Systems Chemistry: Steps Towards De-Novo Life

Publicaciones

An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators

Autores: Joydev Hatai; Yigit Altay; Ankush Sood; Armin Kiani; Marcel Eleveld; Leila Motiei; David Margulies; Sijbren Otto
Publicado en: J. Am. Chem. Soc., Edición 1, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c11594

Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment

Autores: Boris Bartolec; Armin Kiani; Meagan A. Beatty; Meniz Altay; Guillermo Monreal Santiago; Sijbren Otto
Publicado en: VOLUME=13;ISSUE=48;STARTPAGE=14300;ENDPAGE=14304;ISSN=2041-6520;TITLE=Chemical Science, Edición 1, 2022, ISSN 2041-6539
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc03909e

Chance emergence of catalytic activity and promiscuity in a self-replicator

Autores: J. Ottelé, A. S. Hussain, C. Mayer, S. Otto
Publicado en: Nat. Catal., 2020, ISSN 2520-1158
Editor: Springer-Nature
DOI: 10.1038/s41929-020-0463-8

Out‐of‐Equilibrium Self‐Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators

Autores: Bin Liu; Juntian Wu; Marc Geerts; Omer Markovitch; Charalampos G. Pappas; Kai Liu; Sijbren Otto
Publicado en: Angewandte Chemie Int Ed., Edición 1, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202117605

Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators

Autores: Bin Liu; Meagan A Beatty; Charalampos G. Pappas; Kai Liu; Jim Ottelé; Sijbren Otto
Publicado en: Angewandte Chemie (International Ed. in English), Edición 2, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202101052

An Approach to the De Novo Synthesis of Life

Autores: Sijbren Otto
Publicado en: Acc Chem Res, Edición 1, 2021, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.1c00534

(Re-)Directing Oligomerization of a Single Building Block into Two Specific Dynamic Covalent Foldamers through pH

Autores: Yulong Jin; Pradeep K. Mandal; Juntian Wu; Niklas Böcher; Ivan Huc; Sijbren Otto
Publicado en: urn:issn:0002-7863, Edición 1, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c09325

Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries.

Autores: Charalampos G. Pappas; Bin Liu; Ivana Marić; Jim Ottelé; Armin Kiani; Marcus L van der Klok; Patrick Onck; Sijbren Otto
Publicado en: Journal of the American Chemical Society, Edición 1, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c00788

Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator

Autores: G. Monreal Santiago, K. Liu, W. R. Browne, S. Otto
Publicado en: Nat. Chem., 2020, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-020-0494-4

Complex Molecules That Fold Like Proteins Can Emerge Spontaneously

Autores: Bin Liu, Charalampos G. Pappas, Ennio Zangrando, Nicola Demitri, Piotr J. Chmielewski, Sijbren Otto
Publicado en: Journal of the American Chemical Society, Edición 141/4, 2018, Página(s) 1685-1689, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.8b11698

Emergence of Compartments Formed from Unconventional Surfactants in Dynamic Combinatorial Libraries

Autores: Boris Bartolec, Giulia Leonetti, Jianwei Li, Wietse Smit, Meniz Altay, Guillermo Monreal Santiago, Yichen Yan, Sijbren Otto
Publicado en: Langmuir, Edición 35/17, 2019, Página(s) 5787-5792, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.8b03662

Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids

Autores: Bin Liu, Charalampos G. Pappas, Jim Ottelé, Gaël Schaeffer, Christoph Jurissek, Priscilla F. Pieters, Meniz Altay, Ivana Marić, Marc C. A. Stuart, Sijbren Otto
Publicado en: Journal of the American Chemical Society, Edición 142/9, 2020, Página(s) 4184-4192, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b10796

Template-promoted self-replication in dynamic combinatorial libraries made from a simple building block

Autores: B. Bartolec, M. Altay, S. Otto
Publicado en: Chemical Communications, Edición 54/93, 2018, Página(s) 13096-13098, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c8cc06253f

Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

Autores: S. Maity, J. Ottelé, G. Monreal Santiago, P. W. J. M. Frederix, P. Kroon, O. Markovitch, M. C. A. Stuart, S. J. Marrink, S. Otto, W. H. Roos
Publicado en: J. Am. Chem. Soc., 2020, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c02635

Emergence of low-symmetry foldamers from single monomers

Autores: C. G. Pappas, P. K. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Page. I. Huc, S. Otto
Publicado en: Nature Chem., 2020, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-020-00565-2

Automated device for continuous stirring while sampling in liquid chromatography systems

Autores: O. Markovitch, J. Ottelé, O. Veldman, S. Otto
Publicado en: Commun. Chem., 2020, ISSN 2399-3669
Editor: Springer Nature
DOI: 10.1038/s42004-020-00427-5

Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries

Autores: Ivana Marić; Liangliang Yang; Xiufeng Li; Guillermo Monreal Santiago; Charalampos G. Pappas; Xinkai Qiu; Joshua A. Dijksman; Kirill Mikhailov; Patrick van Rijn; Sijbren Otto
Publicado en: urn:issn:14337851, Edición 2, 2023, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202216475

Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library

Autores: Gaël Schaeffer; Marcel J. Eleveld; Jim Ottelé; Peter C. Kroon; Pim W. J. M. Frederix; Shuo Yang; Sijbren Otto
Publicado en: J. Am. Chem. Soc., Edición 1, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c12591

Chemical Fueling Enables Molecular Complexification of Self-Replicators*.

Autores: Shuo Yang; Gaël Schaeffer; Elio Mattia; Omer Markovitch; Kai Liu; Andreas S. Hussain; Jim Ottelé; Ankush Sood; Sijbren Otto
Publicado en: Angewandte Chemie (International Ed. in English), Edición 1, 2021, Página(s) 11344-11349, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202016196

Light-Driven Ecological-Evolutionary Dynamics in a Synthetic Replicator System

Autores: Kai Liu; Alex W. P. Blokhuis; Chris van Ewijk; Armin Kiani; Juntian Wu; Wouter H. Roos; Sijbren Otto
Publicado en: Crossref, Edición 1, 2022
Editor: Cambridge University Press
DOI: 10.26434/chemrxiv-2022-f2lsd

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