Translational implications of the discovery of brain-draining lymphatics

Publications

Characterization of ANGPT2 mutations associated with primary lymphedema

Auteurs: Veli-Matti Leppänen, Pascal Brouillard, Emilia A Korhonen, Tuomas Sipilä, Sawan Kumar Jha, Nicole Revencu, Veerle Labarque, Elodie Fastré, Matthieu Schlögel, Marie Ravoet, Amihood Singer, Claudia Luzzatto, Donatella Angelone, Giovanni Crichiutti, Angela D'Elia, Jaakko Kuurne, Harri Elamaa, Gou Young Koh, Pipsa Saharinen, Miikka Vikkula, Kari Alitalo
Publié dans: Science Translational Medicine, 2020, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8013

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Auteurs: Anaïs Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Müller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe
Publié dans: Brain, Behaviour, & Immunity - Health, 2022, ISSN 2666-3546
Éditeur: Elsevier Inc.
DOI: 10.1016/j.bbih.2022.100466

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Auteurs: Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Publié dans: Nature Cardiovascular Research, 2023, ISSN 2731-0590
Éditeur: Nature Portfolio
DOI: 10.1038/s44161-023-00224-y

Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury

Auteurs: Sara Wojciechowski, Anaïs Virenque, Maria Vihma, Barbara Galbardi, Erin Jane Rooney, Meike Hedwig Keuters, Salli Antila, Jari Koistinaho, Francesco M Noe
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2020.559810

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

Auteurs: Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H Lackman, Amanda Ranta, Karthik A Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Publié dans: Journal of Experimental Medicine, 2022, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20210565

Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation

Auteurs: Zhilin Li, Salli Antila, Harri Nurmi, Dmitri Chilov, Emilia Korhonen, Shentong Fang, Sinem Karaman, Britta Engelhardt, Kari Alitalo
Publié dans: Science Immunology, 2023, ISSN 2470-9468
Éditeur: American association for the advancement of science
DOI: 10.1126/sciimmunol.abq0375

Development and plasticity of meningeal lymphatic vessels

Auteurs: Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H. Voutilainen, Thomas Mathivet, Dmitri Chilov, Zhilin Li, Tapani Koppinen, Jun-Hee Park, Shentong Fang, Aleksanteri Aspelund, Mart Saarma, Anne Eichmann, Jean-Léon Thomas, Kari Alitalo
Publié dans: The Journal of Experimental Medicine, Numéro 214/12, 2017, Page(s) 3645-3667, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20170391

Vascular endothelial growth factor signaling in development and disease

Auteurs: Sinem Karaman, Veli-Matti Leppänen, Kari Alitalo
Publié dans: Development, Numéro 145/14, 2018, Page(s) dev151019, ISSN 0950-1991
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dev.151019

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

Auteurs: Antoine Louveau, Benjamin A. Plog, Salli Antila, Kari Alitalo, Maiken Nedergaard, Jonathan Kipnis
Publié dans: Journal of Clinical Investigation, Numéro 127/9, 2017, Page(s) 3210-3219, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci90603

Anatomy and function of the vertebral column lymphatic network in mice

Auteurs: Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann, Jean-Leon Thomas
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-12568-w

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

Auteurs: Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch
Publié dans: eLife, Numéro 8, 2019, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.44478

Cardiac lymphatics in health and disease

Auteurs: Ebba Brakenhielm, Kari Alitalo
Publié dans: Nature Reviews Cardiology, Numéro 16/1, 2019, Page(s) 56-68, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-018-0087-8

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Auteurs: Zhilin Li, Emilia A. Korhonen, Arianna Merlini, Judith Strauss, Eleonoora Wihuri, Harri Nurmi, Salli Antila, Jennifer Paech, Urban Deutsch, Britta Engelhardt, Sudhakar Chintharlapalli, Gou Young Koh, Alexander Flügel, Kari Alitalo
Publié dans: Journal of Clinical Investigation, Numéro 130/4, 2020, Page(s) 1977-1990, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci130308

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery

Auteurs: Sinem Karaman, Harri Nurmi, Salli Antila, Kari Alitalo
Publié dans: Lymphangiogenesis - Methods and Protocols, Numéro 1846, 2018, Page(s) 291-300, ISBN 978-1-4939-8711-5
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-8712-2_19

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