Faster magic-angle spinning leads to a resolution revolution in biological solid-state NMR

Project Information

FASTER

Grant agreement ID: 741863

DOI 10.3030/741863

Project closed

EC signature date 27 April 2017

Start date 1 October 2017

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 173 375,00

EU contribution € 2 173 375,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

Publications

Peer reviewed articles (37)

Protein NMR Spectroscopy at 150 kHz Magic‐Angle Spinning Continues To Improve Resolution and Mass Sensitivity

Author(s): Schledorn, Maarten; Malär, Alexander A.; Torosyan, Anahit; Penzel, Susanne; Klose, Daniel; Oss, Andres; Org, Mai-Liis; Wang, Shishan; Lecoq, Lauriane; Cadalbert, Riccardo; Samoson, Ago; Böckmann, Anja; Meier, Beat H.
Published in: ChemBioChem, 21 (17), Issue 21, 2020, Page(s) 2540-2548, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.3929/ethz-b-000431267

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

Author(s): Thomas Wiegand, Alexander A. Malär, Riccardo Cadalbert, Matthias Ernst, Anja Böckmann, Beat H. Meier
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2020.582033

CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion

Author(s): Thomas Wiegand, Andreas Hunkeler, Alexander Däpp, Joeri Verasdonck, Riccardo Cadalbert, Luc Bousset, Ronald Melki, Anja Böckmann, Beat H. Meier
Published in: Journal of Biomolecular NMR, Issue 72/3-4, 2018, Page(s) 171-177, ISSN 0925-2738
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0218-x

Temperature-Dependent Solid-State NMR Proton Chemical-Shift Values and Hydrogen Bonding

Author(s): Alexander A Malär, Laura . Völker, Riccardo Cadalbert, Lauriane Lecoq, Matthias Ernst, Anja Böckmann, Beat H. Meier, Thomas Wiegand
Published in: The Journal of Physical Chemistry B, 2021, ISSN 1520-5207
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.1c04061

Origin of the residual line width under frequency-switched Lee–Goldburg decoupling in MAS solid-state NMR

Author(s): Johannes Hellwagner, Liam Grunwald, Manuel Ochsner, Daniel Zindel, Beat H. Meier, Matthias Ernst
Published in: Magnetic Resonance, Issue 1/1, 2020, Page(s) 13-25, ISSN 2699-0016
Publisher: Copernicus
DOI: 10.5194/mr-1-13-2020

Protein Side-Chain-DNA Contacts Probed by Fast Magic-Angle Spinning NMR

Author(s): Denis Lacabanne, Julien Boudet, Alexander A. Malär, Pengzhi Wu, Riccardo Cadalbert, Loic Salmon, Frédéric H.-T. Allain, Beat H. Meier, Thomas Wiegand
Published in: The Journal of Physical Chemistry B, 2020, ISSN 1520-5207
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.0c08150

Paramagnetic Solid-State Nmr to Localize the Metal-Ion Cofactor in an Oligomeric Dnab Helicase

Author(s): Johannes Zehnder, Riccardo Cadalbert, Laurent Terradot, Matthias Ernst, Anja Böckmann, Peter Güntert, Beat H Meier, Thomas Wiegand
Published in: Chemistry, 2021, ISSN 1521-3765
Publisher: Wiley-VCH
DOI: 10.1002/chem.202100462

Prion Amyloid Polymorphs – The Tag Might Change It All

Author(s): Luc Bousset, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schütz, Ronald Melki, Beat H. Meier, Anja Böckmann
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2020.00190

Dimer Organization of Membrane-Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H-Detected Solid-State NMR

Author(s): Vlastimil Jirasko, Alons Lends, Nils-Alexander Lakomek, Marie-Laure Fogeron, Marco E Weber,, Alexander A Malär, Susanne Penzel, Ralf Bartenschlager, Beat H.Meier, Anja Böckmann
Published in: Angewandte Chemie, 2021, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202013296

Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Author(s): Briday, Mathilde; Hallé, François; Lecoq, Lauriane; Radix, Sylvie; Martin, Juliette; Montserret, Roland; Dujardin, Marie; Fogeron, Marie-Laure; Nassal, Michael; Meier, Beat H.; Lomberget, Thierry; Böckmann, Anja
Published in: Chemical Science, 2022, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc02420a

Numerical modeling and design decisions for aerostatic bearings with relatively large nozzle sizes in Magic-Angle Spinning (MAS) systems

Author(s): Rajdeep Deb; Andreas Hunkeler; Dirk Wilhelm; Patrick Jenny; Beat H. Meier
Published in: Tribology International, Issue 5, 2023, ISSN 0301-679X
Publisher: Pergamon Press Ltd.
DOI: 10.3929/ethz-b-000568727

Molecular elucidation of drug- induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Author(s): Lecoq, Lauriane; Brigandat, Louis; Huber, Rebecca; Fogeron, Marie-Laure; Wang, Shishan; Dujardin, Marie; Briday, Mathilde; Wiegand, Thomas; Callon, Morgane; Malär, Alexander; Durantel, David; Burdette, Dara; Berke, Jan Martin; Meier, Beat H.; Nassal, Michael; Böckmann, Anja
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36219-3

Optimized “detectors” for dynamics analysis in solid-state NMR

Author(s): Albert A. Smith, Matthias Ernst, Beat H. Meier
Published in: The Journal of Chemical Physics, Issue 148/4, 2018, Page(s) 045104, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/1.5013316

The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase

Author(s): Thomas Wiegand, Riccardo Cadalbert, Denis Lacabanne, Joanna Timmins, Laurent Terradot, Anja Böckmann, Beat H. Meier
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 31, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07968-3

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Author(s): Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D. Taylor, Tim Norman, John Porter, Lorna C. Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H. Sullivan, David Fox, Mark D. Carr, Alistair Henry, Richard Taylor, Beat H. Meier, Hartmut Oschkinat, Alastair D. Lawson
Published in: PLOS Biology, Issue 16/5, 2018, Page(s) e2006192, ISSN 1545-7885
Publisher: PLOS (Public Library of Science)
DOI: 10.1371/journal.pbio.2006192

Spinning faster: protein NMR at MAS frequencies up to 126 kHz

Author(s): Susanne Penzel, Andres Oss, Mai-Liis Org, Ago Samoson, Anja Böckmann, Matthias Ernst, Beat H. Meier
Published in: Journal of Biomolecular NMR, Issue 73/1-2, 2019, Page(s) 19-29, ISSN 0925-2738
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0219-9

Localized and Collective Motions in HET‐s(218‐289) Fibrils from Combined NMR Relaxation and MD Simulation

Author(s): Albert A. Smith, Matthias Ernst, Sereina Riniker, Beat H. Meier
Published in: Angewandte Chemie International Edition, Issue 58/28, 2019, Page(s) 9383-9388, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201901929

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids

Author(s): Lauriane Lecoq, Maarten Schledorn, Shishan Wang, Susanne Smith-Penzel, Alexander A. Malär, Morgane Callon, Michael Nassal, Beat H. Meier, Anja Böckmann
Published in: Frontiers in Molecular Biosciences, Issue 6, 2019, ISSN 2296-889X
Publisher: Frontiers in Molecular Biosciences
DOI: 10.3389/fmolb.2019.00058

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

Author(s): Wang, Shishan; Fogeron, Marie-Laure; Schledorn, Maarten; Dujardin, Marie; Penzel, Susanne; Burdette, Dara; Berke, Jan,; Nassal, Michael; Lecoq, Lauriane; Meier, Beat; Böckmann, Anja
Published in: "Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, ⟨10.3389/fmolb.2019.00067⟩", Issue 9, 2019, ISSN 2296-889X
Publisher: Frontiers in Molecular Biosciences
DOI: 10.3929/ethz-b-000359784

