Tissue regeneration and aging: the decisive quiescent stem-cell state

Pubblicazioni

Protocol for RNA-seq library preparation starting from a rare muscle stem cell population or a limited number of mouse embryonic stem cells

Autori: Dell'Orso, S., Juan, A.H., Moiseeva, V., García-Prat, L., Muñoz-Cánoves, P., Sartorelli, V.
Pubblicato in: STAR Protocols, 2021, ISSN 2666-1667
Editore: STAR Protocols
DOI: 10.1016/j.xpro.2021.100451

3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Autori: Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J.
Pubblicato in: Nature Aging, 2022, ISSN 2662-8465
Editore: Nature Publishing
DOI: 10.1038/s43587-022-00279-9

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Autori: Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Aznar-Benitah S, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P.
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05535-x

Assessing Autophagy in Muscle Stem Cells

Autori: Campanario, S., Ramírez-Pardo, I., Hong, X., Isern, J., Muñoz-Cánoves, P.
Pubblicato in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2020.620409

Running skeletal muscle clocks on time— the determining factors

Autori: Vaca-Dempere, M., Kumar, A., Sica, V., Muñoz-Cánoves, P.
Pubblicato in: Experimental Cell Research, 2022, ISSN 0014-4827
Editore: Academic Press
DOI: 10.1016/j.yexcr.2021.112989

Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

Autori: Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W., Mou, X., Liew, S.W., Umar, M.I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C.J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y., Nagamine, Y., Kwok, C.K., Sun, H., Muñoz-Cánoves, P., Wang, H.
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25170-w

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage

Autori: Arc-Chagnaud, C., Salvador-Pascual, A., Garcia-Dominguez, E., Olaso-Gonzalez, G., Correas, A.G., Serna, E., Brioche, T., Chopard, A., Fernandez-Marcos, P.J., Serrano, M., Serrano, A.L., Muñoz-Cánoves, P., Sebastiá, V., Viña, J., Gomez-Cabrera, M.C.
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, 2021, ISSN 2190-5991
Editore: Springer Verlag
DOI: 10.1002/jcsm.12792

Context‐dependent roles of cellular senescence in normal, aged, and disease states

Autori: Victoria Moiseeva; Andrés Cisneros; Aina Calls Cobos; Aida Beà Tarrega; Claudia Santos Oñate; Eusebio Perdiguero; Antonio L. Serrano; Pura Muñoz‐Cánoves
Pubblicato in: FEBS Journal, Numero 1, 2022, ISSN 1742-4658
Editore: Federation of European Biochemical Societies
DOI: 10.1111/febs.16573

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

Autori: Prados, B., del Toro, R., MacGrogan, D., Gómez-Apiñániz, P., Papoutsi, T., Muñoz-Cánoves, P., Méndez-Ferrer, S., de la Pompa, J.L.
Pubblicato in: Cell Death and Disease, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-04003-0

Macrophages, Metabolism and Heterophagy in the Heart

Autori: Nicolás-Ávila, J.A., Pena-Couso, L., Muñoz-Cánoves, P., Hidalgo, A.0009-7330
Pubblicato in: Circulation Research, 2022, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319812

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Autori: José A. Nicolás-Ávila, Ana V. Lechuga-Vieco, Lorena Esteban-Martínez, María Sánchez-Díaz, Elena Díaz-García, Demetrio J. Santiago, Andrea Rubio-Ponce, Jackson LiangYao Li, Akhila Balachander, Juan A. Quintana, Raquel Martínez-de-Mena, Beatriz Castejón-Vega, Andrés Pun-García, Paqui G. Través, Elena Bonzón-Kulichenko, Fernando García-Marqués, Lorena Cussó, Noelia A-González, Andr
Pubblicato in: Cell, Numero 183/1, 2020, Pagina/e 94-109.e23, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.08.031

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Autori: Greco, C.M., Koronowski, K.B., Smith, J.G., Shi, J., Kunderfranco, P., Carriero, R., Chen, S., Samad, M., Welz, P.-S., Zinna, V.M., Mortimer, T., Chun, S.K., Shimaji, K., Sato, T., Petrus, P., Kumar, A., Vaca-Dempere, M., Deryagian, O., Van, C., Kuhn, J.M.M., Lutter, D., Seldin, M.M., Masri, S., Li, W., Baldi, P., Dyar, K.A., Muñoz-Cánoves, P., Benitah, S.A., Sassone-Corsi, P.
Pubblicato in: Science Advances, 2021, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.abi7828

Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing

Autori: Potapov, I., García-Prat, L., Ravichandran, S., Muñoz-Cánoves, P., del Sol, A.
Pubblicato in: FEBS Journal, 2021, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15832

Control of satellite cell function in muscle regeneration and its disruption in ageing

Autori: Sousa-Victor, P., García-Prat, L., Muñoz-Cánoves, P.
Pubblicato in: Nature Reviews Molecular Cell Biology, 2022, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-021-00421-2

