Faster magic-angle spinning leads to a resolution revolution in biological solid-state NMR

Publicaciones

Protein NMR Spectroscopy at 150 kHz Magic‐Angle Spinning Continues To Improve Resolution and Mass Sensitivity

Autores: Schledorn, Maarten; Malär, Alexander A.; Torosyan, Anahit; Penzel, Susanne; Klose, Daniel; Oss, Andres; Org, Mai-Liis; Wang, Shishan; Lecoq, Lauriane; Cadalbert, Riccardo; Samoson, Ago; Böckmann, Anja; Meier, Beat H.
Publicado en: ChemBioChem, 21 (17), Edición 21, 2020, Página(s) 2540-2548, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.3929/ethz-b-000431267

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

Autores: Thomas Wiegand, Alexander A. Malär, Riccardo Cadalbert, Matthias Ernst, Anja Böckmann, Beat H. Meier
Publicado en: Frontiers in Molecular Biosciences, Edición 7, 2020, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2020.582033

CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion

Autores: Thomas Wiegand, Andreas Hunkeler, Alexander Däpp, Joeri Verasdonck, Riccardo Cadalbert, Luc Bousset, Ronald Melki, Anja Böckmann, Beat H. Meier
Publicado en: Journal of Biomolecular NMR, Edición 72/3-4, 2018, Página(s) 171-177, ISSN 0925-2738
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0218-x

Temperature-Dependent Solid-State NMR Proton Chemical-Shift Values and Hydrogen Bonding

Autores: Alexander A Malär, Laura . Völker, Riccardo Cadalbert, Lauriane Lecoq, Matthias Ernst, Anja Böckmann, Beat H. Meier, Thomas Wiegand
Publicado en: The Journal of Physical Chemistry B, 2021, ISSN 1520-5207
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.1c04061

Origin of the residual line width under frequency-switched Lee–Goldburg decoupling in MAS solid-state NMR

Autores: Johannes Hellwagner, Liam Grunwald, Manuel Ochsner, Daniel Zindel, Beat H. Meier, Matthias Ernst
Publicado en: Magnetic Resonance, Edición 1/1, 2020, Página(s) 13-25, ISSN 2699-0016
Editor: Copernicus
DOI: 10.5194/mr-1-13-2020

Protein Side-Chain-DNA Contacts Probed by Fast Magic-Angle Spinning NMR

Autores: Denis Lacabanne, Julien Boudet, Alexander A. Malär, Pengzhi Wu, Riccardo Cadalbert, Loic Salmon, Frédéric H.-T. Allain, Beat H. Meier, Thomas Wiegand
Publicado en: The Journal of Physical Chemistry B, 2020, ISSN 1520-5207
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.0c08150

Paramagnetic Solid-State Nmr to Localize the Metal-Ion Cofactor in an Oligomeric Dnab Helicase

Autores: Johannes Zehnder, Riccardo Cadalbert, Laurent Terradot, Matthias Ernst, Anja Böckmann, Peter Güntert, Beat H Meier, Thomas Wiegand
Publicado en: Chemistry, 2021, ISSN 1521-3765
Editor: Wiley-VCH
DOI: 10.1002/chem.202100462

Prion Amyloid Polymorphs – The Tag Might Change It All

Autores: Luc Bousset, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schütz, Ronald Melki, Beat H. Meier, Anja Böckmann
Publicado en: Frontiers in Molecular Biosciences, Edición 7, 2020, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2020.00190

Dimer Organization of Membrane-Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H-Detected Solid-State NMR

Autores: Vlastimil Jirasko, Alons Lends, Nils-Alexander Lakomek, Marie-Laure Fogeron, Marco E Weber,, Alexander A Malär, Susanne Penzel, Ralf Bartenschlager, Beat H.Meier, Anja Böckmann
Publicado en: Angewandte Chemie, 2021, ISSN 1521-3773
Editor: Wiley
DOI: 10.1002/anie.202013296

Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Autores: Briday, Mathilde; Hallé, François; Lecoq, Lauriane; Radix, Sylvie; Martin, Juliette; Montserret, Roland; Dujardin, Marie; Fogeron, Marie-Laure; Nassal, Michael; Meier, Beat H.; Lomberget, Thierry; Böckmann, Anja
Publicado en: Chemical Science, 2022, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc02420a

Numerical modeling and design decisions for aerostatic bearings with relatively large nozzle sizes in Magic-Angle Spinning (MAS) systems

Autores: Rajdeep Deb; Andreas Hunkeler; Dirk Wilhelm; Patrick Jenny; Beat H. Meier
Publicado en: Tribology International, Edición 5, 2023, ISSN 0301-679X
Editor: Pergamon Press Ltd.
DOI: 10.3929/ethz-b-000568727

Molecular elucidation of drug- induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Autores: Lecoq, Lauriane; Brigandat, Louis; Huber, Rebecca; Fogeron, Marie-Laure; Wang, Shishan; Dujardin, Marie; Briday, Mathilde; Wiegand, Thomas; Callon, Morgane; Malär, Alexander; Durantel, David; Burdette, Dara; Berke, Jan Martin; Meier, Beat H.; Nassal, Michael; Böckmann, Anja
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36219-3

Optimized “detectors” for dynamics analysis in solid-state NMR

Autores: Albert A. Smith, Matthias Ernst, Beat H. Meier
Publicado en: The Journal of Chemical Physics, Edición 148/4, 2018, Página(s) 045104, ISSN 0021-9606
Editor: American Institute of Physics
DOI: 10.1063/1.5013316

The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase

Autores: Thomas Wiegand, Riccardo Cadalbert, Denis Lacabanne, Joanna Timmins, Laurent Terradot, Anja Böckmann, Beat H. Meier
Publicado en: Nature Communications, Edición 10/1, 2019, Página(s) 31, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07968-3

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Autores: Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D. Taylor, Tim Norman, John Porter, Lorna C. Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H. Sullivan, David Fox, Mark D. Carr, Alistair Henry, Richard Taylor, Beat H. Meier, Hartmut Oschkinat, Alastair D. Lawson
Publicado en: PLOS Biology, Edición 16/5, 2018, Página(s) e2006192, ISSN 1545-7885
Editor: PLOS (Public Library of Science)
DOI: 10.1371/journal.pbio.2006192

Spinning faster: protein NMR at MAS frequencies up to 126 kHz

Autores: Susanne Penzel, Andres Oss, Mai-Liis Org, Ago Samoson, Anja Böckmann, Matthias Ernst, Beat H. Meier
Publicado en: Journal of Biomolecular NMR, Edición 73/1-2, 2019, Página(s) 19-29, ISSN 0925-2738
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0219-9

Localized and Collective Motions in HET‐s(218‐289) Fibrils from Combined NMR Relaxation and MD Simulation

Autores: Albert A. Smith, Matthias Ernst, Sereina Riniker, Beat H. Meier
Publicado en: Angewandte Chemie International Edition, Edición 58/28, 2019, Página(s) 9383-9388, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201901929

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids

Autores: Lauriane Lecoq, Maarten Schledorn, Shishan Wang, Susanne Smith-Penzel, Alexander A. Malär, Morgane Callon, Michael Nassal, Beat H. Meier, Anja Böckmann
Publicado en: Frontiers in Molecular Biosciences, Edición 6, 2019, ISSN 2296-889X
Editor: Frontiers in Molecular Biosciences
DOI: 10.3389/fmolb.2019.00058

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

Autores: Wang, Shishan; Fogeron, Marie-Laure; Schledorn, Maarten; Dujardin, Marie; Penzel, Susanne; Burdette, Dara; Berke, Jan,; Nassal, Michael; Lecoq, Lauriane; Meier, Beat; Böckmann, Anja
Publicado en: "Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, ⟨10.3389/fmolb.2019.00067⟩", Edición 9, 2019, ISSN 2296-889X
Editor: Frontiers in Molecular Biosciences
DOI: 10.3929/ethz-b-000359784

