Personalised Medicine in Diabetic Chronic Disease Management

Deliverables

Research Training Portfolio This consist of where appropriate i TSPs set up for each ESR M12 ii PROMINENT specific course for all ESRs and pillarspecific course on current topics in the field M13 iii External secondments research training at Partner Organisations M60 iv PhD degree awarded to all ESRs M60

Ethics Report for each call

The Ethics Reports after each call should contain at least the following information: - A short description on how the ethics procedure in place (as described in Annex I of the Grant Agreement) was followed and the adaptations made if relevant. This part should also include a description of the role and composition of the ethics committee if such a committee was involved. - An overview table based on the following structure (only for the successful fellows): name of the researcher; the title of research project with ethical issues; the ethics area(s) concerned; conditions to be fulfilled for funding and ethics requirements to be monitored during implementation; follow-up during the implementation. Only those research projects having ethics issues need to be detailed in this table (M18).

Final Ethics Report

The Final Ethics Report should summarise the ethics procedure followed during the entire project lifecycle and focus on the adaptation made and lessons learned The report should also confirm that all required approvals authorisations were obtained and that the research was conducted in compliance with the ethical principles and applicable international EU and national law under H2020 M60

Report/s on dissemination activities

Report on dissemination activities (containing at least the following information): i) dates of Call Publication and places where is was published (supporting documents required).

Inform for each call the Project Officer

Inform for each call the Project Officer by sending the link to the Euraxess website where the call has been published (M2). This delivarble shall provide the PO with deatils of the publication of the call on the Euraxess website. Note: data on Euraxess shall be prived any time between M1 and M2.

Publications

Less Timely Initiation of Glucose-Lowering Medication Among Younger and Male Patients With Diabetes and Similar Initiation of Blood Pressure-Lowering Medication Across Age and Sex: Trends Between 2015 and 2020

Author(s): Martina Ambrož, Sieta T. de Vries, Klaas Hoogenberg, Petra Denig
Published in: Front Pharmacol, 2022, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.883103

Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70-/- mice with human-like bile acids

Author(s): Hilde D. de Vries, Anna Palmiotti, Rumei Li, Milaine V. Hovingh, Niels L. Mulder, Martijn Koehorst, Vincent W. Bloks, Tim van Zutphen, Folkert Kuipers, Jan Freark de Boer
Published in: Pediatr Res, 2023, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-022-02303-5

Personalizing the Use of a Intermittently Scanned Continuous Glucose Monitoring (isCGM) Device in Individuals With Type 1 Diabetes: A Cost-Effectiveness Perspective in the Netherlands (FLARE-NL 9)

Author(s): Sajad Emamipour, Peter R van Dijk, Henk J G Bilo, Mireille A Edens, Onno van der Galiën, Maarten J Postma, Talitha L Feenstra, Job F M van Boven
Published in: J Diabetes Sci Technol, 2022, ISSN 1932-2968
Publisher: Diabetes Technology Society
DOI: 10.1177/19322968221109841

TEMPO‐Mediated Electrochemical N‐demethylation of Opiate Alkaloids

Author(s): Ali Alipour Najmi, M. Faizan Bhat, Rainer Bischoff, Gerrit J. Poelarends, Hjalmar P. Permentier
Published in: ChemElectroChem, Issue 8/13, 2021, Page(s) 2590-2596, ISSN 2196-0216
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/celc.202100784

HDL particle subspecies and their association with incident type 2 diabetes: the PREVEND study

Author(s): Sara Sokooti, Jose L Flores-Guerrero, Lyanne M Kieneker, Hiddo J L Heerspink, Margery A Connelly, Stephan J L Bakker, Robin P F Dullaart
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab075

Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK

Author(s): Manouk J.W. van Mourik, Vicente Artola Arita, Aurore Lyon, Joost Lumens, Ruben R. De With, Joost P. van Melle, Ulrich Schotten, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra, Dominik K. Linz
Published in: Int J Cardiol, 2022, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.05.044

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Author(s): Deng Chen, Angelina Osipyan, Jeaunice Adriana, Mohammed Kader, Maxim Gureev, Catharina W. J. Knol, Marie-Cathérine Sigmund, Zhangping Xiao, Petra E. van der Wouden, Robbert H. Cool, Gerrit J. Poelarends, and Frank J. Dekker
Published in: J Med Chem, 2023, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00397