Stem cell aging in the skeletal muscle: The importance of communication

Autori: Hong, X., Campanario, S., Ramírez-Pardo, I., Grima-Terrén, M., Isern, J., Muñoz-Cánoves, P.1568-1637
Pubblicato in: Ageing Research Reviews, 2022, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2021.101528

Musculoskeletal senescence: a moving target ready to be eliminated

Autori: Marjolein P Baar, Eusebio Perdiguero, Pura Muñoz-Cánoves, Peter LJ de Keizer
Pubblicato in: Current Opinion in Pharmacology, Numero 40, 2018, Pagina/e 147-155, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2018.05.007

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Autori: Guiomar Solanas, Francisca Oliveira Peixoto, Eusebio Perdiguero, Mercè Jardí, Vanessa Ruiz-Bonilla, Debayan Datta, Aikaterini Symeonidi, Andrés Castellanos, Patrick-Simon Welz, Juan Martín Caballero, Paolo Sassone-Corsi, Pura Muñoz-Cánoves, Salvador Aznar Benitah
Pubblicato in: Cell, Numero 170/4, 2017, Pagina/e 678-692.e20, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.07.035

New mechanisms driving muscle stem cell regenerative decline with aging

Autori: Pedro Sousa-Victor, Laura García-Prat, Pura Muñoz-Cánoves
Pubblicato in: The International Journal of Developmental Biology, Numero 62/6-7-8, 2018, Pagina/e 583-590, ISSN 0214-6282
Editore: University of the Basque Country Press
DOI: 10.1387/ijdb.180041pm

Definitions for adult stem cells debated

Autori: Pura Muñoz-Cánoves, Meritxell Huch
Pubblicato in: Nature, Numero 563/7731, 2018, Pagina/e 328-329, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/d41586-018-07175-6

The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment

Autori: Natasha C. Chang, Marie-Claude Sincennes, Fabien P. Chevalier, Caroline E. Brun, Melanie Lacaria, Jessica Segalés, Pura Muñoz-Cánoves, Hong Ming, Michael A. Rudnicki
Pubblicato in: Cell Stem Cell, Numero 22/5, 2018, Pagina/e 755-768.e6, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2018.03.022

Cilia Control Fat Deposition during Tissue Repair

Autori: Eusebio Perdiguero, Antonio L. Serrano, Pura Muñoz-Cánoves
Pubblicato in: Developmental Cell, Numero 42/2, 2017, Pagina/e 114-116, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2017.06.023

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

Autori: Giorgia Testoni, Jordi Duran, Mar García-Rocha, Francisco Vilaplana, Antonio L. Serrano, David Sebastián, Iliana López-Soldado, Mitchell A. Sullivan, Felipe Slebe, Marta Vilaseca, Pura Muñoz-Cánoves, Joan J. Guinovart
Pubblicato in: Cell Metabolism, Numero 26/1, 2017, Pagina/e 256-266.e4, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2017.06.008

Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging

Autori: Mariana López-Luppo, Joana Catita, David Ramos, Marc Navarro, Ana Carretero, Luísa Mendes-Jorge, Pura Muñoz-Cánoves, Alfonso Rodriguez-Baeza, Victor Nacher, Jesus Ruberte
Pubblicato in: Investigative Opthalmology & Visual Science, Numero 58/7, 2017, Pagina/e 2832, ISSN 1552-5783
Editore: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.16-20312

Proteostatic and Metabolic Control of Stemness

Autori: Laura García-Prat, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Pubblicato in: Cell Stem Cell, Numero 20/5, 2017, Pagina/e 593-608, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2017.04.011

Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q 10 Deficiency

Autori: Damià Romero-Moya, Carlos Santos-Ocaña, Julio Castaño, Gloria Garrabou, José A. Rodríguez-Gómez, Vanesa Ruiz-Bonilla, Clara Bueno, Patricia González-Rodríguez, Alessandra Giorgetti, Eusebio Perdiguero, Cristina Prieto, Constanza Moren-Nuñez, Daniel J. Fernández-Ayala, Maria Victoria Cascajo, Iván Velasco, Josep Maria Canals, Raquel Montero, Delia Yubero, Cristina Jou, José López-Barne
Pubblicato in: STEM CELLS, Numero 35/7, 2017, Pagina/e 1687-1703, ISSN 1066-5099
Editore: AlphaMed Press Inc
DOI: 10.1002/stem.2634

Rejuvenating stem cells to restore muscle regeneration in aging

Autori: Eyal Bengal, Eusebio Perdiguero, Antonio L. Serrano, Pura Muñoz-Cánoves
Pubblicato in: F1000Research, Numero 6, 2017, Pagina/e 76, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.9846.1

Fibrosis development in early-onset muscular dystrophies: Mechanisms and translational implications