Sedimentation Yields Long-Term Stable Protein Samples as Shown by Solid-State NMR

Author(s): Thomas Wiegand, Denis Lacabanne, Anahit Torosyan, Julien Boudet, Riccardo Cadalbert, Frédéric H.-T. Allain, Beat H. Meier, Anja Böckmann
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2020.00017

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Author(s): Lauriane Lecoq, Shishan Wang, Thomas Wiegand, Stéphane Bressanelli, Michael Nassal, Beat H. Meier, Anja Böckmann
Published in: ChemPhysChem, Issue 19/11, 2018, Page(s) 1336-1340, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201800211

Reducing bias in the analysis of solution-state NMR data with dynamics detectors

Author(s): Albert A. Smith, Matthias Ernst, Beat H. Meier, Fabien Ferrage
Published in: The Journal of Chemical Physics, Issue 151/3, 2019, Page(s) 034102, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/1.5111081

Setting the magic angle for fast magic-angle spinning probes

Author(s): Susanne Penzel, Albert A. Smith, Matthias Ernst, Beat H. Meier
Published in: Journal of Magnetic Resonance, Issue 293, 2018, Page(s) 115-122, ISSN 1090-7807
Publisher: Academic Press
DOI: 10.1016/j.jmr.2018.06.002

Including Protons in Solid-State NMR Resonance Assignment and Secondary Structure Analysis: The Example of RNA Polymerase II Subunits Rpo4/7

Author(s): Anahit Torosyan, Thomas Wiegand, Maarten Schledorn, Daniel Klose, Peter Güntert, Anja Böckmann, Beat H. Meier
Published in: Frontiers in Molecular Biosciences, Issue 6, 2019, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2019.00100

Direct amide 15N to 13C transfers for solid-state assignment experiments in deuterated proteins

Author(s): Alons Lends, Francesco Ravotti, Giorgia Zandomeneghi, Anja Böckmann, Matthias Ernst, Beat H. Meier
Published in: Journal of Biomolecular NMR, Issue 72/1-2, 2018, Page(s) 69-78, ISSN 0925-2738
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0207-0

Nucleotide Binding Modes in a Motor Protein Revealed by 31 P‐ and 1 H‐Detected MAS Solid‐State NMR Spectroscopy

Author(s): Thomas Wiegand, Maarten Schledorn, Alexander A. Malär, Riccardo Cadalbert, Alexander Däpp, Laurent Terradot, Beat H. Meier, Anja Böckmann
Published in: ChemBioChem, Issue 21/3, 2019, Page(s) 324-330, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900439

Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach

Author(s): Alexander A. Malär, Susanne Smith-Penzel, Gian-Marco Camenisch, Thomas Wiegand, Ago Samoson, Anja Böckmann, Matthias Ernst, Beat H. Meier
Published in: Physical Chemistry Chemical Physics, Issue 21/35, 2019, Page(s) 18850-18865, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cp03414e

Characterization of H 2 -Splitting Products of Frustrated Lewis Pairs: Benefit of Fast Magic-Angle Spinning

Author(s): Alexander A. Malär, Shunxi Dong, Gerald Kehr, Gerhard Erker, Beat H. Meier, Thomas Wiegand
Published in: ChemPhysChem, Issue 20/5, 2019, Page(s) 672-679, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201900006

Proton‐Detected Solid‐State NMR of the Cell‐Free Synthesized α‐Helical Transmembrane Protein NS4B from Hepatitis C Virus

Author(s): Vlastimil Jirasko, Nils‐Alexander Lakomek, Susanne Penzel, Marie‐Laure Fogeron, Ralf Bartenschlager, Beat H. Meier, Anja Böckmann
Published in: ChemBioChem, 2020, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900765