Older Age, Polypharmacy, and Low Systolic Blood Pressure Are Associated With More Hypotension-Related Adverse Events in Patients With Type 2 Diabetes Treated With Antihypertensives

Author(s): Martina Ambrož, Sieta T. de Vries, Klaas Hoogenberg and Petra Denig
Published in: Frontiers in Pharmacology, Issue 12, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.728911

Plasma creatine concentration is associated with incident hypertension in a cohort enriched for the presence of high urinary albumin concentration

Author(s): Adrian Post, Daan Kremer, J. Casper Swarte, Sara Sokooti, Fabian A. Vogelpohl, Dion Groothof, Ido.P. Kema, Erwin Garcia, Margery A. Connelly, Theo Wallimann, Robin P.F. Dullaart, Casper F.M. Franssen, Stephan J.L. Bakker
Published in: Journal of Hypertension, Issue Publish Ahead of Print, 2021, ISSN 0263-6352
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/hjh.0000000000002996

The transferability and validity of a population-level simulation model for the economic evaluation of interventions in diabetes: the MICADO model

Author(s): Sajad Emamipour, Eva Pagano, Daniela Di Cuonzo, Stefan R. A. Konings, Amber A. van der Heijden, Petra Elders, Joline W. J. Beulens, Jose Leal, Talitha L. Feenstra
Published in: Acta Diabetol, 2022, ISSN 0940-5429
Publisher: Springer Verlag
DOI: 10.1007/s00592-022-01891-2

Separate and combined effects of individual and neighbourhood socio-economic disadvantage on health-related lifestyle risk factors: a multilevel analysis

Author(s): Yinjie Zhu, Ming-Jie Duan, Ineke J Riphagen, Isidor Minovic, Jochen O Mierau, Juan-Jesus Carrero, Stephan J L Bakker, Gerjan J Navis, Louise H Dekker
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab079

Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population

Author(s): Sokooti S, Kieneker LM, de Borst MH, Muller Kobold A, Kootstra-Ros JE, Gloerich J, van Gool AJ, Lambers Heerspink HJ, Gansevoort RT, Dullaart RPF, Bakker SJL
Published in: Journal of Clinical Medicine, 2020, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9093001

Changes in blood pressure thresholds for initiating antihypertensive medication in patients with diabetes: a repeated cross-sectional study focusing on the impact of age and frailty

Author(s): Martina Ambrož, Sieta T de Vries, Grigory Sidorenkov, Klaas Hoogenberg, Petra Denig
Published in: BMJ Open, Issue 10/9, 2020, Page(s) e037694, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-037694

Effects of Education and Income on Incident Type 2 Diabetes and Cardiovascular Diseases: a Dutch Prospective Study

Author(s): Ming-Jie F Duan, Yinjie Zhu, Louise H Dekker, Jochen O Mierau, Eva Corpeleijn, Stephan J L Bakker, Gerjan Navis
Published in: Journal of general internal medicine, 2022, ISSN 0884-8734
Publisher: Blackwell Publishing Inc.
DOI: 10.1007/s11606-022-07548-8

Metabolic features and glucocorticoid-induced comorbidities in patients with giant cell arteritis and polymyalgia rheumatica in a Dutch and Danish cohort

Author(s): Idil Esen, Suzanne Arends, Berit Dalsgaard Nielsen, Philip Therkildsen, Ib Hansen, Anna van 't Ende, Peter Heeringa, Annemieke Boots, Ellen Hauge, Elisabeth Brouwer, Yannick van Sleen
Published in: RMD Open, 2023, ISSN 2056-5933
Publisher: BMJ Publishing Group Ltd
DOI: 10.1136/rmdopen-2022-002640

Prediction of the Effects of Empagliflozin on Cardiovascular and Kidney Outcomes Based on Short-Term Changes in Multiple Risk Markers

Author(s): Sok Cin Tye, Sieta T. de Vries, Christoph Wanner, Petra Denig, Hiddo J. L. Heerspink
Published in: Front Pharmacol, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.786706

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Author(s): Angelina Osipyan, Deng Chen, Frank J. Dekker
Published in: Drug Discovery Today, 2021, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2021.03.012

