Warmt, Roberto Osellame, Josef A Käs
Pubblicato in: New Journal of Physics, Numero 21/8, 2019, Pagina/e 083016, ISSN 1367-2630
Editore: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ab3572

Roadmap to Local Tumour Growth: Insights from Cervical Cancer

Autori: Hans Kubitschke, Benjamin Wolf, Erik Morawetz, Lars-Christian Horn, Bahriye Aktas, Ulrich Behn, Michael Höckel, Josef Käs
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-49182-1

How tissue fluidity influences brain tumor progression

Autori: Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, Ingolf Sack
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/1, 2020, Pagina/e 128-134, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1913511116

Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions

Autori: Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke, Ingolf Sack
Pubblicato in: Cancer Research, Numero 79/22, 2019, Pagina/e 5704-5710, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2150

A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues

Autori: Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzàlez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo
Pubblicato in: Biomechanics and Modeling in Mechanobiology, Numero 19/1, 2020, Pagina/e 189-220, ISSN 1617-7959
Editore: Springer Verlag
DOI: 10.1007/s10237-019-01204-7

Influence of hyaluronic acid binding on the actin cortex measured by optical forces

Autori: Jörg Schnauß, B.U. Sebastian Schmidt, Christina B. Brazel, Senol Dogan, Wolfgang Losert, Ulf Anderegg, Josef A. Käs
Pubblicato in: Journal of Biophotonics, 2020, Pagina/e e201960215, ISSN 1864-063X
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960215

Whole tissue and single cell mechanics are correlated in human brain tumors

Autori: Frank Sauer, Anatol Fritsch, Steffen Grosser, Steve Pawlizak, Tobias Kießling, Martin Reiss-Zimmermann, Mehrgan Shahryari, Wolf C. Müller, Karl-Titus Hoffmann, Josef A. Käs, Ingolf Sack
Pubblicato in: Soft Matter, Numero 17, 2021, Pagina/e 10744 - 10752, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sm01291f

Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma

Autori: Steffen Grosser, Jürgen Lippoldt, Linda Oswald, Matthias Merkel, Daniel M. Sussman, Frédéric Renner, Pablo Gottheil, Erik W. Morawetz, Thomas Fuhs, Xiaofan Xie, Steve Pawlizak, Anatol W. Fritsch, Benjamin Wolf, Lars-Christian Horn, Susanne Briest, Bahriye Aktas, M. Lisa Manning, Josef A. Käs
Pubblicato in: Physical Review X, Numero 11/1, 2021, ISSN 2160-3308
Editore: American Physical Society
DOI: 10.1103/physrevx.11.011033

Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking

Autori: Martin Glaser, Paul Mollenkopf, Dusan Prascevic, Catarina Feraz, Josef A. Käs, Jörg Schnauß, David M. Smith
Pubblicato in: Nanoscale, 2023, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d2nr05615a

From Strain Stiffening to Softening—Rheological Characterization of Keratins 8 and 18 Networks Crosslinked via Electron Irradiation

Autori: Iman Elbalasy, Nils Wilharm, Erik Herchenhahn, Robert Konieczny, Stefan G. Mayr, Jörg Schnauß
Pubblicato in: Polymers, Numero 14/3, 2022, Pagina/e 614, ISSN 2073-4360
Editore: Molecular Diversity Preservation International (MDPI)
DOI: 10.3390/polym14030614

Rigid tumours contain soft cancer cells

Autori: Thomas Fuhs, Franziska Wetzel, Anatol W. Fritsch, Xinzhi Li, Roland Stange, Steve Pawlizak, Tobias R. Kießling, Erik Morawetz, Steffen Grosser, Frank Sauer, Jürgen Lippoldt, Frederic Renner, Sabrina Friebe, Mareike Zink, Klaus Bendrat, Jürgen Braun, Maja H. Oktay, John Condeelis, Susanne Briest, Benjamin Wolf, Lars-Christian Horn, Michael Höckel, Bahriye Aktas, M. Cristina Marchetti, M. Lisa M
Pubblicato in: Nature Physics, 2022, ISSN 1745-2473
Editore: Nature Publishing Group
DOI: 10.1038/s41567-022-01755-0