Tissue regeneration and aging: the decisive quiescent stem-cell state

Project Information

STEM-AGING

Grant agreement ID: 741966

DOI

10.3030/741966

Project closed

EC signature date 20 June 2017

Start date 1 November 2017

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 949,00

EU contribution

€ 2 499 949,00

Coordinated by

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (37)

Protocol for RNA-seq library preparation starting from a rare muscle stem cell population or a limited number of mouse embryonic stem cells

Author(s): Dell'Orso, S., Juan, A.H., Moiseeva, V., García-Prat, L., Muñoz-Cánoves, P., Sartorelli, V.
Published in: STAR Protocols, 2021, ISSN 2666-1667
Publisher: STAR Protocols
DOI: 10.1016/j.xpro.2021.100451

3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Author(s): Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J.
Published in: Nature Aging, 2022, ISSN 2662-8465
Publisher: Nature Publishing
DOI: 10.1038/s43587-022-00279-9

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Author(s): Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Aznar-Benitah S, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P.
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05535-x

Assessing Autophagy in Muscle Stem Cells

Author(s): Campanario, S., Ramírez-Pardo, I., Hong, X., Isern, J., Muñoz-Cánoves, P.
Published in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2020.620409

Running skeletal muscle clocks on time— the determining factors

Author(s): Vaca-Dempere, M., Kumar, A., Sica, V., Muñoz-Cánoves, P.
Published in: Experimental Cell Research, 2022, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2021.112989

Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

Author(s): Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W., Mou, X., Liew, S.W., Umar, M.I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C.J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y., Nagamine, Y., Kwok, C.K., Sun, H., Muñoz-Cánoves, P., Wang, H.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25170-w

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage

Author(s): Arc-Chagnaud, C., Salvador-Pascual, A., Garcia-Dominguez, E., Olaso-Gonzalez, G., Correas, A.G., Serna, E., Brioche, T., Chopard, A., Fernandez-Marcos, P.J., Serrano, M., Serrano, A.L., Muñoz-Cánoves, P., Sebastiá, V., Viña, J., Gomez-Cabrera, M.C.
Published in: Journal of Cachexia, Sarcopenia and Muscle, 2021, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12792

Context‐dependent roles of cellular senescence in normal, aged, and disease states

Author(s): Victoria Moiseeva; Andrés Cisneros; Aina Calls Cobos; Aida Beà Tarrega; Claudia Santos Oñate; Eusebio Perdiguero; Antonio L. Serrano; Pura Muñoz‐Cánoves
Published in: FEBS Journal, Issue 1, 2022, ISSN 1742-4658
Publisher: Federation of European Biochemical Societies
DOI: 10.1111/febs.16573

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

Author(s): Prados, B., del Toro, R., MacGrogan, D., Gómez-Apiñániz, P., Papoutsi, T., Muñoz-Cánoves, P., Méndez-Ferrer, S., de la Pompa, J.L.
Published in: Cell Death and Disease, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-04003-0

Macrophages, Metabolism and Heterophagy in the Heart

Author(s): Nicolás-Ávila, J.A., Pena-Couso, L., Muñoz-Cánoves, P., Hidalgo, A.0009-7330
Published in: Circulation Research, 2022, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319812

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Author(s): José A. Nicolás-Ávila, Ana V. Lechuga-Vieco, Lorena Esteban-Martínez, María Sánchez-Díaz, Elena Díaz-García, Demetrio J. Santiago, Andrea Rubio-Ponce, Jackson LiangYao Li, Akhila Balachander, Juan A. Quintana, Raquel Martínez-de-Mena, Beatriz Castejón-Vega, Andrés Pun-García, Paqui G. Través, Elena Bonzón-Kulichenko, Fernando García-Marqués, Lorena Cussó, Noelia A-González, Andr
Published in: Cell, Issue 183/1, 2020, Page(s) 94-109.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.031

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Author(s): Greco, C.M., Koronowski, K.B., Smith, J.G., Shi, J., Kunderfranco, P., Carriero, R., Chen, S., Samad, M., Welz, P.-S., Zinna, V.M., Mortimer, T., Chun, S.K., Shimaji, K., Sato, T., Petrus, P., Kumar, A., Vaca-Dempere, M., Deryagian, O., Van, C., Kuhn, J.M.M., Lutter, D., Seldin, M.M., Masri, S., Li, W., Baldi, P., Dyar, K.A., Muñoz-Cánoves, P., Benitah, S.A., Sassone-Corsi, P.
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.abi7828

Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing

Author(s): Potapov, I., García-Prat, L., Ravichandran, S., Muñoz-Cánoves, P., del Sol, A.
Published in: FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15832

Control of satellite cell function in muscle regeneration and its disruption in ageing

Author(s): Sousa-Victor, P., García-Prat, L., Muñoz-Cánoves, P.
Published in: Nature Reviews Molecular Cell Biology, 2022, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-021-00421-2

Stem cell aging in the skeletal muscle: The importance of communication

Author(s): Hong, X., Campanario, S., Ramírez-Pardo, I., Grima-Terrén, M., Isern, J., Muñoz-Cánoves, P.1568-1637
Published in: Ageing Research Reviews, 2022, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2021.101528

Musculoskeletal senescence: a moving target ready to be eliminated

Author(s): Marjolein P Baar, Eusebio Perdiguero, Pura Muñoz-Cánoves, Peter LJ de Keizer
Published in: Current Opinion in Pharmacology, Issue 40, 2018, Page(s) 147-155, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2018.05.007

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Author(s): Guiomar Solanas, Francisca Oliveira Peixoto, Eusebio Perdiguero, Mercè Jardí, Vanessa Ruiz-Bonilla, Debayan Datta, Aikaterini Symeonidi, Andrés Castellanos, Patrick-Simon Welz, Juan Martín Caballero, Paolo Sassone-Corsi, Pura Muñoz-Cánoves, Salvador Aznar Benitah
Published in: Cell, Issue 170/4, 2017, Page(s) 678-692.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.07.035

New mechanisms driving muscle stem cell regenerative decline with aging

Author(s): Pedro Sousa-Victor, Laura García-Prat, Pura Muñoz-Cánoves
Published in: The International Journal of Developmental Biology, Issue 62/6-7-8, 2018, Page(s) 583-590, ISSN 0214-6282
Publisher: University of the Basque Country Press
DOI: 10.1387/ijdb.180041pm

Definitions for adult stem cells debated

Author(s): Pura Muñoz-Cánoves, Meritxell Huch
Published in: Nature, Issue 563/7731, 2018, Page(s) 328-329, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-018-07175-6

The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment

Author(s): Natasha C. Chang, Marie-Claude Sincennes, Fabien P. Chevalier, Caroline E. Brun, Melanie Lacaria, Jessica Segalés, Pura Muñoz-Cánoves, Hong Ming, Michael A. Rudnicki
Published in: Cell Stem Cell, Issue 22/5, 2018, Page(s) 755-768.e6, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.03.022

Cilia Control Fat Deposition during Tissue Repair

Author(s): Eusebio Perdiguero, Antonio L. Serrano, Pura Muñoz-Cánoves
Published in: Developmental Cell, Issue 42/2, 2017, Page(s) 114-116, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2017.06.023

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

Author(s): Giorgia Testoni, Jordi Duran, Mar García-Rocha, Francisco Vilaplana, Antonio L. Serrano, David Sebastián, Iliana López-Soldado, Mitchell A. Sullivan, Felipe Slebe, Marta Vilaseca, Pura Muñoz-Cánoves, Joan J. Guinovart
Published in: Cell Metabolism, Issue 26/1, 2017, Page(s) 256-266.e4, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2017.06.008

Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging

Author(s): Mariana López-Luppo, Joana Catita, David Ramos, Marc Navarro, Ana Carretero, Luísa Mendes-Jorge, Pura Muñoz-Cánoves, Alfonso Rodriguez-Baeza, Victor Nacher, Jesus Ruberte
Published in: Investigative Opthalmology & Visual Science, Issue 58/7, 2017, Page(s) 2832, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.16-20312

Proteostatic and Metabolic Control of Stemness

Author(s): Laura García-Prat, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Published in: Cell Stem Cell, Issue 20/5, 2017, Page(s) 593-608, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2017.04.011

Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q 10 Deficiency

Author(s): Damià Romero-Moya, Carlos Santos-Ocaña, Julio Castaño, Gloria Garrabou, José A. Rodríguez-Gómez, Vanesa Ruiz-Bonilla, Clara Bueno, Patricia González-Rodríguez, Alessandra Giorgetti, Eusebio Perdiguero, Cristina Prieto, Constanza Moren-Nuñez, Daniel J. Fernández-Ayala, Maria Victoria Cascajo, Iván Velasco, Josep Maria Canals, Raquel Montero, Delia Yubero, Cristina Jou, José López-Barne
Published in: STEM CELLS, Issue 35/7, 2017, Page(s) 1687-1703, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.2634

