The Role of Neuroinflammation in Alzheimer’s Disease

Información del proyecto

INFLAMM-ALZ

Identificador del acuerdo de subvención: 750403

DOI

10.3030/750403

Proyecto finalizado el 21 Septiembre 2018

Fecha de la firma de la CE 20 Marzo 2017

Fecha de inicio 1 Noviembre 2017

Fecha de finalización 31 Octubre 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 173 857,20

Aportación de la UE

€ 173 857,20

Coordinado por

GOETEBORGS UNIVERSITET
Sweden

Objetivo

Alzheimer’s disease (AD) is a major public health problem with substantial economical and social impacts worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Under homeostasis, a delicate balance is struck between disposal of pathogenic proteins by the brain’s immune cells, microglia, and the inflammation produced by these cells. Indeed, during an acute activation, microglia are protective, but if microglia enter an over-activated state they can induce chronic inflammation through oxidative stress that in turn leads to neuronal damage. Thus, gaining data on the chain of events involved in microglial action is a prerequisite to understanding AD. This project is a large interdisciplinary collaborative effort involving well-established methods such as confocal imaging and transgenic zebrafish, with newly developed photopharmacological tools. Drs Kettunen, Grøtli and Andréasson provide the world-leading expertise required for the project. By coordinating this project, Dr Mourabit will gain invaluable experience in biomedical research, photochemistry, project management, supervision, and the production of scientific results. The novel photoresponsive probes used here will allow for photonic in vivo de/activation of microglia, generating new information on their spatiotemporal activity, in real-time. This state-of-the-art resolution of cell-tracking and control of microglial signalling will provide innovative data on the pathology of neuroinflammation. We believe this interdisciplinary team will push the boundaries of research in AD. This project has the potential to identify new treatments for AD, and influence the direction of neurobiology. This project will create a unique career opportunity for Dr Mourabit, enabling him to crossover from an environmental background to biomedical research. The marrying of such interconnected disciplines will help Dr Mourabit set the foundations of an eclectic and vibrant research group.

Ámbito científico (EuroSciVoc)

• ciencias médicas y de la salud › medicina básica › farmacología y farmacia › descubrimiento de fármacos
• ciencias médicas y de la salud › medicina básica › neurología › epilepsia
• ciencias médicas y de la salud › ciencias de la salud › salud pública y medio ambiental
• ciencias médicas y de la salud › medicina básica › neurología › demencia › alzheimer
• ciencias médicas y de la salud › medicina básica › inmunología

Palabras clave

• Alzheimer's disease
• pathology
• inflammation
• neurodegeneration
• neurobiology
• animal
• behaviour
• microglia
• photopharmacology
• transgenic
• zebrafish
• confocal imaging
• learning
• memory

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2016 - Individual Fellowships
  

Régimen de financiación

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Convocatoria de propuestas

H2020-MSCA-IF-2016

Coordinador

GOETEBORGS UNIVERSITET

• Aportación neta de la UEn: € 173 857,20
• Dirección: VASAPARKEN ; 405 30 Goeteborg ; Suecia
• Región: Södra Sverige › Västsverige › Västra Götalands län
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: € 173 857,20