Sex Differences in Lipid Profile across the Life Span in Patients with Type 2 Diabetes: A Primary Care-Based Study

Author(s): Martina Ambrož, Sieta T. de Vries, Priya Vart, Robin P. F. Dullaart, Jeanine Roeters van Lennep, Petra Denig, Klaas Hoogenberg
Published in: Journal of Clinical Medicine, Issue 10/8, 2021, Page(s) 1775, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10081775

Precision medicine approaches for diabetic kidney disease: opportunities and challenges

Author(s): Sok Cin Tye, Petra Denig, Hiddo J L Heerspink
Published in: Nephrology Dialysis Transplantation, Issue 36/Supplement_2, 2021, Page(s) 3-9, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfab045

Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells

Author(s): Zhangping Xiao, Angelina Osipyan, Shanshan Song, Deng Chen, Reinder A. Schut, Ronald van Merkerk, Petra E. van der Wouden, Robbert H. Cool, Wim J. Quax, Barbro N. Melgert, Gerrit J. Poelarends, and Frank J. Dekker
Published in: J Med Chem, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c01598

Microscopic modulation and analysis of islets of Langerhans in living zebrafish larvae

Author(s): Noura Faraj, B. H. Peter Duinkerken, Elizabeth C. Carroll, Ben N. G. Giepmans
Published in: FEBS Lett, 2022, ISSN 1873-3468
Publisher: John Wiley & Sons, Inc
DOI: 10.1002/1873-3468.14411

Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study

Author(s): Vicente Artola Arita, Martijn E Van De Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M Van Melle, Bastiaan Geelhoed, Ruben R De With, Vanessa Weberndörfer, Ömer Erküner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M H Spronk, Tim Koldenhof, Robert G Tieleman, Ulrich Schotten, Harry J G M Crijns, Isabelle C Van Gelder, Michiel Rienstra
Published in: Europace, 2023, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euac268

Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis

Author(s): Idil Esen, Maria Sandovici, Peter Heeringa, Annemieke M.H. Boots, Elisabeth Brouwer, Yannick van Sleen, Wayel Abdulahad
Published in: Journal of Autoimmunity, Issue 146, 2024, ISSN 1095-9157
Publisher: Elsevier
DOI: 10.1016/j.jaut.2024.103215

Using Structural Equation Modeling to Untangle Pathways of Risk Factors Associated with Incident Type 2 Diabetes: the Lifelines Cohort Study

Author(s): Ming-Jie Duan, Louise H Dekker, Juan-Jesus Carrero, Gerjan Navis
Published in: Prevention science, 2022, ISSN 1389-4986
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11121-022-01357-5

Association between socioeconomic status and self-reported, tested and diagnosed COVID-19 status during the first wave in the Northern Netherlands: a general population-based cohort from 49 474 adults

Author(s): Yinjie Zhu, Ming-Jie Duan, Hermien H. Dijk, Roel D. Freriks, Louise H. Dekker, Jochen O. Mierau
Published in: BMJ Open, Issue 11/3, 2021, Page(s) e048020, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-048020

Initiation of the SGLT2 inhibitor canagliflozin to prevent kidney and heart failure outcomes guided by HbA1c, albuminuria, and predicted risk of kidney failure

Author(s): Sok Cin Tye, Niels Jongs, Steven G. Coca, Johan Sundström, Clare Arnott, Bruce Neal, Vlado Perkovic, Kenneth W. Mahaffey, Priya Vart, Hiddo. J. L. Heerspink
Published in: Cardiovasc Diabetol, 2022, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-022-01619-0

Distinct Pathological Pathways in Patients With Heart Failure and Diabetes

Author(s): Jasper Tromp, Adriaan A Voors, Abhinav Sharma, João P Ferreira, Wouter Ouwerkerk, Hans L Hillege, Karla A Gomez, Kenneth Dickstein, Stefan D Anker, Marco Metra, Chim C Lang, Leong L Ng, Pim van der Harst, Dirk J van Veldhuisen, Peter van der Meer, Carolyn S P Lam, Faiez Zannad, Iziah E Sama
Published in: JACC Heart Fail, 2020, ISSN 2213-1779
Publisher: Elsevier BV
DOI: 10.1016/j.jchf.2019.11.005

