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Telomere metabolism in Genome Stability and Disease

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Publications

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

Author(s): Pol Margalef, Panagiotis Kotsantis, Valerie Borel, Roberto Bellelli, Stephanie Panier, Simon J. Boulton
Published in: Cell, Issue 172/3, 2018, Page(s) 439-453.e14, ISSN 0092-8674
DOI: 10.1016/j.cell.2017.11.047

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination

Author(s): Ana María León-Ortiz, Stephanie Panier, Grzegorz Sarek, Jean-Baptiste Vannier, Harshil Patel, Peter J. Campbell, Simon J. Boulton
Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 292-305.e6, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.12.014

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Author(s): Stephanie Panier, Marija Maric, Graeme Hewitt, Emily Mason-Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura-Bayona, Ondrej Belan, Paulina Marzec, Pierre-Henri L. Gaillard, Rachel L. Flynn, Simon J. Boulton
Published in: Molecular Cell, Issue 76/1, 2019, Page(s) 27-43.e11, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.07.010

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

Author(s): Carlota Colomer, Pol Margalef, Alberto Villanueva, Anna Vert, Irene Pecharroman, Laura Solé, Mónica González-Farré, Josune Alonso, Clara Montagut, Maria Martinez-Iniesta, Joan Bertran, Eva Borràs, Mar Iglesias, Eduard Sabidó, Anna Bigas, Simon J. Boulton, Lluís Espinosa
Published in: Molecular Cell, Issue 75/4, 2019, Page(s) 669-682.e5, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.05.036

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Author(s): Roberto Bellelli, Valerie Borel, Clare Logan, Jennifer Svendsen, Danielle E. Cox, Emma Nye, Kay Metcalfe, Susan M. O’Connell, Gordon Stamp, Helen R. Flynn, Ambrosius P. Snijders, François Lassailly, Andrew Jackson, Simon J. Boulton
Published in: Molecular Cell, Issue 70/4, 2018, Page(s) 707-721.e7, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.04.008

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Author(s): Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, David Van Ly, Pol Margalef, Valerie Borel, Xiao-Feng Zheng, Helen R. Flynn, Ambrosius P. Snijders, Dipanjan Chowdhury, Anthony J. Cesare, Simon J. Boulton
Published in: Nature, Issue 575/7783, 2019, Page(s) 523-527, ISSN 0028-0836
DOI: 10.1038/s41586-019-1744-8

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Author(s): Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Published in: Molecular Cell, Issue 72/1, 2018, Page(s) 112-126.e5, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.08.043

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Author(s): Tatiana Garcia-Muse, U. Galindo-Diaz, M. Garcia-Rubio, J.S. Martin, J. Polanowska, N. O’Reilly, A. Aguilera, Simon J. Boulton
Published in: Cell Reports, Issue 26/3, 2019, Page(s) 775-787.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.12.074