Rejuvenating stem cells to restore muscle regeneration in aging

Author(s): Eyal Bengal, Eusebio Perdiguero, Antonio L. Serrano, Pura Muñoz-Cánoves
Published in: F1000Research, Issue 6, 2017, Page(s) 76, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.9846.1

Fibrosis development in early-onset muscular dystrophies: Mechanisms and translational implications

Author(s): Antonio L. Serrano, Pura Muñoz-Cánoves
Published in: Seminars in Cell & Developmental Biology, Issue 64, 2017, Page(s) 181-190, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2016.09.013

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Author(s): Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13832-9

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Author(s): Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun
Published in: Cell Reports, Issue 31/7, 2020, Page(s) 107652, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107652

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Author(s): Pedro Sousa-Victor, Joana Neves, Pura Muñoz-Cánoves
Published in: Mechanisms of Ageing and Development, Issue 188, 2020, Page(s) 111246, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111246

Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle

Author(s): Francescopaolo Iavarone, Ombretta Guardiola, Alessandra Scagliola, Gennaro Andolfi, Federica Esposito, Antonio Serrano, Eusebio Perdiguero, Silvia Brunelli, Pura Muñoz‐Cánoves, Gabriella Minchiotti
Published in: EMBO reports, Issue 21/4, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201949075

Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

Author(s): Pura Muñoz‐Cánoves, Joana Neves, Pedro Sousa‐Victor
Published in: The FEBS Journal, Issue 287/3, 2020, Page(s) 406-416, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15182

The central clock suffices to drive the majority of circulatory metabolic rhythms.

Author(s): Paul Petrus; Jacob G. Smith; Kevin B. Koronowski; Siwei Chen; Tomoki Sato; Carolina M. Greco; Thomas Mortimer; Patrick-Simon Welz; Valentina M. Zinna; Kohei Shimaji; Marlene Cervantes; Daniela Punzo; Pierre Baldi; Pura Muñoz-Cánoves; Paolo Sassone-Corsi; Salvador Aznar Benitah
Published in: Science advances, vol 8, iss 26, Issue 3, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo2896

Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels

Author(s): Sara González-Hernández, Manuel J. Gómez, Fátima Sánchez-Cabo, Simón Méndez-Ferrer, Pura Muñoz-Cánoves, Joan Isern
Published in: Circulation Research, Issue 127/11, 2020, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317121

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

Author(s): Laura García-Prat, Eusebio Perdiguero, Sonia Alonso-Martín, Stefania Dell’Orso, Srikanth Ravichandran, Stephen R. Brooks, Aster H. Juan, Silvia Campanario, Kan Jiang, Xiaotong Hong, Laura Ortet, Vanessa Ruiz-Bonilla, Marta Flández, Victoria Moiseeva, Elena Rebollo, Mercè Jardí, Hong-Wei Sun, Antonio Musarò, Marco Sandri, Antonio del Sol, Vittorio Sartorelli, Pura Muñoz-Cánoves
Published in: Nature Cell Biology, Issue 22/11, 2020, Page(s) 1307-1318, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-00593-7

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

Author(s): Xiaotong Hong, Joan Isern, Silvia Campanario, Eusebio Perdiguero, Ignacio Ramírez-Pardo, Jessica Segalés, Pablo Hernansanz-Agustín, Andrea Curtabbi, Oleg Deryagin, Angela Pollán, José A González-Reyes, José M Villalba, Marco Sandri, Antonio L Serrano, José A Enríquez, Pura Muñoz-Cánoves
Published in: Cell Stem Cell, 2022, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.07.009

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

Author(s): Sreenivasan, K., Rodríguez-delaRosa, A., Kim, J., Mesquita, D., Segalés, J., Arco, P.G.-D., Espejo, I., Ianni, A., Di Croce, L., Relaix, F., Redondo, J.M., Braun, T., Serrano, A.L., Perdiguero, E., Muñoz-Cánoves, P.
Published in: Stem Cell Reports, 2021, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.07.022

Book chapters (2)

Simultaneous Isolation of Stem and Niche Cells of Skeletal Muscle: Applicability for Aging Studies

Author(s): Eusebio Perdiguero, Victoria Moiseeva, Pura Muñoz-Cánoves
Published in: Methods in Molecular Biology, 2019
Publisher: Humana Press
DOI: 10.1007/7651_2019_210

Monitoring Autophagy in Muscle Stem Cells

Author(s): Laura García-Prat, Pura Muñoz-Cánoves, Marta Martínez-Vicente
Published in: Muscle Stem Cells - Methods and Protocols, Issue 1556, 2017, Page(s) 255-280, ISBN 978-1-4939-6769-8
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6771-1_14