Systems Chemistry: Steps Towards De-Novo Life

Project Information

ToDL

Grant agreement ID: 741774

DOI

10.3030/741774

Project closed

EC signature date 4 May 2017

Start date 1 September 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 974,51

EU contribution

€ 2 499 974,51

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators

Author(s): Joydev Hatai; Yigit Altay; Ankush Sood; Armin Kiani; Marcel Eleveld; Leila Motiei; David Margulies; Sijbren Otto
Published in: J. Am. Chem. Soc., Issue 1, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c11594

Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment

Author(s): Boris Bartolec; Armin Kiani; Meagan A. Beatty; Meniz Altay; Guillermo Monreal Santiago; Sijbren Otto
Published in: VOLUME=13;ISSUE=48;STARTPAGE=14300;ENDPAGE=14304;ISSN=2041-6520;TITLE=Chemical Science, Issue 1, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc03909e

Chance emergence of catalytic activity and promiscuity in a self-replicator

Author(s): J. Ottelé, A. S. Hussain, C. Mayer, S. Otto
Published in: Nat. Catal., 2020, ISSN 2520-1158
Publisher: Springer-Nature
DOI: 10.1038/s41929-020-0463-8

Out‐of‐Equilibrium Self‐Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators

Author(s): Bin Liu; Juntian Wu; Marc Geerts; Omer Markovitch; Charalampos G. Pappas; Kai Liu; Sijbren Otto
Published in: Angewandte Chemie Int Ed., Issue 1, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202117605

Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators

Author(s): Bin Liu; Meagan A Beatty; Charalampos G. Pappas; Kai Liu; Jim Ottelé; Sijbren Otto
Published in: Angewandte Chemie (International Ed. in English), Issue 2, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202101052

An Approach to the De Novo Synthesis of Life

Author(s): Sijbren Otto
Published in: Acc Chem Res, Issue 1, 2021, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.1c00534

(Re-)Directing Oligomerization of a Single Building Block into Two Specific Dynamic Covalent Foldamers through pH

Author(s): Yulong Jin; Pradeep K. Mandal; Juntian Wu; Niklas Böcher; Ivan Huc; Sijbren Otto
Published in: urn:issn:0002-7863, Issue 1, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c09325

Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries.

Author(s): Charalampos G. Pappas; Bin Liu; Ivana Marić; Jim Ottelé; Armin Kiani; Marcus L van der Klok; Patrick Onck; Sijbren Otto
Published in: Journal of the American Chemical Society, Issue 1, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c00788

Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator

Author(s): G. Monreal Santiago, K. Liu, W. R. Browne, S. Otto
Published in: Nat. Chem., 2020, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-0494-4

Complex Molecules That Fold Like Proteins Can Emerge Spontaneously

Author(s): Bin Liu, Charalampos G. Pappas, Ennio Zangrando, Nicola Demitri, Piotr J. Chmielewski, Sijbren Otto
Published in: Journal of the American Chemical Society, Issue 141/4, 2018, Page(s) 1685-1689, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b11698

Emergence of Compartments Formed from Unconventional Surfactants in Dynamic Combinatorial Libraries

Author(s): Boris Bartolec, Giulia Leonetti, Jianwei Li, Wietse Smit, Meniz Altay, Guillermo Monreal Santiago, Yichen Yan, Sijbren Otto
Published in: Langmuir, Issue 35/17, 2019, Page(s) 5787-5792, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.8b03662

Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids

Author(s): Bin Liu, Charalampos G. Pappas, Jim Ottelé, Gaël Schaeffer, Christoph Jurissek, Priscilla F. Pieters, Meniz Altay, Ivana Marić, Marc C. A. Stuart, Sijbren Otto
Published in: Journal of the American Chemical Society, Issue 142/9, 2020, Page(s) 4184-4192, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b10796

Template-promoted self-replication in dynamic combinatorial libraries made from a simple building block

Author(s): B. Bartolec, M. Altay, S. Otto
Published in: Chemical Communications, Issue 54/93, 2018, Page(s) 13096-13098, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc06253f

Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

Author(s): S. Maity, J. Ottelé, G. Monreal Santiago, P. W. J. M. Frederix, P. Kroon, O. Markovitch, M. C. A. Stuart, S. J. Marrink, S. Otto, W. H. Roos
Published in: J. Am. Chem. Soc., 2020, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c02635

Emergence of low-symmetry foldamers from single monomers

Author(s): C. G. Pappas, P. K. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Page. I. Huc, S. Otto
Published in: Nature Chem., 2020, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-00565-2

Automated device for continuous stirring while sampling in liquid chromatography systems

Author(s): O. Markovitch, J. Ottelé, O. Veldman, S. Otto
Published in: Commun. Chem., 2020, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-020-00427-5

Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries

Author(s): Ivana Marić; Liangliang Yang; Xiufeng Li; Guillermo Monreal Santiago; Charalampos G. Pappas; Xinkai Qiu; Joshua A. Dijksman; Kirill Mikhailov; Patrick van Rijn; Sijbren Otto
Published in: urn:issn:14337851, Issue 2, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202216475

Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library

Author(s): Gaël Schaeffer; Marcel J. Eleveld; Jim Ottelé; Peter C. Kroon; Pim W. J. M. Frederix; Shuo Yang; Sijbren Otto
Published in: J. Am. Chem. Soc., Issue 1, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c12591

Chemical Fueling Enables Molecular Complexification of Self-Replicators*.

Author(s): Shuo Yang; Gaël Schaeffer; Elio Mattia; Omer Markovitch; Kai Liu; Andreas S. Hussain; Jim Ottelé; Ankush Sood; Sijbren Otto
Published in: Angewandte Chemie (International Ed. in English), Issue 1, 2021, Page(s) 11344-11349, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202016196

Other (1)

Light-Driven Ecological-Evolutionary Dynamics in a Synthetic Replicator System

Author(s): Kai Liu; Alex W. P. Blokhuis; Chris van Ewijk; Armin Kiani; Juntian Wu; Wouter H. Roos; Sijbren Otto
Published in: Crossref, Issue 1, 2022
Publisher: Cambridge University Press
DOI: 10.26434/chemrxiv-2022-f2lsd