Human iPSC-Derived Cardiomyocytes of Peripartum Patients With Cardiomyopathy Reveal Aberrant Regulation of Lipid Metabolism

Author(s): Martijn F. Hoes, Nils Bomer, Melanie Ricke-Hoch, Tristan V. de Jong, Karla F. Arevalo Gomez, Stefan Pietzsch, Denise Hilfiker-Kleiner, Peter van der Meer
Published in: Circulation, 2020, ISSN 1524-4539
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/circulationaha.119.044962

Remnant lipoprotein cholesterol is associated with incident new onset diabetes after transplantation (NODAT) in renal transplant recipients: results of the TransplantLines Biobank and cohort Studies

Author(s): Tamas Szili-Torok, Sara Sokooti, Maryse C J Osté, Antonio W Gomes-Neto, Robin P F Dullaart, Stephan J L Bakker, Uwe J F Tietge
Published in: Cardiovascular diabetology, Issue 21, 2022, Page(s) 41, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-022-01475-y

Gain-of-function mutation in ubiquitin-ligase KLHL24 causes desmin degradation and dilatation in hiPSC-derived engineered heart tissues

Author(s): Mathilde Csc Vermeer, Maria C Bolling, Jacqueline M Bliley, Karla F Arevalo Gomez, Mario G Pavez-Giani, Duco Kramer, Pedro H Romero-Herrera, B Daan Westenbrink, Gilles Fh Diercks, Maarten P van den Berg, Adam W Feinberg, Herman H W Silljé, Peter van der Meer
Published in: J Clin Invest, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci140615

Chemoenzymatic Asymmetric Synthesis of Complex Heterocycles: Dihydrobenzoxazinones and Dihydroquinoxalinones

Author(s): Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Gerrit J. Poelarends
Published in: ACS Catal, 2022, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c03008

Prediction of the Effects of Liraglutide on Kidney and Cardiovascular Outcomes Based on Short-Term Changes in Multiple Risk Markers

Author(s): Sok Cin Tye, Sieta T. de Vries, Johannes F. E. Mann, Meir Schechter, Ofri Mosenzon, Petra Denig, Hiddo J. L. Heerspink
Published in: Front Pharmacol, 2022, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.786767

The importance of targeting multiple risk markers in patients with type 2 diabetes: A post-hoc study from the CANVAS programme

Author(s): Sok Cin Tye, Megumi Oshima, Clare Arnott, Brendon L. Neuen, Robert A. Fletcher, Bruce Neal, Hiddo J. L. Heerspink
Published in: Diabetes Obes Metab, 2023, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.15018

A novel drug response score more accurately predicts renoprotective drug effects than existing renal risk scores

Author(s): Nienke M. A. Idzerda, Sok Cin Tye, Dick de Zeeuw, Hiddo J. L. Heerspink
Published in: Therapeutic Advances in Endocrinology and Metabolism, Issue 12, 2021, Page(s) 204201882097419, ISSN 2042-0188
Publisher: Sage Periodicals Press
DOI: 10.1177/2042018820974191

Association of asthma genetic variants with asthma‐associated traits reveals molecular pathways of eosinophilic asthma

Author(s): Zaid W. El‐Husseini, Judith M. Vonk, Maarten van den Berge, Reinoud Gosens, Gerard H. Koppelman
Published in: Clin Transl Allergy, 2023, ISSN 2045-7022
Publisher: John Wiley and Sons, Ltd
DOI: 10.1002/clt2.12239

Clinical Outcome in KLHL24 Cardiomyopathy

Author(s): Mathilde C.S.C. Vermeer, Karla F. Arevalo Gomez, Martijn F. Hoes, Jasper Tromp, Job A.J. Verdonschot, Michiel T.H.M. Henkens, Herman H.W. Silljé, Maria C. Bolling, Peter van der Meer
Published in: Circ Genom Precis Med, 2023, ISSN 2574-8300
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/circgen.122.003998

Ultraprocessed food consumption and kidney function decline in a population-based cohort in the Netherlands

Author(s): Qingqing Cai, Ming-Jie Duan, Louise H Dekker, Juan Jesús Carrero, Carla Maria Avesani, Stephan J L Bakker, Martin H de Borst, Gerjan J Navis
Published in: The American journal of clinical nutrition, Issue 116, 2022, Page(s) 263-273, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqac073