A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template

Author(s): Julien Boudet, Jean-Christophe Devillier, Thomas Wiegand, Loic Salmon, Beat H. Meier, Georg Lipps, Frédéric H.-T. Allain
Published in: Cell, Issue 176/1-2, 2019, Page(s) 154-166.e13, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.11.031

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy

Author(s): Guillaume David, Marie-Laure Fogeron, Maarten Schledorn, Roland Montserret, Uta Haselmann, Susanne Penzel, Aurélie Badillo, Lauriane Lecoq, Patrice André, Michael Nassal, Ralf Bartenschlager, Beat H. Meier, Anja Böckmann
Published in: Angewandte Chemie International Edition, Issue 57/17, 2018, Page(s) 4787-4791, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201712091

Correction of field instabilities in biomolecular solid-state NMR by simultaneous acquisition of a frequency reference

Author(s): Václav Rímal, Morgane Callon, Alexander A. Malär, Riccardo Cadalbert, Anahit Torosyan, Thomas Wiegand, Matthias Ernst, Anja Böckmann, and Beat H. Meier
Published in: Magnetic Resonance, 2022, ISSN 2699-0016
Publisher: Copernicus
DOI: 10.5194/mr-3-15-2022

Biomolecular solid‑state NMR spectroscopy at 1200 MHz: the gain in resolution

Author(s): Morgane Callon, Alexander A. Malär, Sara Pfister, Vaclav Rímal, Marco E. Weber, Thomas Wiegand, Johannes Zehnder1, Matías Chávez, Riccardo Cadalbert, Rajdeep Deb, Alexander Däpp, Marie‑Laure Fogeron, Andreas Hunkeler, Lauriane Lecoq, Anahit Torosyan, Dawid Zyla, Rudolf Glockshuber, Stefanie Jonas, Michael Nassal, Matthias Ernst, Anja Böckmann, Beat H. Meier
Published in: Journal of biomolecular NMR, 2021, ISSN 1573-5001
Publisher: Springer Nature
DOI: 10.1007/s10858-021-00373-x

Fast Magic-Angle-Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C-Terminal Domain

Author(s): Callon, Morgane; Malär, Alexander A.; Lecoq, Lauriane; Dujardin, Marie; Fogeron, Marie-Laure; Wang, Shishan; Schledorn, Maarten; Bauer, Thomas; id_orcid0000-0003-2147-1162; Nassal, Michael; Böckmann, Anja; Meier, Beat H.
Published in: Angewandte Chemie. International Edition, 61 (32), Issue 4, 2022, ISSN 0044-8249
Publisher: Wiley-VCH
DOI: 10.3929/ethz-b-000555969

Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR

Author(s): Alexander A Malär, Morgane Callon, Albert A Smith, Shishan Wang, Lauriane Lecoq, Carolina Perez-Segura, Jodi A Hadden-Perrilla, Anja Böckmann, Beat H Meier
Published in: Frontiers in Molecular Biosciences, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.807577

ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter

Author(s): Denis Lacabanne; Thomas Wiegand; Nino Wili; Maria I. Kozlova; Riccardo Cadalbert; Daniel Klose; Armen Y. Mulkidjanian; Beat H. Meier; Anja Böckmann
Published in: "Molecules : a journal of synthetic chemistry and natural product chemistry 25(22), 5268 (2020). doi:10.3390/molecules25225268 special issue: ""Special issue ""The conformational universe of proteins and peptides : tales of order and disorder"" / special issue editor: Marilisa Leone, guest editor""", Issue 1, 2020, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000452889

Spectroscopic glimpses of the transition state of ATP hydrolysis trapped in a bacterial DnaB helicase

Author(s): Alexander A Malär, Nino Wili, Laura A Völker, Maria I Kozlova, Riccardo Cadalbert, Alexander Däpp, Marco . Weber, Johannes Zehnder, Gunnar Jeschke , Hellmut Eckert, Anja Böckmann, Daniel Klose, Armen Y Mulkidjanian, Beat H Meier, Thomas Wiegand
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25599-z