Sedimentation Yields Long-Term Stable Protein Samples as Shown by Solid-State NMR

Autores: Thomas Wiegand, Denis Lacabanne, Anahit Torosyan, Julien Boudet, Riccardo Cadalbert, Frédéric H.-T. Allain, Beat H. Meier, Anja Böckmann
Publicado en: Frontiers in Molecular Biosciences, Edición 7, 2020, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2020.00017

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Autores: Lauriane Lecoq, Shishan Wang, Thomas Wiegand, Stéphane Bressanelli, Michael Nassal, Beat H. Meier, Anja Böckmann
Publicado en: ChemPhysChem, Edición 19/11, 2018, Página(s) 1336-1340, ISSN 1439-4235
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201800211

Reducing bias in the analysis of solution-state NMR data with dynamics detectors

Autores: Albert A. Smith, Matthias Ernst, Beat H. Meier, Fabien Ferrage
Publicado en: The Journal of Chemical Physics, Edición 151/3, 2019, Página(s) 034102, ISSN 0021-9606
Editor: American Institute of Physics
DOI: 10.1063/1.5111081

Setting the magic angle for fast magic-angle spinning probes

Autores: Susanne Penzel, Albert A. Smith, Matthias Ernst, Beat H. Meier
Publicado en: Journal of Magnetic Resonance, Edición 293, 2018, Página(s) 115-122, ISSN 1090-7807
Editor: Academic Press
DOI: 10.1016/j.jmr.2018.06.002

Including Protons in Solid-State NMR Resonance Assignment and Secondary Structure Analysis: The Example of RNA Polymerase II Subunits Rpo4/7

Autores: Anahit Torosyan, Thomas Wiegand, Maarten Schledorn, Daniel Klose, Peter Güntert, Anja Böckmann, Beat H. Meier
Publicado en: Frontiers in Molecular Biosciences, Edición 6, 2019, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2019.00100

Direct amide 15N to 13C transfers for solid-state assignment experiments in deuterated proteins

Autores: Alons Lends, Francesco Ravotti, Giorgia Zandomeneghi, Anja Böckmann, Matthias Ernst, Beat H. Meier
Publicado en: Journal of Biomolecular NMR, Edición 72/1-2, 2018, Página(s) 69-78, ISSN 0925-2738
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0207-0

Nucleotide Binding Modes in a Motor Protein Revealed by 31 P‐ and 1 H‐Detected MAS Solid‐State NMR Spectroscopy

Autores: Thomas Wiegand, Maarten Schledorn, Alexander A. Malär, Riccardo Cadalbert, Alexander Däpp, Laurent Terradot, Beat H. Meier, Anja Böckmann
Publicado en: ChemBioChem, Edición 21/3, 2019, Página(s) 324-330, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900439

Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach

Autores: Alexander A. Malär, Susanne Smith-Penzel, Gian-Marco Camenisch, Thomas Wiegand, Ago Samoson, Anja Böckmann, Matthias Ernst, Beat H. Meier
Publicado en: Physical Chemistry Chemical Physics, Edición 21/35, 2019, Página(s) 18850-18865, ISSN 1463-9076
Editor: Royal Society of Chemistry
DOI: 10.1039/c9cp03414e

Characterization of H 2 -Splitting Products of Frustrated Lewis Pairs: Benefit of Fast Magic-Angle Spinning

Autores: Alexander A. Malär, Shunxi Dong, Gerald Kehr, Gerhard Erker, Beat H. Meier, Thomas Wiegand
Publicado en: ChemPhysChem, Edición 20/5, 2019, Página(s) 672-679, ISSN 1439-4235
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.201900006

Proton‐Detected Solid‐State NMR of the Cell‐Free Synthesized α‐Helical Transmembrane Protein NS4B from Hepatitis C Virus

Autores: Vlastimil Jirasko, Nils‐Alexander Lakomek, Susanne Penzel, Marie‐Laure Fogeron, Ralf Bartenschlager, Beat H. Meier, Anja Böckmann
Publicado en: ChemBioChem, 2020, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900765

