In Vivo Single-Cell Mechanomics of Bone Adaptation and Regeneration in the Aging Mouse

Informazioni relative al progetto

MechAGE

ID dell’accordo di sovvenzione: 741883

DOI

10.3030/741883

Progetto chiuso

Data della firma CE 11 Luglio 2017

Data di avvio 1 Ottobre 2017

Data di completamento 31 Marzo 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Autori: Angad Malhotra; Matthias Walle; Graeme R. Paul; Gisela A. Kuhn; Ralph Müller
Pubblicato in: Scientific Reports, Numero 11, 2021, Pagina/e 1861, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-81132-8

Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics

Autori: Boaretti D, Marques FC, Ledoux C, Singh A, Kendall JJ, Wehrle E, Kuhn GA, Bansod YD, Schulte FA and Müller R
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 11, 2023, Pagina/e 1091294, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1091294

Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model

Autori: Graeme R. Paul; Esther Wehrle; Duncan C. Tourolle; Gisela A. Kuhn; Ralph Müller
Pubblicato in: Scientific Reports, Numero 11, 2021, Pagina/e 13511, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-92961-y

Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice

Autori: Ariane C. Scheuren,Gommaar D'Hulst,Gisela A. Kuhn,Evi Masschelein,Esther Wehrle,Katrien De Bock,Ralph Müller
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, Numero 11, 2020, Pagina/e 1121-1140, ISSN 2190-6009
Editore: Blackwell Wiley
DOI: 10.1002/jcsm.12588

Mechano-Regulation of Trabecular Bone Adaptation Is Controlled by the Local in vivo Environment and Logarithmically Dependent on Loading Frequency

Autori: Scheuren, Ariane C.; Vallaster, Paul; Kuhn, Gisela A.; Paul, Graeme R.; Malhotra, Angad; Kameo, Yoshitaka; Müller, Ralph
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, Pagina/e 566346, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2020.566346

Perspectives on in Silico Bone Mechanobiology: Computational Modelling of Multicellular Systems

Autori: Boaretti, Daniele; id_orcid0000-0001-8411-7465; Wehrle, Esther; id_orcid0000-0003-2723-7342; Bansod, Yogesh Deepak; Tourolle né Betts, Duncan C.; Müller, Ralph; id_orcid0000-0002-5811-7725
Pubblicato in: European Cells & Materials, Numero 44, 2021, Pagina/e 56-73, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v044a04

The local and global geometry of trabecular bone.

Autori: Sebastien J.P. Callens; Duncan C. Tourolle; Ralph Müller; Amir A. Zadpoor
Pubblicato in: Acta Biomaterialia, Numero 130, 2021, Pagina/e 343-361, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2021.06.013

Tissue-Level Regeneration and Remodeling Dynamics are Driven by Mechanical Stimuli in the Microenvironment in a Post-Bridging Loaded Femur Defect Healing Model in Mice

Autori: Paul, Graeme R.; Vallaster, Paul; Rüegg, Michelle; Scheuren, Ariane C.; Tourolle, Duncan C.; Kuhn, Gisela A.; Wehrle, Esther; id_orcid0000-0003-2723-7342; Müller, Ralph; id_orcid0000-0002-5811-7725
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 10, 2022, Pagina/e 856204, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.856204

Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography.

Autori: Esther Wehrle; Duncan C. Tourolle né Betts; Gisela A. Kuhn; Erica Floreani; Malavika H. Nambiar; Bryant J. Schroeder; Sandra Hofmann; Sandra Hofmann; Ralph Müller
Pubblicato in: Scientific Reports, Numero 11, 2021, Pagina/e 8660, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-87788-6

The association between mineralised tissue formation and the mechanical local in vivo environment: Time-lapsed quantification of a mouse defect healing model

Autori: Duncan C. Tourolle né Betts; Esther Wehrle; Graeme R. Paul; Gisela A. Kuhn; Patrik Christen; Sandra Hofmann; Ralph Müller
Pubblicato in: Scientific Reports, Numero 10, 2020, Pagina/e 1100, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-57461-5

Mechanical Stimuli in the Local In Vivo Environment in Bone: Computational Approaches Linking Organ-Scale Loads to Cellular Signals

Autori: Graeme R. Paul, Angad Malhotra, Ralph Müller
Pubblicato in: Current Osteoporosis Reports, Numero 16/4, 2018, Pagina/e 395-403, ISSN 1544-1873
Editore: Current Science Inc.
DOI: 10.1007/s11914-018-0448-6

Evaluation of longitudinal time-lapsed in vivo micro-CT for monitoring fracture healing in mouse femur defect models

Autori: Esther Wehrle, Duncan C. Tourolle né Betts, Gisela A. Kuhn, Ariane C. Scheuren, Sandra Hofmann, Ralph Müller
Pubblicato in: Scientific Reports, Numero 9/1, 2019, Pagina/e 17445, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-53822-x

TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs.

Autori: Elena Cambria; Sally Heusser; Ariane C. Scheuren; Wai Kit Tam; Agnieszka Karol; Wolfgang Hitzl; Victor Y. L. Leung; Ralph Müller; Stephen J. Ferguson; Karin Wuertz-Kozak; Karin Wuertz-Kozak
Pubblicato in: JOR Spine, Numero 4, 2021, Pagina/e e1149, ISSN 2572-1143
Editore: Wiley
DOI: 10.1002/jsp2.1149

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice

Autori: Ariane C. Scheuren, Gisela A. Kuhn, Ralph Müller
Pubblicato in: PLOS ONE, Numero 15/9, 2020, Pagina/e e0239534, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0239534

Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging.

Autori: Esther Wehrle; Graeme R. Paul; Duncan C. Tourolle né Betts; Gisela A. Kuhn; Ralph Müller
Pubblicato in: Scientific Reports, Numero 11, 2021, Pagina/e 23037, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-02368-y

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Autori: Marques FC, Boaretti D, Walle M, Scheuren AC, Schulte FA and Müller R
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 11, 2023, Pagina/e 1140673, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2023.1140673

Clinical Data for Parametrization of In Silico Bone Models Incorporating Cell-Cytokine Dynamics: A Systematic Review of Literature

Autori: Ledoux, Charles; Boaretti, Daniele; id_orcid0000-0001-8411-7465; Sachan, Akanksha; Müller, Ralph; id_orcid0000-0002-5811-7725; Collins, Caitlyn J.; id_orcid0000-0003-0181-878X
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 10, 2022, Pagina/e 901720, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.901720

Thesis and dissertations (2)

Longitudinal assessment of frailty and osteosarcopenia in an in vivo model of premature aging

Autori: Scheuren, Ariane C.
Pubblicato in: Doctoral Thesis, Numero 26738, 2020
Editore: ETH Zurich
DOI: 10.3929/ethz-b-000423860

Individualised multiscale mechanoregulation of fracture healing in mice

Autori: Paul, Graeme R.
Pubblicato in: Doctoral Thesis, Numero 27097, 2020
Editore: ETH Zurich
DOI: 10.3929/ethz-b-000479421