Autori: Antonio L. Serrano, Pura Muñoz-Cánoves
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 64, 2017, Pagina/e 181-190, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2016.09.013

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Autori: Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13832-9

Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Autori: Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilic, Stefan Günther, Eusebio Perdiguero, Marcus Krüger, Simone Spuler, Stefan Offermanns, Pablo Gómez-del Arco, Juan Miguel Redondo, Pura Munoz-Canoves, Johnny Kim, Thomas Braun
Pubblicato in: Cell Reports, Numero 31/7, 2020, Pagina/e 107652, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107652

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Autori: Pedro Sousa-Victor, Joana Neves, Pura Muñoz-Cánoves
Pubblicato in: Mechanisms of Ageing and Development, Numero 188, 2020, Pagina/e 111246, ISSN 0047-6374
Editore: Elsevier BV
DOI: 10.1016/j.mad.2020.111246

Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle

Autori: Francescopaolo Iavarone, Ombretta Guardiola, Alessandra Scagliola, Gennaro Andolfi, Federica Esposito, Antonio Serrano, Eusebio Perdiguero, Silvia Brunelli, Pura Muñoz‐Cánoves, Gabriella Minchiotti
Pubblicato in: EMBO reports, Numero 21/4, 2020, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201949075

Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

Autori: Pura Muñoz‐Cánoves, Joana Neves, Pedro Sousa‐Victor
Pubblicato in: The FEBS Journal, Numero 287/3, 2020, Pagina/e 406-416, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.15182

The central clock suffices to drive the majority of circulatory metabolic rhythms.

Autori: Paul Petrus; Jacob G. Smith; Kevin B. Koronowski; Siwei Chen; Tomoki Sato; Carolina M. Greco; Thomas Mortimer; Patrick-Simon Welz; Valentina M. Zinna; Kohei Shimaji; Marlene Cervantes; Daniela Punzo; Pierre Baldi; Pura Muñoz-Cánoves; Paolo Sassone-Corsi; Salvador Aznar Benitah
Pubblicato in: Science advances, vol 8, iss 26, Numero 3, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo2896

Sox17 Controls Emergence and Remodeling of Nestin-Expressing Coronary Vessels

Autori: Sara González-Hernández, Manuel J. Gómez, Fátima Sánchez-Cabo, Simón Méndez-Ferrer, Pura Muñoz-Cánoves, Joan Isern
Pubblicato in: Circulation Research, Numero 127/11, 2020, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317121

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

Autori: Laura García-Prat, Eusebio Perdiguero, Sonia Alonso-Martín, Stefania Dell’Orso, Srikanth Ravichandran, Stephen R. Brooks, Aster H. Juan, Silvia Campanario, Kan Jiang, Xiaotong Hong, Laura Ortet, Vanessa Ruiz-Bonilla, Marta Flández, Victoria Moiseeva, Elena Rebollo, Mercè Jardí, Hong-Wei Sun, Antonio Musarò, Marco Sandri, Antonio del Sol, Vittorio Sartorelli, Pura Muñoz-Cánoves
Pubblicato in: Nature Cell Biology, Numero 22/11, 2020, Pagina/e 1307-1318, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-020-00593-7

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

Autori: Xiaotong Hong, Joan Isern, Silvia Campanario, Eusebio Perdiguero, Ignacio Ramírez-Pardo, Jessica Segalés, Pablo Hernansanz-Agustín, Andrea Curtabbi, Oleg Deryagin, Angela Pollán, José A González-Reyes, José M Villalba, Marco Sandri, Antonio L Serrano, José A Enríquez, Pura Muñoz-Cánoves
Pubblicato in: Cell Stem Cell, 2022, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2022.07.009

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

Autori: Sreenivasan, K., Rodríguez-delaRosa, A., Kim, J., Mesquita, D., Segalés, J., Arco, P.G.-D., Espejo, I., Ianni, A., Di Croce, L., Relaix, F., Redondo, J.M., Braun, T., Serrano, A.L., Perdiguero, E., Muñoz-Cánoves, P.
Pubblicato in: Stem Cell Reports, 2021, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2021.07.022

Simultaneous Isolation of Stem and Niche Cells of Skeletal Muscle: Applicability for Aging Studies

Autori: Eusebio Perdiguero, Victoria Moiseeva, Pura Muñoz-Cánoves
Pubblicato in: Methods in Molecular Biology, 2019
Editore: Humana Press
DOI: 10.1007/7651_2019_210

Monitoring Autophagy in Muscle Stem Cells

Autori: Laura García-Prat, Pura Muñoz-Cánoves, Marta Martínez-Vicente
Pubblicato in: Muscle Stem Cells - Methods and Protocols, Numero 1556, 2017, Pagina/e 255-280, ISBN 978-1-4939-6769-8
Editore: Springer New York
DOI: 10.1007/978-1-4939-6771-1_14

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