A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template

Autores: Julien Boudet, Jean-Christophe Devillier, Thomas Wiegand, Loic Salmon, Beat H. Meier, Georg Lipps, Frédéric H.-T. Allain
Publicado en: Cell, Edición 176/1-2, 2019, Página(s) 154-166.e13, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2018.11.031

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy

Autores: Guillaume David, Marie-Laure Fogeron, Maarten Schledorn, Roland Montserret, Uta Haselmann, Susanne Penzel, Aurélie Badillo, Lauriane Lecoq, Patrice André, Michael Nassal, Ralf Bartenschlager, Beat H. Meier, Anja Böckmann
Publicado en: Angewandte Chemie International Edition, Edición 57/17, 2018, Página(s) 4787-4791, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201712091

Correction of field instabilities in biomolecular solid-state NMR by simultaneous acquisition of a frequency reference

Autores: Václav Rímal, Morgane Callon, Alexander A. Malär, Riccardo Cadalbert, Anahit Torosyan, Thomas Wiegand, Matthias Ernst, Anja Böckmann, and Beat H. Meier
Publicado en: Magnetic Resonance, 2022, ISSN 2699-0016
Editor: Copernicus
DOI: 10.5194/mr-3-15-2022

Biomolecular solid‑state NMR spectroscopy at 1200 MHz: the gain in resolution

Autores: Morgane Callon, Alexander A. Malär, Sara Pfister, Vaclav Rímal, Marco E. Weber, Thomas Wiegand, Johannes Zehnder1, Matías Chávez, Riccardo Cadalbert, Rajdeep Deb, Alexander Däpp, Marie‑Laure Fogeron, Andreas Hunkeler, Lauriane Lecoq, Anahit Torosyan, Dawid Zyla, Rudolf Glockshuber, Stefanie Jonas, Michael Nassal, Matthias Ernst, Anja Böckmann, Beat H. Meier
Publicado en: Journal of biomolecular NMR, 2021, ISSN 1573-5001
Editor: Springer Nature
DOI: 10.1007/s10858-021-00373-x

Fast Magic-Angle-Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C-Terminal Domain

Autores: Callon, Morgane; Malär, Alexander A.; Lecoq, Lauriane; Dujardin, Marie; Fogeron, Marie-Laure; Wang, Shishan; Schledorn, Maarten; Bauer, Thomas; id_orcid0000-0003-2147-1162; Nassal, Michael; Böckmann, Anja; Meier, Beat H.
Publicado en: Angewandte Chemie. International Edition, 61 (32), Edición 4, 2022, ISSN 0044-8249
Editor: Wiley-VCH
DOI: 10.3929/ethz-b-000555969

Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR

Autores: Alexander A Malär, Morgane Callon, Albert A Smith, Shishan Wang, Lauriane Lecoq, Carolina Perez-Segura, Jodi A Hadden-Perrilla, Anja Böckmann, Beat H Meier
Publicado en: Frontiers in Molecular Biosciences, 2021, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2021.807577

ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter

Autores: Denis Lacabanne; Thomas Wiegand; Nino Wili; Maria I. Kozlova; Riccardo Cadalbert; Daniel Klose; Armen Y. Mulkidjanian; Beat H. Meier; Anja Böckmann
Publicado en: "Molecules : a journal of synthetic chemistry and natural product chemistry 25(22), 5268 (2020). doi:10.3390/molecules25225268 special issue: ""Special issue ""The conformational universe of proteins and peptides : tales of order and disorder"" / special issue editor: Marilisa Leone, guest editor""", Edición 1, 2020, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000452889

Spectroscopic glimpses of the transition state of ATP hydrolysis trapped in a bacterial DnaB helicase

Autores: Alexander A Malär, Nino Wili, Laura A Völker, Maria I Kozlova, Riccardo Cadalbert, Alexander Däpp, Marco . Weber, Johannes Zehnder, Gunnar Jeschke , Hellmut Eckert, Anja Böckmann, Daniel Klose, Armen Y Mulkidjanian, Beat H Meier, Thomas Wiegand
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25599-z

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