Telomere metabolism in Genome Stability and Disease

Project Information

TelMetab

Grant agreement ID: 742437

DOI 10.3030/742437

Project closed

EC signature date 19 July 2017

Start date 1 September 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 118 431,00

EU contribution € 2 118 431,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Publications

Peer reviewed articles (16)

RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

Author(s): Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H, Goldstone R, Poetsch AR, Boulton SJ.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108546

SMCHD 1 promotes ATM ‐dependent DNA damage signaling and repair of uncapped telomeres

Author(s): Aleksandra Vančevska, Wareed Ahmed, Verena Pfeiffer, Marianna Feretzaki, Simon J Boulton, Joachim Lingner
Published in: The EMBO Journal, Issue 39/7, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019102668

TRF2-independent chromosome end protection during pluripotency.

Author(s): Ruis P, Van Ly D, Borel V, Kafer GR, McCarthy A, Howell S, Blassberg R, Snijders AP, Briscoe J, Niakan KK, Marzec P, Cesare AJ, Boulton SJ.
Published in: Nature, 2020, ISSN 2398-9629
Publisher: Nature
DOI: 10.1038/s41586-020-2960-y

Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases

Author(s): Roberto Bellelli, Simon J. Boulton
Published in: Trends in Genetics, 2020, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.09.008

The end protection problem-an unexpected twist in the tail.

Author(s): Ruis P, Boulton SJ.
Published in: Genes & Development, 2021, ISSN 1549-5477
Publisher: CSHL press
DOI: 10.1101/gad.344044.120

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

Author(s): Pol Margalef, Panagiotis Kotsantis, Valerie Borel, Roberto Bellelli, Stephanie Panier, Simon J. Boulton
Published in: Cell, Issue 172/3, 2018, Page(s) 439-453.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.11.047

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination

Author(s): Ana María León-Ortiz, Stephanie Panier, Grzegorz Sarek, Jean-Baptiste Vannier, Harshil Patel, Peter J. Campbell, Simon J. Boulton
Published in: Molecular Cell, Issue 69/2, 2018, Page(s) 292-305.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2017.12.014

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Author(s): Stephanie Panier, Marija Maric, Graeme Hewitt, Emily Mason-Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura-Bayona, Ondrej Belan, Paulina Marzec, Pierre-Henri L. Gaillard, Rachel L. Flynn, Simon J. Boulton
Published in: Molecular Cell, Issue 76/1, 2019, Page(s) 27-43.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.07.010

Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination

Author(s): Justin B. Steinfeld, Ondrej Beláň, Youngho Kwon, Tsuyoshi Terakawa, Amr Al-Zain, Michael J. Smith, J. Brooks Crickard, Zhi Qi, Weixing Zhao, Rodney Rothstein, Lorraine S. Symington, Patrick Sung, Simon J. Boulton, Eric C. Greene
Published in: Genes & Development, Issue 33/17-18, 2019, Page(s) 1191-1207, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.328062.119

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

Author(s): Carlota Colomer, Pol Margalef, Alberto Villanueva, Anna Vert, Irene Pecharroman, Laura Solé, Mónica González-Farré, Josune Alonso, Clara Montagut, Maria Martinez-Iniesta, Joan Bertran, Eva Borràs, Mar Iglesias, Eduard Sabidó, Anna Bigas, Simon J. Boulton, Lluís Espinosa
Published in: Molecular Cell, Issue 75/4, 2019, Page(s) 669-682.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.05.036

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Author(s): Roberto Bellelli, Valerie Borel, Clare Logan, Jennifer Svendsen, Danielle E. Cox, Emma Nye, Kay Metcalfe, Susan M. O’Connell, Gordon Stamp, Helen R. Flynn, Ambrosius P. Snijders, François Lassailly, Andrew Jackson, Simon J. Boulton
Published in: Molecular Cell, Issue 70/4, 2018, Page(s) 707-721.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.04.008

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Author(s): Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, David Van Ly, Pol Margalef, Valerie Borel, Xiao-Feng Zheng, Helen R. Flynn, Ambrosius P. Snijders, Dipanjan Chowdhury, Anthony J. Cesare, Simon J. Boulton
Published in: Nature, Issue 575/7783, 2019, Page(s) 523-527, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1744-8

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Author(s): Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Published in: Molecular Cell, Issue 72/1, 2018, Page(s) 112-126.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.08.043

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Author(s): Tatiana Garcia-Muse, U. Galindo-Diaz, M. Garcia-Rubio, J.S. Martin, J. Polanowska, N. O’Reilly, A. Aguilera, Simon J. Boulton
Published in: Cell Reports, Issue 26/3, 2019, Page(s) 775-787.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.12.074

Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

Author(s): Roberto Bellelli, Jillian Youds, Valerie Borel, Jennifer Svendsen, Visnja Pavicic-Kaltenbrunner, Simon J. Boulton
Published in: Cell Reports, Issue 31/8, 2020, Page(s) 107675, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107675

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

Author(s): Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, Lars M. Koenig, Maria Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker
Published in: Cell Reports, Issue 32/5, 2020, Page(s) 107983, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107983