Translational implications of the discovery of brain-draining lymphatics

Project Information

BrainDrain

Grant agreement ID: 743155

DOI

10.3030/743155

Project closed

EC signature date 14 July 2017

Start date 1 August 2017

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 420 429,00

EU contribution

€ 2 420 429,00

Coordinated by

HELSINGIN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Characterization of ANGPT2 mutations associated with primary lymphedema

Author(s): Veli-Matti Leppänen, Pascal Brouillard, Emilia A Korhonen, Tuomas Sipilä, Sawan Kumar Jha, Nicole Revencu, Veerle Labarque, Elodie Fastré, Matthieu Schlögel, Marie Ravoet, Amihood Singer, Claudia Luzzatto, Donatella Angelone, Giovanni Crichiutti, Angela D'Elia, Jaakko Kuurne, Harri Elamaa, Gou Young Koh, Pipsa Saharinen, Miikka Vikkula, Kari Alitalo
Published in: Science Translational Medicine, 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8013

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Author(s): Anaïs Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Müller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe
Published in: Brain, Behaviour, & Immunity - Health, 2022, ISSN 2666-3546
Publisher: Elsevier Inc.
DOI: 10.1016/j.bbih.2022.100466

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Author(s): Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Published in: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Publisher: Nature Portfolio
DOI: 10.1038/s44161-023-00224-y

Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury

Author(s): Sara Wojciechowski, Anaïs Virenque, Maria Vihma, Barbara Galbardi, Erin Jane Rooney, Meike Hedwig Keuters, Salli Antila, Jari Koistinaho, Francesco M Noe
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.559810

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

Author(s): Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H Lackman, Amanda Ranta, Karthik A Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Published in: Journal of Experimental Medicine, 2022, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20210565

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

Author(s): Zhilin Li, Salli Antila, Harri Nurmi, Dmitri Chilov, Emilia Korhonen, Shentong Fang, Sinem Karaman, Britta Engelhardt, Kari Alitalo
Published in: Science Immunology, 2023, ISSN 2470-9468
Publisher: American association for the advancement of science
DOI: 10.1126/sciimmunol.abq0375

Development and plasticity of meningeal lymphatic vessels

Author(s): Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H. Voutilainen, Thomas Mathivet, Dmitri Chilov, Zhilin Li, Tapani Koppinen, Jun-Hee Park, Shentong Fang, Aleksanteri Aspelund, Mart Saarma, Anne Eichmann, Jean-Léon Thomas, Kari Alitalo
Published in: The Journal of Experimental Medicine, Issue 214/12, 2017, Page(s) 3645-3667, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20170391

Vascular endothelial growth factor signaling in development and disease

Author(s): Sinem Karaman, Veli-Matti Leppänen, Kari Alitalo
Published in: Development, Issue 145/14, 2018, Page(s) dev151019, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.151019

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

Author(s): Antoine Louveau, Benjamin A. Plog, Salli Antila, Kari Alitalo, Maiken Nedergaard, Jonathan Kipnis
Published in: Journal of Clinical Investigation, Issue 127/9, 2017, Page(s) 3210-3219, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci90603

Anatomy and function of the vertebral column lymphatic network in mice

Author(s): Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann, Jean-Leon Thomas
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12568-w

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

Author(s): Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.44478

Cardiac lymphatics in health and disease

Author(s): Ebba Brakenhielm, Kari Alitalo
Published in: Nature Reviews Cardiology, Issue 16/1, 2019, Page(s) 56-68, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-018-0087-8

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Author(s): Zhilin Li, Emilia A. Korhonen, Arianna Merlini, Judith Strauss, Eleonoora Wihuri, Harri Nurmi, Salli Antila, Jennifer Paech, Urban Deutsch, Britta Engelhardt, Sudhakar Chintharlapalli, Gou Young Koh, Alexander Flügel, Kari Alitalo
Published in: Journal of Clinical Investigation, Issue 130/4, 2020, Page(s) 1977-1990, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci130308

Book chapters (1)

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery

Author(s): Sinem Karaman, Harri Nurmi, Salli Antila, Kari Alitalo
Published in: Lymphangiogenesis - Methods and Protocols, Issue 1846, 2018, Page(s) 291-300, ISBN 978-1-4939-8711-5
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8712-2_19