Telomere metabolism in Genome Stability and Disease

Publicaciones

RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

Autores: Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H, Goldstone R, Poetsch AR, Boulton SJ.
Publicado en: Cell Reports, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108546

SMCHD 1 promotes ATM ‐dependent DNA damage signaling and repair of uncapped telomeres

Autores: Aleksandra Vančevska, Wareed Ahmed, Verena Pfeiffer, Marianna Feretzaki, Simon J Boulton, Joachim Lingner
Publicado en: The EMBO Journal, Edición 39/7, 2020, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2019102668

TRF2-independent chromosome end protection during pluripotency.

Autores: Ruis P, Van Ly D, Borel V, Kafer GR, McCarthy A, Howell S, Blassberg R, Snijders AP, Briscoe J, Niakan KK, Marzec P, Cesare AJ, Boulton SJ.
Publicado en: Nature, 2020, ISSN 2398-9629
Editor: Nature
DOI: 10.1038/s41586-020-2960-y

Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases

Autores: Roberto Bellelli, Simon J. Boulton
Publicado en: Trends in Genetics, 2020, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2020.09.008

The end protection problem-an unexpected twist in the tail.

Autores: Ruis P, Boulton SJ.
Publicado en: Genes & Development, 2021, ISSN 1549-5477
Editor: CSHL press
DOI: 10.1101/gad.344044.120

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

Autores: Pol Margalef, Panagiotis Kotsantis, Valerie Borel, Roberto Bellelli, Stephanie Panier, Simon J. Boulton
Publicado en: Cell, Edición 172/3, 2018, Página(s) 439-453.e14, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2017.11.047

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination

Autores: Ana María León-Ortiz, Stephanie Panier, Grzegorz Sarek, Jean-Baptiste Vannier, Harshil Patel, Peter J. Campbell, Simon J. Boulton
Publicado en: Molecular Cell, Edición 69/2, 2018, Página(s) 292-305.e6, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2017.12.014

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Autores: Stephanie Panier, Marija Maric, Graeme Hewitt, Emily Mason-Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura-Bayona, Ondrej Belan, Paulina Marzec, Pierre-Henri L. Gaillard, Rachel L. Flynn, Simon J. Boulton
Publicado en: Molecular Cell, Edición 76/1, 2019, Página(s) 27-43.e11, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.07.010

Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination

Autores: Justin B. Steinfeld, Ondrej Beláň, Youngho Kwon, Tsuyoshi Terakawa, Amr Al-Zain, Michael J. Smith, J. Brooks Crickard, Zhi Qi, Weixing Zhao, Rodney Rothstein, Lorraine S. Symington, Patrick Sung, Simon J. Boulton, Eric C. Greene
Publicado en: Genes & Development, Edición 33/17-18, 2019, Página(s) 1191-1207, ISSN 0890-9369
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.328062.119

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

Autores: Carlota Colomer, Pol Margalef, Alberto Villanueva, Anna Vert, Irene Pecharroman, Laura Solé, Mónica González-Farré, Josune Alonso, Clara Montagut, Maria Martinez-Iniesta, Joan Bertran, Eva Borràs, Mar Iglesias, Eduard Sabidó, Anna Bigas, Simon J. Boulton, Lluís Espinosa
Publicado en: Molecular Cell, Edición 75/4, 2019, Página(s) 669-682.e5, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.05.036

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Autores: Roberto Bellelli, Valerie Borel, Clare Logan, Jennifer Svendsen, Danielle E. Cox, Emma Nye, Kay Metcalfe, Susan M. O’Connell, Gordon Stamp, Helen R. Flynn, Ambrosius P. Snijders, François Lassailly, Andrew Jackson, Simon J. Boulton
Publicado en: Molecular Cell, Edición 70/4, 2018, Página(s) 707-721.e7, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2018.04.008

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Autores: Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, David Van Ly, Pol Margalef, Valerie Borel, Xiao-Feng Zheng, Helen R. Flynn, Ambrosius P. Snijders, Dipanjan Chowdhury, Anthony J. Cesare, Simon J. Boulton
Publicado en: Nature, Edición 575/7783, 2019, Página(s) 523-527, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1744-8

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Autores: Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
Publicado en: Molecular Cell, Edición 72/1, 2018, Página(s) 112-126.e5, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2018.08.043

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Autores: Tatiana Garcia-Muse, U. Galindo-Diaz, M. Garcia-Rubio, J.S. Martin, J. Polanowska, N. O’Reilly, A. Aguilera, Simon J. Boulton
Publicado en: Cell Reports, Edición 26/3, 2019, Página(s) 775-787.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.12.074

Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

Autores: Roberto Bellelli, Jillian Youds, Valerie Borel, Jennifer Svendsen, Visnja Pavicic-Kaltenbrunner, Simon J. Boulton
Publicado en: Cell Reports, Edición 31/8, 2020, Página(s) 107675, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107675

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

Autores: Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, Lars M. Koenig, Maria Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker
Publicado en: Cell Reports, Edición 32/5, 2020, Página(s) 107983, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107983

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