What Factors Make EU Regulators Want to Communicate Drug Safety Issues Related to SGLT2 Inhibitors? An Online Survey Study

Author(s): Sonia Roldan Munoz, Douwe Postmus, Sieta T. de Vries, Liana Gross-Martirosyan, Priya Bahri, Hans Hillege, Peter G. M. Mol
Published in: Drug Saf, 2023, ISSN 0114-5916
Publisher: Adis International Ltd.
DOI: 10.1007/s40264-022-01270-4

Lifestyle patterns and incident type 2 diabetes in the Dutch lifelines cohort study

Author(s): Ming-Jie Duan, Louise H. Dekker, Juan-Jesus Carrero, Gerjan Navis
Published in: Prev Med Rep, 2022, ISSN 2211-3355
Publisher: Elsevier BV
DOI: 10.1016/j.pmedr.2022.102012

Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies

Author(s): Ruben R De With, Vicente Artola Arita, Bao-Oanh Nguyen, Dominik Linz, Hugo Ten Cate, Henri Spronk, Ulrich Schotten, Anton Jan van Zonneveld, Ömer Erküner, M Agustina Bayón, Anders S Schmidt, Justin G L M Luermans, Harry J G M Crijns, Isabelle C Van Gelder, Michiel Rienstra
Published in: EP Europace, 2021, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euab179

Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites

Author(s): Sara Russo, Marcel Kwiatkowski, Natalia Govorukhina, Rainer Bischoff, Barbro N Melgert
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 746151, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.746151.

Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

Author(s): Qian Wang, Angelina Osipyan, Markella Konstantinidou, Roberto Butera, Kumchok C. Mgimpatsang, Svitlana V. Shishkina, Alexander Dömling
Published in: The Journal of Organic Chemistry, 2019, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.9b01258

Differences in medication beliefs between pregnant women using medication, or not, for chronic diseases: a cross-sectional, multinational, web-based study

Author(s): Sonia Roldan Munoz, Angela Lupattelli, Sieta T de Vries, Peter G M Mol, Hedvig Nordeng
Published in: BMJ Open, Issue 10/2, 2020, Page(s) e034529, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2019-034529

Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines

Author(s): Angelina Osipyan, Shabnam Shaabani, Robert Warmerdam, Svitlana V. Shishkina, Harry Boltz, Alexander Dömling
Published in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202000887

High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients

Author(s): Sara Sokooti, Tamas Szili-Torok, Jose L. Flores-Guerrero, Maryse C. J. Osté, António W. Gomes-Neto, Jenny E. Kootstra-Ros, Hiddo J.L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Published in: Biomolecules, Issue 10/3, 2020, Page(s) 481, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom10030481

A personalised screening strategy for diabetic retinopathy: a cost-effectiveness perspective

Author(s): Sajad Emamipour, Amber A. W. A. van der Heijden, Giel Nijpels, Petra Elders, Joline W. J. Beulens, Maarten J. Postma, Job F. M. van Boven, Talitha L. Feenstra
Published in: Diabetologia, 2020, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05239-9

Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid

Author(s): Jan Freark de Boer, Hilde D. de Vries, Anna Palmiotti, Rumei Li, Marwah Doestzada, Joanne A. Hoogerland, Jingyuan Fu, Anouk M. La Rose, Marit Westerterp, Niels L. Mulder, Milaine V. Hovingh, Martijn Koehorst, Niels J. Kloosterhuis, Justina C. Wolters, Vincent W. Bloks, Joel T. Haas, David Dombrowicz, Bart Staels, Bart van de Sluis, Folkert Kuipers
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 11/4, 2021, Page(s) 1045-1069, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.12.004•

Preferences about Future Alzheimer’s Disease Treatments Elicited through an Online Survey Using the Threshold Technique

Author(s): Sonia Roldan Munoz, S. T. de Vries, G. Lankester, F. Pignatti, B. C. van Munster, I. Radford, L. Guizzaro, P. G. M. Mol, H. Hillege, D. Postmus
Published in: The Journal of Prevention of Alzheimer's Disease, 2023, ISSN 2426-0266
Publisher: Springer
DOI: 10.14283/jpad.2023.84

Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70 -/- mice by reducing fat absorption

