Sensitivity of human tumors to T cell attack

Project Information

SENSIT

Grant agreement ID: 742259

DOI

10.3030/742259

Project closed

EC signature date 6 November 2017

Start date 1 December 2017

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 405 625,00

EU contribution

€ 2 405 625,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

CD8+ T cell states in human cancer: insights from single-cell analysis

Author(s): Anne M. van der Leun, Daniela S. Thommen, Ton N. Schumacher
Published in: Nature Reviews Cancer, Issue 20/4, 2020, Page(s) 218-232, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-019-0235-4

QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment

Author(s): Kaspar Bresser; Meike E. W. Logtenberg; Mireille Toebes; Natalie Proost; Justin Sprengers; Bjorn Siteur; Manon Boeije; Lona J. Kroese; Ton N. Schumacher
Published in: Oncoimmunology, Issue 1, 2021, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.1080/2162402x.2022.2049486

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Author(s): Riccardo Mezzadra, Chong Sun, Lucas T. Jae, Raquel Gomez-Eerland, Evert de Vries, Wei Wu, Meike E. W. Logtenberg, Maarten Slagter, Elisa A. Rozeman, Ingrid Hofland, Annegien Broeks, Hugo M. Horlings, Lodewyk F. A. Wessels, Christian U. Blank, Yanling Xiao, Albert J. R. Heck, Jannie Borst, Thijn R. Brummelkamp, Ton N. M. Schumacher
Published in: Nature, Issue 549/7670, 2017, Page(s) 106-110, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature23669

Regulation and Function of the PD-L1 Checkpoint

Author(s): Chong Sun, Riccardo Mezzadra, Ton N. Schumacher
Published in: Immunity, Issue 48/3, 2018, Page(s) 434-452, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.03.014

T Cell Dysfunction in Cancer

Author(s): Daniela S. Thommen, Ton N. Schumacher
Published in: Cancer Cell, Issue 33/4, 2018, Page(s) 547-562, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2018.03.012

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Author(s): Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D. Mertz, Ton N. Schumacher, Alfred Zippelius
Published in: Nature Medicine, Issue 24/7, 2018, Page(s) 994-1004, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0057-z

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing

Author(s): Riccardo Mezzadra, Marjolein de Bruijn, Lucas T. Jae, Raquel Gomez-Eerland, Anja Duursma, Ferenc A. Scheeren, Thijn R. Brummelkamp, Ton N. Schumacher
Published in: PLOS ONE, Issue 14/2, 2019, Page(s) e0212053, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0212053

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

Author(s): Krijn K. Dijkstra, Chiara M. Cattaneo, Fleur Weeber, Myriam Chalabi, Joris van de Haar, Lorenzo F. Fanchi, Maarten Slagter, Daphne L. van der Velden, Sovann Kaing, Sander Kelderman, Nienke van Rooij, Monique E. van Leerdam, Annekatrien Depla, Egbert F. Smit, Koen J. Hartemink, Rosa de Groot, Monika C. Wolkers, Norman Sachs, Petur Snaebjornsson, Kim Monkhorst, John Haanen, Hans Clevers, Ton N. Schu
Published in: Cell, Issue 174/6, 2018, Page(s) 1586-1598.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.07.009

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Author(s): Meike E. W. Logtenberg, J. H. Marco Jansen, Matthijs Raaben, Mireille Toebes, Katka Franke, Arianne M. Brandsma, Hanke L. Matlung, Astrid Fauster, Raquel Gomez-Eerland, Noor A. M. Bakker, Simone van der Schot, Koen A. Marijt, Martijn Verdoes, John B. A. G. Haanen, Joost H. van den Berg, Jacques Neefjes, Timo K. van den Berg, Thijn R. Brummelkamp, Jeanette H. W. Leusen, Ferenc A. Scheeren, Ton N. S
Published in: Nature Medicine, Issue 25/4, 2019, Page(s) 612-619, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0356-z

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Author(s): Hanjie Li, Anne M. van der Leun, Ido Yofe, Yaniv Lubling, Dikla Gelbard-Solodkin, Alexander C.J. van Akkooi, Marlous van den Braber, Elisa A. Rozeman, John B.A.G. Haanen, Christian U. Blank, Hugo M. Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N. Schumacher, Amos Tanay, Ido Amit
Published in: Cell, Issue 176/4, 2019, Page(s) 775-789.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.11.043

Long-distance modulation of bystander tumor cells by CD8+ T-cell-secreted IFN-γ

Author(s): Mirjam E. Hoekstra, Laura Bornes, Feline E. Dijkgraaf, Daisy Philips, Iris N. Pardieck, Mireille Toebes, Daniela S. Thommen, Jacco van Rheenen, Ton N. M. Schumacher
Published in: Nature Cancer, Issue 1/3, 2020, Page(s) 291-301, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-020-0036-4

Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens

Author(s): Chiara M Cattaneo, Thomas Battaglia, Jos Urbanus, Ziva Moravec 1 , Rhianne Voogd, Rosa de Groot, Koen J Hartemink, John B A G Haanen, Emile E Voest, Ton N Schumacher, Wouter Scheper
Published in: Nature Biotechnology, 2023, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01547-0

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

Author(s): Anne M. van der Leun, Mirjam E Hoekstra, Luuk Reinalda, Colinda L G J Scheele, Mireille Toebes, Michel J van de Graaff, Linda Y Y Chen, Hanjie Li, Akhiad Bercovich, Yaniv Lubling, Eyal David, Daniela S Thommen, Amos Tanay, Jacco van Rheenen, Ido Amit, Sander I van Kasteren, Ton N Schumacher
Published in: Nature Chemical Biology, Issue 17, 2021, Page(s) 1139-1147, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-021-00839-x