In Vivo Single-Cell Mechanomics of Bone Adaptation and Regeneration in the Aging Mouse

Project Information

MechAGE

Grant agreement ID: 741883

DOI

10.3030/741883

Project closed

EC signature date 11 July 2017

Start date 1 October 2017

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Author(s): Angad Malhotra; Matthias Walle; Graeme R. Paul; Gisela A. Kuhn; Ralph Müller
Published in: Scientific Reports, Issue 11, 2021, Page(s) 1861, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-81132-8

Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics

Author(s): Boaretti D, Marques FC, Ledoux C, Singh A, Kendall JJ, Wehrle E, Kuhn GA, Bansod YD, Schulte FA and Müller R
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, Page(s) 1091294, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1091294

Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model

Author(s): Graeme R. Paul; Esther Wehrle; Duncan C. Tourolle; Gisela A. Kuhn; Ralph Müller
Published in: Scientific Reports, Issue 11, 2021, Page(s) 13511, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-92961-y

Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice

Author(s): Ariane C. Scheuren,Gommaar D'Hulst,Gisela A. Kuhn,Evi Masschelein,Esther Wehrle,Katrien De Bock,Ralph Müller
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 11, 2020, Page(s) 1121-1140, ISSN 2190-6009
Publisher: Blackwell Wiley
DOI: 10.1002/jcsm.12588

Mechano-Regulation of Trabecular Bone Adaptation Is Controlled by the Local in vivo Environment and Logarithmically Dependent on Loading Frequency

Author(s): Scheuren, Ariane C.; Vallaster, Paul; Kuhn, Gisela A.; Paul, Graeme R.; Malhotra, Angad; Kameo, Yoshitaka; Müller, Ralph
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) 566346, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2020.566346

Perspectives on in Silico Bone Mechanobiology: Computational Modelling of Multicellular Systems

Author(s): Boaretti, Daniele; id_orcid0000-0001-8411-7465; Wehrle, Esther; id_orcid0000-0003-2723-7342; Bansod, Yogesh Deepak; Tourolle né Betts, Duncan C.; Müller, Ralph; id_orcid0000-0002-5811-7725
Published in: European Cells & Materials, Issue 44, 2021, Page(s) 56-73, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v044a04

The local and global geometry of trabecular bone.

Author(s): Sebastien J.P. Callens; Duncan C. Tourolle; Ralph Müller; Amir A. Zadpoor
Published in: Acta Biomaterialia, Issue 130, 2021, Page(s) 343-361, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.06.013

Tissue-Level Regeneration and Remodeling Dynamics are Driven by Mechanical Stimuli in the Microenvironment in a Post-Bridging Loaded Femur Defect Healing Model in Mice

Author(s): Paul, Graeme R.; Vallaster, Paul; Rüegg, Michelle; Scheuren, Ariane C.; Tourolle, Duncan C.; Kuhn, Gisela A.; Wehrle, Esther; id_orcid0000-0003-2723-7342; Müller, Ralph; id_orcid0000-0002-5811-7725
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, Page(s) 856204, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.856204

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography.

Author(s): Esther Wehrle; Duncan C. Tourolle né Betts; Gisela A. Kuhn; Erica Floreani; Malavika H. Nambiar; Bryant J. Schroeder; Sandra Hofmann; Sandra Hofmann; Ralph Müller
Published in: Scientific Reports, Issue 11, 2021, Page(s) 8660, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-87788-6

The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing model

Author(s): Duncan C. Tourolle né Betts; Esther Wehrle; Graeme R. Paul; Gisela A. Kuhn; Patrik Christen; Sandra Hofmann; Ralph Müller
Published in: Scientific Reports, Issue 10, 2020, Page(s) 1100, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-57461-5

Mechanical Stimuli in the Local In Vivo Environment in Bone: Computational Approaches Linking Organ-Scale Loads to Cellular Signals

Author(s): Graeme R. Paul, Angad Malhotra, Ralph Müller
Published in: Current Osteoporosis Reports, Issue 16/4, 2018, Page(s) 395-403, ISSN 1544-1873
Publisher: Current Science Inc.
DOI: 10.1007/s11914-018-0448-6

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

Author(s): Esther Wehrle, Duncan C. Tourolle né Betts, Gisela A. Kuhn, Ariane C. Scheuren, Sandra Hofmann, Ralph Müller
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 17445, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-53822-x

TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs.

Author(s): Elena Cambria; Sally Heusser; Ariane C. Scheuren; Wai Kit Tam; Agnieszka Karol; Wolfgang Hitzl; Victor Y. L. Leung; Ralph Müller; Stephen J. Ferguson; Karin Wuertz-Kozak; Karin Wuertz-Kozak
Published in: JOR Spine, Issue 4, 2021, Page(s) e1149, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1149

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice

Author(s): Ariane C. Scheuren, Gisela A. Kuhn, Ralph Müller
Published in: PLOS ONE, Issue 15/9, 2020, Page(s) e0239534, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239534

Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging.

Author(s): Esther Wehrle; Graeme R. Paul; Duncan C. Tourolle né Betts; Gisela A. Kuhn; Ralph Müller
Published in: Scientific Reports, Issue 11, 2021, Page(s) 23037, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-02368-y

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Author(s): Marques FC, Boaretti D, Walle M, Scheuren AC, Schulte FA and Müller R
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, Page(s) 1140673, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1140673

Clinical Data for Parametrization of In Silico Bone Models Incorporating Cell-Cytokine Dynamics: A Systematic Review of Literature

Author(s): Ledoux, Charles; Boaretti, Daniele; id_orcid0000-0001-8411-7465; Sachan, Akanksha; Müller, Ralph; id_orcid0000-0002-5811-7725; Collins, Caitlyn J.; id_orcid0000-0003-0181-878X
Published in: Frontiers in Bioengineering and Biotechnology, Issue 10, 2022, Page(s) 901720, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.901720

Thesis and dissertations (2)

Longitudinal assessment of frailty and osteosarcopenia in an in vivo model of premature aging

Author(s): Scheuren, Ariane C.
Published in: Doctoral Thesis, Issue 26738, 2020
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000423860

Individualised multiscale mechanoregulation of fracture healing in mice

Author(s): Paul, Graeme R.
Published in: Doctoral Thesis, Issue 27097, 2020
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000479421