Author(s): Rumei Li, Anna Palmiotti, Hilde D de Vries, Milaine V Hovingh, Martijn Koehorst, Niels L Mulder, Yue Zhang, Kim Kats, Vincent W Bloks, Jingyuan Fu, Henkjan J Verkade, Jan Freark de Boer, Folkert Kuipers
Published in: Journal of lipid research, Issue 62, 2021, Page(s) 100134, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2021.100134

Atrial function in paroxysmal AF patients withand without heart failure with preservedejection fraction: Data from the AF-RISK study

Author(s): Vicente Artola Arita, Bernadet T Santema, Ruben R De With, Bao-Oanh Nguyen, Dominik Linz, Ulrich Schotten, Isabelle C Van Gelder, Harry Jgm Crijns, Adriaan A Voors, Michiel Rienstra
Published in: American Heart Journal, Issue 244, 2022, Page(s) 36-41, ISSN 0002-8703
Publisher: Mosby Inc.
DOI: 10.1016/j.ahj.2021.10.183

The genetics of asthma and the promise of genomics-guided drug target discovery

Author(s): Zaid W El-Husseini, Reinoud Gosens, Frank Dekker, Gerard H Koppelman
Published in: The Lancet Respiratory Medicine, 2020, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30363-5

Sex disparities in medication prescribing amongst patients with type 2 diabetes mellitus managed in primary care

Author(s): Martina Ambrož, Marit Geelink, Kirsten P.J. Smits, Sieta T. de Vries, Petra Denig
Published in: Diabet Med, 2023, ISSN 1464-5491
Publisher: Wiley
DOI: 10.1111/dme.14987

Trends in HbA1c thresholds for initiation of hypoglycemic agents: Impact of changed recommendations for older and frail patients

Author(s): Martina Ambrož, Sieta T. de Vries, Klaas Hoogenberg, Petra Denig
Published in: Pharmacoepidemiology and Drug Safety, 2020, ISSN 1099-1557
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/pds.5129

Chemo- and Enantioselective Photoenzymatic Ketone Reductions Using a Promiscuous Flavin-dependent Nitroreductase

Author(s): Alejandro Prats Luján, Mohammad Faizan Bhat, Thangavelu Saravanan, Gerrit J. Poelarends
Published in: ChemCatChem, 2022, ISSN 1867-3899
Publisher: Chemistry Europe
DOI: 10.1002/cctc.202200043

Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population

Author(s): Sara Sokooti, Wendy A Dam, Tamas Szili-Torok, Jolein Gloerich, Alain J van Gool, Adrian Post, Martin H de Borst, Ron T Gansevoort, Hiddo J L Heerspink, Robin P F Dullaart, Stephan J L Bakker
Published in: Journal of personalized medicine, Issue 12, 2022, Page(s) 1131, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm12071131

Differences in Importance Attached to Drug Effects Between Patients With Type 2 Diabetes From the Netherlands and Turkey: A Preference Study

Author(s): Sonia Roldan Munoz, Douwe Postmus, Sieta T. de Vries, Arna H. Arnardottir, İlknur Dolu, Hans Hillege, Peter G. M. Mol
Published in: Frontiers in Pharmacology, Issue 11, 2021, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.617409

Emerging roles of bile acids in control of intestinal functions

Author(s): Jiufang Yang, Anna Palmiotti, Folkert Kuipers
Published in: Current opinion in clinical nutrition and metabolic care, Issue 24, 2021, Page(s) 127-133, ISSN 1363-1950
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mco.0000000000000709

Triglyceride-rich lipoprotein and LDL particle subfractions and their association with incident type 2 diabetes: the PREVEND study

Author(s): Sara Sokooti, Jose L. Flores-Guerrero, Hiddo J. L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Published in: Cardiovascular Diabetology, Issue 20/1, 2021, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-021-01348-w

Lipoprotein particle sizes and incident type 2 diabetes: the PREVEND cohort study

Author(s): Sara Sokooti, José L. Flores-Guerrero, Hiddo J. L. Heerspink, Erwin Garcia, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Published in: Diabetologia, 2021, ISSN 1432-0428
Publisher: Springer
DOI: 10.1007/s00125-021-05603-3

Functionally Heterogenous Macrophage Subsets in the Pathogenesis of Giant Cell Arteritis: Novel Targets for Disease Monitoring and Treatment

Author(s): Idil Esen, William F. Jiemy, Yannick van Sleen, Kornelis S.M. van der Geest, Maria Sandovici, Peter Heeringa, Annemieke M. H. Boots, Elisabeth Brouwer
Published in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10214958

Ultra-processed food and incident type 2 diabetes: studying the underlying consumption patterns to unravel the health effects of this heterogeneous food category in the prospective Lifelines cohort

Author(s): Ming-Jie Duan, Petra C. Vinke, Gerjan Navis, Eva Corpeleijn, Louise H. Dekker
Published in: BMC Medicine, 2022, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-02200-4

Collagen type I alters the proteomic signature of macrophages in a collagen morphology-dependent manner

Author(s): Gwenda F. Vasse, Sara Russo, Andrei Barcaru, Asmaa A. A. Oun, Amalia M. Dolga, Patrick van Rijn, Marcel Kwiatkowski, Natalia Govorukhina, Rainer Bischoff, Barbro N. Melgert
Published in: Sci Rep, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-32715-0

Author(s): Ming-Jie Duan, Louise H. Dekker, Juan-Jesus Carrero, Gerjan Navis
Published in: Clinical Nutrition, Issue 40/7, 2021, Page(s) 4712-4719, ISSN 0261-5614
Publisher: Churchill Livingstone
DOI: 10.1016/j.clnu.2021.04.046

Ultra-processed foods and risk of all-cause mortality in renal transplant recipients

Author(s): Maryse C J Osté, Ming-Jie Duan, Antonio W Gomes-Neto, Petra C Vinke, Juan-Jesus Carrero, Carla Avesani, QingQing Cai, Louise H Dekker, Gerjan J Navis, Stephan J L Bakker, Eva Corpeleijn
Published in: The American journal of clinical nutrition, Issue 115, 2022, Page(s) 1646-1657, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqac053

Association of diuretic use with increased risk for long-term post-transplantation diabetes mellitus in kidney transplant recipients

Author(s): Sara Sokooti, Frank Klont, Sok Cin Tye, Daan Kremer, Rianne M Douwes, Gérard Hopfgartner, Robin P F Dullaart, Hiddo J L Heerspink, Stephan J L Bakker
Published in: Nephrology, diabetes, transplantation, Issue 37, 2022, Page(s) 1375-1383, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfac012

Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study

Author(s): Adrian Post, Wendy A Dam, Sara Sokooti, Dion Groothof, Jolein Gloerich, Alain J van Gool, Daan Kremer, Ron T Gansevoort, Jacob van den Born, Ido P Kema, Casper F M Franssen, Robin P F Dullaart, Stephan J L Bakker
Published in: J Clin Endocrinol Metab, 2023, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgac729

Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis

Author(s): Idil Esen, William F Jiemy, Yannick van Sleen, Johan Bijzet, Daniel M de Jong, Pieter H Nienhuis, Riemer H J A Slart, Peter Heeringa, Annemieke M H Boots, Elisabeth Brouwer
Published in: Rheumatology, 2021, ISSN 1462-0332
Publisher: Oxford Academic
DOI: 10.1093/rheumatology/keab814

Androgens and Development of Posttransplantation Diabetes Mellitus in Male Kidney Transplant Recipients: A Post Hoc Analysis of a Prospective Study

Author(s): Suzanne P Stam, Sara Sokooti, Michele F Eisenga, Anna van der Veen, António W Gomes-Neto, Peter R van Dijk, Jelmer J van Zanden, Michel J Vos, Ido P Kema, André P van Beek, Stephan J L Bakker, TransplantLines Investigators
Published in: Diabetes Care, Issue 44, 2021, Page(s) 2683-2690, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-0237

Bile Acid Sequestration by Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-Like Bile Acid Composition

Author(s): Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Published in: Preprints, 2023, ISSN 2310-287X
Publisher: Preprints
DOI: 10.20944/preprints202308.0779.v1

Comment on: Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis: reply

Author(s): Idil Esen, William F Jiemy, Yannick van Sleen, Rosanne D Reitsema, Johan Bijzet, Daniel M de Jong, Pieter H Nienhuis, Riemer H J A Slart, Peter Heeringa, Annemieke M H Boots, Elisabeth Brouwer
Published in: Rheumatology (Oxford), 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac093

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